Preoperative Hemoglobin Levels, Characteristics, and Resource Utilization in Total Hip Replacement Patients with An Anemia Diagnosis Versus without An Anemia Diagnosis: An Electronic Medical Record Analysis

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4748-4748
Author(s):  
Jamie B. Forlenza ◽  
Lorie Ellis ◽  
Helene Parise ◽  
Marie-Hélène Lafeuille ◽  
Patrick Lefebvre

Abstract Abstract 4748 Purpose: This retrospective analysis describes preoperative hemoglobin (Hb) levels, characteristics, and resource use in total hip replacement (THR) patients who had an anemia diagnosis as compared to those without an anemia diagnosis. Methods: Electronic medical records (EMR) from a large US integrated health delivery system were analyzed for the period 01/2004 to 09/2010. Adult patients with a THR surgery record and ≥1 Hb measurement were studied. Patients with a hip or knee revision before or during surgery, with bilateral surgery, or with an emergency room (ER) visit on the surgery admission date were excluded. Patients were stratified into two groups based upon the presence or absence of an anemia diagnosis (ICD-9 codes 280.xx-285.xx) in the 90 days before or day of surgery. Hemoglobin levels measured in the 45 days prior to but excluding the day of surgery were analyzed. For patients with multiple Hb measurements, the earliest observed Hb measurement (defined as the measurement collected furthest in time from the date of surgery) was evaluated. Other clinical and demographic characteristics in the 90 days before or day of surgery and resource utilization in the 90 days pre-surgery were analyzed. Descriptive statistics were reported as frequencies and means±standard deviations, and groups were compared using the Pearson chi-square test for categorical variables and Student's t-test for continuous variables. Results: The total study population consisted of 1,578 THR patients, of which, 10.5% (n=165) had an anemia diagnosis. In patients with an anemia diagnosis, the first anemia diagnosis in the EMR occurred 33±28 days before surgery. Patients with an anemia diagnosis versus those without an anemia diagnosis tended to be older (mean age 67.2±15.0 vs 64.8±13.0 years, respectively; p=0.045), have a lower proportion that were white (95.2% vs 98.9%, respectively; p<0.001), and have a higher comorbidity burden as measured by the Quan-Charlson Comorbidity Index (Q-CCI) (mean Q-CCI of 1.3±1.7 vs 0.5±0.9, respectively, p<0.001). The mean earliest Hb level for the total population was 13.7±1.4 g/dL and was <13 g/dL in 28.8% of THR patients and <12 g/dL in 9.8% of THR patients. The mean earliest Hb level was 12.3±1.4 g/dL in patients with an anemia diagnosis and was 13.9±1.3 g/dL for the group without an anemia diagnosis (p<0.001). Of patients with an anemia diagnosis, the majority (67.9%) had an earliest Hb level <13 g/dL (versus 24.2% of those without an anemia diagnosis; p<0.001) while 38.8% of those with an anemia diagnosis had an earliest Hb level <12 g/dL (versus 6.4% of those without an anemia diagnosis; p<0.001). Over 15% of patients with an anemia diagnosis had a hospitalization in the 90 days before THR surgery versus 4.9% of those without an anemia diagnosis (p<0.001). In addition, 5.5% of the group with an anemia diagnosis had an ER visit versus 3.0% of those without an anemia diagnosis (p=0.088). In the 90 days pre-THR surgery, the anemia diagnosis group had 4.8±2.8 days with an office/outpatient visit and 12.7±8.6 days with another-type service (e.g., prescription refill, administrative services) while the group without an anemia diagnosis had 3.4±2.0 (p<0.001) and 7.3±4.6 (p<0.001) days with these respective services. Conclusions: In this EMR database analysis, more than 10% of patients had an anemia diagnosis based upon ICD-9 codes in 90 days before or day of THR surgery. Patients with an anemia diagnosis differed from those without an anemia diagnosis for certain characteristics including age, proportion who were white, comorbidity burden, and mean earliest Hb levels. The proportion of patients with a hospitalization in the 90 days preceding THR surgery was significantly greater in patients with an anemia diagnosis as compared to those without an anemia diagnosis. In the total population, over 28% and 9% of patients had an earliest Hb value <13 g/dL and <12 g/dL, respectively, however, in patients without an anemia diagnosis, over 24% and 6% had an earliest Hb level <13 g/dL and <12 g/dL, respectively. This research provides further insight into preoperative Hb levels for a population of THR patients with and without anemia diagnosis codes. Further research is warranted to better understand these variations between groups as well as the implications of these differences on preoperative management and post-operative outcomes in THR populations. Disclosures: Forlenza: Janssen Scientific Affairs, LLC: Employment. Ellis:Janssen Scientific Affairs, LLC: Employment. Parise:Janssen Scientific Affairs, LLC: Consultancy. Lafeuille:Janssen Scientific Affairs, LLC: Consultancy. Lefebvre:Janssen Scientific Affairs, LLC: Consultancy.

