Clinical characteristics and related risk factors of depression in patients with early COPD

Abstract Background: To explore the clinical characteristics of acute myocardial infarction (AMI) with ventricular septal perforation (VSR) and the prognosis comparison of different treatment methods, as well as the analysis of related risk factors.Methods: From January 2006 to February 2020, 29 patients with AMI and VSR diagnosed in the people's Hospital of Peking University were selected as the study object, among them, 16 cases were male (55.2%), 13 cases were female (44.8%), the average age was 64.69 ± 10.32 years old, and they were divided into survival group (n=16) and non-survival group (n=13) according to whether they survive within 30 days of surgical or drug conservative treatment.The clinical characteristics, coronary angiography and treatment of the two groups were summarized, and the prognosis and related risk factors were analyzed.Results: There was no significant difference in the basic clinical characteristics between the two groups(P>0.05)；Compared with the results of coronary angiography in the two groups, the proportion of the culprit vessel which was a simple anterior descending branch in the non-survival group was higher than that in the survival group, there was a statistical difference between the two groups(P<0.05)；The peri-operative data of the two groups showed that the proportion of patients with complete revascularization, simultaneous bypass and recanalization of culprit vessels in the survival group was significantly higher than that in the non- survival group (P < 0.05)；However, the incidence of postoperative low cardiac output and mortality during hospitalization in the survival group were significantly lower than those in the non-survival group (P < 0.05)；Logistic regression analysis showed that complete revascularization (OR = 0.021, 95% CI 0.001-0.374, P = 0.009), recanalization of culprit vessels (OR = 0.045, 95% CI 0.004-0.548, P = 0.015) were independent risk factors for 30 day mortality。Kaplan-Meier survival curve showed that during the follow-up period, the long-term survival rate of patients with operation and complete revascularization was significantly higher than that of patients with drug conservative treatment and incomplete revascularization, there was a statistical difference between the two groups (P < 0.05).Conclusions: Whether complete revascularization and recanalization of culprit vessels or not are independent risk factors for 30 day mortality in patients with AMI and VSR；the long-term survival rate of patients after surgery and complete revascularization is significantly higher than that of patients with conservative medical treatment and incomplete revascularization. Surgery and complete revascularization are important factors affecting the long-term prognosis of patients with AMI and VSR.

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Study on clinical characteristics and related factors of schizophrenic patients with intestinal obstruction

BMC Gastroenterology ◽

10.1186/s12876-021-02091-y ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Mingchao Li ◽

Ping Guo ◽

Jihua Zeng ◽

Chi Li ◽

Qiuming Ji ◽

...

Keyword(s):

Risk Factors ◽

Abdominal Surgery ◽

Intestinal Obstruction ◽

Hospital Stay ◽

Clinical Characteristics ◽

Related Factors ◽

Course Of Disease ◽

Related Risk ◽

History Of ◽

Visiting Time

Abstract Background There are still few studies on the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Our aim is to explore the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Methods This study focused on schizophrenia patients with intestinal obstruction who were hospitalized in the psychiatric department of a hospital in Wuhan from January 2007 to December 2020 as the main research object. We intend to retrospectively analyze the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Results In the 1937 persons with schizophrenia included in this study, 97 patients were complicated with intestinal obstruction, and the incidence was 5.01%.The results of the study showed that patients with age ≥ 60 years old, visiting time ≥ 24 h, hospital stay ≥ 90 days, history of abdominal surgery, course of disease ≥ 5 years, male, and patients with cardiovascular and cerebrovascular diseases are prone to intestinal obstruction; Logistic multiple regression analysis showed that the related risk factors of schizophrenia patients with intestinal obstruction mainly included the patient's age, visiting time, length of hospital stay, history of abdominal surgery, course of disease and gender. Conclusion The older the age, the longer the hospital stay, the longer the course of the disease, the history of previous surgery, and the male schizophrenia who do not see a doctor within 24 h of the onset, the risk of intestinal obstruction is higher, and it is easy to be misdiagnosed and even life-threatening.

