Kaposi Sarcoma of the Penis in an HIV-Negative Patient

2011 ◽  
Vol 15 (2) ◽  
pp. 118-120 ◽  
Author(s):  
Roberto Cecchi ◽  
Michela Troiano ◽  
Maurizia Ghilardi ◽  
Laura Bartoli
Keyword(s):  
Unusual Case ◽  
Kaposi Sarcoma ◽  
Unusual Site ◽  
Case Presentation ◽  
Negative Patient ◽  
Immunodeficiency Virus ◽  
Nodular Lesions ◽  
Immunocompetent Patients ◽  
Hiv Negative

Background: The penis is an unusual site of presentation for Kaposi sarcoma, especially in immunocompetent patients. Case Presentation: A 52-year-old human immunodeficiency virus (HIV)-seronegative man presented with a reddish, 8 mm in diameter nodule on the glans penis near the coronal sulcus. Histopathology after excision of the lesion was consistent with Kaposi sarcoma. No other cutaneous or mucosal manifestations were present. After a follow-up period of 2 years, no recurrence was observed. Conclusion: This unusual case suggests that Kaposi sarcoma should be considered in the differential diagnosis of macular, papular, and nodular lesions involving the penis.

scholarly journals Testicular Plasmablastic Lymphoma in an HIV-Negative Patient: A Rare Case Presentation

2021 ◽  
Vol 9 ◽  
pp. 232470962110174
Author(s):  
Kemnasom Nwanwene ◽  
Noman Ahmed Jang Khan ◽  
Mohamed Alsharedi
Keyword(s):  
Rare Case ◽  
B Cell Lymphoma ◽  
Plasmablastic Lymphoma ◽  
Case Presentation ◽  
Negative Patient ◽  
Left Testicle ◽  
Positron Emission ◽  
Immunodeficiency Virus ◽  
Tomography Scan ◽  
Hiv Negative

Plasmablastic lymphoma (PBL) is a very rare disease and it is usually considered a human immunodeficiency virus (HIV)–related B-cell lymphoma that carries a poor prognosis. It mostly involves the oral cavity, lungs, nasal cavity, gastrointestinal tract, lymph node, and skin. Therapeutic regimens like dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (DA-EPOCH) have shown better results in these aggressive lymphomas. We report a rare case of PBL in an HIV-negative patient who presented to the clinic with a complaint of left testicular swelling for 3 months. Ultrasound showed an enlarged left testicle. He underwent a left orchiectomy and the pathology showed PBL with involvement of the spermatic cord margin. Positron emission tomography scan showed hypermetabolic mediastinal and hilar lymph nodes. He was started on DA-EPOCH but showed no response. Accordingly, salvage therapy with bortezomib in addition to ifosfamide carboplatin and etoposide (B-ICE) chemotherapy was initiated with remarkable response. Several other regimens can be used in the refractory setting; however, the evidence is mostly based on retrospective analysis.

scholarly journals Benign Lymphoepithelial Cyst: An Unusual Cause of Parotid Swelling in Two Immunocompetent Patients

2019 ◽  
Vol 7 (13) ◽  
pp. 2142-2145
Author(s):  
How Kit Thong ◽  
Primuharsa Putra Sabir Husin Athar ◽  
Wan Muhaizan Wan Mustaffa
Keyword(s):  
Histopathological Examination ◽  
Surgical Excision ◽  
Case Presentation ◽  
Important Differential Diagnosis ◽  
Immunodeficiency Virus ◽  
Lymphoepithelial Cysts ◽  
Parotid Swelling ◽  
Slow Growing ◽  
Immunocompetent Patients ◽  
Hiv Negative

BACKGROUND: Lymphoepithelial cysts, which are benign and slow-growing tumours, usually involve the head and neck regions. Benign lymphoepithelial cysts (BLECs) are the most common cause of parotid swelling in human immunodeficiency virus (HIV)-positive patients and are less common in immunocompetent patients. CASE PRESENTATION: Here, we present two cases of immunocompetent patients with long-standing, progressively enlarging parotid swelling. Postoperative histopathological examination of these patients revealed features of BLEC. CONCLUSION: Wide surgical excision is the gold standard for treatment and recurrences is rare. These cases are of particular interest because of the rarity of BLEC in HIV-negative patients and highlight an important differential diagnosis of parotid swelling.