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2089-2089
Author(s):  
Jamie B. Forlenza ◽  
Lorie Ellis ◽  
Helene Parise ◽  
Marie-Hélène Lafeuille ◽  
Patrick Lefebvre

Abstract Abstract 2089 Purpose: This retrospective analysis describes preoperative hemoglobin (Hb) levels, characteristics, and resource use in total knee replacement (TKR) patients who had an anemia diagnosis as compared to those without an anemia diagnosis. Methods: Electronic medical records (EMR) from a large US integrated health delivery system were analyzed for the period 01/2004 to 09/2010. Adult patients with a TKR surgery record and ≥1 Hb measurement were studied. Patients with a hip or knee revision before or during surgery, with bilateral surgery, or with an emergency room (ER) visit on the surgery admission date were excluded. Patients were stratified into two groups based upon the presence or absence of an anemia diagnosis (ICD-9 codes 280.xx-285.xx) in the 90 days before or day of surgery. Hemoglobin levels measured in the 45 days prior to but excluding the day of surgery were analyzed. For patients with multiple Hb measurements, the earliest observed Hb measurement (defined as the measurement collected furthest in time from the date of surgery) was evaluated. Other clinical and demographic characteristics in the 90 days before or day of surgery and resource utilization in the 90 days pre-surgery were analyzed. Descriptive statistics were reported as frequencies and means±standard deviations, and groups were compared using the Pearson chi-square test for categorical variables and Student's t-test for continuous variables. Results: The total study population consisted of 2,984 TKR patients, of which, 9.1% (n=273) had an anemia diagnosis. In patients with an anemia diagnosis, the first anemia diagnosis in the EMR occurred 38±30 days before surgery. Patients with an anemia diagnosis versus those without an anemia diagnosis tended to be older (mean age 70.3±10.2 vs 67.5±10.0 years, respectively; p<0.001), have a lower proportion that were white (95.2% vs 98.5%, respectively; p<0.001), and have a higher comorbidity burden as measured by the Quan-Charlson Comorbidity Index (Q-CCI) (mean Q-CCI of 1.2±1.3 vs 0.6±1.0, respectively, p<0.001). The mean earliest Hb level for the total population was 13.7±1.3 g/dL and was <13 g/dL in 28.2% of TKR patients and <12 g/dL in 9.6% of TKR patients. The mean earliest Hb level was 12.5±1.3 g/dL in patients with an anemia diagnosis and was 13.8±1.2 g/dL for the group without an anemia diagnosis (p<0.001). Of patients with an anemia diagnosis, the majority (62.3%) had an earliest Hb level <13 g/dL (versus 24.8% of those without an anemia diagnosis; p<0.001) while 33.7% of those with an anemia diagnosis had an earliest Hb level <12 g/dL (versus 7.1% of those without an anemia diagnosis; p<0.001). Seven percent of patients with an anemia diagnosis had a hospitalization in the 90 days before TKR surgery versus 3.0% of those without an anemia diagnosis (p<0.001). In addition, 5.9% of the group with an anemia diagnosis had an ER visit versus 2.8% of those without an anemia diagnosis (p=0.005). In the 90 days pre-TKR surgery, the anemia diagnosis group had 5.0±2.7 days with an office/outpatient visit and 11.9±6.0 days with another-type service (e.g., prescription refill, administrative services) while the group without an anemia diagnosis had 3.6±2.0 (p<0.001) and 7.4±4.4 (p<0.001) days with these respective services. Conclusions: In this EMR database analysis, more than 9% of patients had an anemia diagnosis based upon ICD-9 codes in 90 days before or day of TKR surgery. Patients with an anemia diagnosis differed from those without an anemia diagnosis for certain characteristics including age, proportion who were white, comorbidity burden, and mean earliest Hb levels. The proportion of patients with a hospitalization in the 90 days preceding TKR surgery was significantly greater in patients with an anemia diagnosis as compared to those without an anemia diagnosis. In the total population, over 28% and 9% of patients had an earliest Hb value <13 g/dL and <12 g/dL, respectively, however, in patients without an anemia diagnosis, over 24% and 7% had an earliest Hb level <13 g/dL and <12 g/dL, respectively. This research provides further insight into preoperative Hb levels for a population of TKR patients with and without anemia diagnosis codes. Further research is warranted to better understand these variations between groups as well as the implications of these differences on preoperative management and post-operative outcomes in TKR populations. Disclosures: Forlenza: Janssen Scientific Affairs, LLC: Employment. Ellis:Janssen Scientific Affairs, LLC: Employment. Parise:Janssen Scientific Affairs, LLC: Consultancy. Lafeuille:Janssen Scientific Affairs, LLC: Consultancy. Lefebvre:Janssen Scientific Affairs, LLC: Consultancy.