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Clinical characteristics of rheumatoid arthritis patients with peripheral neuropathy and potential related risk factors

Clinical Rheumatology ◽

10.1007/s10067-019-04521-5 ◽

2019 ◽

Vol 38 (8) ◽

pp. 2099-2107 ◽

Cited By ~ 2

Author(s):

Yanshan Li ◽

Li Jiang ◽

Zhenchun Zhang ◽

Hong Li ◽

Liangjun Jiang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Peripheral Neuropathy ◽

Clinical Characteristics ◽

Related Risk

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Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China

Acta Pharmacologica Sinica ◽

10.1038/s41401-021-00627-2 ◽

2021 ◽

Author(s):

Xue-qing Liu ◽

Shan Xue ◽

Jia-bo Xu ◽

Heng Ge ◽

Qing Mao ◽

...

Keyword(s):

Risk Factors ◽

Disease Severity ◽

Clinical Characteristics ◽

Related Risk

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Obesity and Non-Obesity Obstructive Sleep Apnoea Hypertension Syndromes (OOHS & NOOHS): New Clinical Discoveries

10.21203/rs.3.rs-706703/v1 ◽

2021 ◽

Author(s):

Chunsong Hu ◽

Qinghua Wu ◽

Juxiang Li ◽

Yanqing Wu ◽

Menghong Wang ◽

...

Keyword(s):

Risk Factors ◽

Obstructive Sleep Apnoea ◽

Clinical Characteristics ◽

Sleep Apnoea ◽

Major Adverse Cardiovascular Events ◽

Related Risk ◽

Obstructive Sleep ◽

Long Term Follow Up

Abstract Obesity, obstructive sleep apnoea (OSA) and hypertension are common clinical risk factors. Their coexistence is termed Obesity and Non-Obesity OSA Hypertension Syndromes (OOHS & NOOHS) due to high linkage. This study reported the clinical characteristics of OOHS and NOOHS. A total of 163 patients, aged 23–74 years, were randomly enrolled at the outpatients department who were either obese or non-obese, suffered OSA and hypertension. Subjects with a Body Mass Index (BMI) of ≥25 (Chinese criteria), of ≥27 (criteria of this study), and of ≥30 (WHO criteria) were defined as obese or non-obese, respectively. Cases with snoring were classified as mild, moderate and severe OSA by using the Apnoea-Hypopnoea Index where mild is 5–15, moderate is 15–30, and severe is > 30. Daytime blood pressure (BP) was measured to assess any correlation. Data from those with isolated obesity, OSA, hypertension, and metabolic syndrome were compared. Long-term follow-up was carried out. 7 typical cases with OOHS and NOOHS were assessed and included general patient information, initial diagnosis, medical history, related risk factors, BMI, and BP. 163 cases with OOHS and NOOHS often have similar or different clinical characteristics. Both potentially suffer from major adverse cardiovascular events (MACEs) which are associated with increased BMI, OSA, and increased BP. Long-term follow-up showed the outcomes consistently linked to their lifestyle and adherence to treatment. Our new clinical discoveries suggest that both OOHS and NOOHS are high risk conditions in MACEs. There is an urgent need for early lifestyle interventions and related treatments.

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Abnormal immunity of non-survivors with COVID-19: predictors for mortality

10.21203/rs.3.rs-30424/v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Zhao yang ◽

Nie hanxiang ◽

Hu ke ◽

Wu xiaojun ◽

Zhang yunting ◽

...

Keyword(s):

Risk Factors ◽

T Cells ◽

Clinical Characteristics ◽

Signs And Symptoms ◽

Malignant Tumour ◽

Hospital Death ◽

Medical Illness ◽

Specific Information ◽

Laboratory Findings ◽

Related Risk

Abstract Background The outbreak of coronavirus disease 2019 (COVID-19) has rapidly spread all over the world. The specific information about immunity of non-survivors with COVID-19 is scarce. We aimed to describe the clinical characteristics and abnormal immunity of the confirmed COVID-19 non-survivors.Methods In this single-centered, retrospective, observational study, we enrolled 125 patients with COVID-19 who were died between Jan, 13 and Mar 4, 2020 from Renmin Hospital of Wuhan University. 414 randomly recruited patients with confirmed COVID-19 who were discharged from the same hospital during the same period served as control. Demographic and clinical characteristics, laboratory findings and chest computed tomograph results at admission, and treatment were collected. The immunity-related risk factors associated with in-hospital death were detected.Results Non-survivors were older than survivors. More than half of non-survivors was male. Nearly half of the patients had chronic medical illness. The common signs and symptoms at admission of non-survivors were fever. Non-survivors had higher white blood cell (WBC) count, more elevated neutrophil count, lower lymphocytes and platelete count, raised concentration of procalcitonin and C-reactive protein (CRP) than survivors. The levels of CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ T cells, and CD16+56+T cells were significantly decreased in non-survivors when compared with survivors. The concentrations of immunoglobulins (Ig) G, IgA and IgE were increased, whereas the levels of complement proteins (C)3 and C4 were decreased in non-survivors when compared with survivors. Non-survivors presented lower levels of oximetry saturation at rest and lactate. Old age, comorbidity of malignant tumour, neutrophilia, lymphocytopenia, low CD4+ T cells, decreased C3, and low oximetry saturation were the risk factors of death in patients with confirmed COVID-19. The frequency of CD4+ T cells positively correlated with the numbers of lymphocytes and the level of oximetry saturation, whereas CD4+ T cells were negatively correlated with age and the numbers of neutrophils.Conclusion Abnormal cellular immunity and humoral immunity were considerable in non-survivors with COVID-19. Neutrophilia, lymphocytopenia, low CD4+ T cells, and decreased C3 were the immunity-related risk factors predicting mortality of patients with COVID-19.

