LSC Abstract – Changes of peripheral blood eosinophil activity during allergen-induced late-phase airway inflammation in asthma

2016 ◽  
Author(s):  
Ieva Janulaityte ◽  
Simona Lavinskiene ◽  
Deimante Hoppenot ◽  
Kestutis Malakauskas ◽  
Raimundas Sakalauskas
Keyword(s):  
Airway Inflammation ◽  
Peripheral Blood ◽  
Late Phase ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil

LSC Abstract – Changes of peripheral blood eosinophil activity during allergen-induced late-phase airway inflammation in asthma

2016 ◽  
Author(s):  
Ieva Janulaityte ◽  
Simona Lavinskiene ◽  
Deimante Hoppenot ◽  
Kestutis Malakauskas ◽  
Raimundas Sakalauskas
Keyword(s):  
Airway Inflammation ◽  
Peripheral Blood ◽  
Late Phase ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil

scholarly journals Markers that can Reflect Asthmatic Activity before and after Reduction of Inhaled Corticosteroids: A Pilot Study

2013 ◽  
Vol 8 ◽  
pp. BMI.S12537 ◽  
Author(s):  
Go Kato ◽  
Koichiro Takahashi ◽  
Kenji Izuhara ◽  
Kazutoshi Komiya ◽  
Shinya Kimura ◽  
...  
Keyword(s):  
Diurnal Variation ◽  
Airway Inflammation ◽  
Peripheral Blood ◽  
Inhaled Corticosteroids ◽  
Blood Eosinophil ◽  
Life Questionnaire ◽  
Stable Group ◽  
Peripheral Blood Eosinophil ◽  
Before And After ◽  
Serum Periostin

Evaluation of airway inflammation is important in achieving adequate dosing of inhaled corticosteroids (ICS) for treating bronchial asthma. However, there is no evaluation tool that can be used in clinical settings. We examined biomarkers that can precisely reflect airway inflammation when ICS are decreased in stable asthmatic patients. This was a 12-week, single-arm, open-label clinical study performed at a single university hospital. Twenty-five patients (6 male and 19 female) with stable asthma were included in this study. We investigated whether the levels of nitrite and nitrate in exhaled breath condensate (EBC) increase after ICS reduction. We also investigated whether blood eosinophils, serum immunoglobulin E (IgE), high-sensitivity C reactive protein (hs-CRP), interleukin (IL)-13, IL-17, and periostin are different before and after ICS reduction. Peak expiratory flow (PEF), pulmonary function tests, asthma control test (ACT), and asthma quality of life questionnaire (AQLQ) were also examined. We considered an unscheduled hospital visit due to asthmatic symptoms and decline in average PEF over one week by more than 10% to indicate disease instability, and compared patients with stable and unstable disease for analysis. Unstable status was detected in 5 patients. Age, sex, asthma duration, ACT and AQLQ scores, and the level of serum IgE did not differ between stable and unstable groups. In the unstable group, the total concentration of nitrite and nitrate at the last visit was 9.84 (6.65–11.24) μM. Surprisingly, this was similar to the concentration at the first visit (5.58 (2.94–17.29) μM). Serum periostin before ICS reduction (141.9 [107.7–147.7] pg/mL) was higher in the unstable group than in the stable group (91.5 [78.75–103.5] pg/mL). The unstable group had a higher peripheral blood eosinophil count and wider diurnal variation of PEF at the first visit compared to the stable group. Higher eosinophils in peripheral blood and wider diurnal variation of PEF were predictive markers for unstable disease after ICS reduction. Serum periostin is another candidate for the predictive marker.

scholarly journals Association of IL33, IL1RL1, IL1RAP Polymorphisms and Asthma in Chinese Han Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Maolan Wu ◽  
Xiangrong Zheng ◽  
Juan Huang ◽  
Xiaolei Hu
Keyword(s):  
Airway Inflammation ◽  
Peripheral Blood ◽  
Pulmonary Function Tests ◽  
Interleukin 1 ◽  
Blood Eosinophil ◽  
Genome Wide Association Studies ◽  
Chinese Han ◽  
Peripheral Blood Eosinophil ◽  
Asthmatic Children ◽  
Asthma Susceptibility

Background: Genome-wide association studies have identified interleukin 33 (IL33), interleukin 1 receptor-like 1 (IL1RL1), interleukin 1 receptor accessory protein (IL1RAP) as asthma susceptibility loci in Europeans. IL33, IL1RL1, and IL1RAP constitute a ligand-receptor complex.Objective: We analyzed associations of asthma susceptibility, eosinophilic airway inflammation, and response to inhaled corticosteroid (ICS) with single nucleotide polymorphisms (SNPs) of 3 genes encoding IL33, IL1RL1, and its coreceptor IL1RAP in Chinese Han nationality children.Methods: A total of 153 non-asthmatic children and 265 asthmatic children who visited the Xiangya Hospital between September 2015 and August 2019 were recruited for this study. Pulmonary function tests, peripheral blood eosinophil counts (PBEC), and fractional exhaled nitric oxide (FeNO) tests were performed before treatment, and 3 months after treatment. Each participant’s DNA was extracted from the peripheral blood, and a Mass ARRAY system was used to genotype the SNPs.Results: The T allele of rs4742170 in IL33 was associated with a risk of higher FeNO at baseline, and no improvement in FeNO and airway hyperresponsiveness was found after ICS treatment. The A allele of rs10208293 and C allele of rs13424006 in IL1RL1 both were associated with lower susceptibility to asthma and lower FeNO. The TT genotype of rs1420101 and AA genotype of rs4142132 in IL1RL1 were associated with a greater probability of improvement in PBEC after ICS treatment.Conclusion: IL33-IL1RL1-IL1RAP complex polymorphisms are associated with childhood asthma susceptibility, eosinophilic airway inflammation, and ICS response in Chinese Han children in Hunan. We speculate that IL33-IL1RL1-IL1RAP complex polymorphisms affect the development of asthma, airway inflammation, and subsequent ICS response in childhood.

