scholarly journals Lack of association between erythropoietin treatment and risk of depression in patients with end-stage kidney disease on maintenance dialysis: a nationwide database study in Taiwan

2021 ◽  
Vol 12 ◽  
pp. 204062232199569
Author(s):  
Pao-Yen Lin ◽  
Lung-Chih Li ◽  
Liang-Jen Wang ◽  
Yao-Hsu Yang ◽  
Chih-Wei Hsu
Keyword(s):  
Treatment Group ◽  
Kidney Disease ◽  
Depressive Disorder ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Antidepressant Effects ◽  
Catastrophic Illness ◽  
Erythropoietin Treatment ◽  
Maintenance Dialysis ◽  
End Stage

Background: Patients with end-stage kidney disease (ESKD), have been associated with higher risk of developing depression. Erythropoietin (EPO), frequently used for the treatment of anemia in ESKD patients, has been shown to have neuroprotective and antidepressant effects. In this study, we examined whether EPO treatment changed the risk of depression in ESKD patients. Methods: In a nationwide population-based cohort in Taiwan from 1998 to 2013, patients with a diagnosis of ESKD on maintenance dialysis and aged greater than 18 years were classified into EPO treatment group or non-EPO treatment group. All patients were followed up until the diagnosis of depressive disorder or the end of the study period. Results: In this cohort (13,067 patients in the EPO and 67,258 patients in the non-EPO group), 5569 patients were diagnosed as depressive disorder in the follow-up period. We found the risk of depression in EPO group was not significantly different from that in non-EPO group (adjusted hazard ratio = 0.98, 95% confidence interval 0.92–1.04, p = 0.499) after adjusting for sex, age, certification year of catastrophic illness for ESKD, physical co-morbidities, and use of benzodiazepines. Conclusion: In summary, using the nationwide reimbursement data in Taiwan, we found that EPO treatment in ESKD patients was not associated with their general risk of developing depression.

scholarly journals Hematuria and subsequent long-term risk of end-stage kidney disease: A Danish population-based cohort study

2021 ◽  
Author(s):  
Kristine Fogh ◽  
Søren Viborg Vestergaard ◽  
Christian Fynbo Christiansen ◽  
Lars Pedersen ◽  
Dorothea Nitsch ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Disease ◽  
Population Based ◽  
Danish Population ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

2021 ◽  
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
The United States ◽  
Population Based ◽  
Emergency Department Visits ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes ◽  
End Stage ◽  
Event Rates

<b>Objective</b>: We characterized annual trends of severe hypoglycemic and hyperglycemic crises (diabetic ketoacidosis/hyperglycemic hyperosmolar state) in patients with diabetes and end-stage kidney disease (DM/ESKD). <p> </p> <p><b>Design</b>: Nationwide, retrospective study of adults (≥18 years) with DM/ESKD, from the United States Renal Data System registry, 2013 to 2017. Primary outcome was annual rates of emergency department visits or hospitalizations for hypoglycemic and hyperglycemic crises, reported as number of events/1000 person-years. Adjusted event rates and risk factors were adjusted for patient age, sex, race/ethnicity, dialysis modality, comorbidities, treatment regimen and U.S. region.</p> <p> </p> <p><b>Results</b>: Among 521,789 adults with DM/ESKD (median age 65 years [IQR 57-73], 56.1% male, and 46% White), overall adjusted rates of hypoglycemic and hyperglycemic crises were 53.64 and 18.24 per 1000 person-years, respectively. For both hypoglycemia and hyperglycemia crises, the risks decreased with age and were lowest in older patients (≥75 vs 18-44 years: IRR 0.35 [95% CI 0.33-0.37] and 0.03 [0.02-0.03], women (IRR 1.09 [1.06-1.12] and 1.44 [1.35-1.54]), and with smoking (IRR 1.36 [1.28-1.43] and 1.71 [1.53-1.91]), substance abuse (IRR 1.27 [1.15-1.42] and 1.53 [1.23-1.9]), retinopathy (IRR 1.10 [1.06-1.15] and 1.36 [1.26-1.47]), and insulin therapy (vs. no therapy; IRR 0.60 [0.59-0.63] and 0.44 [0.39-0.48]), respectively. For hypoglycemia, specifically, additional risk was conferred by Black race (IRR 1.11 [1.08-1.15]) and amputation history (IRR 1.20 [1.13-1.27]).</p> <p> </p> <p><b>Conclusions</b>: In this nationwide study of patients with DM/ESKD, hypoglycemic crises were three-fold more common than hyperglycemic crises, greatly exceeding national reports in non-dialysis patients with chronic kidney disease. Young, Black, and female patients were disproportionately affected. </p>

