scholarly journals Growth and glycemic control in children with type 1 diabetes and asymptomatic celiac disease treated with a gluten -free diet for 1 year

2019 ◽  
Vol 17 ◽  
pp. 205873921985557
Author(s):  
Maria Giulia Berioli ◽  
Giulia Mancini ◽  
Nicola Principi ◽  
Elisa Santi ◽  
Martina Ascenzi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Glycemic Control ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Age And Gender ◽  
The Mean ◽  
And Gender ◽  
Nutritional Status Of Children

To compare growth and glycemic control in children with type 1 diabetes and silent celiac disease treated with a gluten-free diet for 1 year with those of similar age and gender with type 1 diabetes but without celiac disease, 16 type 1 diabetes patients with silent celiac disease were enrolled and each celiac disease-positive case was matched for age, sex, and duration of diabetes with two type 1 diabetes controls with negative serologic markers of celiac disease. All 16 children with positive celiac disease serology had histologic features consistent with celiac disease despite the absence of symptoms. The mean growth and metabolic control values were similar between children with type 1 diabetes and celiac disease and those with type 1 diabetes but without celiac disease. This study seems to suggest that the early diagnosis of celiac disease and initiation of a gluten-free diet may prevent further deterioration in the nutritional status of children with type 1 diabetes and celiac disease and may reduce the prospect of celiac disease complications without any impact on type 1 diabetes control.

Effect of Gluten-Free Diet on Growth and Glycemic Control in Children with Type 1 Diabetes and Asymptomatic Celiac Disease

2010 ◽  
Vol 23 (11) ◽  
Author(s):  
Vi Lier Goh ◽  
D. Elizabeth Estrada ◽  
Trudy Lerer ◽  
Fabiola Balarezo ◽  
Francisco A. Sylvester
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Glycemic Control ◽  
Gluten Free Diet ◽  
Gluten Free

EFFECT OF GLUTEN-FREE DIET ON METABOLIC CONTROL AND ANTHROPOMETRIC PARAMETERS IN TYPE 1 DIABETES WITH SUBCLINICAL CELIAC DISEASE: A RANDOMIZED CONTROLLED TRIAL

2020 ◽  
Vol 26 (6) ◽  
pp. 660-667 ◽  
Author(s):  
Parjeet Kaur ◽  
Anuja Agarwala ◽  
Govind Makharia ◽  
Shinjini Bhatnagar ◽  
Nikhil Tandon
Keyword(s):  
Randomized Controlled Trial ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Blood Glucose ◽  
Controlled Trial ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Randomized Controlled ◽  
The Mean

Objective: It is unclear whether the institution of gluten-free diet (GFD) is beneficial in patients with type 1 diabetes (T1DM) and subclinical celiac disease (CD). Our primary objective was to evaluate the effect of GFD on the frequency of hypoglycemia, in patients with T1DM and subclinical CD. Our secondary objective was to investigate the effect of GFD on height, weight, glycosylated hemoglobin (HbA1c), insulin dose requirement, and bone mineral homeostasis. Methods: We carried out a prospective open label randomized controlled trial (RCT). Patients with T1DM and subclinical CD were randomized to receive GFD or a normal diet for 1 year. The primary outcome was the frequency of hypoglycemic episodes (blood glucose <70 mg/dL) measured by self-monitoring of blood glucose (SMBG) at the sixth month of the study in the 2 groups. Results: Screening for CD was carried out in 320 T1DM patients. Thirty eligible patients were randomized to receive GFD (n = 15) or a normal diet (n = 15). The mean number of hypoglycemic episodes/month recorded by SMBG and the mean time spent in hypoglycemia measured by CGM (minutes) in the GFD group versus the non-GFD group at six months was 2.3 minutes versus 3.4 minutes ( P = .5) and 124.1 minutes versus 356.9 minutes ( P = .1), respectively. The mean number of hypoglycemic episodes/month significantly declined in the GFD group (3.5 episodes at baseline versus 2.3 episodes at the sixth month; P = .03). The mean HbA1c declined by 0.73% in the GFD group and rose by 0.99% in non-GFD group at study completion. Conclusion: This is the first RCT to assess the effect of GFD in T1DM and subclinical CD. A trend towards a decrease in hypoglycemic episodes and better glycemic control was seen in patients receiving GFD. Abbreviations: BMC = bone mineral content; BMI = body mass index; CD = celiac disease; CGM = continuous glucose monitoring; GFD = gluten-free diet; Hb = hemoglobin; HbA1c = glycosylated hemoglobin; iPTH = intact parathyroid hormone; RCT = randomized controlled trial; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus; tTG-IgA = tissue transglutaminase immunoglobulin A

The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease

Bone ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 322-326 ◽  
Author(s):  
Giuliana Valerio ◽  
Raffaella Spadaro ◽  
Dario Iafusco ◽  
Francesca Lombardi ◽  
Antonio del Puente ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Quantitative Ultrasound ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Design of a dietary intervention to assess the impact of a gluten-free diet in a population with type 1 Diabetes and Celiac Disease

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Esther Assor ◽  
Margaret A. Marcon ◽  
Natasha Hamilton ◽  
Marilyn Fry ◽  
Tammy Cooper ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Dietary Intervention ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
The Impact

Impact of a Gluten-Free Diet on Quality of Life and Health Perception in Patients with Type 1 Diabetes and Asymptomatic Celiac Disease

2021 ◽  
Author(s):  
Daniel I Weiman ◽  
Farid H Mahmud ◽  
Antoine B M Clarke ◽  
Esther Assor ◽  
Charlotte McDonald ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Health Perception ◽  
Lifestyle Changes ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Gi Symptoms

Abstract Context Celiac disease (CD) is a common comorbidity seen in patients with type 1 diabetes (T1D) and is frequently asymptomatic. As chronic conditions requiring significant lifestyle changes, there are limited reports assessing changes in health-related quality of life (HRQoL) during transition to a gluten-free diet (GFD) in patients with both T1D and who are asymptomatic for CD. Objective To prospectively assess HRQoL and health perception in children and adults with T1D and asymptomatic CD after randomization to GFD versus usual diet. Design, Setting, and Participants Patients with T1D aged 8-45 years without CD symptoms were serologically screened for CD, with positive results confirmed with intestinal biopsy. Participants were randomized in an open-label fashion to a GFD or gluten-containing diet (GCD) for 12 months. Generic and diabetes-specific HRQoL and self-perceived wellness (SPW) were assessed longitudinally. Results 2,387 T1D patients were serologically screened. CD was biopsy-confirmed in 82 patients and 51 participants were randomized to a GFD (N=27) or GCD (N=24). Excellent adherence to the assigned diets was observed. Overall, no changes in generic (P=0.73) or diabetes-specific HRQoL (P=0.30), or SPW (P=0.41) were observed between groups over 12 months. HemoglobinA1c (HbA1c) and GI symptoms were consistent predictors of HRQoL and SPW. Conclusions HRQoL and SPW were not significantly impacted by the adoption of a GFD over 12 months, but worsened with symptom onset and increased HbA1c. Our findings indicate that transition to a GFD can be made successfully in this population without adversely impacting quality of life.

The urinary inflammatory profile in gluten free diet—adherent adolescents with type 1 diabetes and celiac disease

2016 ◽  
Vol 30 (2) ◽  
pp. 295-299 ◽  
Author(s):  
Emilia N. De Melo ◽  
Livia Deda ◽  
Ronnie Har ◽  
Heather N. Reich ◽  
James W. Scholey ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Inflammatory Profile
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