Cytokine plasma levels in moderate-to-severe asthmatic children with different asthma control

2020 ◽  
Author(s):  
Svetlana Smirnova ◽  
Nina Gorbacheva ◽  
Vasiliy Belenyuk ◽  
Svetlana Zobova ◽  
Marina Smolnikova
Keyword(s):  
Asthma Control ◽  
Plasma Levels ◽  
Asthmatic Children ◽  
Severe Asthmatic ◽  
Cytokine Plasma

scholarly journals Heart rate recovery in asthmastic children and adolescents after clinical field test

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Élida Pereira Silva ◽  
Bruno Alvarenga Soares ◽  
Mariana M. Reimberg ◽  
Raphael Ritti-Dias ◽  
Karina Silva Nascimento ◽  
...  
Keyword(s):  
Heart Rate ◽  
Children And Adolescents ◽  
Asthma Control ◽  
Functional Capacity ◽  
Heart Rate Recovery ◽  
Statistical Significance ◽  
Categorical Variables ◽  
Control Group ◽  
Asthma Control Test ◽  
Asthmatic Children

Abstract Background Inflammation caused by chronic lung disease in childhood may lead to delayed heart rate recovery (HRR) however, there is lack of evidence on HRR in this population. The aim was to assess HRR after functional capacity testing in asthmatic children and adolescents and to compare with severity and disease control. Method This was a study secondary to a randomized control trial. The modified shuttle test (MST) was performed to assess functional capacity and HRR. This is an externally cadenced test in which the distance walked is the outcome. HRR was assessed after MST and was defined as HR at exercise peak minus HR in the second minute after the end of exercise. Asthma control was assessed by the Asthma Control Test (ACT). Data normality was tested by Shapiro Wilk and the comparison between groups was made by Student’s t test or Mann Whitney test for numerical variables, and by Chi-square test for categorical variables. Statistical significance was considered when p < 0.05. SPSS version 20 was used in the analyzes. Results The sample included 77 patients diagnosed with asthma (asthma group - AG) who were regularly treated for asthma. Control group (CG) consisted of 44 volunteers considered healthy, matched in age and gender to AG. The median age of CG was 12 (10–14) years and in AG 11 (9–13 years) being classified as mild to moderate asthmatic, and 57% of the sample had controlled asthma by ACT. Distance walked in the CG was 952 ± 286 m and AG 799 ± 313 m, p = 0.001. HRR was more efficient in CG (79 ± 15 bpm) compared to AG (69 ± 12 bpm), p = 0.001. The mild (69 ± 12 beats) and severe (72 ± 15 beats) AG presented worse HRR compared to control group (79 ± 15 bpm), p < 0.05. Conclusions Asthmatic children and adolescents have delayed HRR after modified Shuttle test compared to their peers, suggesting that asthma leads to autonomic nervous system imbalance. Trial registration: Registered in Clinical Trials under number NCT02383069 and approved by the Universidade Nove de Julho - UNINOVE Research Ethics Committee, protocol number 738192/2014.

Two Corrections

PEDIATRICS ◽  
1964 ◽  
Vol 33 (5) ◽  
pp. 757-757
Keyword(s):  
Plasma Levels ◽  
Adrenal Function ◽  
Asthmatic Children

2.—In the article "Adrenal Function in Allergy IV. Effect of Dexamethasone Aerosols in Asthmatic Children" by Sheldon C. Siegel, Ernest M. Heimlich, Warren Richards, and Vincent C. Kelley, Pediatrics, 33:45 (February 1964), plasma levels for corticosteroids have been given, in Table I and the text, as mg/100 ml. The designation should have been γgm (micrograms) or γ (gamma)/100 ml.

scholarly journals Discovery and Validation of a Three-Cytokine Plasma Signature as a Biomarker for Diagnosis of Pediatric Tuberculosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Nathella Pavan Kumar ◽  
Syed Hissar ◽  
Kannan Thiruvengadam ◽  
Velayuthum V. Banurekha ◽  
N. Suresh ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Validation Cohort ◽  
Diagnostic Study ◽  
Operating Characteristics ◽  
Discovery Cohort ◽  
Roc Curve Analysis ◽  
Immune Biomarkers ◽  
Cytokine Plasma ◽  
Pediatric Tb ◽  
Pediatric Tuberculosis

