Assessment of baseline adrenal function by measurement of long term cortisol levels in scalp hair of asthmatic children using inhaled corticosteroids compared to healthy controls

2015 ◽  
Author(s):  
Maria Smit ◽  
Ed Van Leer ◽  
Gerard Noppe ◽  
Yolanda De Rijke ◽  
Jurriaan Hoekx ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Scalp Hair ◽  
Adrenal Function ◽  
Healthy Controls ◽  
Asthmatic Children ◽  
Cortisol Levels

scholarly journals Long-Term Cortisol Concentration in Scalp Hair of Asthmatic Children Using Inhaled Corticosteroids: A Case-Control Study

2017 ◽  
Vol 88 (3-4) ◽  
pp. 231-236 ◽  
Author(s):  
Maaike P. Smit ◽  
Ed H.G. van Leer ◽  
Gerard Noppe ◽  
Yolanda B. de Rijke ◽  
Dieneke Kramer van Driel ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Case Control Study ◽  
Inhaled Corticosteroids ◽  
Scalp Hair ◽  
Case Control ◽  
Cortisol Concentration ◽  
Healthy Controls ◽  
Asthmatic Children ◽  
Control Study

Introduction: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a decrease of cortisol production. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure. Data regarding hair cortisol concentration (HCC) in asthmatic children with ICS therapy are scarce. The aim of this study is to compare HCC in asthmatic children under ICS treatment with a healthy control group. Methods: We set up a case-control study measuring the cortisol concentration in scalp hair in asthmatic children (N = 80) treated with ICS and healthy controls (N = 252) aged 4–18 years. Anthropometric characteristics and hair samples from the posterior vertex were obtained. At least 5 mg of the most proximal 3 cm of hair was used for each hair sample. HCC was analyzed by liquid chromatography-tandem mass spectrometry. Results: HCC did not significantly differ between asthmatic children using ICS and healthy controls (p = 0.950) after adjustment for age, gender, height, body mass index, and socioeconomic status. No correlation was found between budesonide dosage and HCC levels (r = –0.031, p = 0.78). Conclusion: There was no evidence of suppression of basal cortisol production, as measured in scalp hair, in asthmatic children using ICS, compared to healthy controls. No conclusions can be drawn on the HPA-axis stress response in these children.

scholarly journals Adrenal Function and Linear Growth in Asthmatic Children Treated with High Dose Inhaled Corticosteroids (ICS)

1998 ◽  
Vol 44 (3) ◽  
pp. 455-455
Author(s):  
C Dunlop ◽  
J McNaboe ◽  
H J Steen ◽  
D Carson ◽  
B Sheridan ◽  
...  
Keyword(s):  
Linear Growth ◽  
Inhaled Corticosteroids ◽  
Adrenal Function ◽  
High Dose ◽  
Asthmatic Children

scholarly journals High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease

2013 ◽  
Vol 98 (5) ◽  
pp. 2078-2083 ◽  
Author(s):  
L. Manenschijn ◽  
L. Schaap ◽  
N. M. van Schoor ◽  
S. van der Pas ◽  
G. M. E. E. Peeters ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Scalp Hair ◽  
History Of ◽  
Cortisol Levels

Endocrine-Immune Interactions in Adrenal Function of Asthmatic Children on Inhaled Corticosteroids

2009 ◽  
Vol 16 (5) ◽  
pp. 333-339 ◽  
Author(s):  
Kostas N. Priftis ◽  
Anastasios Papadimitriou ◽  
Michael B. Anthracopoulos ◽  
Andrew Fretzayas ◽  
George P. Chrousos
Keyword(s):  
Inhaled Corticosteroids ◽  
Adrenal Function ◽  
Asthmatic Children

Effects of long-term inhaled corticosteroids on adrenal function in patients with asthma

2006 ◽  
Vol 96 (3) ◽  
pp. 437-444 ◽  
Author(s):  
Martha White ◽  
Tera Crisalida ◽  
Henry Li ◽  
Athena Economides ◽  
Michael Kaliner
Keyword(s):  
Inhaled Corticosteroids ◽  
Adrenal Function

The effects of long term use of inhaled corticosteroids on linear growth, adrenal function and bone mineral density in children

2005 ◽  
Vol 33 (4) ◽  
pp. 204-209 ◽  
Author(s):  
D. Ufuk Altintas ◽  
G. Bingol Karakoc ◽  
S. Can ◽  
M. Yilmaz ◽  
S. Guneser Kendirli
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Linear Growth ◽  
Inhaled Corticosteroids ◽  
Adrenal Function ◽  
Mineral Density

scholarly journals Effect of inhaled corticosteroids on bone mineral density in asthmatic children

2021 ◽  
Vol 8 (4) ◽  
pp. 672
Author(s):  
Thanuja Basavanagowda ◽  
Savitha Mysore Ramaraj
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Low Dose ◽  
Inhaled Corticosteroids ◽  
High Dose ◽  
Mineral Density ◽  
Asthmatic Children ◽  
Vitamin D Levels

Background: There is a rise in prevalence of asthma world-over. This study was undertaken as there are controversies regarding the effect of long term inhaled-corticosteroids (ICS) on bone mineral density (BMD).Methods: Asthmatic children belonging to 5-18 year age-group as per the global initiative for asthma guidelines (GINA) guidelines, who were on ICS for a minimum period of 6 months were studied. This study was conducted at a tertiary-care teaching hospital in Mysuru. 60 asthmatic children were compared with 60 non-asthmatic controls. Dual-energy x-ray absorptiometry at 6 sites was used for estimating the BMD and vitamin D levels were measured.Results: 0.771±0.114 g/cm2 was the mean total BMD among children on low dose ICS, while it was 0.613±0.192 and 0.564±0.104 g/cm2 respectively for those on medium and high dose ICS, with p value of 0.026. Children on low dose ICS did not have any impact on BMD, while 18.9% of those on medium and high dose ICS had a reduced total BMD. Trochanteric region was a useful predictor site for monitoring BMD in children on long term ICS with 38.7% and 68.9% being affected when on ICS for 6-12 months and more than 12 months respectively (p=0.018).Conclusions: The ICS of medium and high dose, for a duration of more than 6 months had a reduced total BMD. However, no effect was seen with low dose. Trochanter is a useful site for long term monitoring of BMD in children. There was no correlation between vitamin D levels and control of asthma.

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