scholarly journals No Time for Lullabies Tracing down Pharmacological Effects & Uses of H1-Antihistamines in Children Younger than 6 Years

2021 ◽  
Vol 8 ◽  
pp. 2333794X2199217
Author(s):  
Alaa Yehya ◽  
Mohammad Numan ◽  
Laila Matalqah
Keyword(s):  
Cross Sectional Study ◽  
Pharmacological Effects ◽  
Cognitive Effects ◽  
Off Label Use ◽  
Sectional Study ◽  
Chlorpheniramine Maleate ◽  
Self Medication ◽  
Cross Sectional ◽  
Off Label ◽  
H1 Antihistamines

Objectives. To provide a qualitative and a quantitative analysis of H1-antihistamines pharmacological uses pattern among children (<6 years old) and to evaluate the parental-related awareness. Methods. A cross-sectional study was carried out at 5 retail pharmacies in Jordan over 5 months (October/2019-February/2020). Parents who requested any of H1-antihistmine agent for a child (<6 years) were invited to participate. Results. A total of 516 children, most of them were toddlers (1-3) years, received at least 1 H1-antihistamine. More than half of the cases received H1-antihistamine as self-medication (56.3%). Sedating antihistamine agents were the most frequently used among children (<6 years old) (77.9%) among which Chlorpheniramine maleate was the most commonly used agent (62.9%). About half of the children (47.0%) received H1-antihistamine to induce sleep. Whereas, 21.7% and 12.9% received them to manage flu, and allergic rhinitis (AR), respectively. Around 66.6% of the cases were classified as off-label use. Most of the parents (80.5%) were aware of the sedative adverse effects of H1-antihistamines, whereas a fewer number (31.9%) were aware of their cognitive effects. Finally, more than two thirds of parents (79.7%) were unfamiliar with off-label drug use in children. Conclusion. Despite the availability of less-sedating H1-antihistamines with a wide safety and efficacy record, the use of sedating H1-antihistamines remains popular in children.

scholarly journals Off-label drug prescriptions in French general practice: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e026076 ◽  
Author(s):  
François Drogou ◽  
Allison Netboute ◽  
Joris Giai ◽  
Xavier Dode ◽  
David Darmon ◽  
...  
Keyword(s):  
General Practice ◽  
Drug Prescription ◽  
Low Frequency ◽  
Cross Sectional Study ◽  
Drug Prescriptions ◽  
Off Label Use ◽  
Sectional Study ◽  
Cross Sectional ◽  
Off Label ◽  
Label Use

ObjectivesOff-label drug prescribing is a public health and economic issue. The aim of this study was to describe off-label prescription in general practice in France, in terms of frequency and nature, and to identify its main determining factors.DesignMulticentre cross-sectional studySettingTwenty-three training general practice officesParticipantsAll the voluntary patients coming for a medical consultation or visited at home over a cumulative period of 5 days per office between November 2015 and January 2016.MethodsEleven interns, acting as observers, collected data. Two reviewers analysed the drugs prescribed by the trainers, in order to identify those prescribed off-label in terms of their indication or the age of the patient. We used a univariate, then a multivariate model, based on hierarchical mixed-effects logistic regression.ResultsAmong the 4932 drug prescriptions registered, 911 (18.5%[95% CI17.4% to 19.6%]) were off-label, of which 865 (17.6%) due to the indication of the drug and 58 (1.2%) due to the age of the patient. The prescription never mentioned the off-label use, neither was the patient informed of it, as required by the French law. With the multivariate analysis, variables contributing to off-label prescription were the number of drugs (OR=1.05 for each additional drug), the initiation of new drug therapy (OR=1.26) and the non-specific goal of the prescription (OR=1.43); the age of the patient ≤14 years (OR=1.42); the rural location of the physician’s practice (OR=1.38) and the low frequency of the visits of national health insurance representatives (OR=0.93).ConclusionAlmost one out of five drugs prescribed in French general practice was off-label. It seems necessary to better train physicians in clinical pharmacology, to provide them with more effective drug prescription software, to reinforce postmarketing surveillance and to clearly define off-label use by consensus.

Women’s attitude toward gynecological pain in fertile age: Results from a cross-sectional study among Italian community pharmacies

2018 ◽  
Vol 10 (2) ◽  
pp. 88-94
Author(s):  
Corrado Giua Marassi ◽  
Assunta Pistone ◽  
Fabio Parazzini ◽  
Silvia Vannuccini ◽  
Felice Petraglia
Keyword(s):  
Medical Treatment ◽  
Pelvic Pain ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Community Pharmacies ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
Mean Delay ◽  
Italian Community

