T2* Mapping for Hip Joint Cartilage Assessment: Pre-MRI Exercise and Time of Imaging Do Not Bias the T2* Measurement in Asymptomatic Volunteers

Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo steady state (DESS) sequence for morphological cartilage assessment and a multi-echo data image combination sequence for the T2* measurement. T2* values were obtained between 8 and 11 a.m., between 3 and 6 p.m., and after 50 knee-bends at several time points of each measurement (0, 15, 30, 45, 60 minutes). Results We observed no differences ( P = 0.47) between the T2* values obtained in the morning (T2* = 22.9 ± 3.0 ms) and those measured in the afternoon (T2* = 23.2 ± 3.2 ms). We also observed no statistically significant differences between the T2* values at different time points ( P = 0.67) or after 50 knee-bends ( P = 0.43). Conclusions Timing of the scan and pre-imaging exercise clearly did not matter in this modality. This study consolidates the value of T2* imaging in hip joint cartilage that seems to be independent of diurnal effects and physical activity prior to MRI.

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Delayed gadolinium-enhanced magnetic resonance imaging of hip joint cartilage (dGEMRIC): pearls and pitfalls

Orthopedic Reviews ◽

10.4081/or.2011.e11 ◽

2011 ◽

Vol 3 (2) ◽

pp. 11 ◽

Cited By ~ 12

Author(s):

Bernd Bittersohl

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Hip Joint ◽

Cartilage Damage ◽

Mr Arthrography ◽

Image Resolution ◽

Current Status ◽

Joint Cartilage ◽

Resonance Imaging ◽

Joint Preservation

With the increasing advances in hip joint preservation surgery, accurate diagnosis and assessment of femoral head and acetabular cartilage status is becoming increasingly important. Magnetic resonance imaging (MRI) of the hip does present technical difficulties. The fairly thin cartilage lining necessitates high image resolution and high contrast-to-noise ratio (CNR). With MR arthrography (MRA) using intraarticular injected gadolinium, labral tears and cartilage clefts may be better identified through the contrast medium filling into the clefts. However, the ability of MRA to detect varying grades of cartilage damage is fairly limited and early histological and biochemical changes in the beginning of osteoarthritis (OA) cannot be accurately delineated. Traditional MRI thus lacks the ability to analyze the biological status of cartilage degeneration. The technique of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is sensitive to the charge density of cartilage contributed by glycosaminoglycans (GAGs), which are lost early in the process of OA. Therefore, the dGEMRIC technique has a potential to detect early cartilage damage that is obviously critical for decision-making regarding time and extent of intervention for joint-preservation. In the last decade, cartilage imaging with dGEMRIC has been established as an accurate and reliable tool for assessment of cartilage status in the knee and hip joint. This review outlines the current status of dGEMRIC for assessment of hip joint cartilage. Practical modifications of the standard technique including three-dimensional (3D) dGEMRIC and dGEMRIC after intra-articular gadolinium instead of iv-dGEMRIC will also be addressed.

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T2∗ mapping of hip joint cartilage in various histological grades of degeneration

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2012.03.011 ◽

2012 ◽

Vol 20 (7) ◽

pp. 653-660 ◽

Cited By ~ 70

Author(s):

B. Bittersohl ◽

F.R. Miese ◽

H.S. Hosalkar ◽

M. Herten ◽

G. Antoch ◽

...

Keyword(s):

Hip Joint ◽

T2 Mapping ◽

Joint Cartilage

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Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading

Radiation Research ◽

10.1667/rr15216.1 ◽

2019 ◽

Vol 191 (6) ◽

pp. 497 ◽

Cited By ~ 1

Author(s):

Andy T. Kwok ◽

Joseph E. Moore ◽

Samuel Rosas ◽

Bethany A. Kerr ◽

Rachel N. Andrews ◽

...

