scholarly journals Testicular Plasmablastic Lymphoma in an HIV-Negative Patient: A Rare Case Presentation

2021 ◽  
Vol 9 ◽  
pp. 232470962110174
Author(s):  
Kemnasom Nwanwene ◽  
Noman Ahmed Jang Khan ◽  
Mohamed Alsharedi
Keyword(s):  
Rare Case ◽  
B Cell Lymphoma ◽  
Plasmablastic Lymphoma ◽  
Case Presentation ◽  
Negative Patient ◽  
Left Testicle ◽  
Positron Emission ◽  
Immunodeficiency Virus ◽  
Tomography Scan ◽  
Hiv Negative

Plasmablastic lymphoma (PBL) is a very rare disease and it is usually considered a human immunodeficiency virus (HIV)–related B-cell lymphoma that carries a poor prognosis. It mostly involves the oral cavity, lungs, nasal cavity, gastrointestinal tract, lymph node, and skin. Therapeutic regimens like dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (DA-EPOCH) have shown better results in these aggressive lymphomas. We report a rare case of PBL in an HIV-negative patient who presented to the clinic with a complaint of left testicular swelling for 3 months. Ultrasound showed an enlarged left testicle. He underwent a left orchiectomy and the pathology showed PBL with involvement of the spermatic cord margin. Positron emission tomography scan showed hypermetabolic mediastinal and hilar lymph nodes. He was started on DA-EPOCH but showed no response. Accordingly, salvage therapy with bortezomib in addition to ifosfamide carboplatin and etoposide (B-ICE) chemotherapy was initiated with remarkable response. Several other regimens can be used in the refractory setting; however, the evidence is mostly based on retrospective analysis.

scholarly journals Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

2021 ◽  
Author(s):  
Tomoyuki Otani ◽  
Kosuke Murakami ◽  
Masatomo Kimura ◽  
Mitsuru Matsuki ◽  
Takao Satou ◽  
...  
Keyword(s):  
Endometrial Biopsy ◽  
Plasmablastic Lymphoma ◽  
Mri Findings ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Negative Woman ◽  
Epstein Barr ◽  
Abnormal Vaginal Bleeding ◽  
Hiv Negative

Abstract Background Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma in the uterus is rare. Here we report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. Case presentation A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasms and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein–Barr virus was detected in a small number of cells. The histological picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. Conclusions This case underscores the sometimes blurry distinction between benign inflammation and lymphomas.

Kaposi Sarcoma of the Penis in an HIV-Negative Patient

2011 ◽  
Vol 15 (2) ◽  
pp. 118-120 ◽  
Author(s):  
Roberto Cecchi ◽  
Michela Troiano ◽  
Maurizia Ghilardi ◽  
Laura Bartoli
Keyword(s):  
Unusual Case ◽  
Kaposi Sarcoma ◽  
Unusual Site ◽  
Case Presentation ◽  
Negative Patient ◽  
Immunodeficiency Virus ◽  
Nodular Lesions ◽  
Immunocompetent Patients ◽  
Hiv Negative

Background: The penis is an unusual site of presentation for Kaposi sarcoma, especially in immunocompetent patients. Case Presentation: A 52-year-old human immunodeficiency virus (HIV)-seronegative man presented with a reddish, 8 mm in diameter nodule on the glans penis near the coronal sulcus. Histopathology after excision of the lesion was consistent with Kaposi sarcoma. No other cutaneous or mucosal manifestations were present. After a follow-up period of 2 years, no recurrence was observed. Conclusion: This unusual case suggests that Kaposi sarcoma should be considered in the differential diagnosis of macular, papular, and nodular lesions involving the penis.

scholarly journals Rectal plasmablastic lymphoma in Ebstein Barr virus positive and human immunodeficiency virus negative subject after external radiation therapy for prostatic cancer

2021 ◽  
Vol 84 (4) ◽  
pp. 659-661
Author(s):  
L Bricman ◽  
P Yengue ◽  
C Miscu ◽  
S Junius ◽  
F Waignein ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Plasmablastic Lymphoma ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Ebstein Barr Virus ◽  
External Radiation Therapy ◽  
Negative Subject ◽  
Aggressive Subtype ◽  
Hiv Negative

Plasmablastic lymphoma (PBL) represents a rare and aggressive subtype of diffuse large B cells lymphoma (DLBCL) most associated with the human immunodeficiency virus (HIV). Prognosis remains poor despite various treatment approaches. We describe an evolution at six months of HIV negative PBL and Ebstein Barr virus (EBV) positive PBL with chemotherapy. Role of radiotherapy is still unclear.

scholarly journals T. marneffei infection complications in an HIV-negative patient with pre-existing pulmonary sarcoidosis: a rare case report

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiaoming Yu ◽  
Keji Miao ◽  
Changsheng Zhou ◽  
Yuelin Cai ◽  
Xiaoying Huang ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Pulmonary Sarcoidosis ◽  
Negative Patient ◽  
Rare Case Report ◽  
Hiv Negative

scholarly journals Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis—A Case Report

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Anthi Bouchla ◽  
Sotirios G. Papageorgiou ◽  
Zoi Tsakiraki ◽  
Eirini Glezou ◽  
George Pavlidis ◽  
...  
Keyword(s):  
Case Report ◽  
Metabolic Response ◽  
Immunocompetent Patient ◽  
Plasmablastic Lymphoma ◽  
Complete Metabolic Response ◽  
Negative Patient ◽  
Non Hodgkin Lymphoma ◽  
Ring Sideroblasts ◽  
One Year ◽  
Hiv Negative

Plasmablastic lymphoma (PBL) is a rare, aggressive type of B-cell non-Hodgkin lymphoma with the vast majority of patients responding poorly to treatment or progressing shortly thereafter. Cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) or CHOP-like regimens have disappointing results in this setting. We report a case of PBL arising in a previously diagnosed myelodysplastic/myeloproliferative (MDS/MPN) with ring sideroblasts and thrombocytopenia (RS-T), HIV-negative patient treated with the combination of CHOP and bortezomib. The patient achieved complete metabolic response, which has lasted one year, longer by far than would have been expected with the sole use of CHOP.

Plasmablastic lymphoma of the oral cavity in an HIV-negative patient

2011 ◽  
Vol 15 (6) ◽  
pp. 436-440 ◽  
Author(s):  
Bing Guan ◽  
Xinhua Zhang ◽  
Weidong Hu ◽  
Qiu Rao ◽  
Yan Wang ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Plasmablastic Lymphoma ◽  
Negative Patient ◽  
Hiv Negative
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