Introduction: Several epidemiological data on women afferent to clinics for medical treatment of pelvic pain are available, while few studies explored the general population. Thus, this study aimed to investigate women presenting with gynecological pain at the community pharmacy and to evaluate the relevance of pharmacist advice regarding medical treatment. Methods: A cross-sectional study was conducted in a sample of 10 Italian community pharmacies, by administering a structured questionnaire to fertile age women reporting pelvic pain during the last 3 months. Questions were concerning demographic information, pain characteristics, women’s behavior toward gynecological pain, and diagnosis possibly received from a physician. Results: A group of 290 women were interviewed. Severe pain was reported in 58.3%, with a mean ± SD of 4.4 ± 6.8 days of suffering, causing absenteeism from work in 45.3% of cases. Almost half of women reported that the onset of gynecological pain was before 15 years and 72.2% had consulted a physician in the past, with a mean delay of 2.5 ± 4.3 years between the onset of pain and medical consultation. However, only 28% of the overall population received a diagnosis. 51.0% received one treatment, while 39% received two or more. The first therapy was prescribed in 40.2% cases by the physician, while in the remaining it was recommended either by the pharmacist or it was a self-medication. Conclusion: Gynecological pelvic pain is a disabling problem, regardless of the underlying cause, with significant impact on social and working life and requiring a better medical management.

scholarly journals Self-Medication amongst the university students of Multan, Pakistan- A questionnaire based survey

2016 ◽  
Vol 2 (2) ◽  
pp. 142 ◽  
Author(s):  
Samman Chughtai
Keyword(s):  
University Students ◽  
Response Rate ◽  
Cross Sectional Study ◽  
Pharmacy Students ◽  
Common Condition ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
The World ◽  
The University

Self-medication is a common incidence in the world today. This study aims to evaluate self-medication among university students of Multan, Pakistan. This randomized cross sectional study was carried out in Bahauddin Zakariya University, Multan during December 2015- January 216. A sample size of 200 students was randomly selected. Response rate was 90% (n=182).The prevalence of self-medication among the students was determined to be 83%. There was difference in perception of pharmacy students and students of other professions. Most common condition in which students did self-medication was headache (49.66%; n=75). Students also showed tendency of self-medication in case of herbal and essential oil products (46.35%). Awareness concerning insecurity and benefits of self-medication must be spread among students to avoid the complications of self-medication. 

Self-Medication Practices with Antibiotics and Antimalarials Among Sudanese Undergraduate University Students

2007 ◽  
Vol 41 (7-8) ◽  
pp. 1249-1255 ◽  
Author(s):  
Abdelmoneim I Awad ◽  
Idris B Eltayeb
Keyword(s):  
University Students ◽  
Private University ◽  
Cross Sectional Study ◽  
Community Pharmacies ◽  
Age Group ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
Undergraduate University Students ◽  
Study Population

Background: In many developing countries, up to 60–80% of health problems are self-medicated. Objective: To estimate the prevalence of self-medication with antibiotics and/or antimalarials and identify factors promoting such use among university students in Sudan. Methods: A descriptive cross-sectional study was performed, using a pretested questionnaire on a sample of 1300 students selected from 5 universities in Khartoum State, Sudan. Results: Eight hundred ninety-one (79.5%; 95% CI 77.0 to 81.8) students from the study population had used antibiotics or antimalarials without a prescription within 1–2 months prior to the study. Four hundred ninety (55%; 95% CI 51.7 to 58.3) of the respondents stated that they had used antibiotics, 39 (4.4%; 95% CI 3.2 to 6.0) had used antimalarials, and 362 (40.6%; 95% CI 37.4 to 43.9) had used both. Overall, self-medication with antibiotics or antimalarials was significantly more common among students 21 years of age or older compared with those 20 years of age or younger (OR 1.55; 95% CI 1.15 to 2.09; p = 0.004) and among students attending private universities compared with those attending public universities (OR 1.42; 95% CI 1.04 to 1.95; p = 0.028). Self-medication with antibiotics followed a simitar pattern, which was significantly more common among students 21 years of age or older (OR 1.36; 95% CI 1.03 to 1.81; p = 0.03) and private university respondents (OR 1.52; 95% CI 1.15 to 2.02; p = 0.003). Self-medication with antimalarials was found to be significantly less common among females (OR 0.76; 95% CI 0.59 to 0.97; p = 0.028) and higher among the 21 years or older age group (OR 1.84; 95% CI 1.42 to 2.40; p < 0.001), The most common reason indicated for self-medication was the respondents’ previous experiences with similar ailments. The main source of drugs was community pharmacies. Conclusions: The prevalence of self-medication with antibiotics/antimalarials among undergraduate university students in Khartoum State is high. Our findings highlight the need for planning interventions to promote the judicious use of antibiotics/antimicrobials.

Parent induced self-medication among under five children: an observational cross sectional study

2015 ◽  
Vol 14 (2) ◽  
pp. 81 ◽  
Author(s):  
Saima Nazir ◽  
Kanu Goel ◽  
Anshu Mittal ◽  
Jagjeet Singh ◽  
RKD Goel ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
Under Five ◽  
Under Five Children

Perceptions, Knowledge and Practice of Self-Medication among Undergraduate Pharmacy Students in Malaysia: A Cross Sectional Study

2018 ◽  
Vol 4 (3) ◽  
pp. 132-136
Author(s):  
Ramadan Mohamed Elkalmi ◽  
Mohamed Hassan Elnaem ◽  
Ibrahim Khalid Rayes ◽  
Ramez Mohamed Alkodmani ◽  
Tarek Mohamed Elsayed ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Pharmacy Students ◽  
Sectional Study ◽  
Self Medication ◽  
Cross Sectional ◽  
Knowledge And Practice
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