Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit

2018 ◽  
Vol 48 ◽  
pp. 172-177 ◽  
Author(s):  
José Garnacho-Montero ◽  
Cristina León-Moya ◽  
Antonio Gutiérrez-Pizarraya ◽  
Angel Arenzana-Seisdedos ◽  
Loreto Vidaur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Related Risk ◽  
Influenza A H1n1 ◽  
Immunosuppressed Patients

scholarly journals Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission

2013 ◽  
Vol 142 (9) ◽  
pp. 1826-1835 ◽  
Author(s):  
J. REBOLLEDO ◽  
D. IGOE ◽  
J. O'DONNELL ◽  
L. DOMEGAN ◽  
M. BOLAND ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Paediatric Intensive Care Unit ◽  
Influenza A ◽  
Significant Risk ◽  
Influenza Viruses ◽  
Paediatric Intensive Care ◽  
Severe Illness ◽  
Influenza A H1n1

SUMMARYInfluenza causes significant morbidity and mortality in children. This study's objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010/2011 season. In 2010/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.

scholarly journals 1348 Influenza a H1N1 Virus Infection in a Pediactric Intensive Care Unit

2010 ◽  
Vol 68 ◽  
pp. 667-667
Author(s):  
P Neto ◽  
P V Silva ◽  
S Santos ◽  
C Pinto ◽  
A Dinis ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Virus Infection ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
H1n1 Virus Infection

scholarly journals Age as an Independent Risk Factor for Intensive Care Unit Admission or Death Due to 2009 Pandemic Influenza A(H1N1) Virus Infection

2011 ◽  
Vol 126 (3) ◽  
pp. 349-353 ◽  
Author(s):  
Katelin B. Nickel ◽  
Nicola Marsden-Haug ◽  
Kathryn H. Lofy ◽  
Wayne L. Turnberg ◽  
Krista Rietberg ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Virus Infection ◽  
Intensive Care Unit Admission ◽  
Influenza A ◽  
Independent Risk Factor ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
H1n1 Virus Infection

Clinical Presentation of Patients With 2009 Influenza A (H1N1) Virus Admitted to the Medical Intensive Care Unit vs Ambulatory-Treated Patients

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 603A
Author(s):  
Gabriel D. Patarroyo ◽  
Maria M. Patarroyo ◽  
Adriana C. Prada ◽  
Cesar A. Simbaqueba ◽  
Oscar O. Sanabria
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Clinical Presentation ◽  
H1n1 Virus ◽  
Medical Intensive Care Unit ◽  
Influenza A H1n1 ◽  
Medical Intensive Care

scholarly journals Severe Influenza in 33 US Hospitals, 2013–2014: Complications and Risk Factors for Death in 507 Patients

2015 ◽  
Vol 36 (11) ◽  
pp. 1251-1260 ◽  
Author(s):  
Nirav S. Shah ◽  
Jared A. Greenberg ◽  
Moira C. McNulty ◽  
Kevin S. Gregg ◽  
James Riddell ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Influenza Season ◽  
Influenza Infection ◽  
Patient Characteristics ◽  
The United States ◽  
Severe Influenza ◽  
Influenza A H1n1

BACKGROUNDInfluenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season.METHODSA retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes.RESULTSA total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001).CONCLUSIONRisk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.Infect. Control Hosp. Epidemiol. 2015;36(11):1251–1260

scholarly journals Epidemic of influenzae A H1N1 in 2019 in the Zlatibor district

2020 ◽  
Vol 25 (79) ◽  
pp. 7-25
Author(s):  
Slađana Pavić ◽  
Jelena Raković-Radivojević ◽  
Radmila Sparić ◽  
Ivan Janković ◽  
Aleksandra Andrić ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Cardiovascular Diseases ◽  
Influenza A ◽  
Clinical Course ◽  
C Reactive Protein ◽  
Lethal Outcome ◽  
Reactive Protein ◽  
Influenza A H1n1

