scholarly journals Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
H. L. Byrne ◽  
G. Le Duc ◽  
F. Lux ◽  
O. Tillement ◽  
N. M. Holmes ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Radiation Treatment ◽  
Cine Mri ◽  
Clinical Workflow ◽  
Nanoparticle Uptake ◽  
Image Guided Radiotherapy ◽  
Preclinical Evaluation ◽  
Cine Mr ◽  
Mri Guided ◽  
Radiotherapy Treatment

Abstract Background The AGuIX® (NH TherAguix) nanoparticle has been developed to enhance radiotherapy treatment and provide strong MR contrast. These two properties have previously been investigated separately and progressed to clinical trial following a clinical workflow of separate MR imaging followed some time later by radiotherapy treatment. The recent development of MRI-linacs (combined Magnetic Resonance Imaging–linear accelerator systems enabling MRI-guided radiotherapy) opens up a new workflow where MR confirmation of nanoparticle uptake can be carried out at the time of treatment. A preclinical study was carried out to assess the suitability of a gadolinium-containing nanoparticle AGuIX® (NH TherAguix) for nano-enhanced image-guided radiotherapy on an MRI-linac. Methods Treatments were carried out on F344 Fischer rats bearing a 9L glioma brain tumour. Animals received either: (A) no treatment; (B) injection of nanoparticles followed by MRI; (C) radiotherapy with MRI; or (D) injection of nanoparticles followed by radiotherapy with MRI. Pre-clinical irradiations were carried out on the 1.0 T, 6 MV in-line Australian MRI-linac. Imaging used a custom head coil specially designed to minimise interference from the radiotherapy beam. Anaesthetised rats were not restrained during treatment but were monitored with a cine-MRI sequence. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) analysis was used to quantify residual gadolinium in the brain in normal and tumour tissue. Results A preclinical evaluation of nano-enhanced radiation treatment has been carried out on a 1.0 T MRI-linac, establishing a workflow on these novel systems. Extension of life when combining radiotherapy with nanoparticles was not statistically different from that for rats receiving radiotherapy only. However, there was no detrimental effect for animals receiving nanoparticles and radiation treatment in the magnetic field compared with control branches. Cine-MR imaging was sufficient to carry out monitoring of anaesthetised animals during treatment. AGuIX nanoparticles demonstrated good positive contrast on the MRI-linac system allowing confirmation of tumour extent and nanoparticle uptake at the time of treatment. Conclusions Novel nano-enhanced radiotherapy with gadolinium-containing nanoparticles is ideally suited for implementation on an MRI-linac, allowing a workflow with time-of-treatment imaging. Live irradiations using this treatment workflow, carried out for the first time at the Australian MRI-linac, confirm the safety and feasibility of performing MRI-guided radiotherapy with AGuIX® nanoparticles. Follow-up studies are needed to demonstrate on an MRI-linac the radiation enhancement effects previously shown with conventional radiotherapy.

scholarly journals System Integration and Preliminary Clinical Evaluation of a Robotic System for MRI-Guided Transperineal Prostate Biopsy

2019 ◽  
Vol 04 (02) ◽  
pp. 1950001 ◽  
Author(s):  
Niravkumar A. Patel ◽  
Gang Li ◽  
Weijian Shang ◽  
Marek Wartenberg ◽  
Tamas Heffter ◽  
...  
Keyword(s):  
Clinical Study ◽  
Prostate Biopsy ◽  
Modular Design ◽  
Surgical Navigation ◽  
Robotic System ◽  
Clinical Workflow ◽  
Preclinical Evaluation ◽  
Transperineal Prostate Biopsy ◽  
Patient Consent ◽  
Mri Guided

This paper presents the development, preclinical evaluation, and preliminary clinical study of a robotic system for targeted transperineal prostate biopsy under direct interventional magnetic resonance imaging (MRI) guidance. The clinically integrated robotic system is developed based on a modular design approach, comprised of surgical navigation application, robot control software, MRI robot controller hardware, and robotic needle placement manipulator. The system provides enabling technologies for MRI-guided procedures. It can be easily transported and setup for supporting the clinical workflow of interventional procedures, and the system is readily extensible and reconfigurable to other clinical applications. Preclinical evaluation of the system is performed with phantom studies in a 3 Tesla MRI scanner, rehearsing the proposed clinical workflow, and demonstrating an in-plane targeting error of 1.5[Formula: see text]mm. The robotic system has been approved by the institutional review board (IRB) for clinical trials. A preliminary clinical study is conducted with the patient consent, demonstrating the targeting errors at two biopsy target sites to be 4.0[Formula: see text]mm and 3.7[Formula: see text]mm, which is sufficient to target a clinically significant tumor foci. First-in-human trials to evaluate the system’s effectiveness and accuracy for MR image-guided prostate biopsy are underway.

