The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

2021 ◽  
Vol 15 (11) ◽  
pp. 2926-2927
Author(s):  
Zertaj Kashif ◽  
Tooba Fateen ◽  
H. Tufail Chaudhary ◽  
Sehar S. Ali ◽  
M. Bilal Pasha ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Eosinophil Count ◽  
Nasal Polyps ◽  
Past History ◽  
Cross Sectional Study ◽  
Blood Eosinophil ◽  
Cross Sectional ◽  
Peripheral Blood Eosinophil ◽  
Dental Hospital ◽  
History Of

Aim: To observe the association of peripheral blood eosinophil percentage in patients with allergic nasal polyps. Design: Descriptive cross-sectional study Place and duration: Pathology Department of Bakhtawar Amin Medical & Dental Hospital, Multan from September 2020 to August 2021. Methodology: Blood samples of all the cases operated for nasal polyps in Bakhtawar Amin Trust Institute are drawn before surgery to look for eosinophils. Family and past history of allergy is recorded. Histopathology of all the operated specimen of nasal polyps is done and sample for eosinophil count is collected again in cases that proved to be allergic nasal polyps on microscopic examination to look for any alteration in eosinophil percentage in blood on excision of polyps. Results: Twenty nine out of forty (72.5) percent of patients with allergic nasal polyps reveal increase in peripheral blood eosinophil percentage that returned to normal in 26(65%) patient on excision of nasal polyps. Conclusion: The study disclosed a notable link between allergic nasal polyps and peripheral blood eosinophil percentage and this association is further enhanced by the fact that the blood eosinophil count returned to normal on removal of nasal polyps. Keywords: Allergic nasal polyps, peripheral blood eosinophilia, eosinophil count, atopy

Atopic Dermatitis and its Severity Correlation With Absolute Eosinophil Counts

2018 ◽  
Vol 16 (1) ◽  
pp. 18-23
Author(s):  
Sumit Pandey ◽  
Smita Jha ◽  
Nitesh Raj Pokharel ◽  
A. Kadel
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
College Teaching ◽  
Personal History ◽  
Blood Eosinophil ◽  
Dermatology Department ◽  
Peripheral Blood Eosinophil ◽  
Severity Of Disease ◽  
History Of

Background: Atopic dermatitis is one of the common skin disease affecting children and adults. Atopic dermatitis is a common and difficult to manage allergic condition. Till date severity of atopic dermatitis is graded only by clinical findings, which has greater means of individual variation, so a laboratory value may uniform the grading and eosinophils are always thought to be associated with allergic conditions. Objectives: To assess the severity of atopic dermatitis by peripheral blood eosinophil count and SCORAD index, and also to explore  relationship between personal history of atopy, family history of atopy, severity of disease and absolute eosinophil count. Material and Method: This study is a hospital based Cross sectional descriptive study conducted in the Department of Dermatology, Venereology and Leprology of Nepalgunj Medical College Teaching Hospital, Kohalpur between March 2017 to February 2018. Total  of 53 patients fulfilling the criteria of UK refinement of Hanifin and Rajka's criteria for atopic dermatitis presented to the OPD of  dermatology department at Kohalpur were included in the study. Result: A total of 53 patients were enrolled, mean age of the patients was 6.08 (SD 2.83) years and mean age of onset of disease was2.95 (SD 1.57) years. Mean AEC was 537.17(SD 343.92)/mm3 and higher mean AEC was significantly (P<0.001) associated with greater severity of disease and similarly presence of personal history of respiratory atopy was also significantly (P<0.001) associated with higher mean AEC. Per patient AEC and severity of disease according to SCORAD index showed reasonable positive correlation (r=0.514 and P<0.001).  Conclusion: Severity of disease and presence of respiratory atopy are important factors determining peripheral blood eosinophilia inAD patients. Although larger studies are require to replicate these findings.  

scholarly journals Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study

2020 ◽  
Vol 11 ◽  
pp. 215265672095659
Author(s):  
P. Virkkula ◽  
E. Penttilä ◽  
S. I. Vento ◽  
J. Myller ◽  
A. Koskinen ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Eosinophil Count ◽  
Nasal Polyps ◽  
Characteristic Curve ◽  
Threshold Value ◽  
Blood Eosinophil ◽  
Cross Sectional ◽  
Available N ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