1975 ◽  
Author(s):  
Duncan P. Thomas ◽  
S. Sagar ◽  
V. V. Kakkar

Plasma heparin and activated Factor X inhibitor (Xal) levels were measured in 25 patients undergoing total hip replacement. Blood samples were taken before, during and for 5 days after operation. In patients receiving heparin prophylaxis, over 50% of samples taken four hours after a subcutaneous injection of 5,000 units had no detectable plasma heparin; in none of the remaining samples did the level exceed 0.04 units per ml. In patients who developed deep vein thrombosis (DVT) postoperatively, as detected by 125-I-labelled fibrinogen and confirmed by venography, the mean preoperative level of Factor XaI was 73.5% (S. E. M.±6.9). In those patients who did not develop DVT, the mean preoperative level was 101.5% (S. E.M.±4.3) (P > 0.01).It is concluded that a regimen of 5,000 units 8-hour’ly does not give sustained plasma heparin levels after total hip replacement, which may in part explain the reduced effectiveness of low-dose heparin in preventing DVT in patients undergoing hip surgery. Low levels of Factor XaI in the immediate preoperative period correlated well with the subsequent development of thrombosis in these patients.


2012 ◽  
Vol 3 (2) ◽  
pp. 3 ◽  
Author(s):  
Philipp Gebel ◽  
Markus Oszwald ◽  
Bernd Ishaque ◽  
Gaffar Ahmed ◽  
Recha Blessing ◽  
...  

The purpose of this study was to analyse a new concept of using the the minimally invasive direct anterior approach (DAA) in total hip replacement (THR) in combination with the leg positioner (Rotex- Table) and a modified retractor system (Condor). We evaluated retrospectively the first 100 primary THR operated with the new concept between 2009 and 2010, regarding operation data, radiological and clinical outcome (HOOS). All surgeries were perfomed in a standardized operation technique including navigation. The average age of the patients was 68 years (37 to 92 years), with a mean BMI of 26.5 (17 to 43). The mean time of surgery was 80 min. (55 to 130 min). The blood loss showed an average of 511.5 mL (200 to 1000 mL). No intra-operative complications occurred. The postoperative complication rate was 6%. The HOOS increased from 43 points pre-operatively to 90 (max 100 points) 3 months after surgery. The radiological analysis showed an average cup inclination of 43° and a leg length discrepancy in a range of +/- 5 mm in 99%. The presented technique led to excellent clinic results, showed low complication rates and allowed correct implant positions although manpower was saved.


2005 ◽  
Vol 11 (4) ◽  
pp. 211-214 ◽  
Author(s):  
Sanjeev Sharma ◽  
Ravi Shah ◽  
Kingsley Paul Draviraj ◽  
M S Bhamra

We studied the feasibility of telephone interviews to assess hip function in patients who had had a total hip replacement. One hundred patients attending the orthopaedic clinic for follow-up after undergoing total hip replacement were studied. A modified Harris hip score was used. Since range of motion and deformity cannot be assessed by telephone, only pain and function were assessed. The maximum possible score was 100. Patients attending follow-up clinics were contacted by telephone one to two weeks prior to their appointment and a telephone assessment was completed. This was then compared with a face-to-face assessment in the subsequent clinic. The mean hip score obtained with the telephone interview was 85.2 and the mean hip score at face-to-face assessment was 86.1. The mean of the differences between the individual scores was −0.9 (SD 5.5). This difference was not significant ( P=0.11). Only three patients had a clinically significant difference (>20 points) between the two methods. Telephone questionnaires may be a useful adjunct to face-to-face assessment for patient follow-up after total hip replacement.


