scholarly journals Is ventilation heterogeneity related to asthma control?

2016 ◽  
Vol 48 (2) ◽  
pp. 370-379 ◽  
Author(s):  
Sarah Svenningsen ◽  
Parameswaran Nair ◽  
Fumin Guo ◽  
David G. McCormack ◽  
Grace Parraga
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Forced Expiratory Volume ◽  
Life Questionnaire ◽  
Strongly Correlated ◽  
Asthma Control Questionnaire ◽  
Asthma Patients ◽  
Ventilation Heterogeneity ◽  
Magnetic Resonance Imaging Mri

In asthma patients, magnetic resonance imaging (MRI) and the lung clearance index (LCI) have revealed persistent ventilation heterogeneity, although its relationship to asthma control is not well understood. Therefore, our goal was to explore the relationship of MRI ventilation defects and the LCI with asthma control and quality of life in patients with severe, poorly controlled asthma.18 patients with severe, poorly controlled asthma (mean±sd 46±12 years, six males/12 females) provided written informed consent to an ethics board approved protocol, and underwent spirometry, LCI and 3He MRI during a single 2-h visit. Asthma control and quality of life were evaluated using the Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ). Ventilation heterogeneity was quantified using the LCI and 3He MRI ventilation defect percent (VDP).All participants reported poorly controlled disease (mean±sd ACQ score=2.3±0.9) and highly heterogeneous ventilation (mean±sd VDP=12±11% and LCI=10.5±3.0). While VDP and LCI were strongly correlated (r=0.86, p<0.0001), in a multivariate model that included forced expiratory volume in 1 s, VDP and LCI, VDP was the only independent predictor of asthma control (R2=0.38, p=0.01). There was also a significantly worse VDP, but not LCI in asthma patients with an ACQ score >2 (p=0.04) and AQLQ score <5 (p=0.04), and a trend towards worse VDP (p=0.053), but not LCI in asthma patients reporting ≥1 exacerbation in the past 6 months.In patients with poorly controlled, severe asthma MRI ventilation, but not LCI was significantly worse in those with worse ACQ and AQLQ.

scholarly journals Relation of Asthma Control with Quality of Life among a Sample of Egyptian Asthmatic School Children

2019 ◽  
Vol 7 (17) ◽  
pp. 2780-2785
Author(s):  
Hala G. Elnady ◽  
Lobna S. Sherif ◽  
Rania N. Sabry ◽  
Dina Abu Zeid ◽  
Hanan Atta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Asthma Severity ◽  
Physical Symptoms ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Asthmatic Children ◽  
Asthmatic Patients ◽  
Egyptian Children

BACKGROUND: Asthma is considered a chronic health illness that not only resulted in physical symptoms but also emotional effects. It is; therefore, so important to assess the quality of life of asthmatic patients besides their level of disease control. AIM: To determine the correlation of asthma control with the health-related quality of life (HRQOL) of asthmatic children in Egypt. METHODS: One hundred and twenty-eight asthmatic Egyptian children were enrolled in the study. They were subjected to asthma severity grading, asthma control questionnaire (ACQ) and pediatric asthma quality of life questionnaire (PAQLQ). Studied cases were taken from 6 primary and preparatory schools, Giza governorate. RESULTS: The mean child control score was significantly higher in not well-controlled asthmatics compared to well-controlled asthmatics (p < 0.005). The not well controlled asthmatic children showed significantly lower activity limitation score, symptoms score, and overall asthmatic score compared to controlled asthmatic children (p < 0.05). The severity of asthma shows significant positive correlation with symptoms score, emotional function score and overall asthmatic score (p < 0.05). CONCLUSION: The quality of life for the asthmatic children is strongly correlated with the level of asthma control and severity.

scholarly journals A 1-day visit in a severe asthma centre: effect on asthma control, quality of life and healthcare use

2016 ◽  
Vol 48 (3) ◽  
pp. 726-733 ◽  
Author(s):  
Akke-Nynke van der Meer ◽  
Henk Pasma ◽  
Wilma Kempenaar-Okkema ◽  
Jo-Anneke Pelinck ◽  
Myrte Schutten ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Severe Asthma ◽  
Life Questionnaire ◽  
Healthcare Use ◽  
Uncontrolled Asthma ◽  
Control Quality ◽  
Asthma Patients

Patients with uncontrolled asthma report ongoing symptoms, poor quality-of-life and extensive healthcare use (HCU) and might benefit from management by a specialised severe asthma team. It is unknown whether a one-time evaluation by asthma experts, without long-term supervision by a specialised team, provides favourable outcomes. We evaluated asthma control (Asthma Control Questionnaire; ACQ), quality-of-life (Asthma-related Quality of Life Questionnaire; AQLQ) and HCU before and 1 year after a 1-day visit programme in a severe asthma centre, including a multidisciplinary assessment resulting in a personalised management plan to be implemented by patients own pulmonologists.40 uncontrolled asthma patients completed questionnaires (ACQ, AQLQ, HCU) at baseline, and 6 and 12 months follow-up.ACQ improved from 2.6 (interquartile range 1.7–3.2) to 1.8 (1.2–3.2) (p=0.003) and AQLQ from 4.8 (4.0–5.2) to 5.3 (4.4–6.0) (p<0.001). We found a reduction in patients with ≥2 exacerbations (95% versus 17%; p<0.001), ≥1 emergency room visit (78% versus 37%; p<0.001) and ≥1 hospitalisation (47% versus 10%; p=0.001).Evaluation of uncontrolled asthma patients in a 1-day visit programme in a severe asthma centre resulted in significant improvements in asthma control, quality-of-life and healthcare use after 1 year. This 1-day visit approach seems beneficial for uncontrolled asthma patients and might reduce their dependence on expensive treatment modalities and long-term management in specialised centres.

