scholarly journals PReS-FINAL-2005: Prevalence of antinuclear antibodies in schoolchildren across puberty and possible relationship with musculoskeletal pain. A longitudinal study

2013 ◽  
Vol 11 (S2) ◽  
Author(s):  
F Sperotto ◽  
S Brachi ◽  
M Seguso ◽  
F Vittadello ◽  
F Zulian
2014 ◽  
Vol 41 (7) ◽  
pp. 1405-1408 ◽  
Author(s):  
Francesca Sperotto ◽  
Giorgio Cuffaro ◽  
Sara Brachi ◽  
Mara Seguso ◽  
Francesco Zulian

Objective.The role of antinuclear antibodies (ANA) in children has still to be elucidated. The aim of our study was to evaluate the prevalence and persistence of ANA in schoolchildren during the puberty switch, and the possible relationship with chronic noninflammatory musculoskeletal pain (MSP).Methods.Children aged 8–13 years and attending 4 public schools underwent a clinical examination, focusing on pubertal stage and presence of chronic noninflammatory MSP. Laboratory tests to determine the autoantibody-profile were also performed. Subjects with ANA positivity (titer ≥ 1:80) and/or chronic noninflammatory MSP were re-evaluated 3 years later.Results.Two hundred sixty-one subjects enrolled in the study and 12.3% were ANA-positive, equally distributed in terms of sex and pubertal status. Three years later, in the group of patients studied for chronic noninflammatory MSP (n = 67), ANA positivity significantly increased from 13.4% to 44.8%. In the ANA-positive cohort at baseline (n = 28), 92.9% of subjects were confirmed as being ANA-positive with a significantly increased titer. No association between ANA positivity and chronic noninflammatory MSP was found.Conclusion.ANA prevalence and titers increase during puberty, especially in females, but have no relationship with chronic noninflammatory MSP. This finding may be related to the complex hormonal changes during the puberty switch period and opens new insights into autoimmunity.


2012 ◽  
Vol 70 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Eleni Solidaki ◽  
Leda Chatzi ◽  
Panos Bitsios ◽  
David Coggon ◽  
Keith T Palmer ◽  
...  

2020 ◽  
Vol 42 (1) ◽  
pp. 13-26
Author(s):  
Ryosuke SUGANO ◽  
Kazunori IKEGAMI ◽  
Hajime ANDO ◽  
Hiroki NOZAWA ◽  
Satoshi MICHII ◽  
...  

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yutaka Yabe ◽  
Yoshihiro Hagiwara ◽  
Takuya Sekiguchi ◽  
Yumi Sugawara ◽  
Masahiro Tsuchiya ◽  
...  

Abstract Background Functional disability is a significant problem after natural disasters. Musculoskeletal pain is reported to increase after disasters, which can cause functional disability among survivors. However, the effects of musculoskeletal pain on functional decline after natural disasters are unclear. The present study aimed to examine the association between musculoskeletal pain and new-onset poor physical function among elderly survivors after the Great East Japan Earthquake. Methods A longitudinal study was conducted on survivors aged ≥65 years at three and 4 years after the Great East Japan Earthquake. A total of 747 persons were included in this study. Physical function was assessed using the Kihon Checklist. New-onset poor physical function was defined as low physical function not present at 3 years but present at 4 years after the disaster. Knee, hand or foot, low back, shoulder, and neck pain was assessed using a self-reported questionnaire and was defined as musculoskeletal pain. Musculoskeletal pain at 3 years after the disaster was categorized according to the number of pain regions (0, 1, ≥ 2). Multiple logistic regression analyses were performed to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for new-onset poor physical function due to musculoskeletal pain. Results The incidence of new-onset poor physical function was 14.9%. New-onset poor physical function was significantly associated with musculoskeletal pain. Compared with “0” musculoskeletal pain region, the adjusted ORs (95% CI) were 1.39 (0.75–2.58) and 2.69 (1.52–4.77) in “1” and “≥ 2” musculoskeletal pain regions, respectively (p for trend = 0.003). Conclusions Musculoskeletal pain is associated with new-onset poor physical function among elderly survivors after the Great East Japan Earthquake. Monitoring musculoskeletal pain is important to prevent physical function decline after natural disasters.


