scholarly journals Classification of human natural killer cells based on migration behavior and cytotoxic response

Blood ◽  
2013 ◽  
Vol 121 (8) ◽  
pp. 1326-1334 ◽  
Author(s):  
Bruno Vanherberghen ◽  
Per E. Olofsson ◽  
Elin Forslund ◽  
Michal Sternberg-Simon ◽  
Mohammad Ali Khorshidi ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Serial Killer ◽  
Migration Behavior ◽  
Killer Cells ◽  
Key Points ◽  
Human Natural Killer Cells ◽  
Cytotoxic Responses

Key Points Activated NK cells display heterogeneity in their cytotoxic responses that justifies grouping them into 5 distinct classes of NK cells. A subpopulation of particularly active “serial killer” NK cells deliver their lytic hits faster and release more perforin in each hit.

scholarly journals Fewer circulating natural killer cells 28 days after double cord blood transplantation predicts inferior survival and IL-15 response

2016 ◽  
Vol 1 (3) ◽  
pp. 208-218 ◽  
Author(s):  
Rachel J. Bergerson ◽  
Robin Williams ◽  
Hongbo Wang ◽  
Ryan Shanley ◽  
Gretchen Colbenson ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cord Blood ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Cord Blood Transplantation ◽  
Killer Cells ◽  
Cell Numbers ◽  
Blood Transplantation ◽  
Key Points

Key Points Low numbers of reconstituting NK cells at D+28 after dUCBT are associated with inferior DFS. Patients with low NK cell numbers at D+28 have reduced phosphorylation of STAT5 upon IL-15 stimulation and less Eomes expression.

scholarly journals Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 403-411 ◽  
Author(s):  
Shiguo Zhu ◽  
Prasad V. Phatarpekar ◽  
Cecele J. Denman ◽  
Vladimir V. Senyukov ◽  
Srinivas S. Somanchi ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Tyrosine Phosphorylation ◽  
Killer Cells ◽  
Stat3 Signaling ◽  
Key Points ◽  
Activating Receptor

Key Points STAT3 directly regulates expression of NKG2D in NK cells. Defects in STAT3 signaling result in deficient NKG2D responses to cytokine.

scholarly journals MicroRNAs activate natural killer cells through Toll-like receptor signaling

Blood ◽  
2013 ◽  
Vol 121 (23) ◽  
pp. 4663-4671 ◽  
Author(s):  
Shun He ◽  
Jianhong Chu ◽  
Lai-Chu Wu ◽  
Hsiaoyin Mao ◽  
Yong Peng ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Signaling Pathway ◽  
Receptor Signaling ◽  
Toll Like Receptor ◽  
Killer Cells ◽  
Therapeutic Applications ◽  
Key Points

Key Points miRNAs activate NK cells through a TLR–NF-κB signaling pathway and may have therapeutic applications in cancer.

scholarly journals Role for early-differentiated natural killer cells in infectious mononucleosis

Blood ◽  
2014 ◽  
Vol 124 (16) ◽  
pp. 2533-2543 ◽  
Author(s):  
Tarik Azzi ◽  
Anna Lünemann ◽  
Anita Murer ◽  
Seigo Ueda ◽  
Vivien Béziat ◽  
...  
Keyword(s):  
B Cells ◽  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Infectious Mononucleosis ◽  
Killer Cells ◽  
Key Points

Key Points Early-differentiated NK cells accumulate and proliferate during IM. These early-differentiated NK cells preferentially target lytic EBV-infected B cells in vitro.

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