Outcomes of Peripheral Blood Eosinophilia in Hospitalized Exacerbations of COPD

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samar El Sharkawy ◽  
Riham Hazem Raafat ◽  
Reem Osama Mohamed Ahmed Qassem
Keyword(s):  
Peripheral Blood ◽  
Diagnostic Performance ◽  
Leukocyte Count ◽  
Airflow Limitation ◽  
Total Leukocyte Count ◽  
Blood Eosinophil ◽  
Copd Exacerbation ◽  
Peripheral Blood Eosinophil ◽  
Copd Exacerbations ◽  
Cutoff Points

Abstract Background The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines define COPD as a disease state characterized by airflow limitation that is not fully reversible, is usually progressive, and is associated with an abnormal inflammatory response of the lungs to inhaled noxious particles or gases. Objective To identify outcomes of patients with eosinophilic COPD exacerbations requiring hospital admission. Patients and Methods This study is a prospective cohort study that was conducted on two groups of total 60 patients recruited from Ain Shams University hospitals between October 2019 and July 2020. Group 1: Eosinophilic COPD exacerbation if the peripheral blood eosinophil on admission is ≥ 200 cells/µL and/or ≥2% of the total leukocyte count Group 2: Non-eosinophilic COPD exacerbation if the peripheral blood eosinophil on admission is < 200 cells/µL and/or < 2% of the total leukocyte count. Results There was significant high diagnostic performance in predicting readmission at 6-month among eosinophilic group. Eosinophils count, percent (%) and NLR cutoff points had high characteristics (highest in NLR ≥3.1 at discharge) in predicting readmission at 6-month among eosinophilic group. Diagnostic performance of Eosinophils count, percent (%) and NLR were assessed. Eosinophils count, percent (%) and NLR had significant high diagnostic performance in predicting readmission at 6-month among eosinophilic group. Eosinophils count, % and NLR cutoff points had high characteristics (highest in NLR ≥2.1 at discharge) in predicting readmission at 6month among non-eosinophilic group. Conclusion Eosinophils can be used as a prognostic marker in non-infective COPD exacerbations. Validity of eosinophil count and percent as a prognostic parameter in COPD exacerbation can be increased by combining with other parameters for example NLR.

scholarly journals Oral immunotherapy–induced gastrointestinal symptoms and peripheral blood eosinophil responses

2017 ◽  
Vol 139 (4) ◽  
pp. 1388-1390.e4 ◽  
Author(s):  
Michael R. Goldberg ◽  
Arnon Elizur ◽  
Liat Nachshon ◽  
Michael Y. Appel ◽  
Michael B. Levy ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Gastrointestinal Symptoms ◽  
Oral Immunotherapy ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil

The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

2021 ◽  
Vol 15 (11) ◽  
pp. 2926-2927
Author(s):  
Zertaj Kashif ◽  
Tooba Fateen ◽  
H. Tufail Chaudhary ◽  
Sehar S. Ali ◽  
M. Bilal Pasha ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Eosinophil Count ◽  
Nasal Polyps ◽  
Past History ◽  
Cross Sectional Study ◽  
Blood Eosinophil ◽  
Cross Sectional ◽  
Peripheral Blood Eosinophil ◽  
Dental Hospital ◽  
History Of

Aim: To observe the association of peripheral blood eosinophil percentage in patients with allergic nasal polyps. Design: Descriptive cross-sectional study Place and duration: Pathology Department of Bakhtawar Amin Medical & Dental Hospital, Multan from September 2020 to August 2021. Methodology: Blood samples of all the cases operated for nasal polyps in Bakhtawar Amin Trust Institute are drawn before surgery to look for eosinophils. Family and past history of allergy is recorded. Histopathology of all the operated specimen of nasal polyps is done and sample for eosinophil count is collected again in cases that proved to be allergic nasal polyps on microscopic examination to look for any alteration in eosinophil percentage in blood on excision of polyps. Results: Twenty nine out of forty (72.5) percent of patients with allergic nasal polyps reveal increase in peripheral blood eosinophil percentage that returned to normal in 26(65%) patient on excision of nasal polyps. Conclusion: The study disclosed a notable link between allergic nasal polyps and peripheral blood eosinophil percentage and this association is further enhanced by the fact that the blood eosinophil count returned to normal on removal of nasal polyps. Keywords: Allergic nasal polyps, peripheral blood eosinophilia, eosinophil count, atopy

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