scholarly journals Validation of the 2017 revision of the WHO chronic myelomonocytic leukemia categories

2018 ◽  
Vol 2 (15) ◽  
pp. 1807-1816 ◽  
Author(s):  
Sanam Loghavi ◽  
Dawen Sui ◽  
Peng Wei ◽  
Guillermo Garcia-Manero ◽  
Sherry Pierce ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Chronic Myelomonocytic Leukemia ◽  
Key Points ◽  
Myelomonocytic Leukemia

Key Points Validation of the WHO 2017 CMML categories supports distinguishing MP-CMML from MDS–CMML. The prognostic value of the new 3-tiered blast-based CMML stratification scheme is limited.

scholarly journals GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Blood ◽  
2013 ◽  
Vol 121 (25) ◽  
pp. 5068-5077 ◽  
Author(s):  
Eric Padron ◽  
Jeffrey S. Painter ◽  
Sateesh Kunigal ◽  
Adam W. Mailloux ◽  
Kathy McGraw ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Neutralizing Antibody ◽  
Chronic Myelomonocytic Leukemia ◽  
Gm Csf ◽  
Key Points ◽  
Myelomonocytic Leukemia ◽  
Jak2 Inhibitors

Key Points GM-CSF–dependent STAT5 hypersensitivity is detected in 90% of CMML samples and is enhanced by signaling mutations. Treatment with a GM-CSF–neutralizing antibody and JAK2 inhibitors reveals therapeutic potential.

scholarly journals Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines

2017 ◽  
Vol 1 (14) ◽  
pp. 972-979 ◽  
Author(s):  
Yanyan Zhang ◽  
Liang He ◽  
Dorothée Selimoglu-Buet ◽  
Chloe Jego ◽  
Margot Morabito ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transgenic Mice ◽  
Chronic Myelomonocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Engraftment ◽  
Key Points ◽  
Immunocompromised Mice ◽  
Myelomonocytic Leukemia ◽  
Human Cytokines

Key Points Transgenic mice expressing 3 human cytokines enable expansion of CMML cells with limited stem cell engraftment. The mutational profile of CMML cells that expand in mice mirrors that of patient monocytes.

scholarly journals Clinical characteristics and outcomes of therapy-related chronic myelomonocytic leukemia

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2807-2811 ◽  
Author(s):  
Koichi Takahashi ◽  
Naveen Pemmaraju ◽  
Paolo Strati ◽  
Graciela Nogueras-Gonzalez ◽  
Jing Ning ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Clinical Characteristics ◽  
Chronic Myelomonocytic Leukemia ◽  
Myeloid Neoplasms ◽  
Key Points ◽  
Myelomonocytic Leukemia

Key Points t-CMML is associated with higher-risk cytogenetics and manifests poor prognosis. t-CMML should be recognized as one of the therapy-related myeloid neoplasms.

scholarly journals Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

Blood ◽  
2015 ◽  
Vol 125 (23) ◽  
pp. 3618-3626 ◽  
Author(s):  
Dorothée Selimoglu-Buet ◽  
Orianne Wagner-Ballon ◽  
Véronique Saada ◽  
Valérie Bardet ◽  
Raphaël Itzykson ◽  
...  
Keyword(s):  
High Specificity ◽  
Chronic Myelomonocytic Leukemia ◽  
Monocyte Subset ◽  
Hypomethylating Agents ◽  
Monocyte Subsets ◽  
Key Points ◽  
Diagnostic Signature ◽  
Myelomonocytic Leukemia ◽  
Classical Monocytes

Key Points An increase in the classical monocyte subset to >94% of total monocytes discriminates CMML from other monocytoses with high specificity. This characteristic increase in classical monocytes disappears in CMML patients who respond to hypomethylating agents.

