Randomized Clinical Trial of Peganum Oil for Knee Osteoarthritis

2015 ◽  
Vol 20 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Zohreh Abolhassanzadeh ◽  
Elham Aflaki ◽  
Gholamhossein Yousefi ◽  
Abdolali Mohagheghzadeh
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
High Performance ◽  
Herbal Medicines ◽  
Peganum Harmala ◽  
Double Blind ◽  
Significant Difference ◽  
Important Symptom ◽  
Traditional Preparation

Osteoarthritis affects about 50% of people aged older than 65 years. Pain is the most important symptom in this disease. Today public interest in the use of complementary medicine, especially traditional herbal medicines has increased. The present study was designed to investigate the efficacy of traditional preparation of Peganum harmala L oil on patients with knee osteoarthritis. The product has been analyzed and standardized by high-performance liquid chromatography. A double blind controlled randomized clinical trial consisting of 54 patients were performed. Patients rubbed the drug or control (olive oil) on the knee 4 drops 3 times a day for 4 weeks. The patients were asked to fill out the Western Ontario and McMaster Universities Arthritis Index and Visual Analogue Scale questionnaires at week 0 and 4. The adapted results from the questionnaires showed that pain and difficulty in function were significantly decreased in Peganum oil group after 4 weeks. There was no significant difference in stiffness change between 2 groups.

scholarly journals Effect of acupressure on knee osteoarthritis symptoms in the elderly: a double-blind randomized clinical trial

10.19082/7489 ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 7489-7498
Author(s):  
Ali Ansari Jaberi ◽  
Tahere Norouzi ◽  
Shahin Haydari ◽  
Tayebeh Negahban Bonabi
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
The Elderly ◽  
Double Blind

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p<0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p<0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (>0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

scholarly journals Six-month Follow-up of Cervical Composite Restorations Placed With a New Universal Adhesive System: A Randomized Clinical Trial

2016 ◽  
Vol 41 (5) ◽  
pp. 465-480 ◽  
Author(s):  
LS Lopes ◽  
FS Calazans ◽  
R Hidalgo ◽  
LL Buitrago ◽  
F Gutierrez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Retention Rate ◽  
Evaluation Criteria ◽  
Cervical Lesions ◽  
Universal Adhesive ◽  
Double Blind ◽  
Etch And Rinse ◽  
Significant Difference ◽  
Self Etch

SUMMARY Purpose: The objective of this double-blind, randomized clinical trial was to evaluate the six-month clinical performance of a new universal adhesive (Xeno Select, Dentsply) in noncarious cervical lesions (NCCLs) using two evaluation criteria: World Dental Federation (FDI) and the US Public Health Service (USPHS). Methods and Materials: A total of 124 restorations were randomly placed in 31 patients according to the following groups: ER-D = etch-and-rinse/dry dentin; ER-M = etch-and-rinse/moist dentin; SE-et = selective enamel etching; and SET = self-etch. The composite resin EVOLUX (Dentsply) was placed incrementally. The restorations were evaluated after one week (baseline) and at six months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α=0.05). Results: Fifteen restorations were lost or fractured at six months (one for ER-D, three for ER-M, five for SE-et, and six for SET) (p>0.05 at six-month recall). When ER (ER-D and ER-M) was compared with SE (SE-et and SET) there was a significant difference in the retention rate after six months (p=0.001). Marginal staining and postoperative sensitivity to air were only observed in three (one for ER-M and two for SET) and two restorations (two for ER-D) in both evaluation criteria (p>0.05), respectively. Forty-seven restorations were considered to have minor discrepancies in marginal adaptation at the six-month recall using the FDI criteria (13 for ER-D, 10 for ER-M, 11 for SE-et, and 13 for SET; p>0.05 between groups). However, for all groups, a significant difference was detected when baseline and six-month data were compared (p<0.05). Conclusions: The six-month clinical behavior of Xeno Select Universal Adhesive depends on the bonding strategy used. The universal adhesive did not fulfill the American Dental Association criteria for full approval when used in the self-etch mode.

scholarly journals Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial

Rheumatology ◽  
2015 ◽  
Vol 55 (4) ◽  
pp. 755-762 ◽  
Author(s):  
Gian Luca Bagnato ◽  
Giovanni Miceli ◽  
Natale Marino ◽  
Davide Sciortino ◽  
Gian Filippo Bagnato
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
Electromagnetic Fields ◽  
Pulsed Electromagnetic Fields ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Pulsed Electromagnetic

Repeated intra articular injection of bone marrow derived mesenchymal stem cell in knee osteoarthritis: double blind randomized clinical trial

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S14 ◽  
Author(s):  
N. Aghdami ◽  
M. Ghorbani Liastani ◽  
M. Emadedin ◽  
F. Mohseni ◽  
R. Fazeli ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Knee Osteoarthritis ◽  
Randomized Clinical Trial ◽  
Double Blind

scholarly journals The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Alireza Yargholi ◽  
Leila Shirbeigi ◽  
Roja Rahimi ◽  
Parvin Mansouri ◽  
Mohammad Hossein Ayati
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Herbal Medicines ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Skin Area ◽  
Melissa Officinalis ◽  
Double Blind ◽  
Significant Difference ◽  
Pre Treatment

Abstract Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis. Result Among 100 patients, 95 participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P < 0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P = 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration: The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 (https://www.irct.ir/trial/43434; registration number: IRCT20191104045326N1).

scholarly journals Comparison of changes in irregularity and transverse width with nickel-titanium and niobium-titanium-tantalum-zirconium archwires during initial orthodontic alignment in adolescents: A double-blind randomized clinical trial

