Prognoses of different pathological subtypes of colorectal cancer at different stages: A population-based retrospective cohort study

Abstract Background Whether the prognoses of different pathological subtypes of colorectal cancer (CRC) at different stages are distinct is unclear. Methods We extracted data on all cases of CRC from the Surveillance, Epidemiology, and End Results database between 2004 and 2015. The incidence of different pathological subtypes, clinical characteristics, and five-year overall survival (OS) and cause-specific survival (CSS) were analyzed. Results A total of 384,996 cases diagnosed as adenocarcinoma (AC), mucinous adenocarcinoma (MAC), and signet ring cell carcinoma (SRCC) were included in this analysis. Compared with AC, MAC and SRCC were more likely to reach T4, N2, M1, stages III and IV, and grades III and IV, and patients were generally of a younger age (P < 0.001). Compared with those with AC, patients with MAC and SRCC showed poorer OS (50.6 and 26.8% vs. 60.2%, P < .001), with corresponding HR values of 1.238 (95% CI, 1.213–1.263, P < .001) and 1.592 (95% CI, 1.558–1.627, P < .001), respectively. The MAC and SRCC groups also showed poorer overall CCS (60.9 and 32.5% vs. 67.8%, P < .001), with corresponding HR values of 1.271 (95% CI, 1.242–1.302, P < .001) and 1.724 (95% CI, 1.685–1.765, P < .001), respectively. Compared with patients with AC, those with MAC showed poor OS at every stage and poor CSS at every stage except stage II (P < .05), while patients with SRCC revealed poor OS and CSS at every stage except stage 0 (P < .05). Conclusions Patients of different pathological subtypes minimally differed at early stages. However, patients with AC have significantly better prognoses in advanced CRC (stages III and IV) than those with MAC or SRCC. Distinct treatment strategies should be applied depending on a particular histological subtype in advanced CRC.

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Prognostic nomograms for predicting overall survival and cause-specific survival of signet ring cell carcinoma in colorectal cancer patients

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i11.2503 ◽

2021 ◽

Vol 9 (11) ◽

pp. 2503-2518

Author(s):

Fu-Rong Kou ◽

Yang-Zi Zhang ◽

Wei-Ran Xu

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Cell Carcinoma ◽

Cancer Patients ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Signet Ring ◽

Ring Cell ◽

Colorectal Cancer Patients ◽

Cause Specific Survival

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A STUDY OF HISTOPATHOLOGICAL DISTRIBUTION IN COLORECTAL CANCER

10.36106/ijsr/0306321 ◽

2021 ◽

pp. 24-25

Author(s):

Shipra Singh ◽

Kailash Chand Jat ◽

Ajit Singh ◽

Kunal Purohit

Keyword(s):

Colorectal Cancer ◽

Surgical Techniques ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Lymph Node Status ◽

Sex Distribution ◽

Surgical Specimen ◽

Signet Ring ◽

Ring Cell ◽

Causes Of Deaths

Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.

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Colorectal Signet Ring Cell Carcinoma in a Young Pregnant Woman

Case Reports in Oncology ◽

10.1159/000504472 ◽

2020 ◽

Vol 13 (1) ◽

pp. 182-187

Author(s):

Francisco Ibargüengoitia Ochoa ◽

Gerardo Miranda Dévora ◽

Leonardo Silva Lino ◽

Cintia Sepulveda Rivera ◽

Diego González Vázquez ◽

...

Keyword(s):

Colorectal Cancer ◽

Cell Carcinoma ◽

Stage Iv ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

High Morbidity ◽

Cancer Stage ◽

Signet Ring ◽

Histologic Differentiation ◽

Ring Cell

Colorectal cancer during pregnancy is one of the less common neoplasms with an incidence of 0.8 in 100,000 pregnancies. Primary colonic signet ring cell carcinoma is a weird variety, characterized by a poor histologic differentiation, with a high morbidity-mortality rate. The case of a 24-year-old patient with a 22-week-old pregnancy and colorectal cancer stage IV in palliative state is presented, with a devastating result. Early diagnosis represents a challenge because of the presentation form and the histologic aggressiveness of this disease. We suggest that colorectal cancer during pregnancy must be treated by a multidisciplinary team.