scholarly journals Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia

Blood ◽  
2017 ◽  
Vol 129 (15) ◽  
pp. 2148-2160 ◽  
Author(s):  
Yuichiro Nakata ◽  
Takeshi Ueda ◽  
Akiko Nagamachi ◽  
Norimasa Yamasaki ◽  
Ken-ichiro Ikeda ◽  
...  
Keyword(s):  
Chronic Myelomonocytic Leukemia ◽  
Multilineage Dysplasia ◽  
Key Points ◽  
Myelomonocytic Leukemia

Key Points Acquired expression of CblQ367P induces sustained proliferation of myelomonocytes, multilineage dysplasia, and splenomegaly resembling CMML. Combined inhibition of PI3K and JAK2 efficiently suppressed the growth of CblQ367P-induced CMML cells.

Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia

Blood ◽  
2013 ◽  
Vol 121 (15) ◽  
pp. 3005-3015 ◽  
Author(s):  
Esperanza Such ◽  
Ulrich Germing ◽  
Luca Malcovati ◽  
José Cervera ◽  
Andrea Kuendgen ◽  
...  
Keyword(s):  
Scoring System ◽  
Prognostic Score ◽  
Risk Groups ◽  
Chronic Myelomonocytic Leukemia ◽  
Key Points ◽  
Development And Validation ◽  
Myelomonocytic Leukemia

Key Points CMML is a heterogeneous disorder with a highly variable prognosis that clearly requires a specific and widely accepted prognostic scoring system. CPSS is a powerful prognostic score that defines 4 risk groups for survival and AML evolution, developed and validated in the largest CMML series to date.

scholarly journals Leukemoid reaction in chronic myelomonocytic leukemia patients undergoing surgery: perioperative management recommendations

2019 ◽  
Vol 3 (7) ◽  
pp. 952-955 ◽  
Author(s):  
Ami B. Patel ◽  
Erin M. Pettijohn ◽  
Sameem M. Abedin ◽  
Evan Raps ◽  
Michael W. Deininger
Keyword(s):  
Molecular Mechanisms ◽  
Perioperative Management ◽  
Surgical Intervention ◽  
Chronic Myelomonocytic Leukemia ◽  
Leukemoid Reaction ◽  
Key Points ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
Management Recommendations ◽  
Myelomonocytic Leukemia

Key Points CMML patients comprise an elderly and frail patient population with comorbidities that often require surgical intervention. Postsurgical leukemoid reaction, a life-threatening complication in CMML patients, may be driven by molecular mechanisms.

Clonal architecture of chronic myelomonocytic leukemias

Blood ◽  
2013 ◽  
Vol 121 (12) ◽  
pp. 2186-2198 ◽  
Author(s):  
Raphaël Itzykson ◽  
Olivier Kosmider ◽  
Aline Renneville ◽  
Margot Morabito ◽  
Claude Preudhomme ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Chronic Myelomonocytic Leukemia ◽  
Myeloid Differentiation ◽  
Hematopoietic Tissue ◽  
Clonal Architecture ◽  
Myeloid Neoplasms ◽  
Key Points ◽  
Myelomonocytic Leukemia ◽  
Similar Gene

Key Points Early clonal dominance may distinguish chronic myelomonocytic leukemia from other chronic myeloid neoplasms with similar gene mutations. Early dominance of TET2-mutated cells in the hematopoietic tissue promotes myeloid differentiation skewing toward the granulomonocytic line.

scholarly journals Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

Blood ◽  
2016 ◽  
Vol 128 (10) ◽  
pp. 1408-1417 ◽  
Author(s):  
Chiara Elena ◽  
Anna Gallì ◽  
Esperanza Such ◽  
Manja Meggendorfer ◽  
Ulrich Germing ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Risk Stratification ◽  
Clinical Features ◽  
Chronic Myelomonocytic Leukemia ◽  
Key Points ◽  
Myelomonocytic Leukemia

Key Points Risk assessment is crucial in patients with CMML because survival may range from a few months to several years. Integrating clinical features, morphology, and genetic lesions significantly improves risk stratification in CMML.

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