scholarly journals What Are the Risk Factors for Adjacent Vertebral Fracture After Vertebral Augmentation? A Meta-Analysis of Published Studies

2020 ◽  
pp. 219256822097822
Author(s):  
Tianyu Zhang ◽  
Yanhua Wang ◽  
Peixun Zhang ◽  
Feng Xue ◽  
Dianying Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vertebral Fracture ◽  
Cobb Angle ◽  
Meta Analysis ◽  
Cement Leakage ◽  
Thoracolumbar Junction ◽  
Vertebral Augmentation ◽  
T Score ◽  
Intravertebral Cleft ◽  
Adjacent Vertebral Fracture

Study Design: Meta-analysis. Objectives: To provide up-to-date evidence-based outcomes for the incidence and risk factors of adjacent vertebral fracture (AVF) after the vertebral augmentation. Methods: The MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for studies assessing the risk factors of adjacent vertebral fracture after vertebral augmentation until June 2020. The AVF incidence and factors potentially affecting AVF were extracted and pooled. Results: A total of 16 studies, encompassing 2549 patients were included in the meta-analysis. The pooled incidence of AVF was 14% after vertebral augmentation. Female, lower T-score, thoracolumbar junction fracture, intravertebral cleft, more injected cement volume, intradiscal cement leakage significantly increased the risk of AVF. Age, body mass index, steroid medication, Cobb angle change, postoperative Cobb angle showed no significant association with AVF. Conclusions: Identifying the risk factors of AVF can facilitate prevention strategy to avoid the AVF. Female, T-score, thoracolumbar junction fracture, intravertebral cleft, more cement volume, and intradiscal cement leakage increased the risk of AVF.

Identification of Risk Factors for the Occurrence of Cement Leakage During Percutaneous Vertebroplasty for Painful Osteoporotic or Malignant Vertebral Fracture

2013 ◽  
Vol 13 (9) ◽  
pp. S90 ◽  
Author(s):  
Felix Tome-Bermejo ◽  
Luis Alvarez ◽  
Angel R. Pinera ◽  
Carmen Duran ◽  
Belen Lopez-San Roman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vertebral Fracture ◽  
Percutaneous Vertebroplasty ◽  
Cement Leakage

scholarly journals Risk Factors for Cement Loosening after Vertebroplasty for Osteoporotic Vertebral Fracture with Intravertebral Cleft: A Retrospective Analysis

2018 ◽  
Vol 12 (5) ◽  
pp. 935-942 ◽  
Author(s):  
Toshio Nakamae ◽  
Kiyotaka Yamada ◽  
Yasuyuki Tsuchida ◽  
Orso Lorenzo Osti ◽  
Nobuo Adachi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vertebral Fracture ◽  
Retrospective Analysis ◽  
Osteoporotic Vertebral Fracture ◽  
Intravertebral Cleft

Risk factors of cemented vertebral refracture after percutaneous vertebral augmentation: a systematic review and meta-analysis

2020 ◽  
Vol 62 (11) ◽  
pp. 1353-1360
Author(s):  
Shiqi Zhu ◽  
Qingjun Su ◽  
Yaoshen Zhang ◽  
Zhencheng Sun ◽  
Peng Yin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Vertebral Augmentation

Development and internal validation of a clinical prediction model for acute adjacent vertebral fracture after vertebral augmentation

2022 ◽  
Vol 104-B (1) ◽  
pp. 97-102
Author(s):  
Yasukazu Hijikata ◽  
Tsukasa Kamitani ◽  
Masayuki Nakahara ◽  
Shinji Kumamoto ◽  
Tsubasa Sakai ◽  
...  
Keyword(s):  
Decision Making ◽  
Vertebral Fracture ◽  
High Risk ◽  
Prediction Model ◽  
Vertebral Augmentation ◽  
Clinical Prediction ◽  
Internal Validation ◽  
Duration Of Symptoms ◽  
Clinical Prediction Model ◽  
Adjacent Vertebral Fracture

