scholarly journals Characterisation of pulmonary function trajectories: results from a Brazilian cohort

2020 ◽  
Vol 6 (3) ◽  
pp. 00065-2020
Author(s):  
Priscila Weber ◽  
Ana Maria Baptista Menezes ◽  
Helen Gonçalves ◽  
Rogelio Perez-Padilla ◽  
Deborah Jarvis ◽  
...  
Keyword(s):  
Birth Weight ◽  
Family History ◽  
Pulmonary Function ◽  
Birth Cohort ◽  
Respiratory Diseases ◽  
Smoking Status ◽  
Forced Expiratory Volume ◽  
Birth Cohort Study ◽  
History Of ◽  
Brazilian Cohort

BackgroundPulmonary function (PF) trajectories are determined by different exposures throughout the life course. The aim of this study was to investigate characteristics related to PF trajectories from 15 to 22 years in a Brazilian cohort.MethodsA birth cohort study (1993 Pelotas Birth Cohort) was conducted with spirometry at 15, 18 and 22 years. PF trajectories were built based on z-score of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and their ratio using a group-based trajectory model. Associations with exposures reported from perinatal to 22 years were described.ResultsThree trajectories, low (LT), average (AT) and high (HT) were identified in 2917 individuals. Wealthiest individuals belonged to the HT of FEV1 (p=0.023). Lower maternal pregestational body mass index (BMI) (22.4±0.2; p<0.001 and 22.1±0.14; p<0.001) and lower birth weight (3164.8±25.4; p=0.029 and 3132.3±19.4; p=0.005) were related to the LT of FEV1 and FVC. Mother's smoking exposure during pregnancy (37.7%; p=0.002), active smoking at ages 18 and 22 years (20.1% and 25.8%; p<0.001) and family history of asthma (44.8%; p<0.001) were related to the LT of FEV1/FVC. Wheezing, asthma and hospitalisations due to respiratory diseases in childhood were related to the LT of both FEV1 and FEV1/FVC. Higher BMIs were related to the HT of FEV1 and FVC at all ages.ConclusionsPF trajectories were mainly related to income, pregestational BMI, birth weight, hospitalisation due to respiratory diseases in childhood, participant's BMI, report of wheezing, medical diagnosis and family history of asthma, gestational exposure to tobacco and current smoking status in adolescence and young adult age.

scholarly journals The CCC2000 Birth Cohort Study of Register-Based Family History of Mental Disorders and Psychotic Experiences in Offspring

2014 ◽  
Vol 41 (5) ◽  
pp. 1084-1094 ◽  
Author(s):  
Pia Jeppesen ◽  
Janne Tidselbak Larsen ◽  
Lars Clemmensen ◽  
Anja Munkholm ◽  
Martin Kristian Rimvall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Family History ◽  
Mental Disorders ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Psychotic Experiences ◽  
History Of

scholarly journals Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study

2019 ◽  
Vol 55 (3) ◽  
pp. 1900477 ◽  
Author(s):  
S. Hasan Arshad ◽  
Claire Hodgekiss ◽  
John W. Holloway ◽  
Ramesh Kurukulaaratchy ◽  
Wilfried Karmaus ◽  
...  
Keyword(s):  
Lung Function ◽  
Birth Cohort ◽  
Smoking Status ◽  
Early Adulthood ◽  
Adult Life ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Birth Cohort Study ◽  
Irreversible Damage ◽  
Isle Of Wight