scholarly journals Validation of online Asthma Control Questionnaire and Asthma Quality of Life Questionnaire

2020 ◽  
Vol 6 (1) ◽  
pp. 00289-2019
Author(s):  
Rishi J. Khusial ◽  
Persijn J. Honkoop ◽  
Victor van der Meer ◽  
Jiska B. Snoeck-Stroband ◽  
Jacob K. Sont
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Random Order ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Intraclass Correlation Coefficients

ObjectiveSeveral newly developed eHealth applications use online questionnaires to monitor asthma control. The Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ) are two such commonly used questionnaires. These questionnaires are validated for use on paper. This study aims to validate them by assessing the agreement between online and paper versions of the ACQ and AQLQ.MethodsPatients (aged 18 years and older) from the Self-Management in Asthma Supported by Hospitals, ICT, Nurses and General Practitioners (SMASHING)-trial and Davos@home study were included in this study. Patients completed both the paper and online Dutch versions of the ACQ and AQLQ in a random order within a 2-week interval. Agreement between the different versions was assessed with paired t-tests, intraclass correlation coefficients and Bland–Altman plots.ResultsIn total 44 patients were eligible for analysis. The mean difference between the paper and online versions of the ACQ was 0.04 (p=0.40) and for the AQLQ it was 0.08 (p=0.06). The intraclass correlation coefficient scores were 0.94 for the ACQ and 0.95 for the AQLQ.ConclusionThe online versions of the ACQ and AQLQ show high levels of agreement with the paper versions and can therefore be safely used in eHealth applications to respectively monitor asthma control and quality of life.

scholarly journals Quality of life and asthma control in pregnant women with asthma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nasrin Fazel ◽  
Michael Kundi ◽  
Erika Jensen-Jarolim ◽  
Isabella Maria Pali-Schöll ◽  
Asghar Kazemzadeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Respiratory Illness ◽  
Asthma Severity ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Adverse Pregnancy

Abstract Background Asthma is the most commonly occurring respiratory illness during pregnancy. Associations with complications of pregnancy and adverse perinatal outcome have been established. However, little is known about quality of life (QoL) in pregnant women with asthma and how it relates to asthma control particularly for Iran. Objective To determine the relationship between asthma related QoL and asthma control and severity. Methods We conducted a prospective study in pregnant women with asthma. We used the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire (AQLQ) and the guidelines of the Global Initiative for Asthma for assessment of asthma severity. Results Among 1603 pregnant women, 34 were diagnosed with asthma. Of these 13 had intermittent, 10 mild, 8 moderate and 3 severe persistent asthma. There was a significant decrease of QoL with poorer asthma control (p = 0.014). This decline could be due to limitations of activity in those with poorer asthma control, which is underlined by the significant decline of QoL with increasing asthma severity (p = 0.024). Conclusion Although the majority of pregnant women with asthma had a favorable score in AQLQ, reduced QoL was related to increased asthma severity and poor asthma control. This underlines the importance of controlling asthma during pregnancy not only for the prevention of adverse pregnancy outcomes but also for the preservation of QoL.

scholarly journals Características, control de la enfermedad y calidad de vida de los pacientes asignados al ‹‹Programa de Atención al Niño Asmático›› de un centro de atención primaria.

Pediatría ◽  
2020 ◽  
Vol 53 (2) ◽  
pp. 49-55
Author(s):  
Sara María Barbed Ferrández ◽  
María Isabel Moneo Hernández ◽  
Juan José Lasarte Velillas ◽  
Andrés Ruiz Pardo
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Paediatric Asthma ◽  
Quality Of Life Questionnaire ◽  
Calidad De Vida