2018 ◽  
Vol 88 (3) ◽  
pp. 348-354 ◽  
Author(s):  
Barrett Nordstrom ◽  
Toshihiro Shoji ◽  
W. Cameron Anderson ◽  
Henry W. Fields ◽  
F. Michael Beck ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Nickel Titanium ◽  
Initial Alignment ◽  
Double Blind ◽  
Nickel Allergy ◽  
Irregularity Index ◽  
Significant Difference ◽  
Niobium Titanium ◽  
Niti Wires

ABSTRACT Objectives: The purpose of this prospective, double-blind, randomized clinical trial was to compare the clinical efficiency of nickel-titanium (NiTi) and niobium-titanium-tantalum-zirconium (TiNbTaZr) archwires during initial orthodontic alignment. Materials and Methods: All subjects (ages between 12 and 20 years) underwent nonextraction treatment using 0.022-inch brackets. All patients were randomized into two groups for initial alignment with 0.016-inch NiTi archwires (n = 14), or with 0.016-inch TiNbTaZr archwires (n = 14). Digital scans were taken during the course of treatment and were used to compare the improvement in Little's Irregularity Index and the changes in intercanine and intermolar widths. Results: There was approximately a 27% reduction in crowding during the first month with the use of 0.016-inch TiNbTaZr (Gummetal) wire, and an additional 25% decrease in crowding was observed during the next month. There was no significant difference between the two treatment groups in the decrease in irregularity over time (P = .29). There was no significant difference between the two groups in the changes in intercanine and intermolar width (P = .80). Conclusions: It can be concluded that Gummetal wires and conventional NiTi wires possess a similar ability to align teeth, and Gummetal wires have additional advantages over conventional NiTi, such as formability and use in patients with nickel allergy.

scholarly journals The Effect of L-Carnitine Supplementation on Weight and Body Composition in Women with Polycystic Ovary Syndrome: A Double-Blind Randomized Clinical Trial

2020 ◽  
Author(s):  
Fatemeh Pakravanfar ◽  
Akram Ghadiri-Anari ◽  
Azadeh Nadjarzadeh ◽  
Hossein Fallahzadeh ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Clinical Trial ◽  
Body Mass Index ◽  
Body Composition ◽  
Waist Circumference ◽  
Randomized Clinical Trial ◽  
Body Mass ◽  
Fat Mass ◽  
Hip Circumference ◽  
Double Blind ◽  
Significant Difference

Background: Polycystic ovarian syndrome (PCOS), one of the most common causes of endocrine disorders with irregular menstruation, is accompanied by an increase in androgen and polycystic ovarian. The aim of this study was to evaluate the effect of weight loss regimen with and without supplementation. L-carnitine affects lipid profile, insulin, and hormone resistance indices. Methods: This double-blind randomized clinical trial was conducted over women within the age range of 18 to 45 years, who referred to Yazd Diabetes Center in 2019. The participants were divided into the experimental and control groups. The intervention group received 1000 mg L-carnitine (LG = 28) and the placebo group (PG = 28) received the placebo daily. All people followed a low celery diet for 12 weeks. Anthropometric indices and body composition (weight, body mass index, waist circumference, hip circumference, fat mass, and free fat mass) were measured prior to and after the intervention. Data analysis was performed using SPSS software version 22. The independent sample t-test was used to compare the mean changes between the LG and PG. Results: At the end of the study period, patients treated with L-carnitine showed a significant decrease in waist circumference compared to the PG (change: -1 ± 3.15, P = 0.001) and no significant difference was observed between the two groups in terms of other anthropometrics indices and body composition including fat mass, body mass index, and hip circumference (P > 0.05). Conclusion: The present study showed that 1000 mg oral L-carnitine had no significant effect on body weight, body mass index, body composition, and hip circumference, but had a significant effect on waist circumference size.

Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine

Cephalalgia ◽  
2019 ◽  
Vol 40 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Laís Bhering Martins ◽  
Ana Maria dos Santos Rodrigues ◽  
Nayara Mussi Monteze ◽  
Jenneffer Rayane Braga Tibaes ◽  
Matheus Henrique Alves Amaral ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Prophylactic Treatment ◽  
Zingiber Officinale ◽  
Episodic Migraine ◽  
Minas Gerais ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Significant Difference ◽  
Belo Horizonte

Background Previous studies have shown an analgesic effect of ginger in the acute treatment of migraine, and there is anecdotal evidence of its efficacy in migraine prophylaxis. Objective This study aimed to evaluate the potential of ginger to prevent migraine attacks. Methods This double-blind, placebo-controlled randomized clinical trial took place at the Headache Clinic, Universidade Federal de Minas Gerais (Belo Horizonte, Minas Gerais, Brazil), involving 107 patients. Only subjects diagnosed with episodic migraine, aged between 18 and 60 years old, and who were not taking any prophylactic medication, were enrolled in the study. After one month of observation, subjects selected for the study were randomized 1:1 into placebo and treatment groups. Patients received capsules three times per day of 200 mg of dry extract of ginger (5% active ingredient) or placebo (cellulose) for three months. Visits were performed monthly and the patients were asked to fill in a migraine diary. The adherence to treatment was evaluated by counting capsules. Results The percentage of patients who responded to treatment (i.e. a reduction of 50% in the number of migraine attacks at the end of treatment) did not differ between the groups. There was a decrease in the number of days with severe pain, analgesic use for acute migraine and duration of migraine attacks in both groups, without significant difference between ginger and placebo groups. Conclusions Ginger provides no greater benefit in the prophylactic treatment of migraine when compared to placebo. This trial is registered at ClinicalTrials.gov (NCT02570633).

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