The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

SUMMARYThis study aimed to determine the prevalence of serological markers for HIV-1/2, HBV, HCV, Treponema cruzi and T. pallidum infections. The association of these infections with risk factors in a population from Salvador, Bahia, Brazil was also analysed. Of the 780 enrolled individuals, 545 (70%) were female and 235 (30%) were male. Seroprevalence of 0·8% (6/702), 1·3% (9/678), 1·5% (10/684), 3·5% (23/663) and 11·5% (77/668) for HIV-1/2, HBV, HCV, T. cruzi and T. pallidum infections, respectively, was observed. The seroprevalence of T. pallidum was higher in males 20% (43/210) than in females 7% (34/458) (P < 0·01). An association between age and seroprevalence for T. cruzi (P = 0·02) and T. pallidum (P < 0·01) was observed. HBsAg was associated with having tattoos (3/37 vs. 6/623, P = 0·01) and not having a steady sexual partner (5/141 vs. 4/473, P = 0·04), while anti-HIV-1/2 was associated with having tattoos (2/39 vs. 4/647, P = 0·04); however, larger studies are needed to categorically state the relationship of these risk factors with infectious agents. The prevalence of serological markers for HIV-1/2, HBV, HCV and T. cruzi was consistent with other studies.

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Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax

Molecular Biology and Evolution ◽

10.1093/molbev/msn069 ◽

2008 ◽

Vol 25 (6) ◽

pp. 1192-1198 ◽

Cited By ~ 13

Author(s):

S. W. Roy ◽

M. Irimia

Keyword(s):

Plasmodium Falciparum ◽

Plasmodium Vivax ◽

Mitochondrial Genomes ◽

Genomic Changes ◽

Human Malaria ◽

Rare Genomic Changes ◽

Relationship Of ◽

The Relationship

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Further evidence for the relationship of HIV-1 gp120 V3 loops with Ig superfamily members: similarity with the putative CDR3 region of T-cell receptor δ-chains

Immunology Letters ◽

10.1016/0165-2478(95)00056-b ◽

1995 ◽

Vol 47 (1-2) ◽

pp. 25-28 ◽

Cited By ~ 7

Author(s):

R. Metlaš ◽

V. Skerl ◽

V. Veljković ◽

S. Pongor

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Cdr3 Region ◽

Ig Superfamily ◽

Relationship Of ◽

The Relationship ◽

Hiv 1

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A COMPLETE HIV-1 Env CODING SEQUENCES FROM HIV ISOLATED IN CENTRAL JAVA, INDONESIA

KnE Life Sciences ◽

10.18502/kls.v2i1.112 ◽

2015 ◽

Vol 2 (1) ◽

pp. 27

Author(s):

Irvan Raharjo ◽

Afiono Agung Prasetyo

Keyword(s):

Transmembrane Helix ◽

Coding Sequences ◽

Protein Charge ◽

Central Java ◽

Keywords Hiv ◽

Escherichia Coli Expression ◽

Hiv Envelope ◽

Relationship Of ◽

The Relationship ◽

Hiv 1

Background:The HIV envelope glycoprotein (env) plays a central role in viral transmission to target cells.The genetic diversity of env gene contributes a great mechanism on how HIV-1 could survive.Aims:To determine the genotype and genetic relationship of our isolate compared to the other HIV-1 isolates, especially from Indonesia based on the env gene. Also, for further use, the molecular properties of our gene had been analyzed. Methods: A complete coding sequence of HIV-1 env gene was cloned from 09IDSKA-6 (HIV isolated in Central Java, Indonesia), inserted into an Escherichia coli expression plasmid, and sequenced. The sequencing results of the env gene then subjected for virus subtyping and genotyping. The phylogenetic analysis was performed to know the relationship between the isolate with all HIV isolates in Indonesia based on the env gene.The sequencing results were also subjected for bioinformatics analysis.Results: Based on the molecular analysis of HIV-1 env complete coding sequences, the 09IDSKA-6 belong to HIV CRF01_AEwhich is quite common in Southeast Asia. The signal peptide, protein charge, transmembrane helix, antigenicity, hydrophobicity, secondary structure, and proteolytic cleavageof our gene also had been discussed. Keywords: HIV-1, env gene, Indonesia.

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Complicated malaria: relationship of complications and parasite load to outcome

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20180082 ◽

2018 ◽

Vol 5 (1) ◽

pp. 186

Author(s):

G. Keshava Anand ◽

Mallikarjun Rao Sanda

Keyword(s):

Plasmodium Falciparum ◽

Treatment Plan ◽

General Medicine ◽

Parasite Load ◽

Complicated Malaria ◽

Appropriate Treatment ◽

Probability Of Death ◽

Relationship Of ◽

The Relationship ◽

Day By Day

Background: The incidence of complicated malaria cases is increasing day by day. Complicated malaria present in different ways in different places globally. If malaria is diagnosed and treated immediately, then the death rate is less than one percent. The objective was to study the relationship of complications and parasite load to outcome (mortality) among patients with complicated malaria.Methods: The present hospital based Prospective Observational study was carried out among 100 cases of “Complicated malaria.” The present study was carried out at Department of General medicine, Kamineni hospitals, L. B. Nagar, Hyderabad.Results: 71% patients were infected with Plasmodium falciparum, 25% with Plasmodium vivax and 4% with both Plasmodium falciparum and vivax. 12% patients deceased and 88% survived. The relationship between GCS, convulsions, pH, bicarbonate, lactate, hemoglobin, creatinine, SBP, PaO2/FiO2 ratio, PT, INR, aPTT, and outcome was statistically highly significant (p=0.000). The relationship between Total Bilirubin, RBS and outcome was statistically not significant (p=0.351). Multivariate analysis using logistic regression model, to determine the effect of studied variables on the final outcome, revealed no significant influence of studied variables in predicting the outcome (p>0.05). The relationship between increasing parasite load and outcome was studied, and it showed it was statistically highly significant (p=0.000).Conclusions: The prognosis and outcome of patients with complicated malaria worsen as the parasite load increases and the probability of death increases markedly in such patients. The presentation of inappropriate parameters at admission, aid us in predicting poor outcome and appropriate treatment plan.

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