Daptomycin (Cubicin) in patients with complicated skin or soft-tissue infections

2008 ◽  
Vol 9 (3) ◽  
pp. 163-166
Author(s):  
Viola Sacchi
Keyword(s):  
Soft Tissue ◽  
Clinical Characteristics ◽  
Bacterial Resistance ◽  
Surgical Intervention ◽  
Progressive Increase ◽  
Soft Tissue Infections ◽  
Aetiological Agent ◽  
Gram Positive Bacteria ◽  
Co Morbidity ◽  
Complicated Skin

Skin and soft-tissue infections (SSTIs) are commonly observed and differ in terms of site and localization, clinical characteristics, and the aetiological agent; these infections are usually caused by Staphylococcus aureus or beta-haemolytic streptococci, and are the most frequent forms of methicillin-resistant S. aureus (MRSA) infections. SSTIs are considered complicated if they involve deeper skin structures (fascia or muscle layers), require significant surgical intervention or arise in the presence of significant co-morbidity. The progressive increase of bacterial resistance, in particular for Gram-positive bacteria infections, to currently used agents is a serious and growing problem, and in particular MRSA, GISA (glycopeptides-insusceptible S. aureus), VRE and GRE (glycopeptides-resistant enterococci) are of concern. There is, therefore, a need for additional agents active against these difficult-to-treat pathogens.

scholarly journals Telavancin Versus Standard Therapy for Treatment of Complicated Skin and Soft-Tissue Infections Due to Gram-Positive Bacteria

2005 ◽  
Vol 40 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
M. E. Stryjewski ◽  
W. D. O'Riordan ◽  
W. K. Lau ◽  
F. D. Pien ◽  
L. M. Dunbar ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Standard Therapy ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Complicated Skin

Microbial Distribution and Antibiotic Susceptibility in Patients with Complicated Skin and Soft Tissue Infections of the Extremities in North-Eastern China

2020 ◽  
Author(s):  
Jie Ma ◽  
Yanqing Song ◽  
Xiangfeng Wang ◽  
Huiyu Yan ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Antibiotic Susceptibility ◽  
Eastern China ◽  
Severe Infection ◽  
Soft Tissue Infections ◽  
Gram Positive Bacteria ◽  
Microbial Distribution ◽  
Complicated Skin ◽  
North Eastern

Abstract Background For complicated skin and soft tissue infections (cSSTIs), inappropriate initial anti-infective treatment often leads to treatment failure. The microbial distribution in patients with extremities’ cSSTIs has been rarely reported. Moreover, whether gram-negative bacteria (GNB) should be covered in addition to gram-positive bacteria (GPB) has been always a difficult issue in the treatment of cSSTIs. Methods We retrospectively analyzed the microbial distribution and antibiotic susceptibility in 149 hospitalized patients with extremities’ SSTIs, and discussed the risk factors of extremities’ cSSTIs caused by GNB. Results 188 strains of pathogens were isolated, including 113 strains of GPB (64.9%), 61 strains of GNB (32.4%), and 5 strains of fungi (2.7%). Diabetes mellitus (OR=3.606, P =0.034), SSTI severity [moderate infection (OR=19.499, P <0.0001), severe infection (OR=20.114, P <0.0001)], and necrotizing infection (OR=6.064, P <0.0001) were risk factors of extremities’ cSSTIs caused by GNB. For patients with risk factors, ceftazidime, cefepime, piperacillin/tazobactam and carbapenems could be empirical anti-infective agents. Conclusions The results of our study showed that the most common bacteria identified in cSSTIs of the extremities were GPB. For patients with risk factors of extremities’ cSSTIs caused by GNB, the coverage of GNB should be taken into account.

scholarly journals Cost Implications Of Tedizolid Introduction For The Treatment Of Complicated Skin And Soft Tissue Infections In A Russian Multi-Field Hospital

2017 ◽  
Vol 20 (9) ◽  
pp. A782 ◽  
Author(s):  
YA Belkova ◽  
SA Rachina ◽  
RS Kozlov ◽  
AV Golub ◽  
US Portnyagina ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infections ◽  
Field Hospital ◽  
Complicated Skin ◽  
Cost Implications

scholarly journals Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2354 ◽  
Author(s):  
Oscar Forero Doria ◽  
Ricardo Castro ◽  
Margarita Gutierrez ◽  
Diego Gonzalez Valenzuela ◽  
Leonardo Santos ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquids ◽  
Soft Tissue ◽  
Inhibitory Concentration ◽  
Membrane Surface ◽  
Soft Tissue Infections ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Antibacterial Screening ◽  
Mic Value

Keeping in mind the concept of green chemistry, this research aims to synthesize and characterize new ionic liquids (ILs) derived from N-cinnamyl imidazole with different sizes of alkyl chains (1, 6, 8, and 10 carbon atoms), and evaluate their antibacterial activity against Skin and soft tissue infections (SSTIs) causative bacteria. The antibacterial screening was carried out by agar well diffusion and the Minimum Inhibitory Concentration (MIC) and Half Maximum Inhibitory Concentration (IC50) of the different ILs were determined by microdilution in broth, also Molecular dynamics simulations were performed to study the interaction mechanism between ILs and membranes. The MIC value in Gram-positive bacteria showed that as the hydrocarbon chain increases, the MIC value decreases with a dose-dependent effect. Furthermore, Gram-negative bacteria showed high MIC values, which were also evidenced in the antibacterial screening. The molecular dynamics showed an incorporation of the ILs with the longer chain (10 C), corresponding to a passive diffusion towards the membrane surface, for its part, the ILs with the shorter chain due to its lack of hydrophobicity was not incorporated into the bilayer. Finally, the new ILs synthesized could be an alternative for the treatment of Gram-positive bacteria causative of SSTIs.

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