scholarly journals A prospective, multicenter, observational study of complicated skin and soft tissue infections in hospitalized patients: clinical characteristics, medical treatment, and outcomes

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Benjamin A Lipsky ◽  
Gregory J Moran ◽  
Lena M Napolitano ◽  
Lien Vo ◽  
Susan Nicholson ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Observational Study ◽  
Medical Treatment ◽  
Clinical Characteristics ◽  
Hospitalized Patients ◽  
Soft Tissue Infections ◽  
Multicenter Observational Study ◽  
Complicated Skin ◽  
Prospective Multicenter Observational Study

Daptomycin (Cubicin) in patients with complicated skin or soft-tissue infections

2008 ◽  
Vol 9 (3) ◽  
pp. 163-166
Author(s):  
Viola Sacchi
Keyword(s):  
Soft Tissue ◽  
Clinical Characteristics ◽  
Bacterial Resistance ◽  
Surgical Intervention ◽  
Progressive Increase ◽  
Soft Tissue Infections ◽  
Aetiological Agent ◽  
Gram Positive Bacteria ◽  
Co Morbidity ◽  
Complicated Skin

Skin and soft-tissue infections (SSTIs) are commonly observed and differ in terms of site and localization, clinical characteristics, and the aetiological agent; these infections are usually caused by Staphylococcus aureus or beta-haemolytic streptococci, and are the most frequent forms of methicillin-resistant S. aureus (MRSA) infections. SSTIs are considered complicated if they involve deeper skin structures (fascia or muscle layers), require significant surgical intervention or arise in the presence of significant co-morbidity. The progressive increase of bacterial resistance, in particular for Gram-positive bacteria infections, to currently used agents is a serious and growing problem, and in particular MRSA, GISA (glycopeptides-insusceptible S. aureus), VRE and GRE (glycopeptides-resistant enterococci) are of concern. There is, therefore, a need for additional agents active against these difficult-to-treat pathogens.

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