Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase--positive acute leukemia

Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive lymphoblastic cell population at diagnosis and, following initial therapy, a terminal transferase--negative monocytic population.

Download Full-text

Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase--positive acute leukemia

Blood ◽

10.1182/blood.v51.6.1051.1051 ◽

1978 ◽

Vol 51 (6) ◽

pp. 1051-1056 ◽

Cited By ~ 55

Author(s):

R Mertelsmann ◽

B Koziner ◽

R Ralph ◽

D Filippa ◽

S McKenzie ◽

...

Keyword(s):

Stem Cell ◽

Acute Leukemia ◽

Clinical Course ◽

Initial Therapy ◽

Cell Populations ◽

Cell Marker ◽

Terminal Transferase ◽

Distinct Cell ◽

Multiple Cell ◽

Marker Studies

Abstract Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive lymphoblastic cell population at diagnosis and, following initial therapy, a terminal transferase--negative monocytic population.

Download Full-text

Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip

Development ◽

10.1242/dev.119.4.991 ◽

1993 ◽

Vol 119 (4) ◽

pp. 991-1004 ◽

Cited By ~ 32

Author(s):

L.K. Gont ◽

H. Steinbeisser ◽

B. Blumberg ◽

E.M. de Robertis

Keyword(s):

Cell Populations ◽

Fate Map ◽

Stages Of Development ◽

Gene Markers ◽

Distinct Cell ◽

Multiple Cell ◽

Organizer Activity ◽

Dorsal Cells ◽

Late Stages ◽

Lines Of Evidence

Three lines of evidence suggest that tail formation in Xenopus is a direct continuation of events initiated during gastrulation. First, the expression of two gene markers, Xbra and Xnot2, can be followed from the blastopore lip into distinct cell populations of the developing tailbud. Second, the tip of the tail retains Spemann's tail organizer activity until late stages of development. Third, lineage studies with the tracer DiI indicate that the cells of the late blastopore are fated to form specific tissues of the tailbud, and that intercalation of dorsal cells continues during tail elongation. In particular, the fate map shows that the tip of the tail is a direct descendant of the late dorsal blastopore lip. Thus, the tailbud is not an undifferentiated blastema as previously thought, but rather consists of distinct cell populations which arise during gastrulation.

Download Full-text

Mixed lymphoblastic-myelomonoblastic leukemia in treated Hodgkin's disease

Blood ◽

10.1182/blood.v56.1.129.129 ◽

1980 ◽

Vol 56 (1) ◽

pp. 129-133 ◽

Cited By ~ 22

Author(s):

AG Prentice ◽

AG Smith ◽

KF Bradstock

Keyword(s):

Acute Leukemia ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Blast Cell ◽

Cell Populations ◽

Nonspecific Esterase ◽

Terminal Transferase ◽

Strong Expression ◽

A Minor

Abstract In a case of acute leukemia occurring 5.5 yr after diagnosis of Hodgkin's disease, a mixture of lymphoid and myelomonocytoid blasts was identified by morphological, cytochemical, and immunologic methods. The majority of blasts were characterised as lymphoid by their strong expression of nuclear terminal transferase (TdT) enzyme. In contrast, a minor blast population was identified as myelomonocytoid by the strong nonspecific esterase positivity and lack of TdT. The two distinct blast cell populations showed different sensitivity to the various chemotherapeutic protocols used.

Download Full-text

Prom1 expression does not mark a stem/progenitor population in the mouse oviduct epithelium

10.1101/2020.08.19.257923 ◽

2020 ◽

Author(s):

Matthew J Ford ◽

Yojiro Yamanaka

Keyword(s):

Stem Cell ◽

Adult Stem Cell ◽

Lineage Tracing ◽

Stem Cell Marker ◽

Secretory Cells ◽

Cell Populations ◽

Cell Marker ◽

Multiciliated Cells ◽

Cell Property ◽

Stem Cell Populations

SummaryThe oviduct or fallopian tube is the site of fertilization and preimplantation embryonic development. The epithelium lining the oviduct consists of multiciliated and secretory cells, which support fertilization and preimplantation development, however, its homeostasis still remains poorly understood. CD133/Prom1 has been used to identify adult stem cell populations in various organs and often associated with cancer stem cell property. Using a Cre-recombinase based lineage tracing strategy, we found that CD133/Prom1 expression was not associated with a stem/progenitor population in the oviduct but marked a sub population of multiciliated and secretory cells which did not propagate. Interestingly, Prom1 expressing secretory cells rapidly transition to multiciliated cells and progressively migrate to the tips of epithelial folds in the ampulla. Our results show that CD133/Prom1 expression cannot be used as a progenitor/stem cell marker in the mouse oviduct.

Download Full-text

Mixed lymphoblastic-myelomonoblastic leukemia in treated Hodgkin's disease

Blood ◽

10.1182/blood.v56.1.129.bloodjournal561129 ◽

1980 ◽

Vol 56 (1) ◽

pp. 129-133 ◽

Cited By ~ 1

Author(s):

AG Prentice ◽

AG Smith ◽

KF Bradstock

Keyword(s):

Acute Leukemia ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Blast Cell ◽

Cell Populations ◽

Nonspecific Esterase ◽

Terminal Transferase ◽

Strong Expression ◽

A Minor

In a case of acute leukemia occurring 5.5 yr after diagnosis of Hodgkin's disease, a mixture of lymphoid and myelomonocytoid blasts was identified by morphological, cytochemical, and immunologic methods. The majority of blasts were characterised as lymphoid by their strong expression of nuclear terminal transferase (TdT) enzyme. In contrast, a minor blast population was identified as myelomonocytoid by the strong nonspecific esterase positivity and lack of TdT. The two distinct blast cell populations showed different sensitivity to the various chemotherapeutic protocols used.

Download Full-text