Clinical Replacement Strategies for Meniscus Tissue Deficiency

Cartilage ◽  
2021 ◽  
pp. 194760352110605
Author(s):  
Dean Wang ◽  
Erik Gonzalez-Leon ◽  
Scott A. Rodeo ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Young Patients ◽  
Return To Sport ◽  
Short Term ◽  
Clinical Challenge ◽  
Meniscus Tissue ◽  
Collagen Meniscus Implant ◽  
Sport Activities ◽  
Joint Contact ◽  
Contact Pressures

Meniscus tissue deficiency resulting from primary meniscectomy or meniscectomy after failed repair is a clinical challenge because the meniscus has little to no capacity for regeneration. Loss of meniscus tissue has been associated with early-onset knee osteoarthritis due to an increase in joint contact pressures in meniscectomized knees. Clinically available replacement strategies range from allograft transplantation to synthetic implants, including the collagen meniscus implant, ACTIfit, and NUSurface. Although short-term efficacy has been demonstrated with some of these treatments, factors such as long-term durability, chondroprotective efficacy, and return to sport activities in young patients remain unpredictable. Investigations of cell-based and tissue-engineered strategies to treat meniscus tissue deficiency are ongoing.

CLINICAL PROFILE OF PATIENTS OF YOUNG STROKE.

2021 ◽  
pp. 68-70
Author(s):  
Nitin Hiraman Suryawanshi ◽  
Amit Aggarwal ◽  
Abhijit Kadam
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Young Patients ◽  
Behavioural Pattern ◽  
Long Term Outcomes ◽  
Short Term ◽  
Traditional Risk Factors ◽  
The Individual ◽  
Stroke In Young

A study of stroke in young patients has recently become a subject of interest. This is due to a lot of impact on the individual and society. Study of stroke in young patients can lead to therapeutical results affecting both short term and long-term outcomes. Our study is hospital based retrospective study for duration of 1 year. Thi Methods: Results: s study revealed stroke in young in 25.16% of all stroke cases, with cerebral infarction in 56% and followed by intracerebral haemorrhage in 25.64%, and cerebral venous thrombosis in 18%. The most common presenting symptom was hemiparesis. The most prevalent risk factor for stroke in young was hypertension followed by diabetes mellitus, alcohol consumption and smoking. Stroke in young requires a differe Conclusion: nt approach to investigate and treat. This is due to different underlying etilogy as compared to elderly. Although traditional risk factors are associated with stroke, behavioural pattern such as smoking and alcohol may cause and promote development of stroke in young.

Short Term Relaxation of Stuffing Box Packings

2007 ◽  
Author(s):  
Mohammed Diany ◽  
Abdel-Hakim Bouzid
Keyword(s):  
Contact Pressure ◽  
Threshold Value ◽  
Element Model ◽  
Packing Material ◽  
Ansys Software ◽  
Short Term ◽  
Creep Properties ◽  
Contact Pressures ◽  
Key Parameter

The long term tightness performance of stuffing box packings, used in valves, is conditioned by the capacity of its material to maintain a contact pressure to a predetermined minimal threshold value. Due to creep, this contact pressure decrease with time depending on the creep properties and the stiffness of the housing. Assessing relaxation is a key parameter in determining the tightness performance of the stuffing box packing over time. Using Ansys software, an axisymmetric 2D finite element model is developed to assess the contact pressures between the packing material and the stem and the housing and its variation with time. The assessment of the packing relaxation is a major obstacle to the good leakage performance of the Stuffing Box Packing.

scholarly journals Long Term Clinical–Functional and Ultrasound Outcomes in Recreational Athletes after Achilles Tendon Rupture: Ma and Griffith Versus Tenolig

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1073
Author(s):  
Carlo Biz ◽  
Mariachiara Cerchiaro ◽  
Elisa Belluzzi ◽  
Nicola Luigi Bragazzi ◽  
Giacomo De Guttry ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Tendon Rupture ◽  
Achilles Tendon Rupture ◽  
Return To Sport ◽  
Functional Results ◽  
Return To Sports ◽  
Recreational Athletes ◽  
Sport Activities ◽  
Long Term Follow Up

