scholarly journals The Effect of L-Carnitine Supplementation on Weight and Body Composition in Women with Polycystic Ovary Syndrome: A Double-Blind Randomized Clinical Trial

Author(s):  
Fatemeh Pakravanfar ◽  
Akram Ghadiri-Anari ◽  
Azadeh Nadjarzadeh ◽  
Hossein Fallahzadeh ◽  
Mahdieh Hosseinzadeh

Background: Polycystic ovarian syndrome (PCOS), one of the most common causes of endocrine disorders with irregular menstruation, is accompanied by an increase in androgen and polycystic ovarian. The aim of this study was to evaluate the effect of weight loss regimen with and without supplementation. L-carnitine affects lipid profile, insulin, and hormone resistance indices. Methods: This double-blind randomized clinical trial was conducted over women within the age range of 18 to 45 years, who referred to Yazd Diabetes Center in 2019. The participants were divided into the experimental and control groups. The intervention group received 1000 mg L-carnitine (LG = 28) and the placebo group (PG = 28) received the placebo daily. All people followed a low celery diet for 12 weeks. Anthropometric indices and body composition (weight, body mass index, waist circumference, hip circumference, fat mass, and free fat mass) were measured prior to and after the intervention. Data analysis was performed using SPSS software version 22. The independent sample t-test was used to compare the mean changes between the LG and PG. Results: At the end of the study period, patients treated with L-carnitine showed a significant decrease in waist circumference compared to the PG (change: -1 ± 3.15, P = 0.001) and no significant difference was observed between the two groups in terms of other anthropometrics indices and body composition including fat mass, body mass index, and hip circumference (P > 0.05). Conclusion: The present study showed that 1000 mg oral L-carnitine had no significant effect on body weight, body mass index, body composition, and hip circumference, but had a significant effect on waist circumference size.

2015 ◽  
Vol 11 (6) ◽  
pp. S1-S2 ◽  
Author(s):  
Hilde Risstad ◽  
Marius Svanevik ◽  
Jon A Kristinsson ◽  
Jøran Hjelmesæth ◽  
Erlend T. Aasheim ◽  
...  

2018 ◽  
Vol 2 (73) ◽  
Author(s):  
Sandrija Čapkauskienė ◽  
Kristina Visagurskienė ◽  
Rima Bakienė ◽  
Irena Vitkienė ◽  
Daiva Vizbaraitė

Childhood obesity is a key public health issue around the globe in developed and developing countries (Dugan, 2008). The recent worldwide increase in the prevalence of childhood obesity may be due in part to a decrease in children’s physical activity levels (Ball et al., 2001). It is necessary to develop early interventions to improve physical fitness in children and to prevent the increase of childhood obesity (Brunet et al., 2006). So, the aim of this study was to evaluate the body composition and physical fitness of children aged 5—7 years and to estimate the interaction between body composition components and physical fitness tests. Participants: 216 children participated in this study: 104 girls, mean age 5.90 ± 0.63 years and 112 boys — mean age 5.98 ± 0.50 years from Kaunas city (Lithuania) preschools. Methods: all the subjects have been measured for their height, body mass, waist circumference (WC) and skinfolds at 2 different places — triceps and subscapular. Body mass index (BMI) and percentage body fat mass (BFM) were evaluated. All the participants did four physical fitness tests including speed shuttle run, 20 meters distance run, standing long jump and throwing 1 kg ball. General physical fitness level was evaluated based on B. Sekita (1988) methods. Results. Results showed that BMI did not significantly differ between boys and girls, and was evaluated as “optimal” for both groups. BFM was significantly higher in girls (p < 0.001), and WC did not differ between genders. But WC had a tendency to increase with age in both boys and girls. Strong relationship was observed between BMI and BFM (r = 0.660, r = 0.660 respectively; p < 0.01), and between BMI and WC (r = 0.703, r = 0.826 respectively; p < 0.01) for both boys and girls. The results of physical tests showed that boys did all the tests better than girls (p < 0.01). When we evaluated the general physical fitness of each child, the results indicated that their physical fitness waslow, evaluated as “good enough” for most boys and girls. General physical fitness of children negatively but slightly correlated with BFM (r = –0.201; p < 0.001), it indicated that higher BFM determined lower evaluation of general physical fitness.Conclusions. Optimal body weight, according to body mass index, percentage body fat mass and waist circumference, was established for the bigger part of children, aged 5—7 years old. This study shows that physical fitness of children was low — evaluated as “good enough” and negatively correlated with body fat mass, showing that high body fat mass negatively impacted physical fitness.Key words: body mass index, percentage body fat mass, waist circumference, physical fitness.