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Clinical characteristics and related risk factors of depression in patients with early COPD

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s157165 ◽

2018 ◽

Vol Volume 13 ◽

pp. 1583-1590 ◽

Cited By ~ 7

Author(s):

Ji-Hoon Lee ◽

MinA Park ◽

Myung Jae Park ◽

Yong Suk Jo

Keyword(s):

Risk Factors ◽

Clinical Characteristics ◽

Related Risk

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The Clinical Characteristics of Acute Myocardial Infarction with Ventricular Septal Perforation and the Prognosis Comparison of Different Treatment Methods

The Heart Surgery Forum ◽

10.1532/hsf.3921 ◽

2021 ◽

Vol 24 (4) ◽

pp. E757-E763

Author(s):

Chun Fu ◽

Qing Gao ◽

Zhou Zhao ◽

Yu ◽

Jian Liu ◽

...

Keyword(s):

Risk Factors ◽

Clinical Characteristics ◽

Complete Revascularization ◽

Septal Perforation ◽

Survival Group ◽

Term Survival ◽

Related Risk ◽

Incomplete Revascularization ◽

Independent Risk Factors

Objective: To explore the clinical characteristics of acute myocardial infarction (AMI) with ventricular septal perforation (VSR), the prognosis comparison of different treatment methods, and analysis of related risk factors. Methods: From January 2006 to February 2020, 29 patients with AMI and VSR diagnosed in the People's Hospital of Peking University were selected as the study group. Among them, 16 cases were male (55.2%), 13 cases were female (44.8%), and the average age was 64.69 ± 10.32 years old. They were divided into two groups: the survival group (N = 16) and non-survival group (N = 13), according to whether they survived within 30 days of surgical or drug conservative treatment. The clinical characteristics, coronary angiography, and treatment of the two groups were summarized, and the prognosis and related risk factors were analyzed. Results: There was no significant difference in the basic clinical characteristics between the two groups (P > 0.05). Compared with the results of coronary angiography in the two groups, the proportion of the culprit vessel, which was a simple anterior descending branch in the non-survival group, was higher than that in the survival group. There was a statistical difference between the two groups (P < 0.05). The perioperative data of the two groups showed that the proportion of patients with complete revascularization, simultaneous bypass, and recanalization of culprit vessels in the survival group was significantly higher than that in the non-survival group (P < 0.05). However, the incidence of postoperative low cardiac output and mortality during hospitalization in the survival group were significantly lower than those in the non-survival group (P < 0.05). Logistic regression analysis showed that complete revascularization (OR = 0.021, 95% CI 0.001-0.374, P = 0.009) and recanalization of culprit vessels (OR = 0.045, 95% CI 0.004-0.548, P = 0.015) were independent risk factors for 30-day mortality. Kaplan-Meier survival curve showed that during the follow-up period, the long-term survival rate of patients with operation and complete revascularization was significantly higher than that of patients with drug conservative treatment and incomplete revascularization. There was a statistical difference between the two groups (P < 0.05). Conclusion: Complete revascularization and recanalization of culprit vessels are independent risk factors for 30-day mortality in patients with AMI and VSR. The long-term survival rate of patients after surgery and complete revascularization is significantly higher than that of patients with conservative medical treatment and incomplete revascularization. Surgery and complete revascularization are important factors affecting the long-term prognosis of patients with AMI and VSR.

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