Relationship between HLA-DQA1, -DQB1 gene polymorphism and susceptibility to pollen allergy in Russians

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

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HLA-DQA1 and -DQB1 gene haplotypes in familial cardiomyopathy

The American Journal of Cardiology ◽

10.1016/0002-9149(94)90918-0 ◽

1994 ◽

Vol 74 (5) ◽

pp. 510-512 ◽

Cited By ~ 9

Author(s):

Catherine Limas ◽

Constantinos J. Limas ◽

Harisios Boudoulas ◽

Robert Bair ◽

Libby Sparks ◽

...

Keyword(s):

Familial Cardiomyopathy ◽

Dqb1 Gene ◽

Hla Dqa1

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HLA-DQA1 and DQB1 Gene Polymorphisms in Type I Diabetic Patients from Central Italy and Their Use for Risk Prediction

Diabetes ◽

10.2337/diab.42.8.1173 ◽

1993 ◽

Vol 42 (8) ◽

pp. 1173-1178 ◽

Cited By ~ 10

Author(s):

R. Buzzetti ◽

L. Nistico ◽

J. F. Osborn ◽

C. Giovannini ◽

A. Chersi ◽

...

Keyword(s):

Risk Prediction ◽

Gene Polymorphisms ◽

Central Italy ◽

Diabetic Patients ◽

Type I ◽

Dqb1 Gene ◽

Hla Dqa1

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CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

Gut ◽

10.1136/gut.43.2.187 ◽

1998 ◽

Vol 43 (2) ◽

pp. 187-189 ◽

Cited By ~ 143

Author(s):

I Djilali-Saiah ◽

J Schmitz ◽

E Harfouch-Hammoud ◽

J-F Mougenot ◽

J-F Bach ◽

...

Keyword(s):

Gene Polymorphism ◽

Coeliac Disease ◽

T Cell Activation ◽

Cell Activation ◽

Cytotoxic T Lymphocyte ◽

Class Ii ◽

Hla Class Ii ◽

Restriction Enzyme Digestion ◽

Cell Surface Molecule ◽

Hla Dqa1

Background—Susceptibility to coeliac disease is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. Among candidate genes is the CTLA-4 (cytotoxic T lymphocyte associated) gene located on chromosome 2q33 in humans, which encodes a cell surface molecule providing a negative signal for T cell activation.Aims—To investigate CTLA-4 exon 1 polymorphism (position 49 A/G) in patients with coeliac disease.Patients—101 patients with coeliac disease and 130 healthy controls.Methods—Allele specific hybridisation and restriction enzyme digestion of polymerase chain reaction amplified genomic DNA.Results—The A allele of the CTLA-4 position 49 polymorphism was found on 82.2% of chromosomes in patients with coeliac disease compared with 65.8% in controls (p<0.0001), mostly in the homozygous form (68.3% in patients versus 47.7% in controls; odds ratio (OR) 2.36, 95% confidence interval (CI) 1.37 to 4.06, p=0.002). Four patients only had the G/G genotype compared with 21 controls (OR 0.21, CI 10.07 to 0.64, p=0.002). These differences were maintained when subjects were stratified according to the HLA class II phenotype, in particular when patients and controls were matched for the presence of the predisposing HLA DQB1*02 (DQ2) allele or HLA-DQA1*0501/DQB1*02 heterodimer.Conclusion—The CTLA-4 gene polymorphism is a non-HLA determinant that predisposes to coeliac disease. Whether it directly contributes to disease susceptibility or represents a marker for a locus in linkage disequilibrium with CTLA-4 needs further investigation.

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An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-2019-2-315-324 ◽

2019 ◽

Vol 9 (2) ◽

pp. 315-324 ◽

Cited By ~ 1

Author(s):

O. M. Kudryavtseva ◽

S. A. Bugorkova ◽

T. N. Shchukovskaya ◽

N. I. Mikshis ◽

A. Yu. Goncharova ◽

...

Keyword(s):

Immune Response ◽

Gene Polymorphism ◽

High Efficiency ◽

Human Leukocyte ◽

Class Ii ◽

Hla Class Ii ◽

Live Attenuated Vaccine ◽

Leukocyte Antigen ◽

Immune Factor ◽

Hla Dqa1

In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underlying variability of developing immune response. Of note, HLA (Human Leukocyte Antigen) gene polymorphism plays an important role in this process. In our study, we identified HLA class II haplotypes for HLA-DRB1, HLA-DQA1, and HLA-DQB1 in 120 residents of theterritoryofPre-Caspiannatural plague focus, who were immunized against plague. In addition, level of TNFα production correlated with detecting allelic groups HLA-DRB1*04 (р = 0.05) and DRB1*12 (р = 0.01). The data obtained show that HLA class II gene polymorphism can affect the level of cytokine secretion in response to plague immunization. Examining the genes regulating immune factor production will allow to get better insight into the mechanisms underlying immune response variations after vaccination as well as contribute to predicting immunogenicity and efficiency of developing vaccine preparations.

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