Expression of c-fos, c-myb, and c-myc in human monocytes: correlation with monocytic differentiation
Keyword(s):
Abstract Terminal differentiation of human monocytic leukemia cells (THP-1 cells) was associated with the induction of c-fos, the down regulation of c-myb, and no significant change in the level of c-myc expression. Gamma interferon, which resulted in a slight decrease in c-myb but no change in c-fos or c-myc expression, had a transient antiproliferative effect without a morphological or functional differentiation of THP-1 cells. Resting human peripheral blood monocytes have a high c-fos, a low c-myc, and no detectable c-myb expression. These findings suggest that a switch in c-fos/c-myb expression is associated with the terminal differentiation of cells of the monocytic lineage.
2015 ◽
Vol 2015
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pp. 1-8
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1993 ◽
Vol 177
(3)
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pp. 699-705
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1989 ◽
Vol 121
(1)
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pp. 75-84
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2009 ◽
Vol 53
(2)
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pp. 159-163
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1996 ◽
Vol 18
(1)
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pp. 37-44
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