scholarly journals Hyperprogression in a Patient With Hepatocellular Cancer Treated With Atezolizumab and Bevacizumab: A Case Report and Review of Literature

2021 ◽  
Vol 9 ◽  
pp. 232470962199220
Author(s):  
Balraj Singh ◽  
Parminder Kaur ◽  
Michael Maroules
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Disease Burden ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Hepatocellular Cancer ◽  
Past Medical History ◽  
Review Of Literature ◽  
Novel Treatment ◽  
Accelerated Growth

Immune checkpoint inhibitors have emerged as a novel treatment in a wide variety of malignancies; however, it is associated with a distinctive array of side effects known as immune-related adverse events. Hyperprogression is defined as an accelerated growth of disease burden in patients treated with immunotherapy. Limited literature is available regarding hyperprogression in hepatocellular cancer. We report a case of a 36-year-old male with no past medical history who presented with nausea, vomiting, and abdominal pain and was diagnosed with unresectable hepatocellular cancer and thereby started on atezolizumab and bevacizumab. The patient got only 1 cycle of treatment and unfortunately had hyperprogression of disease.

scholarly journals Idiopathic ovarian vein thrombosis causing pulmonary embolism: case report and literature review

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110106
Author(s):  
Wenrui Li ◽  
Saisai Cao ◽  
Renming Zhu ◽  
Xueming Chen
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Abdominal Pain ◽  
Case Report ◽  
Literature Review ◽  
Ovarian Vein ◽  
Review Of Literature ◽  
Vein Thrombosis ◽  
Medical Disorder ◽  
Ovarian Vein Thrombosis

Ovarian vein thrombosis (OVT) is a rare medical disorder, which is most often found in the immediate postpartum period. OVT is rarely considered idiopathic. We report a case of idiopathic OVT with pulmonary embolism in a 33-year-old woman who presented with abdominal pain. Computed tomography and postoperative pathology confirmed the diagnosis of idiopathic OVT. To date, only 12 cases of idiopathic OVT have been reported. In this case report, we present a summary of these cases and a review of literature regarding management of idiopathic OVT.

scholarly journals Immune checkpoint inhibitors in neuroendocrine tumors: A single institution experience with review of literature

Oncotarget ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 8801-8809 ◽  
Author(s):  
Aman Chauhan ◽  
Millicent Horn ◽  
Gray Magee ◽  
Kurt Hodges ◽  
Mark Evers ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Review Of Literature ◽  
Single Institution

Bluish-gray fingernail discoloration due to the use of nivolumab

2020 ◽  
pp. 107815522092997
Author(s):  
Miguel Michel Ocampo ◽  
Jaren Lerner ◽  
Constantin A Dasanu
Keyword(s):  
Case Report ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Skin Toxicity ◽  
Unique Case ◽  
First Case ◽  
Nail Discoloration ◽  
Wide Range ◽  
Causality Relationship

Introduction Immune checkpoint inhibitors have improved clinical outcomes in a wide range of cancers. While skin toxicity is not uncommon with immune checkpoint inhibitors, generalized nail discoloration has not been reported with their use in oncology. Case report Herein, we report a unique case of bluish-gray fingernail discoloration due to nivolumab therapy for relapsed melanoma. Management and outcome: This condition reversed completely 10 weeks after nivolumab discontinuation. Naranjo nomogram assessment renders the causality relationship between nivolumab and nail discoloration probable. Discussion To our knowledge, this is the first case report of an unusual bluish-gray nail discoloration due to therapy with nivolumab. The mechanism by which nivolumab causes this side effect remains to be elucidated.

scholarly journals Conservative Management of Segmental Infarction of the Greater Omentum: A Case Report and Review of Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Ramawad Soobrah ◽  
Mohammad Badran ◽  
Simon G. Smith
Keyword(s):  
Computed Tomography ◽  
Abdominal Pain ◽  
Case Report ◽  
Ct Scan ◽  
Conservative Management ◽  
Acute Abdominal Pain ◽  
Correct Diagnosis ◽  
Greater Omentum ◽  
Review Of Literature ◽  
Segmental Infarction

Segmental omental infarction (SOI) is a rare cause of acute abdominal pain. Depending on the site of infarction, it mimics conditions like appendicitis, cholecystitis, and diverticulitis. Before the widespread use of Computed Tomography (CT), the diagnosis was usually made intraoperatively. SOI produces characteristic radiological appearances on CT scan; hence, correct diagnosis using this form of imaging may prevent unnecessary surgery. We present the case of a young woman who was treated conservatively after accurate radiological diagnosis.

scholarly journals How to Suspect and Manage an Hypoplasic Gallbladder: A Case Report and Review of Literature

2020 ◽  
pp. 1-3
Author(s):  
David Martínez Cecilia ◽  
Anna Trinidad Borràs ◽  
Jara Hernández Gutiérrez ◽  
David Martínez Cecilia
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Magnetic Resonance ◽  
Congenital Anomalies ◽  
Imaging Techniques ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Biliary Colic ◽  
Review Of Literature ◽  
Persistent Abdominal Pain ◽  
Decisional Algorithm

Background: Malformations related to the gallbladder are uncommon, with an incidence lower than 0,1%. The majority of them are asymptomatic, however when symptoms appear are non-specific with a similar presentation to biliary colic. Methods: We report a case of a 29-year-old woman with persistent upper right abdominal pain and no visualization of the gallbladder in the ultrasound (US), CT scan or in the magnetic resonance cholangiopancreatography (MRCP). Results: A laparoscopic exploration was performed due to persistent abdominal pain which confirmed an hypoplasic gallbladder. After cholecystectomy, symptoms were relieved. Herein we propose a decisional algorithm when suspecting a gallbladder with agenesis or hypoplasia. Conclusion: Surgeons need to take into consideration congenital anomalies of the gallbladder. Performing imaging techniques is important in order not to misdiagnose hypoplasia.

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