Objetivos: Evaluar las características clínicas, el grado de control de la enfermedad y calidad de vida de cuidadores de pacientes y pacientes asignados al «Programa de Atención al Niño Asmático» en un centro de atención primaria. Métodos: Estudio descriptivo observacional, con recolección prospectiva de datos procedentes de 3 cuestionarios estandarizados, entregados al paciente o cuidadores: Asthma Control Questionnaire(ACQ)TM, Paediatric Asthma Quality of Life Questionnaire(PAQLQ)TM y Paediatric Asthma Caregivers Quality of Life Questionnaire(PACQLQ)TM y recolección retrospectiva de datos procedentes de la historia clínica.  La muestra proviene del “Programa de Atención al Niño Asmático” de un centro de salud. Resultados: El 40% de los pacientes presentaban antecedente materno o paterno de asma y el 80% antecedente personal de dermatitis atópica, rinitis alérgica o alergia alimentaria. La media de los resultados de las escalas fue de ACQTM: 0.87 +/- 1.06 puntos (rango 0 – 3.6). Media de resultado PAQLQTM: 6.08 +/- 0.77 (rango 5 – 7).  Media de PACQLQTM: 5.48 +/- 1.06 (rango 3 – 7). En pacientes con ACQTM <0.5 puntos, la media de puntuación en PACQLQTM fue de: 6.30 +/- 0.83. En pacientes con ACQTM >1 fue de: 4.66 +/- 0.72. Conclusiones: La presencia de atopia personal y el antecedente familiar de asma es el factor de riesgo más relacionado con el desarrollo de asma en nuestro estudio. El grado de control de asma en la muestra es mejorable, relacionándose un peor control de la enfermedad con peor puntuación en la escala de calidad de vida, siendo necesario implementar medidas de mejora en el ámbito educativo, clínico y asistencial.

scholarly journals Factors associated with quality of life in patients with severe asthma: the impact of pharmacotherapy

2015 ◽  
Vol 41 (6) ◽  
pp. 496-501 ◽  
Author(s):  
Daiane Silva Souza ◽  
Lúcia de Araújo Costa Beisl Noblat ◽  
Pablo de Moura Santos
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Inhaled Corticosteroids ◽  
Activity Limitation ◽  
Dose Inhaler ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Cross Sectional ◽  
The Impact

ABSTRACT OBJECTIVE: To identify, characterize, and quantify associations of various factors with quality of life (QoL) in patients with asthma, according to the pharmacotherapy employed. METHODS: This was a cross-sectional study involving 49 patients (≥ 18 years of age) with severe uncontrolled or refractory asthma treated at a specialized outpatient clinic of the Brazilian Unified Health Care System, regularly using high doses of inhaled corticosteroids (ICs) or other medications, and presenting comorbidities. At a single time point, QoL was assessed with the Asthma Quality of Life Questionnaire (AQLQ). The overall AQLQ score and those of its domains were correlated with demographic variables (gender and age); Asthma Control Questionnaire score; pharmacotherapy (initial IC dose, inhaler devices, and polytherapy); and comorbidities. RESULTS: Better AQLQ scores were associated with asthma control-overall (OR = 0.38; 95% CI: 0.004-0.341; p < 0.001), "symptoms" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001), and "emotional function" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001)-and with IC dose ≤ 800 µg-"activity limitation" domain (OR = 0.249; 95% CI: 0.070-0.885; p = 0.029). Worse AQLQ scores were associated with polytherapy-"activity limitation" domain (OR = 3.651; 95% CI: 1.061-12.561; p = 0.036)-and number of comorbidities ≤ 5-"environmental stimuli" domain (OR = 5.042; 95% CI: 1.316-19.317; p = 0.015). CONCLUSIONS: Our results, the importance of this issue, and the lack of studies taking pharmacotherapy into consideration warrant longitudinal studies to establish a causal relationship between the identified factors and QoL in asthma patients.

The correlation between self-related adherence, asthma-related quality of life and control of asthma in adult patients

2021 ◽  
Vol 32 (4) ◽  
pp. 453-458
Author(s):  
Elida Zairina ◽  
Gesnita Nugraheni ◽  
Gusti Noorrizka Veronika Achmad ◽  
Arie Sulistyarini ◽  
Yunita Nita ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Cross Sectional Study ◽  
Life Questionnaire ◽  
Asthma Therapy ◽  
Asthma Control Questionnaire ◽  
Cross Sectional ◽  
Wide Range ◽  
Related Quality

Abstract Objectives Medication non-adherence mostly occurs in patients with a wide range of disease severity, including asthma. The aim of the study was to assess the self reported adherence to asthma therapy and investigate the relationship between adherence, asthma control and asthma-related quality of life. Methods The study was a cross-sectional study in which participants were recruited from an outpatient department, in one hospital in Surabaya. Patients (aged≥18 years) with asthma who had used any regular asthma medications were included. Standardised questionnaires, including Juniper’s Asthma Control Questionnaire (ACQ), Adherence to Refills and Medications Scales (ARMS) and Juniper’s Asthma Quality of Life Questionnaire (AQLQ) were used. Results A total of 82 adults with asthma were recruited in the study. Male participants’ mean age was 49.13 ± 14.10 years (n = 23). Approximately 59 participants (72.0%) were females, 30 participants (36.5%) were using Budesonide inhaler, and 73 participants (89.0%) never smoked. The mean of ACQ, AQLQ, and ARMS scores were 1.62 ± 1.19, 4.96 ± 1.24, and 16.98 ± 4.12, respectively. Of 82 patients studied 53 (64.6 %) had “uncontrolled asthma” and more than 85% participants both showed “non adherence” to asthma therapy and nearly 46% of them indicated that their quality of life was affected by asthma. There was a significant association between ACQ and AQLQ (p<0.05), whereas no statistically significant association was found between ACQ and ARMS. Conclusions The majority of patients reported non-adherence to asthma medications. Poor controlled asthma has been associated with lower asthma-related quality of life.

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