Introduction: Influenza A H1N1 occurs worldwide sporadically or epidemically. There have been several epidemics of this disease in recent decades. Millions of people fell ill and hundreds of thousands died. The clinical picture varies from asymptomatic to lethal outcome. Older age, male gender and obesity are the most common risk factors for adverse disease. The aim of the research was to examine the clinical course and outcome of the disease of patients with pneumonia during the epidemic of influenza A H1N1 in 2019 in the Zlatibor district. Methods: Epidemiological, clinical, microbiological and radiographic data of patients with influenza A H1N1 treated at the Department of Infectious and Tropical Diseases and the Intensive Care Unit of the General Hospital of Uzice were retrogradely collected and analyzed. Virological and serological analyzes were performed at the Institute of Immunology and Virology "Torlak" in Belgrade. The diagnosis of acute respiratory distress syndrome (ARDS) was made according to the Berlin definition. Statistical analysis was performed using the Statistical Package for Social Sciences SPSS (version 16.0). Results: Out of a total of 274 patients, women accounted for 52.9%. The most common age was 61 to 70 years. 55.4% of patients had comorbidities, 61.8% of that had cardiovascular disease. C reactive protein was elevated in 79.2% of patients. Pneumonia confirmed by radiographic findings was present in 82.8% of patients, 51.5% of that had bilateral pneumonia. Four patients were pregnant, GML 5-9. Two of them had a mild clinical course of infection, one moderate with unilateral pneumonia. All three had a favorable disease outcome. A fourth pregnant woman was admitted in a severe clinical condition and was immediately referred to a tertiary health institution where the disease ended in death. 10.2% of patients were treated in the intensive care unit. Complications occurred in 23.7% of patients, ARDS in 52.3% of that. 55.9% of patients with ARDS were aged 61 to 70 years, and 58.8% were male. Among patients with ARDS, 94.1% had associated diseases, most often CVD (85.3%). C reactive protein was elevated in 85.3% of patients with ARDS. In 8.4% of patients, the disease had an unfavorable course and ended in death. Among these patients, 65.2% were women, and 73.9% were over 65 years of age. Associated diseases were present in 95.6% of these patients, cardiovascular diseases was present in 87% of that. Conclusion: During the influenza epidemic in 2019 in the Zlatibor district, pneumonia, most often bilateral, was most often in patients aged 61-70 with associated cardiovascular diseases. These were also the main risk factors for complications and adverse disease outcome. ARDS was the most common comlication and risk factor for the lethal outcome of the diseases.

scholarly journals New influenza A(H1N1) virus infections in France, April – May 2009

2009 ◽  
Vol 14 (21) ◽  
Author(s):  
Collective New influenza A(H1N1) investigation teams*
Keyword(s):  
North America ◽  
Active Surveillance ◽  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Virus Infections ◽  
Influenza A H1n1 ◽  
Set Up

Since the emergence of a new influenza A(H1N1) virus in North America and its international spread, an active surveillance of cases of infection due to this virus has been set up in France in order to undertake appropriate measures to slow down the spread of the new virus. This report describes the epidemiological and clinical characteristics of the 16 laboratory confirmed cases diagnosed in France as of 20 May 2009.

scholarly journals Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania

Medicina ◽  
2011 ◽  
Vol 47 (1) ◽  
pp. 11-18 ◽  
Author(s):  
◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Symptom Onset ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Clinical Course ◽  
Antiviral Treatment ◽  
Course Of Illness ◽  
Influenza A H1n1 ◽  
Complicated Course

The objective of this study was to identify case characteristics and clinical course of the disease in patients hospitalized with 2009 pandemic influenza A (H1N1) infection during the first wave of the pandemic and to identify risk factors associated with the complicated course of illness. Material and methods. A retrospective study of adult cases of the laboratory-confirmed 2009 pandemic influenza A (H1N1) virus admitted to three hospitals in Kaunas between November 1, 2009, and March 15, 2010, was carried out. The main outcome measures were clinical characteristics, risk factors for complicated disease, treatment, and clinical course of the disease. Results. The study enrolled 121 of the 125 patients hospitalized due to 2009 pandemic influenza A (H1N1) virus infection. The median age was 31 years (range, 18–83); 5% of the patients were aged more than 65 years. Pregnant and postpartum women comprised 26% of all hospitalized cases. Nearly half (49.5%) of those who underwent chest radiography had findings consistent with pneumonia, which was bilateral in one-third of cases. The risk to have pandemic influenza complicated by pneumonia increased significantly with one-day delay from symptom onset to antiviral treatment (OR, 2.241; 95% CI, 1.354–3.710). More than half (57%) of the patients received antiviral treatment. In 45% of the treated patients, antiviral drugs were administered within 48 hours from symptom onset. Intensive care was required in 7.4% of the cases. The overall mortality was 5% (6/121). The median age of the patients who died was 43.5 years (range, 23–62); 4 patients had been previously healthy, 1 patient suffered from chronic lympholeukemia, and 1 patient was a pregnant woman. Conclusion. The 2009 pandemic influenza A (H1N1) caused considerable morbidity in a significant proportion of hospitalized adults. The main risk factor associated with the complicated course of illness was delayed antiviral treatment.

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