scholarly journals Infective Endocarditis Hospitalizations and Outcomes in Patients With End‐Stage Kidney Disease: A Nationwide Data‐Linkage Study

2021 ◽  
Author(s):  
Peter J. Gallacher ◽  
David A. McAllister ◽  
Nicholas L. Mills ◽  
Nicholas L. Cruden ◽  
Anoop S. V. Shah ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Kidney Disease ◽  
Population Based ◽  
Linkage Study ◽  
Mortality Data ◽  
End Stage Kidney Disease ◽  
Patient Demographics ◽  
History Of ◽  
Short And Long Term ◽  
End Stage

Background We investigated the clinical features, microbiology, and short‐ and long‐term outcomes of incident infective endocarditis (IE) hospitalizations in patients with end‐stage kidney disease (ESKD) requiring dialysis or with a kidney transplant over 25 years in Scotland. Methods and Results In this retrospective, population‐based cohort study linking national hospitalization and mortality data, we identified patients with a history of ESKD and hospitalized with IE in Scotland between January 1, 1990 and December 31, 2014. From January 1, 2008, individual IE hospitalizations were additionally linked to national microbiology data. Multivariable logistic regression, adjusting for patient demographics and comorbidities, evaluated the association between ESKD and all‐cause death at 1 and 3 years. Of 7638 incident IE hospitalizations between 1990 and 2014, 2.8% (216/7638) occurred in 210 patients with ESKD and 97.2% (7422/7638) occurred in 7303 patients without ESKD. Positive findings from blood cultures were identified in 42% (950/2267) of incident IE hospitalizations from 2008. Staphylococcus aureus was isolated in 25.9% (21/81) and 12.8% (280/2186) of patients with and without ESKD, respectively ( P =0.002). ESKD was associated with an increased odds of death at 1 (44.9% versus 31.4%; adjusted odds ratio [aOR], 2.47, 95% CI, 1.85–3.30;, P <0.001) and 3 years (63.9% versus 42.8%; aOR, 3.77; 95% CI, 2.79–5.12; P <0.001). Conclusions IE is associated with a poor prognosis in patients with ESKD, especially in the longer term. Compared with patients without ESKD, patients with ESKD were twice as likely to die within 1 year, and 3 times as likely to die within 3 years of IE hospitalization.

scholarly journals Long-term risk for end-stage kidney disease and death in a large population-based cohort

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Emanuel Zitt ◽  
Constanze Pscheidt ◽  
Hans Concin ◽  
Reinhard Kramar ◽  
Raphael S. Peter ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Large Population ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Smoking and risk of incident end-stage kidney disease in general population: A Nationwide Population-based Cohort Study from Korea

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hong Sang Choi ◽  
Kyung-Do Han ◽  
Tae Ryom Oh ◽  
Chang Seong Kim ◽  
Eun Hui Bae ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Insurance ◽  
Kidney Disease ◽  
National Health Insurance ◽  
National Health ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Smoking Duration ◽  
Korean National Health Insurance ◽  
End Stage