We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood.The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, and at 1, 2, 4, 10, 18 and 26 years. Asthma was defined as physician diagnosis plus current wheeze and/or treatment. Spirometry was conducted at 10 (n=981), 18 (n=839) and 26 years (n=547). Individuals were subdivided into nonsmokers without asthma, nonsmokers with asthma, smokers without asthma and smokers with asthma, based on asthma and smoking status at 26 years. Their lung function trajectories from 10 to 26 years were examined using longitudinal models.Nonsmokers with asthma had smaller forced expiratory volume in 1 s (FEV1), FEF25–75% (forced expiratory flow at 25–75% of forced vital capacity (FVC)) and FEV1/FVC ratio compared to nonsmokers without asthma at age 10 and 18 years, with differences reduced after bronchodilator (pre-bronchodilator FEV1 at 26 years 3.75 L versus 4.02 L, p<0.001; post-bronchodilator 4.02 L versus 4.16 L, p=0.08). This lung function deficit did not worsen after 18 years. Smokers without asthma had smaller FEF25–75% and FEV1/FVC ratio (but not FEV1) at 26 years compared to nonsmokers without asthma, with the deficit appearing after 18 years and persisting despite bronchodilator response (for FEV1/FVC ratio at 26 years 0.80 versus 0.81, p=0.002; post-bronchodilator 0.83 versus 0.85, p=0.005). Smokers with asthma had worse lung function compared to other groups.Lung function deficits associated with asthma and smoking occur early in life. They are not fully responsive to bronchodilators, indicating a risk for long-term lung health, which highlights the need to institute preventive measures in adolescence and early adult life before irreversible damage occurs.

scholarly journals Family History of Hypertension and the Risk of Overweight in Japanese Children: Results From the Toyama Birth Cohort Study

2014 ◽  
Vol 24 (4) ◽  
pp. 304-311 ◽  
Author(s):  
Jufen Liu ◽  
Michikazu Sekine ◽  
Takashi Tatsuse ◽  
Shimako Hamanishi ◽  
Yuko Fujimura ◽  
...  
Keyword(s):  
Cohort Study ◽  
Family History ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Japanese Children ◽  
History Of ◽  
Family History Of Hypertension

scholarly journals Physical Activity in Early Adolescence and Pulmonary Function Gain From 15 to 18 Years of Age in a Birth Cohort in Brazil

2016 ◽  
Vol 13 (11) ◽  
pp. 1164-1173 ◽  
Author(s):  
Bruna Gonçalves Cordeiro da Silva ◽  
Fernando César Wehrmeister ◽  
Philip H. Quanjer ◽  
Rogelio Pérez-Padilla ◽  
Helen Gonçalves ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pulmonary Function ◽  
Birth Cohort ◽  
Early Adolescence ◽  
Forced Expiratory Volume ◽  
Self Report ◽  
Birth Cohort Study ◽  
Mediation Analyses ◽  
Intensity Physical Activity ◽  
Active Leisure

Background:The aim of this study was to evaluate the association between physical activity from 11 to 15 years of age and pulmonary function (PF) gain from 15 to 18 years of age among adolescents in a birth cohort in Brazil.Methods:Longitudinal analysis of the individuals participating in the 1993 Pelotas Birth Cohort Study. Physical activity was assessed by self-report at ages 11 and 15, spirometry was performed at ages 15 and 18 (n = 3571). Outcome variables assessed were gains in forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and peak expiratory flow (PEF). Crude and adjusted linear regressions, stratified by sex, and mediation analyses were performed.Results:Boys who were active (leisure-time and total physical activity) at ages 11 and 15 had higher gains in FEV1, FVC, and PEF than those who were inactive. Vigorous-intensity physical activity in boys was also associated with FEV1 and FVC gains. Mediation analyses showed that height at age 18 accounted for 5% to 75% of the association between physical activity and PF gains. No significant associations were found among girls.Conclusions:Physical activity in early adolescence is associated with gains in PF by the end of adolescence in boys.

scholarly journals Asthma prevalence and associated factors among lebanese adults: the first national survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zeina Akiki ◽  
Danielle Saadeh ◽  
Rita Farah ◽  
Souheil Hallit ◽  
Hala Sacre ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Family History ◽  
Respiratory Diseases ◽  
Fruits And Vegetables ◽  
Asthma Prevalence ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Current Asthma ◽  
Chronic Respiratory Diseases ◽  
History Of

