A study investigating the effect over 12 weeks of the novel herbal composition SR2004 on haemoglobin A1c, fasting blood glucose and lipids in type 2 diabetic patients

2017 ◽  
Author(s):  
Dov Fogel
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Haemoglobin A1c ◽  
The Novel ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals STUDY OF RELATIONSHIP BETWEEN THE PROTEIN OXIDATION MARKERS AND ADIPOKINES IN OBESE TYPE 2 DIABETIC PATIENTS

2019 ◽  
pp. 204-209 ◽  
Author(s):  
SUKHPAL SINGH ◽  
AMITA MAHAJAN ◽  
JASPREET KAUR
Keyword(s):  
Blood Glucose ◽  
Protein Oxidation ◽  
Fasting Blood Glucose ◽  
Protein Carbonyl ◽  
Postprandial Blood Glucose ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objective: This study was done to explore the correlation if any, between obesity markers adiponectin, leptin, and protein oxidative stress (OS) status in obese with and without type 2 diabetic mellitus (T2DM) patients. Methods: In the present study, 30 healthy subjects, 30 obese non-diabetics, and 30 obese T2DM patients were enrolled. Protein OS parameters such as advanced oxidation of protein products (AOPPs) and protein carbonyl (PC) were estimated. Serum leptin, adiponectin, and insulin levels were measured by ELISA. Results: The AOPP, PC, leptin, leptin adiponectin ratio (LAR), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were significantly higher in obese non-diabetic and obese T2DM as compared to healthy control (p<0.001). However, serum adiponectin levels were significantly lower in obese non-diabetic and obese T2DM as compared to control (p<0.001). HOMA-IR and LAR both the index of IR were increased in obese non-diabetic and obese T2DM. Positive correlations were observed for AOPP with body mass index, PC in obese non-diabetic and with fasting blood glucose, postprandial blood glucose, HOMA-IR, and PC in obese T2DM. A negative correlation was found between PC and adiponectin in obese non-diabetic and obese T2DM. A significant inverse correlation was obtained between leptin and adiponectin in obese T2DM only. Conclusion: The present study suggested that increased protein OS, hyperinsulinemia, and hyperleptinemia may lead to hypoadiponectinemia in obese with and without T2DM. Moreover, determination of protein oxidation markers can be useful for monitoring the dysregulation of adipokines and glucose metabolism in obesity and T2DM.

scholarly journals Increased H2S synthesizing activity in plasma correlated to fasting blood glucose levels: A study in type 2 diabetes patients

2016 ◽  
Vol 7 (6) ◽  
pp. 6-10
Author(s):  
Pinaki Saha ◽  
Sayantan Dasgupta ◽  
Sukla Nath ◽  
Pradipta Ghosh ◽  
Santanu Sen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Small Sample ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Major Health Problem ◽  
Type 2 Diabetic ◽  
Diabetes Patients

Background: Diabetes mellitus is a major health problem not only in India but worldwide. Our country presently is undergoing an epidemic stage of this non-communicable disease.Though several etiological background of type 2 diabetes has been well explained, yet a number of recent literatures suggested a potential role H2S producing enzymes in the etiology and management of this metabolic disorder.Aims and Objectives: Our aim was to elucidate the relationship of H2S synthesizing activity in plasma and fasting blood glucose in type 2 diabetic patients. Materials and Methods: Sixty-two newly diagnosed type 2 diabetes patients and equal number of non-diabetic controls were included in the study. Enzymatic activity of synthesizing H2S in plasma was estimated following methods described earlier with further modification and standardization in our laboratory. All other parameters were estimated by using standardized kits.Results:  FBG, PPBG, HbA1C, Fasting Insulin,  H2S synthesizing activity in plasma in patients are significantly higher (p< 0.05) than the corresponding values in healthy controls H2S synthesizing activity in plasma is positively correlated with fasting plasma glucose and the correlations is significant(p=0.05).Conclusion: Our study though a pilot study with a small sample size, has elucidated that the values of H2S synthesizing activity in plasma are significantly elevated in type 2 diabetic patients and this may help researchers to develop H2S modifying agents and enzyme inhibitors which may open up new horizon in the treatment modalities of type 2 diabetes mellitus.Asian Journal of Medical Sciences Vol.7(6) 2016 6-10

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