Aims To develop and internally validate a preoperative clinical prediction model for acute adjacent vertebral fracture (AVF) after vertebral augmentation to support preoperative decision-making, named the after vertebral augmentation (AVA) score. Methods In this prognostic study, a multicentre, retrospective single-level vertebral augmentation cohort of 377 patients from six Japanese hospitals was used to derive an AVF prediction model. Backward stepwise selection (p < 0.05) was used to select preoperative clinical and imaging predictors for acute AVF after vertebral augmentation for up to one month, from 14 predictors. We assigned a score to each selected variable based on the regression coefficient and developed the AVA scoring system. We evaluated sensitivity and specificity for each cut-off, area under the curve (AUC), and calibration as diagnostic performance. Internal validation was conducted using bootstrapping to correct the optimism. Results Of the 377 patients used for model derivation, 58 (15%) had an acute AVF postoperatively. The following preoperative measures on multivariable analysis were summarized in the five-point AVA score: intravertebral instability (≥ 5 mm), focal kyphosis (≥ 10°), duration of symptoms (≥ 30 days), intravertebral cleft, and previous history of vertebral fracture. Internal validation showed a mean optimism of 0.019 with a corrected AUC of 0.77. A cut-off of ≤ one point was chosen to classify a low risk of AVF, for which only four of 137 patients (3%) had AVF with 92.5% sensitivity and 45.6% specificity. A cut-off of ≥ four points was chosen to classify a high risk of AVF, for which 22 of 38 (58%) had AVF with 41.5% sensitivity and 94.5% specificity. Conclusion In this study, the AVA score was found to be a simple preoperative method for the identification of patients at low and high risk of postoperative acute AVF. This model could be applied to individual patients and could aid in the decision-making before vertebral augmentation. Cite this article: Bone Joint J 2022;104-B(1):97–102.

Risk Factors for Cement Leakage After Vertebroplasty or Kyphoplasty: A Meta-Analysis of Published Evidence

2017 ◽  
Vol 101 ◽  
pp. 633-642 ◽  
Author(s):  
Yi Zhan ◽  
Jianzhong Jiang ◽  
Haifen Liao ◽  
Haitao Tan ◽  
Keqin Yang
Keyword(s):  
Risk Factors ◽  
Meta Analysis ◽  
Cement Leakage ◽  
Published Evidence

scholarly journals Ibandronate: A Review of its Vertebral and Nonvertebral Antifracture Efficacy

2009 ◽  
Vol 5 (5) ◽  
pp. 467-473 ◽  
Author(s):  
Michael Amling ◽  
Andreas Kurth
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Oral Treatment ◽  
Meta Analysis ◽  
Cumulative Exposure ◽  
High Efficacy ◽  
Mineral Density ◽  
Good Tolerability ◽  
T Score ◽  
Tolerability Data

After the Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE) study had demonstrated the strong vertebral and nonvertebral antifracture efficacy of daily and intermittent oral ibandronate, the Monthly Oral Ibandronate In Ladies (MOBILE) study gave evidence for an increased efficacy on the bone mineral density (BMD) of higher intermittent oral ibandronate doses (150 mg monthly) compared with 2.5 mg daily. The BONE study also observed nonvertebral antifracture efficacy in patients with a high risk for fractures (mean femoral neck T score of −3.0 or less). A recently published meta-analysis assessing the nonvertebral antifracture efficacy corresponding to the annual cumulative exposure (ACE) of ibandronate demonstrated a significantly better antifracture efficacy of higher compared with lower doses of ibandronate. The Dosing Intravenous Administration (DIVA) study demonstrated evidence for the high efficacy and good tolerability of intravenous ibandronate delivered by quarterly injections. This review summarizes the efficacy and tolerability data of ibandronate concerning monthly oral treatment as well as quarterly injection therapy.

scholarly journals Risk factors of the Secondary Fractures for Osteoporotic Vertebral Compression Fractures after Percutaneous Vertebroplasty