Background Developing tools to identify chronic rhinosinusitis with nasal polyps (CRSwNP) patients requiring surgical treatment would help clinicians treat patients more effectively. The aim of this retrospective cross-sectional study was to identify cut-off values ​​for eosinophil percentage, nasal polyps (NP), and Lund-Mackay (LM) scores that may predict the need for surgical treatment in Finnish CRSwNP patients. Methods Data of CRSwNP patients (N = 378) undergoing consultation for ESS in 2001–19 were used. Data was collected from patient records and Lund-Mackay scores were determined from sinus computed tomography scans. The percentage of eosinophils was microscopically evaluated from the polyp samples available (n = 81). Associations were analyzed by Mann Whitney U test, and cut-off values by the area under the receiver operating characteristic curve (AUROC). Results ESS was performed to 293 (77.5%) of patients. Polyp eosinophilia was associated significantly with ESS (p = 0.001), whereas peripheral blood eosinophil count, LM- score and endoscopic NP- score were not (p > 0.05). AUROC values (95% CI) for detecting those needing ESS were for polyp eosinophilia 0.71 (0.60–0.83), p = 0.001, for LM score 0.59 (0.50–0.67), p = 0.054; for NP score 0.56 (0.48–0.64), p = 0.17, and for blood eosinophil count 0.68 (0.46–0.90), p = 0.08. With the threshold value of polyp eosinophilia (>25%), the sensitivity and specificity were optimal for detecting the group needing ESS from the group not undergoing ESS. The cut-off value of blood eosinophil count (>0.26 × 109/L) had relatively good, yet statistically insignificant (underpowered), predictive potential. Moderate cut-off values were found for endoscopic LM score (≥14/24) and NP score (≥4/8). Conclusions Polyp eosinophilia (>25%) predicted ESS among Finnish hospital-level CRSwNP patients. A future challenge would be to find less invasive and cost-effective clinical factors predicting uncontrolled CRSwNP.

scholarly journals Diagnostic, therapeutic and prognostic aspects of uterine synechiae managed by hysteroscopy in the gyanecological endoscopic surgery and human reproductive teaching hospital

2017 ◽  
Vol 7 (1) ◽  
pp. 56
Author(s):  
Etienne Belinga ◽  
Isidore Tompeen ◽  
Claude Cyrille Noa Ndoua ◽  
Junie Metogo Ntsama ◽  
Sandrine Mendibi ◽  
...  
Keyword(s):  
Past History ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Qualitative Variables ◽  
Preoperative Diagnostic ◽  
Chi Square Test ◽  
Human Reproductive ◽  
History Of

Background: Uterine synechiae refers to a total or partial union of the inner walls of the uterus resulting from endometrial trauma. It is a cause of reproductive failure. Until now, synechia was not optimally treated and has remained understudied in Cameroon. Objective of present study was to Evaluate the diagnostic, therapeutic and prognostic aspects of uterine synechiae treated by hysteroscopy.Methods: We conducted a descriptive cross-sectional study with an analytical component from January 1st 2015 to July 31st 2017 at Yaounde. All patients diagnosed with uterine synechiae and treated with hysteroscopy were our sample. Sampling was consecutive. The chi-square test was used for the comparison of qualitative variables and Fisher's test for ANOVA variance analysis. The comparison of the averages was made by the Student's test. P-value less than 0.05 was considered as statistically significant.Results: Hysteroscopies were indicated for uterine synechiae in 14.50%. Nulliparous were 56.67%. A history of curettage/aspiration was present in 66.66%. All of the patients had a form of infertility and 83.33% had menstrual disorders. Hysterosalpingography showed a better sensitivity (88%). After hysteroscopic treatment, 63.30% had a complete anatomical restitution. There is a significant correlation between the stage of severity of synechia and anatomical restitution (p=0.008; Spearman correlation coefficient=-0.477).Conclusions: Uterine synechiae represent one-sixth of all indications for hysteroscopy and present clinically as menstrual disorder associated with infertility. A past history of uterine curettage is common. Hysterosalpingography has a better preoperative diagnostic sensitivity. Hysteroscopy allows optimal treatment.

scholarly journals Prévalence De La Douleur Neuropathique Chez Des Patients Souffrant De Lomboradiculalgie Commune En Consultation Rhumatologique À Lomé (Togo)

2017 ◽  
Vol 13 (24) ◽  
pp. 267
Author(s):  
Kodjo Kakpovi ◽  
Komi Cyrille Tagbor ◽  
Eyram Fianyo ◽  
Agbeko Komlan Doleagbenou ◽  
Kokou Mensah Guinhouya ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Past History ◽  
Cross Sectional Study ◽  
Radicular Pain ◽  
Low Back ◽  
Cross Sectional ◽  
Study Results ◽  
History Of

