Diagnostic challenge of a radiological mass post partial nephrectomy in a patient with a single functioning kidney: Surgicel® granuloma

2020 ◽  
pp. 205141582093061
Author(s):  
Siobhan Duffy ◽  
Flora Rodger ◽  
Sioban Fraser ◽  
Grenville Oades
Keyword(s):  
Cell Carcinoma ◽  
Partial Nephrectomy ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Case Review ◽  
Diagnostic Challenge ◽  
Level Of Evidence ◽  
Evidence Level ◽  
Functioning Kidney

Here we describe a case review of a 61-year-old female who developed a Surgicel® granuloma following a partial nephrectomy for clear cell carcinoma in a single functioning kidney. We discuss the biodynamics of Surgicel®, the challenge of reaching the diagnosis and the implications of a Surgicel® granuloma for patients. Level of evidence: Level 5

Clear cell carcinoma of Mullerian origin in the urinary bladder: A rare entity

2021 ◽  
pp. 205141582098766
Author(s):  
Harshit Garg ◽  
Brusabhanu Nayak ◽  
Tripti Nakra ◽  
Prabhjot Singh ◽  
Seema Kaushal
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Rare Entity ◽  
Level Of Evidence ◽  
History Of ◽  
Carcinoma Of The Bladder

Mullerian neoplasms of the urinary system are rare but complex tumor-like lesions. The identification of the Mullerian neoplasm is crucial for patient management owing to its etiology, natural history, and prognosis. We present a case of a 42-year-old female with a history of three lower segment cesarean sections presenting with complaints of dysmenorrhea and suprapubic pain with no history of hematuria or any urinary symptoms. Magnetic resonance imaging revealed a 2 cm×2 cm exophytic lesion suspicious of being either a bladder lesion or an endometrial lesion infiltrating the urinary bladder. Cystoscopy and transurethral biopsy of this suspicious bladder tumor revealed a malignant tumor with papillary and tubulocystic architecture. Based on the overall histomorphological and immunohistochemical features, a diagnosis of clear cell carcinoma of Mullerian origin was made, and the patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and partial cystectomy. The patient was kept on regular surveillance and showed no signs of recurrence at the one-year follow-up. Clear cell carcinoma of the bladder of Mullerian origin is a rare entity and is established on histopathology. Prompt diagnosis and a multidisciplinary approach are indispensable for management. Level of evidence: Level 4.

scholarly journals Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Renal Clear Cell Carcinoma

2019 ◽  
Author(s):  
Kun Wang ◽  
Tingchun Wu ◽  
Yiming Chen ◽  
Guanglai Song ◽  
Xiaozhou He ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Partial Nephrectomy ◽  
Apolipoprotein B ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Surgical Patients ◽  
Apo B ◽  
Apob Level ◽  
Prognostic Effect

Abstract Objectives To assess the prognostic value of preoperative apolipoprotein B level in surgical patients with renal clear cell carcinoma (ccRCC). Materials and Methods The study included 308 ccRCC patients receiving radical or partial nephrectomy between 2003 and 2012 in our center. The correlations among the preoperative ApoB, clinico -pathological parameters, and overall survival (OS) were evaluated. Results A total of 193 men (62.9%) and 114 women (37.1%) with ccRCC underwent radical or partial nephrectomy were enrolled in the present study. The OS at five years after operation was 90.6% for all patients, 87.4% for the lower ApoB group, and 97.0% for the higher ApoB group. The CSS at 5 years after surgery was 90.2% for all patients, 86.7% for the lower ApoB group, and 97.0% for the higher ApoB group. A higher ApoB level was related to a better OS and CSS in ccRCC patients (P = 0.001 and P < 0.001, respectively). In multivariate analysis, age >60 (P=0.008 and P=0.023), lower Apo B level (P= 0.019 and P= 0.018), were independent prognostic factors for OS and CSS, respectively. Conclusions In the Apo apolipoprotein family, the preoperative ApoB level has an important clinical significance for predicting the prognosis survival rate of the ccRCC patients.

Adnexal Clear Cell Carcinoma With Comedonecrosis: Clinicopathologic Analysis of 12 Cases

2007 ◽  
Vol 131 (11) ◽  
pp. 1655-1664
Author(s):  
Iskander H. Chaudhry ◽  
Artur Zembowicz
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Antigen Expression ◽  
Distant Metastases ◽  
Older Individuals ◽  
Diagnostic Challenge ◽  
Apocrine Differentiation ◽  
Anatomic Distribution ◽  
Aggressive Clinical Course

