First report of adult Hyalomma marginatum rufipes (vector of Crimean-Congo haemorrhagic fever virus) on cattle under a continental climate in Hungary

The complete nucleotide sequences of the small (S) and medium (M) segments of three independent strains of Crimean-Congo haemorrhagic fever (CCHF) virus isolated in Uzbekistan, Iraq and Pakistan have been determined. Partial S and M segment sequences from two additional strains and partial large segment sequences from five strains of CCHF virus have also been obtained. These data have been compiled and compared with published full-length and partial sequences of other CCHF virus strains. Analysis of virus strains for which complete and partial S and M segment sequences are available reveals that the phylogenetic grouping of some strains differ between these two segments. Data provided in this report suggest that this discrepancy is not the result of recombination, but rather the consequence of reassortment events that have occurred in some virus lineages. Although described in other genera of the Bunyaviridae family, this is the first report of segment reassortment occurring in the Nairovirus genus.

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Adult Hyalomma marginatum tick positive for Rickettsia aeschlimannii in Austria, October 2018

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.48.1800595 ◽

2018 ◽

Vol 23 (48) ◽

Cited By ~ 7

Author(s):

Georg Gerhard Duscher ◽

Adnan Hodžić ◽

Peter Hufnagl ◽

Walpurga Wille-Piazzai ◽

Anna-Magarita Schötta ◽

...

Keyword(s):

Tick Species ◽

Migratory Birds ◽

Fever Virus ◽

Northern Europe ◽

Haemorrhagic Fever ◽

Potential Threat ◽

Hyalomma Marginatum ◽

Crimean Congo Haemorrhagic Fever ◽

Rickettsia Aeschlimannii

We report on a non-indigenous adult Hyalomma marginatum tick in Austria carrying the human pathogenic Rickettsia aeschlimannii; presumably introduced as a nymph via migratory birds and completed the moulting within the same year. It was negative for Crimean-Congo haemorrhagic fever virus, but the finding of R. aeschlimannii represents a potential threat for humans due to its zoonotic character. Awareness of invasive tick species and carried pathogens should be improved in central and northern Europe.

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DETECTION AND GENETIC CHARACTERISTICS OF RNA ISOLATES OF CRIMEAN-CONGO HAEMORRHAGIC FEVER VIRUS FROM THE HYALOMMA MARGINATUM TICKS COLLECTED IN THE ASTRAKHAN REGION (2016)

Epidemiology and Infectious Diseases (Russian Journal) ◽

10.17816/eid40999 ◽

2017 ◽

Vol 22 (5) ◽

pp. 248-253

Author(s):

Elena V. Vakalova ◽

A. S Volynkina ◽

E. S Kotenev ◽

L. N Kulikova ◽

N. V Viktorova

Keyword(s):

Infection Rate ◽

Genetic Variant ◽

Fever Virus ◽

Viral Resistance ◽

Haemorrhagic Fever ◽

Rt Pcr ◽

Genetic Characteristics ◽

Hyalomma Marginatum ◽

Cchf Virus ◽

Crimean Congo Haemorrhagic Fever

1,746 specimens of H. marginatum ticks collected in the Astrakhan region were examined by RT-PCR, their infection rate with CCHF virus amounted to 1.5%. This is comparable with results of earlier studies performed in different years in the Astrakhan and Rostov regions and testified to such indices of viral resistance as 0.1; 0.9; 2.4; 0.6; 0.9 and 2.3%. As a result of sequencing of fragments of the genome (fourteen of the 26 isolates of RNA, they refer to the genotype Europe-1. Seven out of 14 isolates belong to the subtype Va Stavropol-Rostov-Astrakhan, two represent the reassortant genetic variant S-Vc; M-Vb; L-Va.

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Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

Veterinary Medicine and Science ◽

10.1002/vms3.597 ◽

2021 ◽

Author(s):

Médiha Khamassi Khbou ◽

Rihab Romdhane ◽

Faten Bouaicha Zaafouri ◽

Mohsen Bouajila ◽

Limam Sassi ◽

...

Keyword(s):

North Africa ◽

Fever Virus ◽

Haemorrhagic Fever ◽

Crimean Congo Haemorrhagic Fever

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Haemorrhagic fever caused by Crimean Congo Haemorrhagic Fever virus in Mauritania

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1016/0035-9203(85)90356-6 ◽

1985 ◽

Vol 79 (2) ◽

pp. 268 ◽

Cited By ~ 19

Author(s):

J.F. Saluzzo ◽

P. Aubry ◽

J. McCormick ◽

J.P. Digoutte

Keyword(s):

Fever Virus ◽

Haemorrhagic Fever ◽

Crimean Congo Haemorrhagic Fever

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Next-generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment reassortment

Epidemiology and Infection ◽

10.1017/s0950268814000818 ◽

2014 ◽

Vol 142 (9) ◽

pp. 1952-1962 ◽

Cited By ~ 15

Author(s):

D. GOEDHALS ◽

P. A. BESTER ◽

J. T. PAWESKA ◽

R. SWANEPOEL ◽

F. J. BURT

Keyword(s):

Next Generation Sequencing ◽

High Frequency ◽

Complete Genome ◽

Fever Virus ◽

Likelihood Method ◽

Haemorrhagic Fever ◽

Next Generation ◽

Genome Sequences ◽

Crimean Congo Haemorrhagic Fever ◽

Generation Sequencing

SUMMARYCrimean Congo haemorrhagic fever virus (CCHFV) is a bunyavirus with a single-stranded RNA genome consisting of three segments (S, M, L), coding for the nucleocapsid protein, envelope glycoproteins and RNA polymerase, respectively. To date only five complete genome sequences are available from southern African isolates. Complete genome sequences were generated for 10 southern African CCHFV isolates using next-generation sequencing techniques. The maximum-likelihood method was used to generate tree topologies for 15 southern African plus 26 geographically distinct complete sequences from GenBank. M segment reassortment was identified in 10/15 southern African isolates by incongruencies in grouping compared to the S and L segments. These reassortant M segments cluster with isolates from Asia/Middle East, while the S and L segments cluster with strains from South/West Africa. The CCHFV M segment shows a high level of genetic diversity, while the S and L segments appear to co-evolve. The reason for the high frequency of M segment reassortment is not known. It has previously been suggested that M segment reassortment results in a virus with high fitness but a clear role in increased pathogenicity has yet to be shown.

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