Objective: To determine the prevalence and factors associated with neuropathic pain in patients with non-specific low back pain. Methods: This was a cross-sectional study conducted from May to July 2016 in the Rheumatology, Neurology and Neurosurgery departments of Lome. The DN4 questionnaire was used for the diagnosis of neuropathic pain in the 200 patients with low back pain included in this study. Results: Of the 200 patients (147 women and 53 men) included in the study, neuropathic pain was present in 92 (46%). The average age of the 92 patients (67 women vs 25 men, p = 0.04) was 55.5 ± 12.4 years (women 55.2 ± 12.8 vs. men 54.6 ± 11.4, p = 0.5). The characteristics of neuropathic pain mainly found were: burning sensation (n = 67, 72.8%); electrical discharges (n = 64, 69.6%); tingling (n = 90; 97.8%); tickling (n = 57; 62%); numbness (n = 89; 96.7%); hypoesthesia (n = 52; 56.5%). Factors significantly associated with the presence of neuropathic pain in LBP were age (p = 0.005), duration of LBP (p = 0.04), high blood pressure (p = 0.001), radicular pain (p = 0.00002) and the past history of the LBP (0.000000). Conclusion: Neuropathic pain is common in patients with LBP at Lome. The duration of LBP, past history of LBP, previous NSAID use, BMI, pain severity and radicular pain appear to be predictive of the occurrence of these neuropathic pains.

Evaluation of the peripheral blood eosinophil count as a predictor for fractional exhaled nitric oxide or bronchodilator reversibility test outcome

2021 ◽  
Vol 42 (3) ◽  
pp. 228-234
Author(s):  
Bo Zhao ◽  
Haiming Zheng ◽  
Xiaopan Li ◽  
Rui Zheng
Keyword(s):  
Nitric Oxide ◽  
Roc Curve ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Test Results ◽  
Fractional Exhaled Nitric Oxide ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Feno Level

Objective: This study aimed to explore the usefulness of the peripheral blood eosinophil count (PBEC) in assessing the level of fractional exhaled nitric oxide (FeNO) and predicting bronchodilation test results. Methods: We retrospectively analyzed the data of 384 outpatients who underwent FeNO measurement at our Department of Respiratory and Critical Care Medicine from March to June 2019. The FeNO level was compared among different PBECs to explore the association among them. Furthermore, the sensitivity and specificity of PBECs in predicting bronchodilation test results were assessed by using receiver operating characteristic (ROC) curve analysis. Results: There was a moderate correlation between PBECs and FeNO levels (r = 0.414; p < 0.05). In the subjects with PBECs ≥ 0.3 × 109/L, the median FeNO level was 39 ppb (interquartile range, 22.5‐65.5 ppb), significantly higher than in the subjects with PBECs < 0.3 × 109/L. The area under the ROC curve was 0.707 (p < 0.05). The maximum Youden index (0.348) was at PBECs = 0.205 × 109/L, which achieved sensitivity and specificity of 63% and 71.8%, respectively. Conclusion: PBECs ≥ 0.3 × 109/L can predict a positive bronchodilation test result and a high FeNO level, with a probability of 50% in the subjects with chronic cough and shortness of breath; in the absence of corresponding symptoms and a low PBEC, the predictive value was small. For hospitals not able to conduct FeNO measurements, for outpatients with poor economic conditions, and for patients with confirmed or suspected novel coronavirus disease 2019, the PBEC, in conjunction with a patient's clinical symptoms, can improve the diagnostic accuracy of allergic asthma and assessment of airway inflammation while reducing the risk of infection.

Peripheral blood eosinophil count correlates with survival in lung cancer

Lung Cancer ◽  
2010 ◽  
Vol 67 ◽  
pp. S40-S41 ◽  
Author(s):  
A. Shelton ◽  
R.H. Green ◽  
P. Bradding ◽  
C.M. Free
Keyword(s):  
Lung Cancer ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Peripheral Blood Eosinophil ◽  
Blood Eosinophil Count

scholarly journals Evaluation of elderly patients with hearing impairment.

2020 ◽  
Vol 27 (10) ◽  
pp. 2154-2158
Author(s):  
Syed Ali Naqi ◽  
Syed Maisam Ali ◽  
Arslan Akhtar ◽  
Tabassum Aziz ◽  
Tahira Sajid ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
Past History ◽  
Clinical History ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Variable Degree ◽  
Cross Sectional ◽  
Detailed Clinical History ◽  
History Of ◽  
Study Setting

Hearing is decreased in later age is due to aging and is normally seen in most of the elderly people all over the world. Objectives: To ascertain the degree of hearing in elders in relation to age, pattern and extent of hearing weakness in old age so that interventional strategies can be planned to improve their wellbeing. Study Design: Cross Sectional Study. Setting: ENT Outdoor Clinic of Akbar Niazi Teaching Hospital of Islamabad Medical and Dental College, Bhara Kahu, Islamabad. Period: December 2017 to October 2018. Material & Methods: 200 patients were part of the study with age > 50 years and no past history of drug therapy. Data was gathered by detailed clinical history, clinical examination and audiometric findings. Result: 57% patients were found with normal hearing and 43% had variable degree of hearing deterioration. Highest number of hearing weakness was found in 9th decade. Most of hearing deterioration was found in both the ears and that of sensorineural in type. Conclusion: Sensorineural type of hearing impairment is very frequently occurring problem seen in the latter part of life in our community. The frequency and severity of decreased hearing is directly proportional to age.

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