Abstract Background No national research has yet explored the prevalence of asthma among adults in Lebanon. This study aims to evaluate the prevalence of physician-diagnosed asthma and current asthma, and their determinants among Lebanese adults 16 years old or above. Methods A cross-sectional study was carried out using a multistage cluster sampling. The questionnaire used collected information on asthma, respiratory symptoms, and risk factors. Results The prevalence of physician-diagnosed asthma was 6.7% (95% CI 5–8.7%), and that of current asthma was 5% (95% CI 3.6–6.9%). Chronic symptoms such as cough, wheezing, and shortness of breath were worst at night. Factors positively associated with physician-diagnosed asthma were a secondary educational level (adjusted OR, aOR = 4.45), a family history of chronic respiratory diseases (aOR = 2.78), lung problems during childhood (15.9), and allergic rhinitis (4.19). Additionally, consuming fruits and vegetables less than once per week (3.36), a family history of chronic respiratory diseases (3.92), lung problems during childhood (9.43), and allergic rhinitis (8.12) were positively associated with current asthma. Conclusions The prevalence of asthma was within the range reported from surrounding countries. However, repeated cross-sectional studies are necessary to evaluate trends in asthma prevalence in the Lebanese population.

scholarly journals Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Dennis Liang Fei ◽  
Devin C Koestler ◽  
Zhigang Li ◽  
Camilla Giambelli ◽  
Avencia Sanchez-Mejias ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Arsenic Exposure ◽  
In Utero ◽  
Birth Cohort Study ◽  
Infant Birth

scholarly journals Fetal Thyroid Function, Birth Weight, andin UteroExposure to Fine Particle Air Pollution: A Birth Cohort Study

2017 ◽  
Vol 125 (4) ◽  
pp. 699-705 ◽  
Author(s):  
Bram G. Janssen ◽  
Nelly D. Saenen ◽  
Harry A. Roels ◽  
Narjes Madhloum ◽  
Wilfried Gyselaers ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Thyroid Function ◽  
Fine Particle ◽  
Birth Cohort Study ◽  
Fetal Thyroid

History of mental disorders and leukocyte telomere length in late adulthood: The Helsinki Birth Cohort Study (HBCS)

2012 ◽  
Vol 46 (10) ◽  
pp. 1346-1353 ◽  
Author(s):  
Katri Savolainen ◽  
Katri Räikkönen ◽  
Laura Kananen ◽  
Eero Kajantie ◽  
Iiris Hovatta ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mental Disorders ◽  
Telomere Length ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Leukocyte Telomere Length ◽  
Late Adulthood ◽  
History Of

Regional differences in birth size: a comparison between the Helsinki Birth Cohort Study and contemporaneous births on the Åland Islands

2015 ◽  
Vol 6 (4) ◽  
pp. 263-267 ◽  
Author(s):  
S. Sandboge ◽  
J. Fellman ◽  
P. M. Nilsson ◽  
A. W. Eriksson ◽  
C. Osmond ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Marital Status ◽  
Birth Cohort ◽  
Regional Differences ◽  
Multiple Linear Regression Model ◽  
Life Course Perspective ◽  
Birth Cohort Study ◽  
Average Birth Weight ◽  
Birth Characteristics

The Åland Islands were recently ranked as Finland’s healthiest region with lower prevalence of several non-communicable diseases compared with the national mean. We have compared birth characteristics of 1697 individuals born on the Åland Islands between 1937 and 1944 with contemporaneous data from the Helsinki Birth Cohort Study (HBCS;n=11,808). This is a first step towards a potential future analysis of Ålandic health from a life-course perspective. Mean birth weight and length were calculated for both cohorts. Birth weight was entered into a multiple linear regression model with sex, maternal age, marital status and birth year as predictors. Mean birth weight in the Åland cohort was 3499 g, 87 g (95% CI 62; 111) higher compared with the HBCS. Sex and maternal marital status were the strongest predictors of birth weight. More detailed studies are needed to explore the potential effects of this difference in average birth weight between cohorts.

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