Abstract Context.—Cutaneous clear cell tumors can pose a diagnostic challenge even to the experienced dermatopathologist; this is partly because of limitations of existing diagnostic categories. Objective.—To describe a previously unrecognized, distinctive cutaneous adnexal carcinoma capable of an aggressive clinical course. Design.—Clinicopathologic analysis of a series of 12 cases. Results.—The patients were older individuals (median age, 71 years) with equal gender frequency. The lesions showed wide anatomic distribution with predilection for the head and neck area, especially the scalp. The lesions presented as rapidly growing, erythematous to flesh-colored, solitary papules/nodules that were capable of quickly reaching a size of several centimeters. Histologically, adnexal clear cell carcinoma with comedonecrosis was characterized by dermal proliferation of nests of epithelial cells showing distinctive zonal arrangement. The periphery of the tumor nests was formed by squamoid cells merging with centrally located clear cell areas containing foci of comedonecrosis. The lesions often showed multilobular or trabecular growth pattern and infiltrating border. Nuclear pleomorphism was variable; mitotic count ranged from 2 to 32/mm2 (median, 8/mm2). No ductal, cuticular, or apocrine differentiation was seen. All cases showed expression of epithelial membrane antigen and cytokeratin 17 in clear cells, with focal carcinoembryonic antigen expression in some cases. Follow-up (average, 37 months) revealed local recurrence (4 cases) and regional and distant metastases (2 cases). Conclusions.—Adnexal clear cell carcinoma with comedonecrosis appears to be a distinctive adnexal neoplasm that has to be distinguished from more indolent squamous cell and tricholemmal carcinomas.

Prognostic role of BAP1 in pT1 clear cell carcinoma in partial nephrectomy specimens

2017 ◽  
Vol 471 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Daniele Minardi ◽  
Guendalina Lucarini ◽  
Giulio Milanese ◽  
Rodolfo Montironi ◽  
Roberto Di Primio
Keyword(s):  
Cell Carcinoma ◽  
Partial Nephrectomy ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Prognostic Role

scholarly journals Sternal resection of a solitary renal cell carcinoma metastasis: a case report and a literature review

2019 ◽  
Vol 25 (4) ◽  
pp. 226-233
Author(s):  
Minija Čerškutė ◽  
Marius Kinčius ◽  
Tomas Januškevičius ◽  
Saulius Cicėnas ◽  
Albertas Ulys
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Partial Nephrectomy ◽  
Renal Cell ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Abdominal Ct ◽  
Postoperative Course ◽  
Carcinoma Metastasis

Background. Renal cell carcinoma (RCC) may be metastatic, although solitary sternal metastasis of RCC is a rare medical condition. Here we report an unusual case of a 63-year-old male with a solitary sternal metastasis as an initial presentation of clear-cell renal cell carcinoma. Materials and methods. A 63-year-old male presented with a small sternal mass. Chest computer tomography (CT) and a biopsy from the sternal tumour were performed. Histopathological examination revealed the diagnosis of renal clear cell carcinoma metastasis to the sternal bone. On the basis of a subsequently performed abdominal CT the patient was confirmed with a suspicion of a left renal lower pole tumour. Treatment with sunitinib was initiated. Due to the limited response and a growing sternal mass, the patient was admitted to the National Cancer Institute after two cycles of sunitinib therapy. Open left partial nephrectomy was performed followed by the resection of the sternal metastasis two months later. The chest wall was reconstructed with polypropylene mesh combined with transversal rectus abdominis musculocutaneous flap. Results. The postoperative course after the partial nephrectomy was uneventful. The postoperative course of metastasectomy complicated with the right pneumothorax which was successfully treated by insertion of a chest tube. Bleeding from the upper digestive tract also occurred on the seventh postoperative day but was successfully controlled by haemostasis with three 20 ml endoscopic injections of 1:10,000 solution of epinephrine. The patient had been followed up after the surgery for 30 months with biannual chest and abdominal CT scans that showed neither local nor distant recurrence of the disease. Conclusions. Radical surgical treatment of a solitary renal clear cell carcinoma metastasis may offer the best cancer-specific outcomes and improve the quality of life in some patients.

scholarly journals Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Shashikant C. U. Patne ◽  
Nidhi Johri ◽  
Richa Katiyar ◽  
Sameer Trivedi ◽  
Uday Shankar Dwivedi
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Prostate

Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes: A Population-Based Analysis

2019 ◽  
Vol 128 (11) ◽  
pp. 989-996 ◽  
Author(s):  
Daniel D. Sharbel ◽  
Aykut A. Unsal ◽  
Michael W. Groves ◽  
William G. Albergotti ◽  
J. Kenneth Byrd
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hazard Ratio ◽  
Low Grade ◽  
Level Of Evidence ◽  
Clinicopathologic Characteristics ◽  
Clinicopathologic Factors ◽  
Localized Disease ◽  
Worse Prognosis

Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P = .632). Five-, 10-, and 20-year DSS rates were 81.3% (n = 117), 69.6% (n = 94), and 55.3% (n = 68), respectively. Men (hazard ratio, 4.74; P = .0087) and patients with regional (hazard ratio, 5.59; P = .018) or distant (hazard ratio, 8.9; P = .01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36%, P < .0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3%) compared with treatment with combination radiation and surgery (57.6%) or radiation monotherapy (18.75%, P < .0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A

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