2020 ◽  
Author(s):  
Yutaka Yabe ◽  
Yoshihiro Hagiwara ◽  
Takuya Sekiguchi ◽  
Yumi Sugawara ◽  
Masahiro Tsuchiya ◽  
...  

Abstract Background: Low back pain (LBP) is a common health problem experienced after natural disasters. LBP is often concurrent with other musculoskeletal pain; however, the effects of preexisting musculoskeletal pain on the development of LBP are not clear. The purpose of this study was to elucidate the association of musculoskeletal pain in other body sites with new-onset LBP among survivors of the Great East Japan Earthquake (GEJE). Methods: A longitudinal study was conducted with survivors of the GEJE. The survivors who did not have LBP at the three year time period after the GEJE were followed up one year later (n = 1,782). Musculoskeletal pain, such as low back, hand and/or foot, knee, shoulder, and neck pain, were assessed with self-reported questionnaires. The outcome of interest was new-onset LBP, which was defined as LBP absent at three years but present at four years after the disaster. The main predictor was musculoskeletal pain in other body sites three years after the GEJE, which was categorized according to the number of pain sites (0, 1, ≥ 2). Multiple regression analyses were performed to calculate the odds ratio (OR) and 95% confidence interval (CI) for new-onset LBP due to musculoskeletal pain in other body sites. Results: The incidence of new-onset LBP was 14.1% (251/1,782). Musculoskeletal pain in other body sites was significantly associated with new-onset LBP. Including people without other musculoskeletal pain as a reference, the adjusted OR and 95% CI for new-onset LBP were 1.73 (1.16-2.57) for people with one musculoskeletal pain site and 3.20 (2.01-5.09) for people with ≥ 2 sites (p < 0.001). Conclusions: Preexisting musculoskeletal pain in other body sites was associated with new-onset LBP among survivors in the recovery period after the GEJE .


BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041804
Author(s):  
Yoshihiro Hagiwara ◽  
Yutaka Yabe ◽  
Takuya Sekiguchi ◽  
Yumi Sugawara ◽  
Masahiro Tsuchiya ◽  
...  

ObjectiveShoulder pain is a common health problem coexisting with other musculoskeletal pain. However, the effects of pre-existing musculoskeletal pain on the development of shoulder pain are not clear. The present study aimed to elucidate the association between coexisting musculoskeletal pain at other body sites and new-onset shoulder pain among survivors of the Great East Japan Earthquake (GEJE).DesignThis is a longitudinal study.SettingThe study was conducted at the severely damaged coastal areas in Ishinomaki and Sendai cities.ParticipantsThe survivors who did not have shoulder pain at 3 years after the GEJE were followed up 1 year later (n=2131).InterventionsMusculoskeletal pain (low back, hand and/or foot, knee, shoulder and neck pain) was assessed using self-reported questionnaires.Main outcome measuresThe outcome of interest was new-onset shoulder pain, which was defined as shoulder pain absent at 3 years but present at 4 years after the disaster. The main predictive factor for new-onset shoulder pain was musculoskeletal pain in other body parts at 3 years after the GEJE; this was categorised according to the number of pain sites (0, 1, ≥2). Multiple regression analyses were conducted to calculate the odds ratio (OR) and 95% confidence interval (CI) for new-onset shoulder pain due to musculoskeletal pain in other body parts.ResultsThe incidence of new-onset shoulder pain was 6.7% (143/2131). Musculoskeletal pain in other body parts was significantly associated with new-onset shoulder pain. Using the survivors without other musculoskeletal pain as reference, the adjusted OR and 95% CI for new-onset shoulder pain were 1.86 (1.18 to 2.94) for those with one body part and 3.22 (2.08 to 4.98) for those with ≥2 body parts presenting with musculoskeletal pain (p<0.001).ConclusionsPre-existing musculoskeletal pain in other body parts was significantly associated with new-onset shoulder pain among survivors; this provides useful information for clinical and public health policies.


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