Pediatric TB poses challenge in diagnosis due to the paucibacillary nature of the disease. We conducted a prospective diagnostic study to identify immune biomarkers of pediatric TB and controls (discovery cohort) and obtained a separate “validation” cohort of confirmed cases of pediatric TB and controls. Multiplex ELISA was performed to examine the plasma levels of cytokines. Discovery and validation cohorts revealed that baseline plasma levels of IFNγ, TNFα, IL-2, and IL-17A were significantly higher in active TB (confirmed TB and unconfirmed TB) in comparison to unlikely TB children. Receiver operating characteristics (ROC) curve analysis revealed that IFNγ, IL-2, TNFα, and IL-17A (in the discovery cohort) and TNFα and IL-17A (in the validation cohort) could act as biomarkers distinguishing confirmed or unconfirmed TB from unlikely TB with the sensitivity and specificity of more than 90%. In the discovery cohort, cytokines levels were significantly diminished following anti-tuberculosis treatment. In both the cohorts, combiROC models offered 100% sensitivity and 98% to 100% specificity for a three-cytokine signature of TNFα, IL-2, and IL-17A, which can distinguish confirmed or unconfirmed TB children from unlikely TB. Thus, a baseline cytokine signature of TNFα, IL-2, and IL-17A could serve as an accurate biomarker for the diagnosis of pediatric tuberculosis.

Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients

2001 ◽  
Vol 26 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Andreas Schuld ◽  
Thomas Kraus ◽  
Monika Haack ◽  
Dunja Hinze-Selch ◽  
Astrid W Zobel ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Plasma Levels ◽  
Depressed Patients ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Cytokine Plasma ◽  
White Blood Cell Counts

scholarly journals The upper-airway microbiota and loss of asthma control among asthmatic children

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanjiao Zhou ◽  
Daniel Jackson ◽  
Leonard B. Bacharier ◽  
David Mauger ◽  
Homer Boushey ◽  
...  
Keyword(s):  
Asthma Control ◽  
Asthma Exacerbation ◽  
Upper Airway ◽  
Severe Exacerbation ◽  
Asthmatic Children ◽  
Time Points ◽  
Asthma Exacerbations ◽  
Severe Asthma Exacerbation ◽  
Airway Microbiome ◽  
One Year

AbstractThe airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota’s dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium’s relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).

scholarly journals Anxiety and depression in asthmatic children: impact on asthma control

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
T Deraz ◽  
M Morsy ◽  
W Youssef ◽  
B Ezz
Keyword(s):  
Asthma Control ◽  
Anxiety And Depression ◽  
Asthmatic Children

scholarly journals Yoga Education Program for Reducing Drug Dependency and Promoting Better Asthma Control for Chronic Asthmatic Children: A Multicity Experiment

2019 ◽  
Vol 6 ◽  
pp. 2333794X1983745 ◽  
Author(s):  
Samta Pandya
Keyword(s):  
Asthma Control ◽  
Education Program ◽  
Intervention Group ◽  
Control Group ◽  
Act Scores ◽  
Asthma Control Test ◽  
Drug Dependency ◽  
Asthmatic Children ◽  
Standard Family ◽  
Family Setups

This article reports a 1-year long yoga education program (YEP) experiment aimed at reducing drug dependency and promoting better asthma control for chronic asthmatic children. Participants were 450 chronic asthmatic children across 4 cities. Two measures were used: Pediatric Asthma Diary (PAD) and Childhood Asthma Control Test (C-ACT). Results indicated that intervention group children had better asthma control in terms of lower average PAD scores and higher C-ACT scores and reduced drug intake vis-à-vis the control group. Within the intervention cohort, asthma symptoms persistence was lower and control was higher for children from Asian cities, boys, Hindus, middle-class children, those whose mothers were their primary caregivers, who lived in standard family setups, who also attended the optional YEP rounds, and regularly self-practiced. The strongest predictor of lower posttest PAD scores and higher C-ACT scores was self-practice. The YEP can be used as an effective complementary treatment for chronic asthmatic children.

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