scholarly journals Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
H. Diao ◽  
A. R. Jiao ◽  
B. Yu ◽  
X. B. Mao ◽  
D. W. Chen
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Barrier Function ◽  
Weaned Piglets ◽  
Chain Fatty Acids

scholarly journals Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180190 ◽  
Author(s):  
Warren N. D’Souza ◽  
Jason Douangpanya ◽  
Sharon Mu ◽  
Peter Jaeckel ◽  
Ming Zhang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Immune Responses ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Barrier Function ◽  
Chain Fatty Acids

scholarly journals Neutral detergent fibre in piglet diets: performance and gastrointestinal implications

2016 ◽  
Vol 40 (2) ◽  
pp. 205-216 ◽  
Author(s):  
Rafael Carlos Nepomuceno ◽  
Pedro Henrique Watanabe ◽  
Ednardo Rodrigues Freitas ◽  
Luiz Euquerio de Carvalho ◽  
Emanuela Lima de Oliveira ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Transit Time ◽  
Gastrointestinal Transit ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Feed Conversion ◽  
Weaned Piglets ◽  
Quadratic Effect ◽  
Neutral Detergent Fibre ◽  
Chain Fatty Acids

ABSTRACT The intestinal health of piglets depends on the balance between diet, microflora and mucosal integrity. Disruption of this balance can compromise the digestive functions, leading to diarrhoeal frame and decline in performance of piglets. However, the level and type of fibre can limit digestive disorders. Thirty newly weaned piglets were used to evaluate the levels of neutral detergent fibre (NDF) in diets regarding performance, pH, viscosity and concentration of short chain fatty acids of digestive contents, gastrointestinal transit time, morphology of the intestinal mucosa, weights of organs and occurrence of diarrhoea. NDF level had quadratic effect on weight gain and feed conversion ratio of piglets, estimating best results at the level of 10.4%. NDF level had no effect on the pH, viscosity and concentration of short chain fatty acids. NDF levels below 10.2% or above 13.5% reduced the transit time of digesta. There was quadratic effect on villus height in the duodenum and jejunum and in the crypt depth of jejunum. There was linear increase in stomach, caecum and colon weights and linear decrease in the occurrence of diarrhoea according to increasing NDF levels. It is concluded that levels below 10.2% and above 13.5% reduce the transit time of digesta, whereas 12.2% NDF level results in better mucosa structure of the small intestinal, with an increase in the weights of the stomach, caecum and colon and a reduction in the occurrence of diarrhoea with increasing NDF level in diets, resulting in better performance of weaned piglets with 10.4% of NDF.

scholarly journals Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

2015 ◽  
Vol 17 (5) ◽  
pp. 662-671 ◽  
Author(s):  
Caleb J. Kelly ◽  
Leon Zheng ◽  
Eric L. Campbell ◽  
Bejan Saeedi ◽  
Carsten C. Scholz ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Epithelial ◽  
Chain Fatty Acids

Short-chain fatty acids promote jejunal barrier function and caecal muscle contractibility in laying hens ex vivo

2021 ◽  
Author(s):  
Fitra Yosi ◽  
Suchitra Sharma ◽  
Arife Sener-Aydemir ◽  
Simone Koger ◽  
Aji P. Baskara ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Laying Hens ◽  
Ex Vivo ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals Influenza infection impairs the gut’s barrier properties and favors secondary enteric bacterial infection through reduced production of short-chain fatty acids

2021 ◽  
Author(s):  
Valentin Sencio ◽  
Alexandre Gallerand ◽  
Marina Gomes Machado ◽  
Lucie Deruyter ◽  
Séverine Heumel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Influenza A ◽  
Influenza Infection ◽  
Intestinal Barrier ◽  
Barrier Properties ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

Along with respiratory tract disease per se , viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (IAV) infection to investigate the nature and outcome of the associated gut disorders. In IAV-infected mice, the signs of intestinal injury and inflammation, altered gene expression, and compromised intestinal barrier functions peaked on day 7 post-infection. As a likely result of bacterial component translocation, gene expression of inflammatory markers was upregulated in the liver. These changes occurred concomitantly with an alteration of the composition of the gut microbiota and with a decreased production of the fermentative, gut microbiota-derived, products short-chain fatty acids (SCFAs). Gut inflammation and barrier dysfunction during influenza were not attributed to reduced food consumption, which caused in part gut dysbiosis. Treatment of IAV-infected mice with SCFAs was associated with an enhancement of intestinal barrier properties, as assessed by a reduction in translocation of dextran and a decrease in inflammatory gene expression in the liver. Lastly, SCFA supplementation during influenza tended to reduce the translocation of the enteric pathogen Salmonella enterica serovar Typhimurium and to enhance the survival of doubly infected animals. Collectively, influenza infection can remotely impair the gut’s barrier properties and trigger secondary enteric infections. The latter phenomenon can be partially countered by SCFA supplementation.

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