Implementation of daily goals in the ICU reduces length of ICU stay and errors of omission in patient care

Background.No information is available about the financial impact of central venous catheter (CVC)-associated bloodstream infection (BSI) in Mexico.Objective.To calculate the costs associated with BSI in intensive care units (ICUs) in Mexico City.Design.An 18-month (June 2002 through November 2003), prospective, nested case-control study of patients with and patients without BSI.Setting.Adult ICUs in 3 hospitals in Mexico City.Patients and Methods.A total of 55 patients with BSI (case patients) and 55 patients without BSI (control patients) were compared with respect to hospital, type of ICU, year of hospital admission, length of ICU stay, sex, age, and mean severity of illness score. Information about the length of ICU stay was obtained prospectively during daily rounds. The daily cost of ICU stay was provided by the finance department of each hospital. The cost of antibiotics prescribed for BSI was provided by the hospitals' pharmacy departments.Results.For case patients, the mean extra length of stay was 6.1 days, the mean extra cost of antibiotics was $598, the mean extra hospital cost was $11,591, and the attributable extra mortality was 20%.Conclusions.In this study, the duration of ICU stay for patients with central venous catheter-associated BSI was significantly longer than that for control patients, resulting in increased healthcare costs and a higher attributable mortality. These conclusions support the need to implement preventive measures for hospitalized patients with central venous catheters in Mexico.

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Clinical outcomes of gastroscopy in critically ill patients using high-dose proton pump inhibitor for suspected bleeding

10.21203/rs.3.rs-106503/v1 ◽

2020 ◽

Author(s):

Won Gun Kwack

Keyword(s):

Retrospective Study ◽

Proton Pump Inhibitor ◽

Proton Pump ◽

Hemoglobin Level ◽

High Dose ◽

Gi Bleeding ◽

Icu Mortality ◽

Icu Patients ◽

Icu Stay ◽

Length Of Icu Stay

Abstract Background: Gastroscopy is a useful procedure for gastrointestinal (GI) bleeding. No definite clinical guidelines recommend on the choice of gastroscopy implementation in the intensive care unit (ICU) patient with suspected GI bleeding. The objective of this retrospective study was to compare the clinical effectiveness of gastroscopy in critically ill patients using high-dose proton pump inhibitor for suspected bleeding.Methods: ICU patients using a high-does proton pump inhibitor for suspected GI bleeding from January 2015 to February 2020 were retrospectively included. Massive GI bleeding, such as hematemesis and hematochezia, were excluded. After propensity score matching (PSM) between the gastroscopy and no gastroscopy groups, the change in hemoglobin level, requirement of RBC transfusion, length of ICU stay, and ICU mortality were compared. Results: Of the 116 subjects included, 34 patients had gastroscopy during ICU stay. Among the gastroscopy group, 13 (38.2%) patients showed normal findings, and the most frequent abnormal finding was gastric ulcer (n = 9, 26.5%), and 12 patients (35.3%) had a hemostatic procedure. After PSM, the gastroscopy group needed more red blood cell transfusion than the no-gastroscopy group (P = 0.01). There was no significant difference in the change in hemoglobin level (P = 0.10), length of ICU stay (P = 0.64), and ICU mortality (P = 0.55).Conclusion: This retrospective study showed that gastroscopy had no definite clinical benefit in ICU patients using high-dose proton pump inhibitor for suspected GI bleeding.

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Beta-adrenergic receptor polymorphisms associated with length of ICU stay in pediatric status asthmaticus

Pediatric Pulmonology ◽

10.1002/ppul.21544 ◽

2011 ◽

Vol 47 (3) ◽

pp. 233-239 ◽

Cited By ~ 15

Author(s):

Christopher L. Carroll ◽

Kathleen A. Sala ◽

Aaron R. Zucker ◽

Craig M. Schramm

Keyword(s):

Adrenergic Receptor ◽

Status Asthmaticus ◽

Beta Adrenergic Receptor ◽

Beta Adrenergic ◽

Icu Stay ◽

Length Of Icu Stay

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Outcome Difference in Neurosurgical Patients Based on Timing of Tracheostomy and Ventilator Associated Pneumonia

Nepal Journal of Neuroscience ◽

10.3126/njn.v15i1.20022 ◽

2018 ◽

Vol 15 (1) ◽

pp. 19-22

Author(s):

Pratyush Shrestha ◽

Subash Lohani ◽

Sunita Shrestha ◽

Upendra P Devkota

Keyword(s):

