scholarly journals Fewer circulating natural killer cells 28 days after double cord blood transplantation predicts inferior survival and IL-15 response

2016 ◽  
Vol 1 (3) ◽  
pp. 208-218 ◽  
Author(s):  
Rachel J. Bergerson ◽  
Robin Williams ◽  
Hongbo Wang ◽  
Ryan Shanley ◽  
Gretchen Colbenson ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cord Blood ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Cord Blood Transplantation ◽  
Killer Cells ◽  
Cell Numbers ◽  
Blood Transplantation ◽  
Key Points

Key Points Low numbers of reconstituting NK cells at D+28 after dUCBT are associated with inferior DFS. Patients with low NK cell numbers at D+28 have reduced phosphorylation of STAT5 upon IL-15 stimulation and less Eomes expression.

Recovery of natural killer cells and prognosis after cord blood transplantation

2013 ◽  
Vol 37 (11) ◽  
pp. 1522-1526 ◽  
Author(s):  
Wataru Yamamoto ◽  
Eriko Ogusa ◽  
Kenji Matsumoto ◽  
Atsuo Maruta ◽  
Yoshiaki Ishigatsubo ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cord Blood ◽  
Natural Killer ◽  
Cord Blood Transplantation ◽  
Killer Cells ◽  
Blood Transplantation

Two cytotoxic pathways of natural killer cells in human cord blood: implications in cord blood transplantation

1997 ◽  
Vol 98 (4) ◽  
pp. 1037-1040 ◽  
Author(s):  
Masakazu Umemoto ◽  
Eiichi Azuma ◽  
Masahiro Hirayama ◽  
Masataka Nagai ◽  
Shinnya Hiratake ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cord Blood ◽  
Natural Killer ◽  
Cord Blood Transplantation ◽  
Human Cord Blood ◽  
Killer Cells ◽  
Blood Transplantation

scholarly journals Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Blood ◽  
2014 ◽  
Vol 123 (5) ◽  
pp. 678-686 ◽  
Author(s):  
Holbrook E. Kohrt ◽  
Ariane Thielens ◽  
Aurelien Marabelle ◽  
Idit Sagiv-Barfi ◽  
Caroline Sola ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Mhc Class I ◽  
Nk Cell ◽  
Class I ◽  
Lymphoma Cells ◽  
Killer Cells ◽  
Key Points ◽  
Anti Cd20 ◽  
Cd20 Antibodies

Key Points Blockade of inhibitory KIRs with MHC class I antigens on lymphoma cells by anti-KIR antibodies augments NK-cell spontaneous cytotoxicity. In combination with anti-CD20 mAbs, anti-KIR induces enhanced NK cell–mediated, rituximab-dependent cytotoxicity against lymphoma.

scholarly journals Classification of human natural killer cells based on migration behavior and cytotoxic response

Blood ◽  
2013 ◽  
Vol 121 (8) ◽  
pp. 1326-1334 ◽  
Author(s):  
Bruno Vanherberghen ◽  
Per E. Olofsson ◽  
Elin Forslund ◽  
Michal Sternberg-Simon ◽  
Mohammad Ali Khorshidi ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Serial Killer ◽  
Migration Behavior ◽  
Killer Cells ◽  
Key Points ◽  
Human Natural Killer Cells ◽  
Cytotoxic Responses

Key Points Activated NK cells display heterogeneity in their cytotoxic responses that justifies grouping them into 5 distinct classes of NK cells. A subpopulation of particularly active “serial killer” NK cells deliver their lytic hits faster and release more perforin in each hit.

scholarly journals Role of Defective Thymic Function in Onset of Ganciclovir-Resistant Cytomegalovirus after Cord Blood Transplantation

2012 ◽  
Vol 19 (12) ◽  
pp. 1994-1998 ◽  
Author(s):  
Sara Cantisán ◽  
Carmen Martín ◽  
María C. Romero-Sánchez ◽  
Sara Ferrando-Martínez ◽  
Francisco Martínez ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer Cells ◽  
Cord Blood ◽  
Cell Count ◽  
Natural Killer ◽  
Cord Blood Transplantation ◽  
Thymic Function ◽  
Blood Transplantation ◽  
Seropositive Woman

ABSTRACTA case of recurrent cytomegalovirus reactivations in a cytomegalovirus-seropositive woman who received allogeneic cord blood transplantation is described. Thirteen months posttransplantation, her CD3+T cell count was extremely low whereas natural killer cells represented 66% of her total lymphocytes. She showed defective thymic function that might contribute to the onset of valganciclovir resistance.