Keyword(s):

Hip Joint ◽

Low Dose ◽

Cartilage Damage ◽

Hindlimb Unloading ◽

Joint Cartilage ◽

Low Dose Radiation ◽

Dose Radiation

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Delayed gadolinium-enhanced magnetic resonance imaging (dGEMRIC) of hip joint cartilage: better cartilage delineation after intra-articular than intravenous gadolinium injection

Acta Radiologica ◽

10.1080/02841850600596792 ◽

2006 ◽

Vol 47 (4) ◽

pp. 391-396 ◽

Cited By ~ 34

Author(s):

M. Boesen ◽

K. E. Jensen ◽

E. Qvistgaard ◽

B. Danneskiold-SamsØe ◽

C. Thomsen ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Hip Joint ◽

Sagittal Plane ◽

Spin Echo ◽

Cartilage Damage ◽

Hip Osteoarthritis ◽

Joint Cartilage ◽

Resonance Imaging ◽

Ultrasound Guided

Purpose: To investigate and compare delayed gadolinium (Gd-DTPA)-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in the hip joint using intravenous (i.v.) or ultrasound-guided intra-articular (i.a.) Gd-DTPA injection. Material and Methods: In 10 patients (50% males, mean age 58 years) with clinical and radiographic hip osteoarthritis (OA; Kellgren score II–III), MRI of the hip was performed twice on a clinical 1.5T MR scanner: On day 1, before and 90–180 min after 0.3 mmol/kg body weight i.v. Gd-DTPA and, on day 8, 90–180 min after ultrasound-guided i.a. injection of a 4 mmol/l Gd-DTPA solution. Coronal STIR, coronal T1 fat-saturated spin-echo, and a cartilage-sensitive gradient-echo sequence (3D T1 SPGR) in the sagittal plane were applied. Results: Both the post-i.v. and post-i.a. Gd-DTPA images showed significantly higher signal-to-noise (SNR) and contrast-to-noise (CNR) in the joint cartilage compared to the non-enhanced images ( P<0.002). I.a. Gd-DTPA provided significantly higher SNR and CNR compared to i.v. Gd-DTPA ( P<0.01). Furthermore, a better delineation of the cartilage in the synovial/cartilage zone and of the chondral/subchondral border was observed. Conclusion: The dGEMRIC MRI method markedly improved delineation of hip joint cartilage compared to non-enhanced MRI. The i.a. Gd-DTPA provided the best cartilage delineation. dGEMRIC is a clinically applicable MRI method that may improve identification of early subtle cartilage damage and the accuracy of volume measurements of hip joint cartilage.

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T2* Mapping of Acetabular and Femoral Hip Joint Cartilage at 3 T

Investigative Radiology ◽

10.1097/rli.0b013e3182518d57 ◽

2012 ◽

Vol 47 (7) ◽

pp. 392-397 ◽

Cited By ~ 43

Author(s):

Bernd Bittersohl ◽

Falk R. Miese ◽

Harish S. Hosalkar ◽

Tallal C. Mamisch ◽

Gerald Antoch ◽

...

Keyword(s):

Hip Joint ◽

T2 Mapping ◽

Joint Cartilage

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Levels of physical activity in four domains and affective wellbeing before and during the Covid-19 pandemic

Archives of Public Health ◽

10.1186/s13690-021-00651-y ◽

2021 ◽

Vol 79 (1) ◽

Author(s):

Eliane S. Engels ◽

Michael Mutz ◽

Yolanda Demetriou ◽

Anne K. Reimers

Keyword(s):

Mental Health ◽

Physical Activity ◽

Protective Factor ◽

Total Sample ◽

Poor Mental Health ◽

German Population ◽

Time Points ◽

Sport And Exercise ◽

Over Time ◽

Time Point

Abstract Background Latest studies indicated that the general mental health level is low during the pandemic. Probably, this deterioration of the mental health situation is partly due to declines in physical activity. The aim of this study was to investigate differences in and the association between affective wellbeing and levels of different domains of physical activity at three time points before and during the pandemic. Method We used a nationwide online panel with a trend data design encompassing a total sample of N = 3517, representing the German population (> 14 years). Four different activity domains (sport and exercise, light outdoor activity, housework/gardening, active travel) and affective wellbeing (positive and negative affect) were assessed at three time points before and during the Covid-19 pandemic (October 2019, March 2020, October 2020). Results Multivariate analyses of variance (MANOVA) indicate differences regarding affective wellbeing over the three time points with the lowest values at the second time point. Levels of activity in the four domains differed significantly over time with the strongest decrease for sport and exercise from the first to the second time point. Partial correlations indicated that the relationships between sport and exercise and positive affect were most consistent over time. Conclusions Overall, our findings suggest that physical activity plays a particularly important role in the pandemic period as a protective factor against poor mental health. Especially sports and exercise seem to be supportive and should be encouraged, e.g. by providing additional support in finding adequate outdoor, home-based or digital substitutes.