2020 ◽  
Author(s):  
Xiao-kui Kang ◽  
Sheng-fu Guo ◽  
Hui-xin Liu ◽  
Li-li Huang ◽  
Qun-long Jiang
Keyword(s):  
Risk Factors ◽  
Percutaneous Vertebroplasty ◽  
Meta Analysis ◽  
Thoracolumbar Spine ◽  
Cement Leakage ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Secondary Fracture ◽  
Compression Fractures ◽  
Secondary Fractures

Abstract Background Percutaneous vertebroplasty related postoperative secondary fractures risk factors were not consistent in patients with osteoporotic vertebral compression Fractures. The purpose was to identify the risk factors of the secondary fractures for osteoporotic vertebral compression fractures after percutaneous vertebroplasty.Methods Potential academic articles were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect and other databases. The time range we retrieved from was that from the inception of electronic databases to August 2019. Gray studies were identified from the references of included literature reports. STATA version 11.0 (Stata Corporation, College Station, Texas, USA) was used to analyze the pooled data.Results Fourteen studies involving 1910 patients, 395 of whom had secondary fracture following the surgery were included in this meta-analysis. The results of meta-analysis showed the risk factors of the secondary fractures for osteoporotic vertebral compression fractures after percutaneous vertebroplasty was related to bone mineral density [WMD= -0.518, 95%CI(-0.784,-0.252), P=0.000], cement leakage [RR=0.596, 95%CI (0.444,0.798), P=0.001] and kyphosis after primary operation [WMD=4.510, 95%CI (3.061,6.004),P=0.000], but not to gender, age, body mass index (BMI), cement volume, thoracolumbar spine, and cement injection approaches.Conclusions BMD, cement leakage and kyphosis after primary operation are the risk factors closely correlative to the secondary fracture after percutaneous vertebroplasty. There has not been enough evidence to support the association between the secondary fracture and gender, age, body mass index, cement volume, thoracolumbar spine, and cement injection approach.

scholarly journals A Study of Risk Factors for Early-Onset Adjacent Vertebral Fractures After Kyphoplasty

2019 ◽  
Vol 10 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Masayoshi Morozumi ◽  
Yuji Matsubara ◽  
Akio Muramoto ◽  
Yoshinori Morita ◽  
Kei Ando ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Onset ◽  
Odds Ratio ◽  
Multivariate Analyses ◽  
Thoracolumbar Junction ◽  
Spinal Level ◽  
Related Factors ◽  
Adjacent Vertebral Fracture ◽  
Vertebral Bodies ◽  
Risks Factors

Study Design: Retrospective study. Objectives: To elucidate risk factors for early-onset (2 months after initial kyphoplasty) adjacent vertebral fracture (EO-AVF) after kyphoplasty. Methods: A total of 108 vertebral bodies (95 patients) were included in this study. We examined patient backgrounds, the spinal level of EO-AVFs, surgery-related factors, and imaging findings. We divided the cases into 2 groups: patients with EO-AVF and patients without EO-AVF. Univariate, correlation, and multivariate analyses were conducted to reveal the risks factors for EO-AVFs for these 2 groups. Results: EO-AVFs developed in 28 vertebral bodies; they did not develop in 80 vertebral bodies. The overall EO-AVF incidence rate was 26%. The spinal level was the thoracolumbar junction for 93% of patients and another level for 7%, thus demonstrating the concentration of EO-AVFs in the thoracolumbar junction. For patients without EO-AVF and those with EO-AVF, there were significant differences in age (76 and 80 years, respectively), preoperative vertebral angles (VAs) (17.8° and 23°, respectively), and corrected VAs (7.3° and 12.7°, respectively). Significant differences were not observed for other factors. Pearson’s correlation coefficient was 0.661 ( P < .000), thereby showing a significantly positive correlation between preoperative VAs and corrected VAs. Logistic regression analysis indicated that age (odds ratio, 1.112; 95% CI, 1.025-1.206) and preoperative VAs (odds ratio, 1.08; 95% CI, 1.026-1.135) were covariates and that the presence of an EO-AVF was a dependent variable. Therefore, both were predictable risk factors for EO-AVFs. Conclusion: Age, preoperative VAs, and corrected VAs are risk factors for EO-AVFs after kyphoplasty.

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