scholarly journals Leaf Essential Oil of Manekia naranjoana (Piperaceae) from Costa Rica and its Cytotoxic Activity

2011 ◽  
Vol 6 (1) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Carlos Chaverri ◽  
Cecilia Díaz ◽  
José F. Cicció
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Tumor Cell Lines ◽  
Capillary Gc ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Low Toxicity

The chemical composition of the leaf oil of Manekia naranjoana (C. DC.) Callejas (Piperaceae) from Costa Rica was analyzed by capillary GC/FID and GC/MS. Fifty-five compounds were identified. Major compounds from the leaf oil were β-pinene (30.6%), α-pinene (18.8%), limonene (13.7%), and β-caryophyllene (6.1%). The oil presented very low toxicity to tumor and non-tumor cell lines, even though it contains components, such as α- and β-pinene, limonene and others, which have been shown to be cytotoxic. This is the first report of the chemical composition of the essential oil obtained from this species.

scholarly journals Caryophyllene-Rich Essential Oil of Didymocarpus Tomentosa: Chemical Composition and Cytotoxic Activity

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Prameela Javarayi Gowda ◽  
Hanumanthaiah Ramakrishnaiah ◽  
Venkatarangaiah Krishna ◽  
Sivakrishna Narra ◽  
Nataraj Jagannath
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Mtt Assay ◽  
Tumor Cell Line ◽  
Caryophyllene Oxide ◽  
Leaf Oil ◽  
Leaf Essential Oil

The essential oil from the leaves of Didymocarpus tomentosa was extracted by hydrodistillation and analyzed by GC/FID and GC/MS. Twenty five constituents amounting to 81.6% of the oil were identified. The leaf oil contained 78.7% sesquiterpenes and 2.9% monoterpenes. The leaf essential oil of D. tomentosa is a unique caryophyllene-rich natural source containing β-caryophyllene, caryophyllene oxide, α-humulene and humulene oxide. The cytotoxic activity of the oil was determined by the BSLT using shrimp larva and the MTT assay using HeLa tumor cell line. The oil showed significant cytotoxic activity with LC50 and IC50 values of 12.26 and 11.4 μg/mL, respectively. This is the first report on the chemical composition and cytotoxic activity of the essential oil of D. tomentosa.

scholarly journals Composition and in vitro Anticancer Activities of the Leaf Essential Oil of Neolitsea variabillima from Taiwan

2013 ◽  
Vol 8 (4) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Yu-Chang Su ◽  
Kuan-Ping Hsu ◽  
Eugene I-Chen Wang ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Anticancer Activities ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in vitro anticancer activities of the essential oil isolated from the leaf of Neolitsea variabillima. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Sixty-seven compounds were identified, representing 100% of the oil. The main components identified were trans-β-ocimene (13.4%), α-cadinol (10.5%), terpinen-4-ol (9.3%), τ-cadinol (9.2%), β-caryophyllene (8.8%), and sabinene (6.7%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The presence of β-caryophyllene, τ-cadinol, and α-cadinol significantly contributed to the anticancer activities of N. variabillima leaf oil.

scholarly journals Chemical Composition and Cytotoxic Activity of the Leaf Essential Oil of Ocotea tonduzii from Monteverde, Costa Rica

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Anita Bansal ◽  
Debra M. Moriarity ◽  
Sayaka Takaku ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activities ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Oil Components ◽  
Mcf 7

The leaf essential oil of Ocotea tonduzii from Monteverde, Costa Rica has been obtained by hydrodistillation and analyzed by GC-MS. The principal constituents of O. tonduzii leaf oil were the monoterpenes α-pinene (41.4%) and pinene (25.1%) and the sesquiterpenes α-humulene (6.9%), β-caryophyllene (5.8%), and germacrene D (3.8%). O. tonduzii leaf oil was notably cytotoxic on MCF-7, MDA-MB-231, MDA-MB-468, and UACC-257 cells in vitro. The major essential oil components showed cytotoxic activities comparable to doxorubicin ( LC50, 20–70 μg/mL).

scholarly journals Chemical Composition of the Leaf Essential Oil of Casimiroa Edulis La Llave & Lex. (Rutaceae) from Monteverde, Costa Rica

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Sarah L. Miller ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Traditional Use ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Casimiroa Edulis ◽  
Leaf Oil ◽  
Leaf Essential Oil

The leaf essential oil of Casimiroa edulis (Rutaceae), collected from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC-MS. The leaf oil was dominated by sesquiterpene hydrocarbons, predominately germacrene D (16-22%) and ( E)-caryophyllene (16-17%), consistent with the traditional use of this plant as a sedative, sleep inducer and hypotensive.

scholarly journals Chemical Composition of the Essential Oil from the Fresh Fruits of Xylopia Laevigata and its Cytotoxic Evaluation