AbstractWe analyzed data from the Korean National Health Insurance Service (NHIS) to investigate whether smoking increases the risk of end-stage kidney disease (ESKD). This retrospective nationwide population-based cohort study included the data of 23,232,091 participants who underwent at least one health examination between 2009 and 2012. Smoking status was recorded at baseline. The incidence of ESKD was identified via ICD-10 codes and special medical aid codes from the Korean National Health Insurance Service database till December 2016. A Cox proportional-hazards model with multivariable adjustment was used to evaluate the association between smoking and ESKD incidence. Overall, 24.6% of participants were current smokers; 13.5% and 61.9%, were ex- and non-smokers, respectively. Overall, 45,143 cases of ESKD developed during the follow-up period. Current smokers (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.35–1.43) and ex-smokers (HR, 1.09; 95% CI, 1.06–1.12) demonstrated a significant increase in the adjusted risk of ESKD compared to non-smokers. The risk of ESKD was directly proportional to the smoking duration, number of cigarettes smoked daily, and pack-years. In conclusion, smoking is associated with a greater risk of ESKD in the general Korean population; the risk increases with an increase in the smoking duration, number of cigarettes smoked daily, and pack-years.

scholarly journals The incidence and survival after in-hospital cardiopulmonary cerebral resuscitation in end-stage kidney disease patients: A nationwide population-based study

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238029
Author(s):  
Chia-Hung Yang ◽  
Jia-Jin Chen ◽  
Jih-Kai Yeh ◽  
George Kuo ◽  
Cheng-Chia Lee ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
End Stage

scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

Diabetes Care ◽  
2021 ◽  
pp. dc211579
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Population Based ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
End Stage

scholarly journals Hypoglycemic and Hyperglycemic Crises Among U.S. Adults With Diabetes and End-stage Kidney Disease: Population-Based Study, 2013–2017

2021 ◽  
Author(s):  
Rodolfo J. Galindo ◽  
Mohammed K. Ali ◽  
Shealeigh A. Funni ◽  
Andrew B. Dodge ◽  
Shaheen S. Kurani ◽  
...  
Keyword(s):  
Kidney Disease ◽  
The United States ◽  
Population Based ◽  
Emergency Department Visits ◽  
End Stage Kidney Disease ◽  
Population Based Study ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes ◽  
End Stage ◽  
Event Rates

<b>Objective</b>: We characterized annual trends of severe hypoglycemic and hyperglycemic crises (diabetic ketoacidosis/hyperglycemic hyperosmolar state) in patients with diabetes and end-stage kidney disease (DM/ESKD). <p> </p> <p><b>Design</b>: Nationwide, retrospective study of adults (≥18 years) with DM/ESKD, from the United States Renal Data System registry, 2013 to 2017. Primary outcome was annual rates of emergency department visits or hospitalizations for hypoglycemic and hyperglycemic crises, reported as number of events/1000 person-years. Adjusted event rates and risk factors were adjusted for patient age, sex, race/ethnicity, dialysis modality, comorbidities, treatment regimen and U.S. region.</p> <p> </p> <p><b>Results</b>: Among 521,789 adults with DM/ESKD (median age 65 years [IQR 57-73], 56.1% male, and 46% White), overall adjusted rates of hypoglycemic and hyperglycemic crises were 53.64 and 18.24 per 1000 person-years, respectively. For both hypoglycemia and hyperglycemia crises, the risks decreased with age and were lowest in older patients (≥75 vs 18-44 years: IRR 0.35 [95% CI 0.33-0.37] and 0.03 [0.02-0.03], women (IRR 1.09 [1.06-1.12] and 1.44 [1.35-1.54]), and with smoking (IRR 1.36 [1.28-1.43] and 1.71 [1.53-1.91]), substance abuse (IRR 1.27 [1.15-1.42] and 1.53 [1.23-1.9]), retinopathy (IRR 1.10 [1.06-1.15] and 1.36 [1.26-1.47]), and insulin therapy (vs. no therapy; IRR 0.60 [0.59-0.63] and 0.44 [0.39-0.48]), respectively. For hypoglycemia, specifically, additional risk was conferred by Black race (IRR 1.11 [1.08-1.15]) and amputation history (IRR 1.20 [1.13-1.27]).</p> <p> </p> <p><b>Conclusions</b>: In this nationwide study of patients with DM/ESKD, hypoglycemic crises were three-fold more common than hyperglycemic crises, greatly exceeding national reports in non-dialysis patients with chronic kidney disease. Young, Black, and female patients were disproportionately affected. </p>

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