scholarly journals Nonstochastic Coexpression of Activation Receptors on Murine Natural Killer Cells

2000 ◽  
Vol 191 (8) ◽  
pp. 1341-1354 ◽  
Author(s):  
Hamish R.C. Smith ◽  
Hubert H. Chuang ◽  
Lawrence L. Wang ◽  
Margarita Salcedo ◽  
Jonathan W. Heusel ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Inhibitory Receptors ◽  
Antigen Receptors ◽  
Killer Cells ◽  
Histocompatibility Complex ◽  
Nk Cell Cytotoxicity

Murine natural killer cells (NK) express lectin-like activation and inhibitory receptors, including the CD94/NKG2 family of receptors that bind Qa-1, and the Ly-49 family that recognizes major histocompatibility complex class I molecules. Here, we demonstrate that cross-linking of NK cells with a new specific anti–Ly-49H mAb induced NK cell cytotoxicity and cytokine production. Ly-49H is expressed on a subset of NK cells and can be coexpressed with Ly-49 inhibitory receptors. However, unlike Ly-49 inhibitory receptors, Ly-49H is not detectable on naive splenic CD3+ T cells, indicating that Ly-49H may be an NK cell–specific activation receptor. In further contrast to the stochastically expressed Ly-49 inhibitory receptors, Ly-49H is preferentially expressed with the Ly-49D activation receptor, and expression of both Ly-49H and Ly-49D is augmented on NK cells that lack receptors for Qa-1 tetramers. On developing splenic NK1.1+ cells, Ly-49D and Ly-49H are expressed later than the inhibitory receptors. These results directly demonstrate that Ly-49H activates primary NK cells, and suggest that expression of Ly-49 activation receptors by NK cells may be specifically regulated on NK cell subsets. The simultaneous expression of multiple activation receptors by individual NK cells contrasts with that of T cell antigen receptors and is relevant to the role of NK cells in innate immunity.

An Infant with Precursor Natural Killer (NK) Cell Leukemia Successfully Treated with an Unrelated Cord Blood Transplantation

2000 ◽  
Vol 39 (5-6) ◽  
pp. 641-646 ◽  
Author(s):  
Aiko Suminoe ◽  
Akinobu Matsuzaki ◽  
Hidetoshi Takada ◽  
Hiroyoshi Hattori ◽  
Kenji Furuno ◽  
...  
Keyword(s):  
Cord Blood ◽  
Natural Killer ◽  
Nk Cell ◽  
Cord Blood Transplantation ◽  
Cell Leukemia ◽  
Unrelated Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Unrelated Cord Blood

scholarly journals Allotype-specific processing of the CD16a N45-glycan from primary human natural killer cells and monocytes

Glycobiology ◽  
2020 ◽  
Vol 30 (7) ◽  
pp. 427-432
Author(s):  
Kashyap R Patel ◽  
Jacob T Roberts ◽  
Adam W Barb
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Viral Infections ◽  
Nk Cell ◽  
Cell Surface Receptor ◽  
Mass Spectrometry Analysis ◽  
Healthy Human ◽  
Killer Cells ◽  
Spectrometry Analysis

Abstract Fc γ receptor IIIa/CD16a is an activating cell surface receptor with a well-defined role in natural killer (NK) cell and monocyte effector function. The extracellular domain is decorated with five asparagine (N)-linked glycans; N-glycans at N162 and N45 directly contribute to high-affinity antibody binding and protein stability. N-glycan structures at N162 showed significant donor-dependent variation in a recent study of CD16a isolated from primary human NK cells, but structures at N45 were relatively homogeneous. In this study, we identified variations in N45 glycan structures associated with a polymorphism coding for histidine instead of leucine at position 48 of CD16a from two heterozygous donors. It is known that H48 homozygous individuals suffer from immunodeficiency and recurrent viral infections. A mass spectrometry analysis of protein isolated from the primary natural killer cells of individuals expressing both CD16a L48 and H48 variants demonstrated clear processing differences at N45. CD16a H48 displayed a greater proportion of complex-type N45 glycans compared to the more common L48 allotype with predominantly hybrid N45-glycoforms. Structures at the four other N-glycosylation sites showed minimal differences from data collected on donors expressing only the predominant L48 variant. CD16a H48 purified from a pool of monocytes similarly displayed increased processing at N45. Here, we provide evidence that CD16a processing is affected by the H48 residue in primary NK cells and monocytes from healthy human donors.

Sign in / Sign up

Export Citation Format

Share Document