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100
Author(s):  
Emmanoel Vilaça Costa ◽  
Thanany Brasil Da Silva ◽  
Cinara Oliveira D'Souza Costa ◽  
Milena Botelho Pereira Soares ◽  
Daniel Pereira Bezerra
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Tumor Cells ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Ionization Detector ◽  
Flame Ionization

The essential oil obtained by hydrodistillation from the fresh fruits of Xylopia laevigata was analyzed by gas chromatography using a flame ionization detector (GC–FID) coupled to a mass spectrometer (GC–MS). Monoterpenes predominated, forming 95.0% of the total essential oil. The major constituents identified were limonene (56.2%), α-pinene (28.0%), and β-pinene (5.5%). Cytotoxic activity against tumor cell lines and non-tumor cells was also investigated; however, neither the essential oil nor its major constituents evaluated presented any cytotoxic activity (IC50 > 25.0 μg mL−1).

scholarly journals Essential oil Composition of Dendropanax Gonatopodus from Monteverde, Costa Rica. An ab Initio Examination of Aromadendrane Sesquiterpenoids

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Ab Initio ◽  
Density Functional ◽  
Essential Oil Composition ◽  
Oil Composition ◽  
Hartree Fock ◽  
Leaf Oil ◽  
Leaf Essential Oil

The leaf essential oil of Dendropanax gonatopodus from Monteverde, Costa Rica, has been obtained by hydrodistillation and the chemical composition determined by GC-MS. The major components in the leaf oil were ( E)-2-hexenal (16.9%), terpinolene (14.8%), δ-cadinene (13.5%), ( E)-caryophyllene (9.9%), and α-copaene (7.3%). Minor amounts of the aromadendrane sesquiterpenoids aromadendrene (0.3%), alloaromadendrene (0.3%), spathulenol (0.6%) and globulol (0.6%) were also detected. An ab initio investigation of the aromadendrane sesquiterpenoids has been carried out using both density functional (B3LYP/6-31G*) and post Hartree-Fock (MP2/6-31G**) methods. The calculated relative energies of the aromadendranes belie their relative concentrations generally observed in essential oil compositions.

Chemical composition and cytotoxic activity of the leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica

2007 ◽  
Vol 61 (4) ◽  
pp. 414-417 ◽  
Author(s):  
Ramona A. Cole ◽  
Anita Bansal ◽  
Debra M. Moriarity ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Leaf Essential Oil

scholarly journals Composition and in-vitro CytotoxicActivities of the Leaf Essential Oil of Beilschmiedia erythrophloia from Taiwan

2013 ◽  
Vol 8 (1) ◽  
pp. 1934578X1300800
Author(s):  
Yu-Chang Su ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in-vitro cytotoxic activities of the essential oil isolated from the leaf of Beilschmiedia erythrophloia. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Fifty-five compounds were identified, representing 100% of the oil. The main components identified were β-caryophyllene (22.6%), α-humulene (21.9%), terpinen-4-ol (5.3%), cis-β-ocimene (5.1%), sabinene (5.0%) and limonene (4.5%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells.

scholarly journals Leaf Essential Oil Composition of Five Species of Beilschmiedia from Monteverde, Costa Rica

2007 ◽  
Vol 2 (1) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
William N. Setzer ◽  
William A. Haber
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Carbonyl Compounds ◽  
Essential Oil Composition ◽  
Chemical Compositions ◽  
Oil Composition ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Cis And Trans

The leaf essential oils of five species of Beilschmiedia from Monteverde, Costa Rica (Beilschmiedia alloiophylla, B. brenesii, B. costaricensis, B. tilaranensis, and an undescribed Beilschmiedia species “chancho blanco”) have been obtained by hydrodistillation and analyzed by GC-MS in order to discern the differences and similarities between the volatile chemical compositions of these species. The principal constituents of B. alloiophylla leaf oil were germacrene D (18.9%), cis- and trans-β-ocimene (18.8% and 9.3%, respectively), α-pinene (11.8%), and bicyclogermacrene (9.1%). The leaf oil of B. brenesii was composed largely of the sesquiterpenes germacrene D (19.3%), β-caryophyllene (13.4%), α-copaene (9.0%), α-humulene (8.1%), and δ-cadinene (5.8%), and the carbonyl compounds 2-undecanone (12.8%), trans-2-hexenal (8.8%), and 2-tridecanone (3.8%). α-Bisabolol (72.1%) dominated the leaf oil of B. costaricensis, while B. tilaranensis had germacrene D (54.9%), β-caryophyllene (14.8%), and δ-cadinene (5.1%) as major components. Beilschmiedia “chancho blanco” leaf oil was composed largely of β-caryophyllene (16.6%), bicyclogermacrene (14.1%), and α-pinene (12.1%).

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