Background and Objectives: The purpose of this retrospective study was to compare the long-term clinical–functional and ultrasound outcomes of recreational athletes treated with two percutaneous techniques: Ma and Griffith (M&G) and the Tenolig technique (TT). Materials and Methods: recreational athletes, between 18 and 50 years of age, affected by acute Achilles tendon rupture (AATR), treated by M&G or Tenolig techniques were recruited. Clinical–functional outcomes were evaluated using Achilles Tendon Rupture Score (ATRS), AOFAS Ankle–Hindfoot score, VAS (for pain and satisfaction) questionnaires, and ultrasound analysis (focal thickening, hypoechoic areas, presence of calcifications, tendinitis and alteration of normal fibrillar architecture). Results: 90 patients were included: 50 treated by M&G, 40 by TT. In all, 90% of patients resumed sports activities, with pre-injury levels in 56% of cases after M&G and in 60% after TT. In the M&G group, the averages of the questionnaires were ATRS 90.70 points, AOFAS 91.03, VAS satisfaction 7.08, and VAS pain 1.58. In the TT group: ATRS 90.38 points, AOFAS 90.28, VAS satisfaction 7.76, and VAS pain 1.34. The TT group showed a significantly higher satisfaction and return to sport activities within a shorter time. In the M&G group, ultrasound check showed a significantly greater incidence of thickening and an alteration of fibrillar architecture in the treated tendon. Three infections were reported, including one deep after M&G, two superficial in the TT group, and two re-ruptures in the Tenolig group following a further trauma. Conclusions: At long-term follow-up, M&G and TT are both valid techniques for the treatment of AATRs in recreational athletes, achieving comparable clinical–functional results. However, TT seems to have a higher patient satisfaction rate, a faster return to sports and physical activities, and fewer ultrasound signs of tendinitis. Finally, the cost of the device makes this technique more expensive.

scholarly journals Biceps Tenodesis is a Viable Option for Management of Proximal Biceps Injuries in Patients Less Than 25 Years of Age

2017 ◽  
Vol 5 (3_suppl3) ◽  
pp. 2325967117S0011 ◽  
Author(s):  
Justin W. Griffin ◽  
Gregory L. Cvetanovich ◽  
Jonathan Charles Riboh ◽  
Timothy Sean Leroux ◽  
Bernard R. Bach ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Young Patients ◽  
Return To Sport ◽  
Activity Level ◽  
Functional Score ◽  
Biceps Tenodesis ◽  
Overhead Athletes ◽  
Additional Surgery

Objectives: Biceps tenodesis has been proposed as an alternative to superior labral anterior posterior (SLAP) repair in older individuals, and there is evidence to suggest it is a reliable operation with low failure rate in these patients. Despite this, there has been some trepidation to adopt this in young active patients due to concern for altered postoperative glenohumeral kinematics and stability. To date no studies have examined younger individuals less than 25 undergoing proximal biceps tenodesis as an intervention for proximal biceps related pain and dysfunction. Methods: Between February 2011 and February 2013, 45 consecutive patients underwent biceps tenodesis for a diagnosis of biceps tendinopathy or biceps-labral complex injuries including SLAP tears and those with at least two-year follow up were analyzed. Thirty-five patients (77%), with a mean age of 19.8 ± 2.5 years were available for follow-up at a mean of 38.6 ± 9.5 months postoperatively. Functional outcomes were assessed with Visual Analog Scale (VAS), American Shoulder and Elbow Surgeons (ASES) Score, ASES Functional Score, Simple Shoulder Test (SST), and range of motion (ROM). Patient activity level and return to sport was followed postoperatively. Pre and postoperative scores were compared utilizing paired t-tests between groups. Results: 35 patients less than 25 years of age underwent biceps tenodesis and were available for follow up at two years (77%). 33 of 35 patients were athletes with 15 patients playing at the collegiate level with softball and baseball representing the most common sports. 22 patients were overhead athletes. 16 patients had no prior shoulder surgery with 19 representing revision shoulder procedures. Overall, mean VAS improved from 5.0 ± 1.2 to 2.0 ± 1.1 (p<0.0001). All clinical outcome scores improved with ASES score improving from 54.7 to 81.7 (mean difference 27.0±3.7, 95% CI 19.5,34.6), (p<0.0001), ASES functional score improved from 17.5 to 25.1 (7.5±1.2, 95% CI 5.0,10.0) (p<0.001), and SST improved from 7.4 to 10.1 (2.7±0.5, 95% CI 1.7,3.7) (p<0.0001). Range of motion was maintained postoperatively. Patients with higher BMI trended toward less improvement in function (p=0.0854) and SST (p=0.0355). At the time of follow-up, four patients (11%) had undergone revision surgery. 22 of 33 (66%) patients returned to sports with 16 returning at the same level and 6 at a lower level of play. 16 of 21 (76%) overhead athletes return to sport with 4 requiring additional surgery after biceps tenodesis. There was no difference in scores for overhead versus nonoverhead athletes. Conclusion: In the present study, biceps tenodesis in patients less than 25 years of age yields excellent outcomes with two thirds of patients able to return to sport. Additionally, we found a low revision rate. Of note, BMI appears to be a risk factor for a negative outcome following biceps tenodesis. Future long-term multicenter comparative studies with long term follow up are needed to demonstrate durability of biceps tenodesis in young patients.

