The clinical value of indocyanine green fluorescence navigation system for laparoscopic partial nephrectomy in the case of complex renal clear cell carcinoma (R.E.N.A.L score ≥7)

Kidney renal clear cell carcinoma (KIRC) is one of the most malignant diseases with poor survival rate over the world. The tumor microenvironment (TME) is highly related to the oncogenesis, development, and prognosis of KIRC. Thus, making the identification of KIRC biomarkers and immune infiltrates critically important. Microtubule Interacting and Trafficking Domain containing 1(MITD1) was reported to participate in cytokinesis of cell division. In the present study, multiple bioinformatics tools and databases were applied to investigate the expression level and clinical value of MITD1 in KIRC. We found that the expression of MITD1 was significantly increased in KIRC tissues. Further, the KIRC patients with high MITD1 levels showed a worse overall survival (OS) rate and disease free survival (DFS) rate. Otherwise, we found a significant correlation MITD1 expression and the abundance of CD8+ T cells. Functional enrichment analyses revealed that immune response and cytokine-cytokine receptor are very critical signaling pathways which associated with MITD1 in KIRC. In conclusion, our findings indicated that MITD1 may be a potential biomarker and associated with immune infiltration in KIRC.

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Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Renal Clear Cell Carcinoma

10.21203/rs.2.13038/v1 ◽

2019 ◽

Author(s):

Kun Wang ◽

Tingchun Wu ◽

Yiming Chen ◽

Guanglai Song ◽

Xiaozhou He ◽

...

Keyword(s):

Cell Carcinoma ◽

Partial Nephrectomy ◽

Apolipoprotein B ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Surgical Patients ◽

Apo B ◽

Apob Level ◽

Prognostic Effect

Abstract Objectives To assess the prognostic value of preoperative apolipoprotein B level in surgical patients with renal clear cell carcinoma (ccRCC). Materials and Methods The study included 308 ccRCC patients receiving radical or partial nephrectomy between 2003 and 2012 in our center. The correlations among the preoperative ApoB, clinico -pathological parameters, and overall survival (OS) were evaluated. Results A total of 193 men (62.9%) and 114 women (37.1%) with ccRCC underwent radical or partial nephrectomy were enrolled in the present study. The OS at five years after operation was 90.6% for all patients, 87.4% for the lower ApoB group, and 97.0% for the higher ApoB group. The CSS at 5 years after surgery was 90.2% for all patients, 86.7% for the lower ApoB group, and 97.0% for the higher ApoB group. A higher ApoB level was related to a better OS and CSS in ccRCC patients (P = 0.001 and P < 0.001, respectively). In multivariate analysis, age >60 (P=0.008 and P=0.023), lower Apo B level (P= 0.019 and P= 0.018), were independent prognostic factors for OS and CSS, respectively. Conclusions In the Apo apolipoprotein family, the preoperative ApoB level has an important clinical significance for predicting the prognosis survival rate of the ccRCC patients.

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Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma

Journal of Personalized Medicine ◽

10.3390/jpm11040263 ◽

2021 ◽

Vol 11 (4) ◽

pp. 263

Author(s):

Hyo Jae Shin ◽

Kyung Jin Lee ◽

Minchan Gil

Keyword(s):

Lung Adenocarcinoma ◽

Cell Carcinoma ◽

Cancer Progression ◽

Cutaneous Melanoma ◽

Prognostic Value ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Clinical Value ◽

Cancer Types

Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of CRBN in solid tumors have been conducted to date. Here, we analyzed CRBN expression and its clinical value using several bioinformatic databases. CRBN mRNA expression was downregulated in various cancer types compared to normal cells. Survival analysis demonstrated that overall survival was significantly positively correlated with CRBN expression in some cancer types including lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC), and skin cutaneous melanoma (SKCM). CRBN expression was downregulated regardless of clinicopathological characteristics in LUAD and KIRC. Analysis of genes that are commonly correlated with CRBN expression among KIRC, LUAD, and SKCM samples elucidated the potential CRBN-associated mechanisms of cancer progression. Overall, this study revealed the prognostic value of CRBN and its potential associated mechanisms, which may facilitate the development of anti-cancer therapeutic agents.

