Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women

Abstract Background: An important number of breast and ovarian cancer cases is due to a strong genetic predisposition. The main tool for identifying individuals at risk is recognizing a suggestive family history of cancer. We present a prospective study on applying three selected clinical guidelines to a cohort of 1000 Slovenian women to determine the prevalence of at-risk women according to each of the guidelines and analyze the differences amongst the guidelines.Methods: Personal and family history of cancer was collected for 1000 Slovenian women. Guidelines by three organizations: National Comprehensive Cancer Network (NCCN), American College of Medical Genetics in cooperation with National Society of Genetic Counselors (ACMG/NSGC), and Society of Gynecologic Oncology (SGO) were applied to the cohort. The number of women identified, the characteristics of the high-risk population, and the agreement between the guidelines were explored. Results: NCCN guidelines identify 16.7 % of women, ACMG/NSGC guidelines identify 7.1 % of women, and SGO guidelines identify 7.0 % of women from the Slovenian population, while 6.2 % of women are identified by all three guidelines as having high-risk for hereditary breast and ovarian cancer.Conclusions: We identified 17.4 % of women from the Slovenian population as being at an increased risk for breast and ovarian cancer based on their personal and family history of cancer using all of the guidelines. There are important differences between the guidelines. NCCN guidelines are the most inclusive, identifying more than twice the amount of women as high-risk for hereditary breast and ovarian cancer as compared to the AGMG/NSCG and SGO guidelines in the Slovenian population.

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Breast and Ovarian Cancer Screening Practices in Healthy Women with a Strong Family History of Breast or Ovarian Cancer

Breast Cancer Research and Treatment ◽

10.1023/a:1013800409238 ◽

2002 ◽

Vol 71 (2) ◽

pp. 103-112 ◽

Cited By ~ 58

Author(s):

Claudine Isaacs ◽

Beth N. Peshkin ◽

Marc Schwartz ◽

Tiffani A. DeMarco ◽

David Main ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Screening ◽

Family History ◽

Strong Family History ◽

Breast And Ovarian Cancer ◽

Ovarian Cancer Screening ◽

Screening Practices ◽

Healthy Women ◽

History Of

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The incidence of PALB2 c.3113G>A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia

Familial Cancer ◽

10.1007/s10689-013-9620-4 ◽

2013 ◽

Vol 12 (4) ◽

pp. 587-595 ◽

Cited By ~ 8

Author(s):

Zhi L. Teo ◽

Sarah D. Sawyer ◽

Paul A. James ◽

Gillian Mitchell ◽

Alison H. Trainer ◽

...

Keyword(s):

Ovarian Cancer ◽

Family History ◽

Familial Cancer ◽

Strong Family History ◽

Breast And Ovarian Cancer ◽

History Of

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Population Prevalence of First-Degree Family History of Breast and Ovarian Cancer in the United States: Implications for Genetic Testing§

The Open Health Services and Policy Journal ◽

10.2174/1874924000801010034 ◽

2008 ◽

Vol 1 (1) ◽

pp. 34-37 ◽

Cited By ~ 4

Author(s):

Ingrid J. Hall ◽

Andrea Middlebrooks ◽

Steven S. Coughlin

Keyword(s):

United States ◽

Ovarian Cancer ◽

Genetic Testing ◽

Family History ◽

The United States ◽

Breast And Ovarian Cancer ◽

Population Prevalence ◽

History Of

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Adiposity post prophylactic oophorectomy in young women at high risk for breast and ovarian cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.1572 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 1572-1572

Author(s):

Kala Visvanathan ◽

Minh-Huy Huynh ◽

Rawan Al-Lozi ◽

Jessica Oidtman ◽

Betty J May ◽

...

Keyword(s):