scholarly journals Type VIII Slap Repair: Patient-Reported Outcomes Of 34 Patients With Minimum 4-year Follow-up

2018 ◽  
Vol 6 (7_suppl4) ◽  
pp. 2325967118S0017
Author(s):  
Justin W. Arner ◽  
Mitchell Stephen Fourman ◽  
Steven Bayer ◽  
Darren L. De SA ◽  
Dharmesh Vyas ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Surgical Repair ◽  
Return To Sport ◽  
Functional Score ◽  
Short Term ◽  
Type Viii ◽  
Slap Repair ◽  
Patient Reported

Objectives: Type VIII superior labrum anterior posterior (SLAP) tears - described as SLAP II injuries with posterior extension of the labral tear to the 6 o’clock aspect of the glenoid - have been shown in short-term outcome work to be a source of noted shoulder instability, pain, and reduced function/range of motion in both throwing and non-throwing athletes. Limiting our evaluation and effective treatment of these injuries in both the professional athlete and weekend warrior is our lack of mid- and long-term post-operative outcomes after surgical repair. It is hypothesized that Type VIII SLAP repairs would fare poorly, particularly in the throwing cohort, at mid- to long-term follow-up. Methods: With a minimum 4-year follow-up after Type VIII SLAP repair by a single surgeon, return to sport, KJOC, ASES, stability, range of motion, and pain were compared between throwers, contact, and non-contact athletes. Results: With an average follow-up of 6.2 years, 34 athletes (19 throwers, 5 contact athletes, 10 non-contact athletes), with a mean age of 24.4 years were evaluated. Significant (p < .0001) improvements were observed between pre- and post-operative pain, range of motion, and ASES total and functional scores in throwers and non-throwers. Stability improved but was not significant (Table 1). There were no post-operative differences between throwers and non-throwers (Table 2). Pre-operative ASES functional score was significantly lower in contact athletes than in throwers and non-contact athletes (p < .01), but post-operatively improved significantly with no difference between groups (Table 3, 4). Overall, there was no difference in return to sport between groups as 73.7% of throwers and 93.3% of non-throwers returned (Table 4) and 62.5% of throwers and 57.9% of non-throwers (p = .73) returned to the same level. Further, 89.5% of throwers and 100% of non-throwers (p = .49) said that their surgery was worthwhile. Conclusion: Given the paucity of literature, current surgical outcomes of athletes who have undergone Type VIII SLAP repairs is limited, particularly in mid- and long-term function and return to sport. The current findings suggest that surgical repair of Type VIII SLAP lesions contributes to significant improvements in pain, function, and shoulder range of motion that persists >4 years after repair. However, stability changes after injury appear more chronic in nature. Further, thrower and non-throwers appear to have similar outcomes, which has not previously been seen in short term studies. [Table: see text][Table: see text][Table: see text][Table: see text]

scholarly journals Rates and causes of readmissions following index admissions for Takotsubo syndrome-a meta-analysis of 118,941 index hospitalizations