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Location, Location, Location: Accelerometer Placement Affects Steps-Based Physical Activity Outcomes During Pregnancy and Postpartum

American Journal of Lifestyle Medicine ◽

10.1177/15598276211030472 ◽

2021 ◽

pp. 155982762110304

Author(s):

Mallory R. Marshall ◽

Alexander H. K. Montoye ◽

Michelle R. Conway ◽

Rebecca A. Schlaff ◽

Karin A. Pfeiffer ◽

...

Keyword(s):

Physical Activity ◽

Repeated Measures ◽

Time Points ◽

Repeated Measures Analysis ◽

Pregnancy And Postpartum ◽

Vigorous Intensity ◽

The Right ◽

Physical Changes ◽

Intensity Classification ◽

Measurement Validity

As pregnancy progresses, physical changes may affect physical activity (PA) measurement validity. n = 11 pregnant women (30.1 ± 3.8 years) wore ActiGraph GT3X+ accelerometers on the right hip, right ankle, and non-dominant wrist for 3–7 days during the second and third trimesters (21 and 32 weeks, respectively) and 12 weeks postpartum. Data were downloaded into 60-second epochs from which stepping cadence was calculated; repeated-measures analysis of variance was used to determine significant differences among placements. At all time points, the wrist accelerometer measured significantly more daily steps (9930–10 452 steps/d) and faster average stepping cadence (14.5–14.6 steps/min) than either the hip (4972–5944 steps/d, 7.1–8.6 steps/min) or ankle (7161–8205 steps/d, 10.3–11.9 steps/min) placement, while moderate- to vigorous-intensity activity at the wrist (1.2–1.7 min/d) was significantly less than either hip (3.0–5.9 min/d) or ankle (6.1–7.3 min/d). Steps, cadence, and counts were significantly lower for the hip than the ankle at all time points. Kappa calculated for agreement in intensity classification between the various pairwise comparisons ranged from .06 to .41, with Kappa for hip–ankle agreement (.34–.41) significantly higher than for wrist–ankle (.09–.11) or wrist–hip (.06–.16). These data indicate that wrist accelerometer placement during pregnancy likely results in over counting of PA parameters and should be used with caution.

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ENERGY EXPENDITURE AND PHYSICAL ACTIVITY AMONG OLDER PARTICIPANTS FROM THE MULTICENTER AIDS COHORT STUDY (MACS)

Innovation in Aging ◽

10.1093/geroni/igz038.2023 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S549-S549

Author(s):

Jennifer A Schrack ◽

Todd T Brown ◽

Joseph B Margolick

Keyword(s):

Physical Activity ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Functional Decline ◽

Time Of Day ◽

Energy Utilization ◽

Hiv Viral Load ◽

Cross Sectional ◽

And Function ◽

Lower Physical Activity

Abstract Energy utilization becomes more inefficient with age and is linked to low physical activity and functional decline. Persons aging with HIV exhibit accelerated functional decline, but the effect of chronic HIV infection on energy utilization and free-living physical activity remains unclear. We investigated cross-sectional associations between age and: resting metabolic rate, peak walking energy (VO2), and 7-day physical activity by accelerometry in 100 men in the MACS (age: 60.8+/-6.8 years, 35% black, 46.1% HIV+, 94% virally suppressed). In multivariable regression models adjusted for age, BMI, race, chronic conditions, and HIV viral load, HIV+ men had a higher resting metabolic rate (β=103.2 kcals/day, p=0.03) and lower peak walking VO2 (β=-1.8 ml/kg/min, p<0.02) than HIV- men. Moreover, HIV+ men demonstrated lower physical activity, overall and by time of day (p<0.05). These results suggest that energy utilization differs by HIV serostatus, which may contribute to lower physical activity and function with aging.

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