Author(s):  
Ümit Görkem ◽  
Ferit Kerim Küçükler ◽  
Cihan Toğrul ◽  
Şebnem Gülen

<p><strong>Objective:</strong> To evaluate the potential role of vitamin D on ovarian reserve markers in infertile women with different reserve patterns.</p><p><strong>Study design:</strong> This prospective cross-sectional study included the infertile women attending the Hitit University Hospital. The initial examination included the measurements of waist circumference and hip circumference, body mass index, and waist/hip ratio. A total of 171 women were divided into three groups according to ovarian reserve patterns: (i) adequate ovarian reserve pattern (AOR, n=77), (ii) high ovarian reserve pattern (polycystic ovarian syndrome, n=62), and (iii) diminished ovarian reserve pattern (DOR, n=32). The serum estradiol (E2), follicle stimulating hormone, total testosterone, 17-hydroxy-progesterone (17(OH) P), dehydroepiandrosterone sulfate, anti-mullerian hormone, and hydroxycholecalciferol (25(OH) D) levels were analyzed. </p><p><strong>Results:</strong> No significant difference between three different groups was detected in terms of body mass index, waist circumference, hip circumference, waist/hip ratio, E2 and 17OHP levels (p&gt;0.05, for all). One-hundred-sixty-nine (98.2%) women in all groups had vitamin D concentration below 30 ng/mL as a cut-off value. The circulating 25 (OH) D levels did not show a significant difference between all ovarian reserve groups (p=0.804). No correlation between 25(OH) D and anti-mullerian hormone levels was documented in women with AOR, polycystic ovarian syndrome and DOR patterns (r=-0.099 p=0.393, r=0.034 p=0.794 and r=0.157 p=0.390 respectively). 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group (r=-0.355 p=0.002, r=-0.305 p=0.007 and r=-0.322 p=0.004 respectively).</p><p><strong>Conclusions:</strong> There is no association between 25 (OH) D and ovarian reserve markers. 25 (OH) D levels were significantly correlated with body mass index, waist circumference and hip circumference parameters only in AOR group.</p>


2019 ◽  
Vol 44 (1) ◽  
pp. 147-158
Author(s):  
Felipe Mazzoleni ◽  
Luiz Edmundo Mazzoleni ◽  
Carlos Fernando de Magalhães Francesconi ◽  
Guilherme Becker Sander ◽  
Pâmela Schitz Von Reisswitz ◽  
...  

2020 ◽  
Author(s):  
Salma Ahi ◽  
Fatemeh Gholami ◽  
Naser Hatami ◽  
Fatemeh Golabi

Abstract Background: Vitamin D deficiency is one of the most prevalent disorders worldwide. Considering the magnitude of growth in adolescence, the aim of this study was to ascertain the prevalence of vitamin D deficiency and discover the association between anthropometric indices and vitamin D levels and the effect of vitamin D treatment on anthropometric indices in adolescent girls. Method: we performed this randomized clinical trial study (approved by Iranian Registry of Clinical Trials with code of IRCT20200615047785N2) conducting 313 high school girl students in a random cluster sampling from Jahrom city schools. Blood samples were collected from participants to determine the serum level (OH) D25. We divided vitamin D deficient patients into two groups: control who received placebo (n=150) and intervention group (n=150) who were prescribed one tablet of 50,000 units of vitamin D per week for eight weeks. Anthropometric indices of participants were measured before and after the intervention. Datas were analyzed by SPSS software version 19.Results: The prevalence of vitamin D deficiency was 95%. Body mass index had no significant difference before the intervention in both groups (P = 0.76). After intervention in the case group, body mass index increased significantly (P = 0.01), but there was no significant difference in the control group after treatment (P = 0.42). There was no significant difference in waist circumference, height and weight before and after the intervention in both groups (P > 0.05). There was also a weak but significant correlation between height, weight, and baseline 25OHD levels of participants.Conclusion: The results of this study showed that there is a reverse and significant relationship between height and weight index with 25OHD. Further monitoring and prolonged studies with extended follow ups might improve the anthropometric parameters after treatment.


Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3122
Author(s):  
Eduard Isenmann ◽  
Joshua Dissemond ◽  
Stephan Geisler

The number of people suffering from being overweight or obese has risen steadily in recent years. Consequently, new forms of nutrition and diets were developed as potential solutions. In the last years, the time-restricted feeding and continuous energy restriction via macronutrient-based diets were increasingly popular. Both diets were exclusively studied separately. A comparison of the two diets for people with a high body mass index despite regular physical activity has not yet been studied in detail. Therefore, this study aimed to compare the effects of these two diets on body composition and adherence. For this study, a total of 42 subjects (m = 21, f = 21) with a BMI above 25 were recruited from a local fitness gym. After a two-week familiarisation period, one of the two diets was followed over 14 weeks. Dietary behaviour was monitored throughout the period with a food diary. The primary measurement parameters were body weight, lean body mass, fat mass, body mass index, and waist and hip circumference. In addition, adherence was assessed and calculated by food diary and questionnaire. In total, the data of 35 participants (m = 14, f = 21) were analysed. Significant reductions in body weight, fat mass, body mass index, and waist and hip circumference were observed in both groups (p < 0.05). No significant change could be observed in lean body mass in either category. No group and gender differences were detected in any of the primary parameters. For the secondary parameters, a significantly higher adherence was observed in the time-restricted feeding group (p < 0.05). In addition, it can be assumed that an adherence of 60–70% cannot lead to positive changes in body composition. In conclusion, there were no differences between the two diets on the primary parameters. However, it seemed that time-restricted feeding can be better implemented in everyday life, and an adherence of more than 70% is required for both diets to prove effective.


Author(s):  
Dmitry S. Korolev ◽  
Dmitry A. Pustovalov ◽  
Oleg P. Karazhelyaskov ◽  
Anna N. Arkhangelskaya ◽  
Victoria A. Zaborova ◽  
...  

BACKGROUND: One of the indicators for assessing the state of human health is the body mass index. But this indicator does not give an objective picture, for example, it does not reflect the features of a person's physique. To assess the type of obesity, the ratio of waist circumference to hip circumference is used. This can lead to an incorrect assessment of the nutritional status, and, accordingly, incorrect recommendations for the prevention of non-communicable human diseases. АIMS: To evaluate the indicators: body mass index and the ratio of waist circumference to hips, the results were compared with the data of a bioimpedance study. MATERIALS AND METHODS: 154 people of different physical fitness were examined (105 people are athletes, 49 are not engaged in sports). All the surveyed are men, from 15 to 25 years old. The results were obtained for the following indicators: body mass index, waist-to-hip ratio, bioimpedance study (assessment of fat mass, lean mass, active cell mass, dry muscle mass, total, extracellular and intracellular water). RESULTS: Тhe body mass index significantly correlates with such indicators as fat mass, lean mass, dry muscle mass, as well as the water content in the body. The correlation relationship with fat mass is positive, with other indicators ― negative. There is no reliable correlation with the active cell mass. The ratio of waist circumference to hips had a reliable relationship with all the indicators we evaluated. A negative correlation was noted with the fat mass, and a positive correlation was observed for the rest of the indicators. In people who are actively engaged in sports, the relationship between the body mass index and the content of adipose tissue in the body is more pronounced. The body mass index and the ratio of waist circumference to hip circumference in athletes are more correlated with the data of the bioimpedance study. A reliable relationship between the body mass index and the ratio of the waist circumference to the hips has not been established. Thus, it is necessary to conclude that when assessing the state of the body, it is necessary to take into account both indicators. None of these parameters can be used to determine the risks of developing non-communicable diseases. CONCLUSION: Body mass index indicators, as well as the ratio of waist circumference to hips, significantly correlate with the results of bioimpedance examination, with the exception of active cell mass. It is advisable to use the body mass index and the ratio of waist circumference to hips as one of the simplest ways to determine risk groups for the development of non-communicable diseases during a mass screening study.


PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32213 ◽  
Author(s):  
Tina Landsvig Berentzen ◽  
Lars Ängquist ◽  
Anna Kotronen ◽  
Ronald Borra ◽  
Hannele Yki-Järvinen ◽  
...  

2021 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Shakeela Ishrat ◽  
Marufa Hossain ◽  
Subrata Kumar Biswas

The objective of this study is to explore how hyperinsulinemia and insulin resistance relate to the clinical, endocrine and metabolic factors in the infertile women with polycystic ovary syndrome. This study was conducted on 121 consecutive infertile women with polycystic ovary syndrome attending the Infertility unit from January 2017 to December 2017. They were divided into two groups: insulin resistant and insulin sensitive. There was significant difference in body mass index and waist circumference between the two groups. Serum lipids were not associated with insulin resistance. Hyperinsulinemia was significantly associated with metabolic syndrome. Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome. Screening the infertile women with polycystic ovary syndrome for hyperinsulinemia and insulin resistance and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.


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