Arthroplasty ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Javahir A. Pachore ◽  
Vikram Indrajit Shah ◽  
Sachin Upadhyay ◽  
Kalpesh Shah ◽  
Ashish Sheth ◽  
...  

Abstract Background The objective of this study is to share our experience in total hip replacement for the treatment of ochronotic hip arthritis, in particular to report how to establish the diagnosis and some tips to limit complications. Method A cohort comprised of 10 patients (12 hips) with alkaptonuric hip arthritis. There were six men and four women with the mean age of 62.80 ± 7.57 years. All patients had a stiff spine, grossly restricted movements of hip joints, and severely limited daily routine activities. Total hip replacement was performed in all patients. The patients were evaluated at 6, 12, and 24 months after surgery, as well as every 4 years thereafter. Harris hip score was used to assess the functional outcome. The level of significance was set at p < 0.05. Results The mean follow-up lasted 16.70 ± 6.82 years (3 to 24 years). At the final available follow-up, nine patients returned to work, ambulate without an orthosis, and achieve complete pain relief. Harris hip score was improved from poor to excellent. One patient died 16 years after surgery due to breast cancer. No complication relating to prosthetic failures was detected. Conclusion Total hip replacement gives long-term satisfactory results in patients with alkaptonuric hip arthritis, resulting in comparable function of the hips in patients who undergo primary osteoarthrosis.


2021 ◽  
Vol 5 (1) ◽  
pp. 751-757
Author(s):  
Vilson Ruci ◽  
Edvin Selmani ◽  
Agron Dogjani

Background: Total hip replacement (THR) is one treatment option for failed hip fracture fixation. It is considered as a salvage procedure for older patients, patients with poor bone stock, avascular necrosis of the femoral head, associated with damaged acetabular articular cartilage. Patients and Methods: Total hip replacement was done for forty patients with failed internal fixation of trochanteric femoral fractures, 28 males and 12 females completed the follow up and six patients were lost. The procedure was carried out through a lateral exposure in all cases. Harris hip score (HHS) was used for clinical evaluation preoperatively, postoperatively. Radiographic evaluation comprising anteroposterior radiographic views of the pelvis and femur and a lateral view of the femur were performed at follow-up visits. Results: The mean time of follow up was 48 months (range from 36-72 months). The mean Harris hip score was improved from a mean of 24 points preoperative to 88 points at final follow up. Pain relief and gait correction were noted at the final follow up. Twenty-eight patients (70%) could freely walk outdoors using a cane or elbow crutch; eight patients (20 %) had a limited walking ability using two axillary crutches, and four patients (10 %) were able to walk indoors only. Conclusion: Total hip arthroplasty is a good salvage procedure after failed internal fixation of trochanteric femoral fractures. Individual selection of the implant depends upon the age of patient, level of activity, the bone stock of proximal femur, and the condition of the acetabulum. To maintain stability, reattachment of the greater trochanter should be done. To avoid intraoperative fractures of osteoporotic bone, dislocation of the hip should be very careful.


2018 ◽  
Vol 31 (03) ◽  
pp. 218-221 ◽  
Author(s):  
Sarah Israel ◽  
William Liska

Objective The objective of this study was to determine morbidity and mortality rates in dogs that had undergone a total hip replacement surgery with implantation of either a cemented or a cementless prosthesis (BioMedtrix LLC, Whippany, NJ). Methods The survival time after surgery, the date of death and the cause of death were collated from an ongoing registry maintained on consecutive total hip replacement procedures by a single surgeon. Results A review of the 1,864 dogs entered in the total hip replacement registry revealed 642 in which the date of death and cause of death were known. The mean life span of the dogs in this study was 11.3 years, with the longest being 17.1 years. The mean survival after total hip replacement was 4.66 years, with the longest being 16.1 years. Multiorgan system failure was more common than any single organ system failure. The most common pathophysiological process leading to death was neoplasia. Clinical Significance Morbidity and mortality rates are helpful for surgeons to compare outcomes and to inform animal owners about anaesthesia and procedural risks when contemplating this surgery. This information can be used for a better understanding of expectations for a dog's health after total hip replacement surgery.


