ESPriT2 – a multicentre clinical trial to determine whether surgical removal of superficial peritoneal endometriosis improves pain symptoms and quality of life

2021 ◽  
Author(s):  
Ann Doust
2020 ◽  
Vol 1 (2) ◽  
pp. 29-34
Author(s):  
Mahnaz Ahangari ◽  
Amin Norouzi Fashkhami ◽  
Hamid Zinalpoor ◽  
Hamed Ahangari ◽  
Mohamad Reza Minator Sajjadi

Introduction: Today, increased degenerative disease of the knee, which reduces the efficiency of the activity and quality of life, is one of the most common causes of many population complaints. It is important to properly plan and carry out non-invasive and non-pharmacological therapies to treat the pain and its consequences.  The question of which of methods effectively relieves pain, improve function and efficiently increases life quality led to a comparison of two methods, interferential and ultra-reiz (Träbert) currents therapy. Methods: Randomized Block clinical trial carried out at Taleghani general hospital Shahid Beheshti University of Medical Sciences from November 2017 to February 2019. The study included 104 patients of both sexes, aged 38-74 years, with knee osteoarthritis. They were selected based on exclusion and inclusion criteria. The patients were randomly assigned to two groups: A and B.  Group A, n: 52 patients, were received ultra-reiz current, and group B, n: 52 patients, were subjected to interferential current. Parameters assessment were evaluated by the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire with 5 domains:  pain, symptoms, ADL, sports/recreational activity, and quality of life. Data were collected at the 1st session and at the end of treatment (at least three times a week). The obtained results were subject to statistical analysis. Results: Data were analyzed in SPSS software by using paired and two independent sample t-test. The mean scores before and after treatment with p-value range 0.002~0.764 showed that there were differences in pain, other symptoms, ADL, sport/recreational activity, and quality of life status between ultra-reiz and IFT groups, but the results were statistically more significant in the ultra-reiz group (p < 0.0001). Conclusions: Our study showed that ultra-reiz and IFT were effective for patients with knee OA, but ultra-reiz became a more effective modality than IFT in OA patients.


2021 ◽  
Author(s):  
Ying Cao ◽  
Juan Pei Wang ◽  
Yan Lu ◽  
Yue Chen ◽  
Si Chen ◽  
...  

Abstract Introduction Premature Ovarian Insufficiency (POI) seriously affects the quality of life, endocrine function, and fertility of women of childbearing age. Currently, Hormone replacement therapy for POI has some limitations, either with low efficacies or high side effects. Bushen Huoxue (BSHX) plays an important role in alleviating clinical symptoms and improving health status of POI patients. This placebo-controlled, randomised, double-blind, and multicentre clinical trial protocol aims to evaluate the effectiveness and safety of BSHX in women with POI.Methods and Design We plan to recruit 150 women with POI from four participating hospitals in China. Participants will be randomised in a 1:1 to receive oral BSHX or BSHX placebo. All participants will be treated for 3-month and will be followed up for another 3-month. The primary outcome is questionnaire scores based on the changes in the total symptoms, which is the Chinese version of the Menopause-Specific Quality of Life (CMS)1. The other measurements include serum sex hormone levels, anti-mullerian hormone (AMH) levels, ovarian peak systolic velocity (PSV; cm/s), and antral follicle count (AFC). In this study, the regulatory effects of traditional Chinese medicine on hormones was evaluated by the changes of serum sex hormone levels, which include serum estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). Ethics and dissemination This study was approved by the Research Ethics Committee of Jiangsu Province Hospital on Integration of Chinese and Western Medicine (2019LWKY014). All participants will provide written informed consent prior to randomization. The results of this research will be presented to academic conferences and peer-reviewed journals.Trial registration number ChiCTR1900028451.Registered 22 December 2019, www.chictr.org.


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