MR Evaluation of Ventricular Function: True Fast Imaging with Steady-State Precession versus Fast Low-Angle Shot Cine MR Imaging: Feasibility Study

Radiology ◽  
2001 ◽  
Vol 219 (1) ◽  
pp. 264-269 ◽  
Author(s):  
Jörg Barkhausen ◽  
Stefan G. Ruehm ◽  
Mathias Goyen ◽  
Thomas Buck ◽  
Gerhard Laub ◽  
...  
Keyword(s):  
Steady State ◽  
Mr Imaging ◽  
Ventricular Function ◽  
Feasibility Study ◽  
Fast Imaging ◽  
Cine Mr ◽  
Steady State Precession

scholarly journals Multi-Ethnic Study of Atherosclerosis: Association between Left Atrial Function Using Tissue Tracking from Cine MR Imaging and Myocardial Fibrosis

Radiology ◽  
2014 ◽  
Vol 273 (3) ◽  
pp. 703-713 ◽  
Author(s):  
Masamichi Imai ◽  
Bharath Ambale Venkatesh ◽  
Sanaz Samiei ◽  
Sirisha Donekal ◽  
Mohammadali Habibi ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Myocardial Fibrosis ◽  
Left Atrial ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Ethnic Study ◽  
Cine Mr ◽  
Tissue Tracking

scholarly journals ACTIVE INVOLVEMENT OF RADIOLOGIST IN RADIATION ONCOLOGY PRACTICE

2021 ◽  
Vol 10 (4) ◽  
pp. 3199-3201
Author(s):  
Anurag A. Luharia
Keyword(s):  
Radiation Oncology ◽  
Normal Tissue ◽  
Radiation Treatment ◽  
Imaging Modality ◽  
Tumour Volume ◽  
Target Volume ◽  
Ct Images ◽  
Radiotherapy Planning ◽  
Internal Target Volume ◽  
Radiotherapy Treatment

Advancements in Radiation Oncology from conventional to 3D conformal radiotherapy treatment demands expertise in many steps of radiation planning, the horizon of radiologist is now expanded by many folds and made radiologist as a integral part of the Radiation Oncology Department. A critical aspect of radiotherapy treatment planning (RTP) is determining how to deliver the required radiation dosage to cancer cells while minimising the exposure to normal tissue for which the prerequisite is identification and accurate delineation of tumour volume as well as normal structure resulted in an increase in the therapeutic ratio by reducing complication associated with normal tissue and allowing for higher target dosage and better local control. In modern radiotherapy CT images are the standard set of imaging modality required for the radiotherapy planning along with it many other modalities like MRI, PET or DSA are used by superimposing on original CT images in order to contour or delineate the structures defined by International Commission on Radiation Units and Measurements in Reports 50, 62 and 71 (ICRU) for radiotherapy planning which comprise of Gross tumour volume, clinical target volume, planning target volume, irradiated volume, Internal target volume and the normal structures as Organ at risk. It is self-evident that the contribution of a radiologist with a thorough knowledge of the development of these new modalities is critical for optimising the potential of these novel modes of radiation treatment delivery.

Flow pattern analysis in the abdominal aorta with velocity-encoded cine MR imaging

1993 ◽  
Vol 3 (4) ◽  
pp. 617-623 ◽  
Author(s):  
Gerhard H. Mostbeck ◽  
Matthias C. Dulce ◽  
Gary R. Caputo ◽  
Evelyn Proctor ◽  
Charles B. Higgins
Keyword(s):  
Mr Imaging ◽  
Flow Pattern ◽  
Abdominal Aorta ◽  
Pattern Analysis ◽  
Cine Mr

scholarly journals 68Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model

2019 ◽  
Vol 3 (3) ◽  
pp. 255-265
Author(s):  
Heli Savolainen ◽  
Alessia Volpe ◽  
Alkystis Phinikaridou ◽  
Michael Douek ◽  
Gilbert Fruhwirth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Metastatic Breast ◽  
Lymph Node Biopsy ◽  
Cancer Model ◽  
Preclinical Evaluation ◽  
Node Biopsy ◽  
Breast Cancer Model ◽  
Mri Guided

scholarly journals Tumor motion in lung cancers: An overview of four-dimensional radiotherapy treatment of lung cancers

2017 ◽  
Vol 03 (02) ◽  
pp. 128-132
Author(s):  
Anusheel Munshi ◽  
Nilaxi Khataniar ◽  
Tharmar Ganesh
Keyword(s):  
Intensity Modulated Radiotherapy ◽  
Critical Question ◽  
Active Motion ◽  
Image Guided Radiotherapy ◽  
Lung Cancers ◽  
Image Guided ◽  
Intensity Modulated ◽  
A Site ◽  
Head Neck ◽  
Radiotherapy Treatment

AbstractMost modern radiotherapy centers have adopted contouring based treatment. Sparing of the normal structures has been made more achievable than ever before by use of technologies such as Intensity Modulated Radiotherapy (IMRT) and Image guided radiotherapy (IGRT). However, unlike, sites such as brain or head neck, thorax is a site in active motion, mostly contributed by patient's respiratory movement. 4 D radiotherapy, that addresses the issues of motion in thoracic tumours answers this critical question. The present article outlines the scope of need for 4 D radiotherapy and discusses the options available for 4 D treatments of cancer patients.

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