2010 ◽  
Vol 23 (06) ◽  
pp. 424-432 ◽  
Author(s):  
O. I. Lanz ◽  
S. R. Werre ◽  
D. W. Hummel

SummaryCementless total hip implants are relatively new to the veterinary market and therefore complication rates and prognostic indicators associated with the procedure have not been thoroughly documented. The objective of this study was to determine the prevalence of complications and identify prognostic indicators of success or failure for the Zurich cementless total hip replacement (THR). Medical records of 163 dogs that underwent Zurich cementless-THR were reviewed continuous and categorical variables, clinical outcomes and complications were recorded. Complications were separated into intra-operative (IOC), short-term (STC), and long-term (LTC). Bivariate and multivariate statistical analysis was used to compare complications. The clini-cal significance of this study was to provide surgeons with prognostic indicators of success or failure when evaluating prospective Zurich cementless-THR patients, and to report the complication rate of Zurich cementlessTHR. The complication rates of Zurich cementless-THR were then compared to previously-reported complication rates of cemented-THR and other cementless-THR systems. Short-term complications, LTC, and IOC rates of Zurich cementless-THR were found to be 6.75%, 10.4%, and 11.0% respectively. The most common complications were intra-operative femoral fracture, luxation of the implant, and septic loosening of the implant. Increased body weight and prior cemented-THR or fe-moral head and neck ostectomy of the contra-lateral hip were identified as negative prognostic indicators. The overall complication rate identified was greater than those previously reported for other cementless- and cemented-THR systems.


1996 ◽  
Vol 24 (3) ◽  
pp. 334-341 ◽  
Author(s):  
B. Venkatesh ◽  
D. W. Pigott ◽  
A. Fernandez ◽  
S. P. Hendry

The arterial blood gas chemistry was measured continuously in ten patients during primary cemented total hip replacement in order to define more precisely the patterns of changes in blood gases during various stages of the operation. All ten patients demonstrated significant drops in PaO2 after femoral cement implantation and nine of the ten after acetabular cement implanation. The mean drop in PaO2 following acetabular cement expressed as mean ± SD was 18±8 mmHg (16±6%) (P<0.05) and femoral cement application was 25±11 mmHg (23±9%) (P<0.05). For changes in PaO2 there were corresponding drops in SpO2 in all patients with the femoral cement and in eight patients with the acetabular cement. The mean drop in SpO2 following the application of acetabular and femoral cements respectively were 1.7±1.5% and 3±2.45%. No changes in blood PaO2 were observed during dislocation of the hip joint or reaming of acetabulum and femur. In vitro studies revealed no effect of the liquid monomer or the cured cement on the performance of the Clark electrode of the sensor. We suggest that significant drops in PaO2 occur with both acetabular and femoral cement implantation and that the derangements in blood PaO2 last longer than detected by pulse oximetry following cement implantation.


2017 ◽  
Vol 56 (205) ◽  
pp. 158-162
Author(s):  
Pankaj Chand ◽  
Sushil Rana Magar ◽  
Bishnu Babu Thapa ◽  
Bikal Shrestha

Introduction: Total hip replacement is one of the most widely performed and amongst the most successful orthopedic procedures performed worldwide. Even though it is a common orthopedic procedure in developed nations, it is performed only in selected centers in Nepal.  This study will review the functional outcome of total hip replacements carried out in Shree Birendra Hospital. Methods: We reviewed the records of total hip replacements, which were carried out in Shree Birendra Hospital, Kathmandu. Twenty-one hips were cemented and nineteen were uncemented.  Cases were followed up in six weeks, twelve weeks, six months and every year from then on. Outcome in terms of Harris hip score of 40 osteoarthritic hips were measured pre-operatively as well as post-operatively. Results: The mean age of the patients was 50.63 years (range 22-79 years). The commonest reason for the replacement was primary osteoarthritis of the hip. Thirty-nine patients underwent unilateral total hip replacement while in one patient both hips were replaced. The mean Harris hip score for the forty hips that were available at the latest follow-up examination at an average of five years (range two to six and a half years) after the operation was 85.2 ± 7.65 points as compared to the pre-operative mean Harris hip score of 32.38 ± 3.4. Conclusions: Based on improved Harris hip scores, we believe that THR is a good option in patients with end stage arthritis of the hip. Keywords: cemented; primary osteoarthritis; total hip replacement.


Sign in / Sign up

Export Citation Format

Share Document