scholarly journals 0895. Identification and validation of a mirna as a diagnostic biomarker of diffuse alveolar damage in an animal model of acute lung injury and adult respiratory distress syndrome in mechanically ventilated patients

2014 ◽  
Vol 2 (Suppl 1) ◽  
pp. O21
Author(s):  
P Cardinal-Fernández ◽  
A Ferruelo ◽  
N Rego ◽  
Y Rojas ◽  
A Ballén-Barragán ◽  
...  
Keyword(s):  
Animal Model ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Diffuse Alveolar Damage ◽  
Diagnostic Biomarker ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Ventilated Patients

scholarly journals What Tidal Volumes Should Be Used in Patients without Acute Lung Injury?

2007 ◽  
Vol 106 (6) ◽  
pp. 1226-1231 ◽  
Author(s):  
Marcus J. Schultz ◽  
Jack J. Haitsma ◽  
Arthur S. Slutsky ◽  
Ognjen Gajic ◽  
David C. Warltier
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Distress Syndrome ◽  
Management Strategies ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
The Past ◽  
Ventilator Management ◽  
Ventilated Patients

Mechanical ventilation practice has changed over the past few decades, with tidal volumes (VT) decreasing significantly, especially in patients with acute lung injury (ALI). Patients without acute lung injury are still ventilated with large--and perhaps too large--VT. Studies of ventilator-associated lung injury in subjects without ALI demonstrate inconsistent results. Retrospective clinical studies, however, suggest that the use of large VT favors the development of lung injury in these patients. Side effects associated with the use of lower VT in patients with ALI seem to be minimal. Assuming that this will be the case in patients without ALI/acute respiratory distress syndrome too, the authors suggest that the use of lower VT should be considered in all mechanically ventilated patients whether they have ALI or not. Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI.

Practice of Excessive FIO2 and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury

2012 ◽  
Vol 57 (11) ◽  
pp. 1887-1893 ◽  
Author(s):  
Sonal Rachmale ◽  
Guangxi Li ◽  
Gregory Wilson ◽  
Michael Malinchoc ◽  
Ognjen Gajic
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Ventilated Patients
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