Physical Activity ◽

Ovarian Cancer ◽

Family History ◽

Hormone Therapy ◽

Body Fat ◽

Young Women ◽

Age Distribution ◽

Abdominal Circumference ◽

Breast And Ovarian Cancer ◽

History Of

1572 Background: Bilateral prophylactic salpingo-oophorectomy (BPSO) is the current standard of care for BRCA1/2 mutation carriers and women with a strong family history of ovarian cancer. We have previously demonstrated an association between early oophorectomy, adiposity and mortality in the general population. Methods: A cross sectional study was conducted between November 2009 and January 2013 in 87 women with a family history of breast and ovarian cancer and/or BRCA1/2 mutation to identify the effect of early BPSO on multiple health outcomes. Twenty-two women who underwent BPSO within 1 to 5 years of enrollment while premenopausal and not on hormone therapy were compared to 44 premenopausal women with intact ovaries and the same age distribution and 21 postmenopausal women with intact ovaries and not on hormone therapy. Multiple anthropometric measures were taken and % body fat assessed by DEXA scan. Linear regression was used to estimate differences in these measures between the three groups. Results: The mean ages were 47, 47, and 54 years in the BPSO, premenopausal and postmenopausal groups respectively. Parity, alcohol intake, smoking and race did not significantly differ between groups. Fewer BPSO women had ever used oral contraceptives (OCP) compared to the premenopausal group (p =0.05). The BPSO group had lower mean physical activity (p = 0.05) compared to the two other groups. BMI was increased in the BPSO group but was not statistically different across groups. However, mean waist and abdominal circumference and trunk % body fat were significantly higher among women who underwent BPSO compared to both groups. In multivariate analyses adjusting for age, physical activity, and OCP use, the average waist circumference was 7.92 cm (95% CI 1.46, 14.37) higher and 8.98 cm (95% CI 0.40, 17.46) higher in the BPSO group compared to the postmenopausal and premenopausal groups, respectively. A similar pattern was seen for abdominal circumference. Association with % body fat were not statistically significant. Conclusions: This pilot study suggests that increased central adiposity, is a sequelae of BPSO in young women. Longitudinal studies are needed to confirm results and evaluate the efficacy of interventions.

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Family history of breast and/or ovarian cancer (FHBOC) as an independent prognostic factor in triple negative breast cancer overall survival.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e12579 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e12579-e12579

Author(s):

Patricia Rioja ◽

Rossana Ruiz ◽

Zaida Morante ◽

Raul Mantilla ◽

Gabriel Antonio De la Cruz Ku ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Overall Survival ◽

Family History ◽

Prognostic Factor ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Independent Prognostic Factor ◽

Inheritance Pattern ◽

History Of

e12579 Background: Triple negative breast cancer (TNBC) seems to be associated with a hereditary disease cause based on the earlier age of onset, the high rate of TNBC cases with a positive family history of cancer, and the higher prevalence of breast cancer susceptibility genes. The impact of family history in breast and/or ovarian cancer (FHBOC) in TNBC overall survival is unclear, we conducted this study to evaluate this factor in a Peruvian cohort. Methods: Retrospectively reviewed the medical files from TNBC patients diagnosed at Instituto Nacional de Enfermedades Neoplásicas (INEN) in Lima, Peru, from 2000 to 2014. New cases with histologically confirmed TNBC defined as lack of expression of estrogen and progesterone receptors by immunohistochemistry and HER2- were included. A positive FHBOC was defined as a history of breast and/or ovarian cancer in 1st, 2nd and/or 3rd degree relatives at any age. Patients who had three affected relatives in two generations with two of them being first-degree relatives were considered as exhibiting a clinical autosomal dominant (AD) inheritance pattern. Results: 2006 patients, 99.8% were females. Mean age was 50.2 years old (19 - 95) and 54.6% were postmenopausal. According clinical staging: stage I, 7.2%; stage II, 34.2%; stage III, 51.0%; and stage IV, 6.5%. 76.5% of women underwent surgery. 13% (n=266) had a positive FHBOC. Of these, 44.0% (n=117), 35.0% (n=93), and 13.5% (n=36) had 1st, 2nd, and 3rd degree affected relatives, respectively. An AD inheritance pattern was observed in 20.7% (n=55) of patients with FHBOC. With a median follow-up of 80 months (range 0 - 249), 5y-overall survival (OS) for the whole population was 53.8%. 5 year-OS was significantly better in patients with FHBOC as compared to those without it; 64.5% vs. 52.2%, respectively (HR 0.73; 95% CI [0.60-0.88] p=0.001). FHBOC showed a positive impact on survival rates among patients with stages III and IV (5-year OS 42.3% vs. 32.7%; HR 0.79; 95% CI [0.64-0.99], p=0.041) but not in stages I and II (5-year OS 88.4% vs. 81.3%; HR 0.72; 95% CI [0.49-1.08], p=0.11). The 5y-OS for the patients with an AD inheritance pattern was 70.9%. However, pairwise multiple comparison did not find a significant difference between these patients and those with FHBOC without an AD inheritance pattern (62.8%). On multivariate analysis, FHBOC (HR: 0.80; 95% CI [0.66-0.97], p=0.023), had an independent effect on OS, adjusted for age, menopausal status, clinical stage and surgery. Conclusions: A positive FHBOC was associated with an improved survival in patients with TNBC, suggesting FHBOC as an independent prognostic factor. These results need validation and confirmation through additional retrospective cohorts and analysis in prospective clinical trials.

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