Intramedullary tuberculoma of the spinal cord

1999 ◽  
Vol 90 (1) ◽  
pp. 125-128 ◽  
Author(s):  
John K. Ratliff ◽  
Edward S. Connolly
Keyword(s):  
Spinal Cord ◽  
World Literature ◽  
Unusual Case ◽  
Spinal Tuberculosis ◽  
Tuberculosis Infection ◽  
Hiv Positive ◽  
Content Type ◽  
First Case ◽  
Immunodeficiency Virus ◽  
Hiv Negative

✓ Intramedullary spinal tuberculosis infection remains an extremely rare disease entity. In the most recent reviews only 148 cases have been reported in the world literature, although numerous recent reports from developing countries and on human immunodeficiency virus (HIV)—positive patients have increased this number. The authors present an unusual case of intramedullary tuberculoma in an HIV—negative patient from the southern United States who demonstrated no other signs or symptoms of tuberculosis infection. The authors believe that this is the first case of its kind to be presented in recent literature. The presentation of miliary disease via an isolated intramedullary spinal mass in a patient with no evident risk factors for tuberculosis infection emphasizes the importance of including tuberculosis in the differential diagnosis of spinal cord masses.

Kaposi Sarcoma in an HIV-Negative Patient

2018 ◽  
Vol 126 (3) ◽  
pp. e45
Author(s):  
Aline Fernanda Cruz ◽  
José Augusto Dias Araújo ◽  
Samuel Macedo Costa ◽  
Júlio César Tanos De Lacerda ◽  
Patrícia Carlos Caldeira ◽  
...  
Keyword(s):  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Hiv Negative

ABCL-281: An Unusual Case of Plasmablastic Non-Hodgkin Lymphoma Reported in an HIV-Negative Patient

2020 ◽  
Vol 20 ◽  
pp. S271
Author(s):  
Jessy Alchidiac ◽  
Charbel Khalil ◽  
Mariana Mezher ◽  
Therese Abou Nasr
Keyword(s):  
Hodgkin Lymphoma ◽  
Unusual Case ◽  
Negative Patient ◽  
Non Hodgkin Lymphoma ◽  
Hiv Negative

Tonsillar Kaposi sarcoma in an HIV-negative patient

AIDS ◽  
2019 ◽  
Vol 33 (7) ◽  
pp. 1263-1264 ◽  
Author(s):  
Alessandra Latini ◽  
Lavinia Alei ◽  
Renato Covello ◽  
Antonio Cristaudo ◽  
Manuela Colafigli ◽  
...  
Keyword(s):  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Hiv Negative

The simultaneous diagnosis of Kaposi sarcoma and MDS RAEB-II in a human immunodeficiency virus-negative patient

2008 ◽  
Vol 88 (4) ◽  
pp. 389-391
Author(s):  
Gülsüm Emel Pamuk ◽  
Erkan Aydogdu ◽  
Burhan Turgut ◽  
Muzaffer Demir
Keyword(s):  
Human Immunodeficiency Virus ◽  
Kaposi Sarcoma ◽  
Negative Patient ◽  
Immunodeficiency Virus

A Case of Kaposi’s Sarcoma in a HIV Negative Patient with CLL Treated with Rituximab

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4970-4970
Author(s):  
Anuradha Avinash Belur ◽  
Arun Kumar Arumugam Raajasekar ◽  
Srikant Nannapaneni ◽  
Thandavababu Chelliah
Keyword(s):  
Kaposi's Sarcoma ◽  
Conflicts Of Interest ◽  
Kaposi Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions ◽  
Elisa Test ◽  
Lymphocytic Leukemia ◽  
Cell Mediated Immunity ◽  
Negative Patient ◽  
Hiv Negative

Abstract Case Description: - A 76 year old lady was diagnosed with Chronic Lymphocytic Leukemia (CLL) with 11 q deletion after she presented with generalized lymphadenopathy and anemia. She was treated with rituximab 375mg/m2 day1 and bendamustine 60mg/m2 on day 1 and day 2 and completed six cycles of treatment. After the sixth cycle she developed multiple itchy, papular lesions with bleeding on both lower extremities. She was evaluated multiple times by vascular surgery and dermatology without a definitive diagnosis. She underwent a biopsy with staining for HHV-8, CD31 and CD34 which was positive confirming the diagnosis of Kaposi sarcoma. ELISA test for HIV was negative. She was started on treatment with Doxorubicin 20 mg/m2every 3 weeks and with 3 cycles there was significant regression of the lesions. Discussion-: We describe a case of CLL which was initially started on treatment with rituximab and bendamustine. She tolerated the treatment well, but a few months later presented with skin lesions which on biopsy was diagnosed as Kaposi sarcoma. It is very uncommon for Kaposi sarcoma to develop in a HIV negative patient. This patient was immunocompromised with recent chemotherapy. Rituximab specifically depletes B cells and leads to impaired T cell mediated immunity. This case illustrates the importance of a high index of suspicion in patients treated with rituximab as it is used for a number of hematologic malignancies like leukemia, lymphoma as well as non-malignant conditions like autoimmune disorders. While infusion reactions and reactivation of hepatitis B are side effects physicians are aware of and cautious of while using rituximab, Kaposi’s Sarcoma remains a less known side effect. Awareness of this possibility is important in physicians prescribing rituximab. Footnotes * Asterisk with author names denotes non-ASH members. Disclosures No relevant conflicts of interest to declare.

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