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Desai ◽  
S Sachdeva ◽  
S Singh ◽  
S.K Rajan ◽  
A.S Shaik ◽  
...  
Keyword(s):  
Readmission Rate ◽  
Large Scale ◽  
Meta Analysis ◽  
Young Patients ◽  
Takotsubo Syndrome ◽  
Short Term ◽  
Random Effects Models ◽  
Study Heterogeneity ◽  
The Usa

Abstract Background Rising trends in takotsubo syndrome (TTS)-related complications warrant data to identify the rate, causes and predictors of readmission on a large scale. We conducted the first-ever meta-analysis to evaluate the pooled rate of short-term and long-term readmissions after index TTS admissions. Methods PubMed/Medline, EMBASE and SCOPUS databases were systematically reviewed to find studies through October 2019 reporting rates and causes of readmission following index TTS admissions. Random effects models were used to estimate pooled rates and causes of readmissions and I2 statistics were used to report inter-study heterogeneity. Results A total of 16 cohorts with 118,941 TTS index admissions (mean age 65–75 yrs; female &gt;85%, median follow-up 272.5 days) revealed a 16.6% [95% CI-13.2%-20.3%, I2=99%] pooled rate of readmission. Short-term and long-term pooled readmission rates are displayed in Fig.1. The readmission rate was higher in cohorts with young patients (&lt;70 vs. &gt;70 yrs), smaller sample size (n&lt;100 vs. n&gt;100) and single-centres vs. multicentres. Studies published from the USA (16.4% vs. 14.9%) had a higher readmission rate as compared to Italy. The most frequent causes were cardiac (40.6%), respiratory (15.7%) and renal (7.0%). Among readmissions with cardiac diagnoses, heart failure was most common (40.1%). Conclusions This global meta-analysis revealed that the pooled rate of readmission following index TTS admissions was ∼17% and causes were mainly cardiac or respiratory. Funding Acknowledgement Type of funding source: None

scholarly journals Study of the Polycarbonate-Urethane/Metal Contact in Different Positions during Gait Cycle

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Sergio Gabarre ◽  
Antonio Herrera ◽  
Jesús Mateo ◽  
Elena Ibarz ◽  
Antonio Lobo-Escolar ◽  
...  
Keyword(s):  
Body Weight ◽  
Young Patients ◽  
Element Model ◽  
Heel Strike ◽  
Virtual Surgery ◽  
Wear Rates ◽  
Polycarbonate Urethane ◽  
Value Range ◽  
Joint Contact ◽  
Contact Pressures

Nowadays, a growing number of young and more active patients receive hip replacement. More strenuous activities in such patients involve higher friction and wear rates, with friction on the bearing surface being crucial to ensure arthroplasty survival in the long term. Over the last years, the polycarbonate-urethane has offered a feasible alternative to conventional bearings. A finite element model of a healthy hip joint was developed and adjusted to three gait phases (heel strike, mid-stance, and toe-off), serving as a benchmark for the assessment of the results of joint replacement model. Three equivalent models were made with the polycarbonate-urethane Tribofit system implanted, one for each of the three gait phases, after reproducing a virtual surgery over the respective healthy models. Standard body-weight loads were considered: 230% body-weight toe-off, 275% body-weight mid-stance, and 350% body-weight heel strike. Contact pressures were obtained for the different models. When comparing the results corresponding to the healthy model to polycarbonate-urethane joint, contact areas are similar and so contact pressures are within a narrower value range. In conclusion, polycarbonate-urethane characteristics are similar to those of the joint cartilage. So, it is a favorable alternative to traditional bearing surfaces in total hip arthroplasty, especially in young patients.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

Sign in / Sign up

Export Citation Format

Share Document