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Preoperative radiotherapy improves survival in rectal signet-ring cell carcinoma-a population-based study

Radiation Oncology ◽

10.1186/s13014-017-0874-0 ◽

2017 ◽

Vol 12 (1) ◽

Cited By ~ 4

Author(s):

San-Gang Wu ◽

Wen-Wen Zhang ◽

Jia-Yuan Sun ◽

Zhen-Yu He ◽

Guo-Qiang Su ◽

...

Keyword(s):

Cell Carcinoma ◽

Preoperative Radiotherapy ◽

Population Based ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Population Based Study ◽

Signet Ring ◽

Ring Cell

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Trends in the Incidence and Survival Rates of Colorectal Signet-Ring Cell Carcinoma in the South Korean Population: Analysis of the Korea Central Cancer Registry Database

Journal of Clinical Medicine ◽

10.3390/jcm10184258 ◽

2021 ◽

Vol 10 (18) ◽

pp. 4258

Author(s):

Ji-Hoon Kim ◽

Hyunil Kim ◽

Jin Woo Kim ◽

Hee Man Kim

Keyword(s):

Colorectal Cancer ◽

Cell Carcinoma ◽

Cancer Registry ◽

Survival Rates ◽

Relative Survival ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Signet Ring ◽

Ring Cell ◽

Central Cancer Registry

Objective: Signet-ring cell carcinoma (SRCC) is a rare histopathological subtype of colorectal cancer (CRC) constituting approximately 1% of CRC cases. This study analyzed the incidence and survival rates of colorectal SRCC. Methods: We analyzed the incidence and survival rates of colorectal SRCCs based on patients’ data of the Korea Central Cancer Registry. Results: The age-standardized incidence rates of colon and rectum SRCC in 2017 were 0.17 and 0.07 individuals per 100,000, respectively. Between 1993 and 2017, the 1-, 2-, 3-, 4-, and 5-year relative survival rates of patients with colon SRCC were 65.6%, 49.0%, 38.9%, 34.9%, and 33.0%, respectively, while those of patients with rectum SRCC were 69.6%, 47.8%, 38.5%, 32.8%, and 29.4%, respectively. According to the Surveillance, Epidemiology, and End Results summary stages, the 5-year relative survival rates of colon SRCC between 1993 and 2017 were 70.4% for the localized stage, 41.0% for the regional stage, and 7.0% for the distant stage, while those for rectum SRCC were 60.7%, 34.4, and 3.3%, respectively. Conclusions: Although the incidence of colorectal SRCC is extremely low in South Korea, it has been increasing in recent decades. As the prognosis of colorectal SRCC is extremely poor; clinicians should be aware of the differential diagnosis of SRCC in colorectal cancer cases.

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Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

10.21203/rs.2.11558/v1 ◽

2019 ◽

Author(s):

Hui Sheng ◽

Xiaoli Wei ◽

Minjie Mao ◽

Jincan He ◽

Tianqi Luo ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Markers ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Seer Database ◽

Histologic Subtype ◽

Prognostic Relevance ◽

Signet Ring ◽

Study Population ◽

Ring Cell

Abstract Background: Though there have been studies investigating the clinicopathologic and prognostic relevance of mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) compared with classic adenocarcinoma (CA), little is known about the prognosis of adenocarcinoma with mixed subtypes (AM) and the differences among these four subtypes. Methods: The statistics of colorectal cancer registered in the Surveillance, Epidemiology and End Results (SEER) database were retrieved and analyzed. We also compared the clinicopathologic and prognostic relevance between CA, SRCC, MAC and AM. Results: The frequencies of these four subtypes were 69.9% (CA, n=15,812), 25.1% (MAC, n=5,689), 3.6% (SRCC, n=814) and 1.4% (AM, n=321). All of MAC, SRCC and AM were significantly related with aggressive features. Only SRCC and AM were independent poor prognostic markers for overall survival by multivariate analysis. The malignancy degree of AM was between MAC and SRCC according to the clinicopathologic associations. The prognosis of AM was significantly worse than MAC but comparable with SRCC. Conclusions: We confirmed the clinicopathologic relevance with aggressive features of MAC and SRCC, as well as the poor prognostic relevance of SRCC by analyzing a large study population. Furthermore, we identified AM as a rare but aggressive histologic subtype in colorectal cancer, which particular attention should be given in clinical practice.

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