Hospital Stay ◽

Tracheostomy Tube ◽

Length Of Hospital Stay ◽

Ventilator Associated Pneumonia ◽

Early Tracheostomy ◽

Icu Stay ◽

Neurosurgical Patients ◽

Significant Difference ◽

Length Of Icu Stay

Background and Objective: Tracheostomy in neurosurgical patients has been shown in various studies to lower the length of ICU stay and the length of hospital stay by decreasing the incidence of ventilator associated pneumonia. In this regard, we wanted to evaluate the outcome of neurosurgical ICU patients based on timing of tracheostomy and ventilator associated pneumonia.Methods: This is a retrospective single centre study performed over a period of two and a half years. Early tracheostomy was defi ned as those done three days of intubation or earlier and late as those done then after. Statistical analysis was done using SPSS.Results: There were 56 patients over the study period of which 18 patients underwent early tracheostomy and 38 patients underwent late tracheostomy. There was no statistically significant difference between the two groups with regards to the length of ICU stay, the length of hospital stay or the length of tracheostomy tube in situ. But based on tracheal aspirate culture positivity, length of tracheostomy tube in situ was signifi cantly longer in those with positive bacterial cultures.Early tracheostomy does not improve neurosurgical outcome while documented pneumonia prolongs the length of tracheostomy tube in situ.Nepal Journal of Neuroscience 15:19-22, 2018

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Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study

Critical Care ◽

10.1186/s13054-019-2681-5 ◽

2019 ◽

Vol 23 (1) ◽

Cited By ~ 3

Author(s):

Philippe Montravers ◽

Elie Kantor ◽

Jean-Michel Constantin ◽

Jean-Yves Lefrant ◽

Thomas Lescot ◽

...

Keyword(s):

Acute Pancreatitis ◽

Hospital Mortality ◽

Therapeutic Interventions ◽

Therapeutic Management ◽

Pulmonary Infections ◽

Prescribing Practices ◽

Icu Patients ◽

Icu Stay ◽

Large Heterogeneity ◽

Length Of Icu Stay

Abstract Background Recent international guidelines for acute pancreatitis (AP) recommend limiting anti-infective therapy (AIT) to cases of suspected necrotizing AP or nosocomial extrapancreatic infection. Limited data are available concerning empirical and documented AIT prescribing practices in patients admitted to the intensive care unit (ICU) for the management of AP. Methods Using a multicentre, retrospective (2009–2014), observational database of ICU patients admitted for AP, our primary objective was to assess the incidence of AIT prescribing practices during the first 30 days following admission. Secondary objectives were to assess the independent impact of centre characteristics on the incidence of AIT and to identify factors associated with crude hospital mortality in a logistic regression model. Results In this cohort of 860 patients, 359 (42%) received AIT on admission. Before day 30, 340/359 (95%) AIT patients and 226/501 (45%) AIT-free patients on admission received additional AIT, mainly for intra-abdominal and lung infections. A large heterogeneity was observed between centres in terms of the incidence of infections, therapeutic management including AIT and prognosis. Administration of AIT on admission or until day 30 was not associated with an increased mortality rate. Patients receiving AIT on admission had increased rates of complications (septic shock, intra-abdominal and pulmonary infections), therapeutic (surgical, percutaneous, endoscopic) interventions and increased length of ICU stay compared to AIT-free patients. Patients receiving delayed AIT after admission and until day 30 had increased rates of complications (respiratory distress syndrome, intra-abdominal and pulmonary infections), therapeutic interventions and increased length of ICU stay compared to those receiving AIT on admission. Risk factors for hospital mortality assessed on admission were age (adjusted odds ratio [95% confidence interval] 1.03 [1.02–1.05]; p < 0.0001), Balthazar score E (2.26 [1.43–3.56]; p < 0.0001), oliguria/anuria (2.18 [1.82–4.33]; p < 0.0001), vasoactive support (2.83 [1.73–4.62]; p < 0.0001) and mechanical ventilation (1.90 [1.15–3.14]; p = 0.011), but not AIT (0.63 [0.40–1.01]; p = 0.057). Conclusions High proportions of ICU patients admitted for AP receive AIT, both on admission and during their ICU stay. A large heterogeneity was observed between centres in terms of incidence of infections, AIT prescribing practices, therapeutic management and outcome. AIT reflects the initial severity and complications of AP, but is not a risk factor for death.

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Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Nutrients ◽

10.3390/nu11040708 ◽

2019 ◽

Vol 11 (4) ◽

pp. 708 ◽

Cited By ~ 53

Author(s):

Harri Hemilä ◽

Elizabeth Chalker

Keyword(s):

Mechanical Ventilation ◽

Length Of Stay ◽

Vitamin C ◽

Meta Analysis ◽

Kidney Injury ◽

Practical Significance ◽

Controlled Trials ◽

Elective Cardiac Surgery ◽

Icu Stay ◽

Length Of Icu Stay

A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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