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Sternal resection of a solitary renal cell carcinoma metastasis: a case report and a literature review

Acta medica Lituanica ◽

10.6001/actamedica.v25i4.3933 ◽

2019 ◽

Vol 25 (4) ◽

pp. 226-233

Author(s):

Minija Čerškutė ◽

Marius Kinčius ◽

Tomas Januškevičius ◽

Saulius Cicėnas ◽

Albertas Ulys

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Partial Nephrectomy ◽

Renal Cell ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Abdominal Ct ◽

Postoperative Course ◽

Carcinoma Metastasis

Background. Renal cell carcinoma (RCC) may be metastatic, although solitary sternal metastasis of RCC is a rare medical condition. Here we report an unusual case of a 63-year-old male with a solitary sternal metastasis as an initial presentation of clear-cell renal cell carcinoma. Materials and methods. A 63-year-old male presented with a small sternal mass. Chest computer tomography (CT) and a biopsy from the sternal tumour were performed. Histopathological examination revealed the diagnosis of renal clear cell carcinoma metastasis to the sternal bone. On the basis of a subsequently performed abdominal CT the patient was confirmed with a suspicion of a left renal lower pole tumour. Treatment with sunitinib was initiated. Due to the limited response and a growing sternal mass, the patient was admitted to the National Cancer Institute after two cycles of sunitinib therapy. Open left partial nephrectomy was performed followed by the resection of the sternal metastasis two months later. The chest wall was reconstructed with polypropylene mesh combined with transversal rectus abdominis musculocutaneous flap. Results. The postoperative course after the partial nephrectomy was uneventful. The postoperative course of metastasectomy complicated with the right pneumothorax which was successfully treated by insertion of a chest tube. Bleeding from the upper digestive tract also occurred on the seventh postoperative day but was successfully controlled by haemostasis with three 20 ml endoscopic injections of 1:10,000 solution of epinephrine. The patient had been followed up after the surgery for 30 months with biannual chest and abdominal CT scans that showed neither local nor distant recurrence of the disease. Conclusions. Radical surgical treatment of a solitary renal clear cell carcinoma metastasis may offer the best cancer-specific outcomes and improve the quality of life in some patients.

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Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Renal Clear Cell Carcinoma

10.21203/rs.2.24461/v1 ◽

2020 ◽

Author(s):

Kun Wang ◽

Tingchun Wu ◽

zhen chen

Keyword(s):

Cell Carcinoma ◽

Partial Nephrectomy ◽

Apolipoprotein B ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Surgical Patients ◽

Apo B ◽

Apob Level ◽

Prognostic Effect

Abstract Background To assess the prognostic value of preoperative apolipoprotein B level in surgical patients with renal clear cell carcinoma (ccRCC). Materials and Methods The study included 307 ccRCC patients receiving radical or partial nephrectomy between 2003 and 2012 in our center. The correlations among the preoperative ApoB, clinico-pathological parameters, and overall survival (OS) were evaluated. Results A total of 193 men (62.9%) and 114 women (37.1%) with ccRCC underwent radical or partial nephrectomy were enrolled in the present study. The OS at five years after operation was 90.6% for all patients, 87.4% for the lower ApoB group, and 97.0% for the higher ApoB group. The CSS at 5 years after surgery was 90.2% for all patients, 86.7% for the lower ApoB group, and 97.0% for the higher ApoB group. A higher ApoB level was related to a better OS and CSS in ccRCC patients (P = 0.001 and P < 0.001, respectively). In multivariate analysis, age >60 (P=0.008 and P=0.023), lower Apo B level (P= 0.019 and P= 0.018), were independent prognostic factors for OS and CSS, respectively. Conclusions In the Apo apolipoprotein family, the preoperative ApoB level has an important clinical significance for predicting the prognosis survival rate of the ccRCC patients.

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Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

Acta Chirurgica Latviensis ◽

10.2478/chilat-2014-0016 ◽

2013 ◽

Vol 13 (2) ◽

pp. 79-80

Author(s):

Zane Simtniece ◽

Gatis Kirsakmens ◽

Ilze Strumfa ◽

Andrejs Vanags ◽

Maris Pavars ◽

...

Keyword(s):

Abdominal Pain ◽

Surgical Treatment ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Primary Tumour ◽

Renal Clear Cell Carcinoma ◽

Pancreatic Metastasis ◽

Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

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