Survey of Intravitreal Injection Practice Patterns Among Retina Specialists

2020 ◽  
Vol 4 (4) ◽  
pp. 306-311
Author(s):  
Thérèse M. Sassalos ◽  
Nish Patel ◽  
Chris Andrews ◽  
Stephen J. Smith ◽  
David C. Musch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intravitreal Injection ◽  
Practice Patterns ◽  
Povidone Iodine ◽  
Needlestick Injury ◽  
Current Trends ◽  
Injection Practice ◽  
Corneal Toxicity ◽  
Lidocaine Gel ◽  
Small Gauge

Purpose: Intravitreal injection therapy (IVT) is the most performed procedure in ophthalmology. This study was conducted to determine current trends in IVT delivery. Methods: An online, 31-question, multiple-choice survey was sent to 1677 retina specialists. The survey consisted of 3 sections: general questions, procedure technique, and postprocedure technique. Results: A total of 264 (16%) retina specialists completed the survey. The use of povidone-iodine (100%) and small-gauge needles (97%) was common, whereas ocular anesthesia was split among lidocaine gel (31%), lidocaine drops (25%), subconjunctival lidocaine (28%), and lidocaine-soaked pledgets (15%). More than 85% indicated povidone-iodine contributes to post-IVT corneal toxicity, and 12% reported that a needlestick injury to physician or staff occurred during IVT. Conclusions: Key areas for IVT improvement include optimized ocular anesthesia, development of a guarded needle for ocular drug delivery, and formulation of a less toxic ocular antiseptic.

Nanomaterials as drug delivery systems with antibacterial properties: current trends and future priorities

2021 ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Homa Sadat Esfahani ◽  
Saeedeh Keyvani-Ghamsari ◽  
Saeed Ur Rahman
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antibacterial Properties ◽  
Delivery Systems ◽  
Current Trends

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

scholarly journals Assessment of Intravitreal Injection Training among U.S.-Based Ophthalmology Residents

2019 ◽  
Vol 11 (01) ◽  
pp. e43-e49
Author(s):  
Jacob J. Liechty ◽  
Michael J. Wilkinson ◽  
Esther M. Bowie
Keyword(s):  
United States ◽  
Intravitreal Injection ◽  
Povidone Iodine ◽  
The United States ◽  
Intravitreal Injections ◽  
First Year ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Residency Program Directors ◽  
Procedure Room

Purpose To describe the intravitreal injection training of ophthalmology residents in the United States in 2018. Design Cross-sectional survey. Methods An anonymous, 29-question, internet-based survey was emailed to 119 ophthalmology residency program directors with the instructions to forward the survey to their ophthalmology residents. Results A total of 117 ophthalmology residents (7.89%) responded to the survey. The majority of residents stated that their intravitreal injection training began during their first year of ophthalmology training, PGY 2 year, (92.3%). The majority of residents performed at least 25 injections per year (78.6%). All residents use antiseptic on the conjunctiva prior to the injection, 94% use a lid speculum, and 84.6% avoided talking in the procedure room. Most injections are performed with gloves (83.8%). A minority of residents stated that they are trained to use povidone-iodine on the eyelids prior to performing an injection (45.3%). Only 6.0% of residents claimed to use postinjection antibiotic drops. Performance of bilateral, simultaneous intravitreal injections was split with nearly half of residents not being trained in this method (47.9%). Conclusion Ophthalmology residents from across the country experience a variety of different injection protocols when being trained on how to perform intravitreal injections. Conjunctival antisepsis has reached a clear consensus while topics such as simultaneous, bilateral injections and eyelid antisepsis are still uncertain among the resident community.

Laparoscopic Living Donor Nephrectomy: A Look at Current Trends and Practice Patterns at Major Transplant Centers Across the United States

2008 ◽  
Vol 179 (4) ◽  
pp. 1488-1492 ◽  
Author(s):  
Andrew D. Wright ◽  
Thomas A. Will ◽  
David R. Holt ◽  
Thomas M.T. Turk ◽  
Kent T. Perry
Keyword(s):  
United States ◽  
Living Donor ◽  
Practice Patterns ◽  
The United States ◽  
Donor Nephrectomy ◽  
Living Donor Nephrectomy ◽  
Current Trends
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