scholarly journals Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection

2011 ◽  
Vol 8 (1) ◽  
Author(s):  
Jun Li ◽  
Yaping Han ◽  
Ke Jin ◽  
Yufeng Wan ◽  
Shixia Wang ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Nk Cells ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Nkt Cells ◽  
Hepatitis B Infection ◽  
Dynamic Changes ◽  
Acute Hepatitis B

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

2015 ◽  
Vol 308 (4) ◽  
pp. G269-G276 ◽  
Author(s):  
Sidsel Støy ◽  
Anders Dige ◽  
Thomas Damgaard Sandahl ◽  
Tea Lund Laursen ◽  
Christian Buus ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Nk Cells ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Alcoholic Hepatitis ◽  
Nk Cell ◽  
Alcoholic Cirrhosis ◽  
Nkt Cells ◽  
Receptor Expression ◽  
Healthy Controls

The dynamics and role of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and NKT cells in the life-threatening inflammatory disease alcoholic hepatitis is largely unknown. These cells directly kill infected and damaged cells through, e.g., degranulation and interferon-γ (IFNγ) production, but cause tissue damage if overactivated. They also assist tissue repair via IL-22 production. We, therefore, aimed to investigate the frequency, functionality, and activation state of such cells in alcoholic hepatitis. We analyzed blood samples from 24 severe alcoholic hepatitis patients followed for 30 days after diagnosis. Ten healthy abstinent volunteers and 10 stable abstinent alcoholic cirrhosis patients were controls. Using flow cytometry we assessed cell frequencies, NK cell degranulation capacity following K562 cell stimulation, activation by natural killer group 2 D (NKG2D) expression, and IL-22 and IFNγ production. In alcoholic hepatitis we found a decreased frequency of CTLs compared with healthy controls ( P < 0.001) and a similar trend for NK cells ( P = 0.089). The NK cell degranulation capacity was reduced by 25% compared with healthy controls ( P = 0.02) and by 50% compared with cirrhosis patients ( P = 0.04). Accordingly, the NKG2D receptor expression was markedly decreased on NK cells, CTLs, and NKT cells ( P < 0.05, all). The frequencies of IL-22-producing CTLs and NK cells were doubled compared with healthy controls ( P < 0.05, all) but not different from cirrhosis patients. This exploratory study for the first time showed impaired cellular cytotoxicity and activation in alcoholic hepatitis. This is unlikely to cause hepatocyte death but may contribute toward the severe immune incompetence. The results warrant detailed and mechanistic studies.

scholarly journals A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients

2008 ◽  
Vol 151 (3) ◽  
pp. 441-447 ◽  
Author(s):  
H.-G. Liu ◽  
Z.-P. Fan ◽  
W.-W. Chen ◽  
H.-Y. Yang ◽  
Q.-F. Liu ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Cytotoxic T Lymphocytes ◽  
Hbs Antigen ◽  
Acute Hepatitis B

Improvement of Bell’s palsy associated with resolution of acute hepatitis B infection

2015 ◽  
Vol 116 (2) ◽  
pp. 233-234
Author(s):  
Sebahat Basyigit ◽  
Bora Aktas ◽  
Ferdane Sapmaz ◽  
Tolga Akkan
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Bell’S Palsy ◽  
Hepatitis B Infection ◽  
Bell's Palsy ◽  
Acute Hepatitis B

Acute hepatitis B infection associated with drug-resistant hepatitis B virus

2010 ◽  
Vol 48 (4) ◽  
pp. 270-274 ◽  
Author(s):  
Zhihui Xu ◽  
Yan Liu ◽  
Teng Xu ◽  
Li Chen ◽  
Lanlan Si ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Drug Resistant ◽  
Hepatitis B Infection ◽  
B Virus ◽  
Acute Hepatitis B
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