scholarly journals How I treat hypereosinophilic syndromes

Blood ◽  
2009 ◽  
Vol 114 (18) ◽  
pp. 3736-3741 ◽  
Author(s):  
Amy D. Klion
Keyword(s):  
Kinase Inhibitors ◽  
Therapeutic Agents ◽  
Peripheral Eosinophilia ◽  
Therapeutic Decisions ◽  
Organ Manifestations ◽  
Diagnosis And Classification ◽  
Humanized Monoclonal Antibodies ◽  
Peripheral Blood Eosinophilia

Abstract Hypereosinophilic syndromes (HESs) are a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end organ manifestations attributable to the eosinophilia or unexplained in the clinical setting. Whereas corticosteroids remain the mainstay of treatment for most patients, recent diagnostic advances and the development of novel targeted therapies, including tyrosine kinase inhibitors and humanized monoclonal antibodies, have increased the complexity of therapeutic decisions in HESs. This review presents a treatment-based approach to the diagnosis and classification of patients with peripheral blood eosinophilia of 1.5 × 109/L (1500/mm3) or higher and discusses the role of currently available therapeutic agents in the treatment of these patients.

scholarly journals How I treat hypereosinophilic syndromes

Blood ◽  
2015 ◽  
Vol 126 (9) ◽  
pp. 1069-1077 ◽  
Author(s):  
Amy D. Klion
Keyword(s):  
Kinase Inhibitors ◽  
Clinical Presentation ◽  
Rare Disorders ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Organ Manifestations ◽  
Neoplastic Disorders ◽  
Peripheral Blood Eosinophilia

Abstract Hypereosinophilic syndromes (HESs) are a group of rare disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L or higher and evidence of end organ manifestations attributable to the eosinophilia and not otherwise explained in the clinical setting. HESs are pleomorphic in clinical presentation and can be idiopathic or associated with a variety of underlying conditions, including allergic, rheumatologic, infectious, and neoplastic disorders. Moreover, the etiology of the eosinophilia in HESs can be primary (myeloid), secondary (lymphocyte-driven), or unknown. Although corticosteroids remain the first-line therapy for most forms of HESs, the availability of an increasing number of novel therapeutic agents, including tyrosine kinase inhibitors and monoclonal antibodies, has necessarily altered the approach to treatment of HESs. This review presents an updated treatment-based approach to the classification of patients with presumed HES and discusses the roles of conventional and novel agents in the management of these patients.

scholarly journals Role of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and classification of lymphomas.

2020 ◽  
Author(s):  
Javier Tejedor-Tejada ◽  
Carlos Chavarría ◽  
Beatriz Burgueño ◽  
Ignacio Fanjul ◽  
Francisco Javier Garcia-Alonso ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Diagnosis And Classification

The role of EEG in the diagnosis and classification of the epilepsy syndromes: a tool for clinical practice by the ILAE Neurophysiology Task Force (Part 1)

2017 ◽  
Vol 19 (3) ◽  
pp. 233-298 ◽  
Author(s):  
Michalis Koutroumanidis ◽  
Alexis Arzimanoglou ◽  
Roberto Caraballo ◽  
Sushma Goyal ◽  
Anna Kaminska ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Task Force ◽  
Diagnosis And Classification

scholarly journals Sexual dysfunction: classification and assessment

2013 ◽  
Vol 19 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Dinesh Bhugra ◽  
Gabriele Colombini
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Dysfunctions ◽  
Success Rates ◽  
Medical Interventions ◽  
Assessment And Treatment ◽  
Icd 10 ◽  
Diagnosis And Classification ◽  
Dsm Iv

SummarySexual dysfunction is one of the most common psychiatric disorders, but it is often ignored in assessment. It can be primary or secondary (a result of psychiatric disorder or medication). Success rates in managing sexual dysfunction are relatively high, with good response to psychological and medical interventions. In ICD-10 and DSM-IV-TR, sexual dysfunctions are broadly classified on the basis of the stages of sexual activity, from arousal to orgasm. There are major similarities between ICD and DSM in diagnosis and classification of sexual dysfunction, but both systems raise challenges. These include definitions of what is ‘normal’ and how abnormality is defined. In this article, we describe the role of the two systems and possible amendments that might help researchers and clinicians. We also present key principles for the assessment and treatment of people who experience sexual dysfunction. We consider problems that need to be managed in engaging and in the therapeutic alliance.

scholarly journals Clinical and Pathological Roles of Ro/SSA Autoantibody System

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Ryusuke Yoshimi ◽  
Atsuhisa Ueda ◽  
Keiko Ozato ◽  
Yoshiaki Ishigatsubo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Clinical Importance ◽  
Systemic Lupus ◽  
Systemic Autoimmune Diseases ◽  
Nuclear Antigens ◽  
Diagnosis And Classification

Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

Role of Multidetector CT in Diagnosis and Classification of Acute Pancreatitis

2015 ◽  
Vol 43 (1) ◽  
pp. 179-189
Author(s):  
Ashraf M. Enite ◽  
Hamed Ahmed El Badawy
Keyword(s):  
Acute Pancreatitis ◽  
Multidetector Ct ◽  
Diagnosis And Classification
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