scholarly journals The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Leonardo Ruiz-Casas ◽  
Jonathan Evans ◽  
Alison Rose ◽  
Gabriel Ghizzi Pedra ◽  
Alan Lobo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Medical Cost ◽  
Resource Use ◽  
Index Date ◽  
Public Involvement ◽  
Cross Sectional ◽  
Annual Total ◽  
Socioeconomic Burden

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine the socioeconomic burden of UC in adult patients in European countries in a real-world setting. Methods In this retrospective, cross-sectional and observational pan-European study, patients with moderate or severe UC were assigned to ARM 1 and patients who had moderate or severe UC but achieved mild or remission status 12 months before index date (or clinical consultation date), were assigned to ARM 2. Clinical and medical resource use data were collected via electronic case report forms, and data on non-medical and indirect costs, and health-related quality of life (HRQoL) were collected via patient and public involvement and engagement (PPIE) questionnaires. Per-patient annual total costs per ARM and per country were calculated using the collated resource use in the last 12 months (between the start of the documentation period and patient consultation or index date) and country specific unit costs. Quality of life was described by arm and by country. Results In the physician-reported eCRF population (n = 2966), the mean annual direct medical cost was €4065 in ARM 1 (n = 1835) and €2935 in ARM 2 (n = 1131). In the PPIE population (ARM 1, n = 1001; ARM 2, n = 647), mean annual direct cost was €4526 in ARM 1 and €3057 in ARM 2, mean annual direct non-medical cost was €1162 in ARM 1 and €1002 in ARM 2, mean annual indirect cost was €3098 in ARM 1 and €2309 ARM 2, and mean annual total cost was in €8787 in ARM 1 and €6368 in ARM 2. HRQoL scores showed moderate to high burden of UC in both groups. Conclusions The cost and HRQoL burden were high in patients in both ARM 1 and ARM 2 indicating unmet needs in the UC active population.

scholarly journals The LUCID Study: Living With Ulcerative Colitis; Identifying the Socioeconomic Burden in Europe

2020 ◽  
Author(s):  
Leonardo Ruiz Casas ◽  
Jonathan Evans ◽  
Alison Rose ◽  
Gabriel Ghizzi Pedra ◽  
Alan Lobo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Medical Cost ◽  
Resource Use ◽  
Index Date ◽  
Public Involvement ◽  
Treatment Strategies ◽  
Cross Sectional ◽  
Annual Total ◽  
Socioeconomic Burden

Abstract BackgroundUlcerative Colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine the socioeconomic burden of UC in adult patients in European countries in a real-world setting.MethodsIn this retrospective, cross-sectional and observational pan-European study, patients with moderate or severe UC were assigned to ARM 1 and patients who had moderate or severe UC but achieved mild or remission status 12 months before index date (or clinical consultation date), were assigned to ARM 2. Clinical and medical resource use data were collected via electronic case report forms (eCRFs), and data on non-medical and indirect costs, and health-related quality of life (HRQoL) were collected via patient and public involvement and engagement (PPIE) questionnaires. Per-patient annual total costs per ARM and per country were calculated using the collated resource use in the last 12 months (between the start of the documentation period and patient consultation or index date) and country specific unit costs. Quality of life and was described by arm and by country. ResultsIn the physician-reported eCRF population (n=2,966), the mean annual direct medical cost was 4,065 in ARM 1 (n=1,835) and €2,935 in ARM 2 (n=1,131). In the PPIE population (ARM 1, n=1,001; ARM 2, n=647), mean annual direct cost was €4,526 in ARM 1 and €3,057 in ARM 2, mean annual direct non-medical cost was €1,162 in ARM 1 and €1,002 in ARM 2, mean annual indirect cost was €3,098 in ARM 1 and €2,309 ARM 2, and mean annual total cost was in €8,787 in ARM 1 and €6,368 in ARM 2. HRQoL scores showed moderate to high burden of UC in both groups.ConclusionsThe cost and HRQoL burden were high in patients in both ARM 1 and ARM 2 indicating unmet needs in the UC active population.

P.07.26 QUALITY OF LIFE ASSESSMENT IN ULCERATIVE COLITIS OUTPATIENTS: A CROSS SECTIONAL STUDY

2018 ◽  
Vol 50 (2) ◽  
pp. e204
Author(s):  
C. Marinelli ◽  
F. Zingone ◽  
M. Inferrera ◽  
G. Lorenzon ◽  
A. Rigo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Cross Sectional Study ◽  
Life Assessment ◽  
Sectional Study ◽  
Quality Of Life Assessment ◽  
Cross Sectional

scholarly journals Disease status, patient quality of life and healthcare resource use for ulcerative colitis in the UK: an observational study

2014 ◽  
Vol 5 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Carolynne J Vaizey ◽  
Peter R Gibson ◽  
Christopher M Black ◽  
Rebecca J Nicholls ◽  
Adèle R Weston ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Observational Study ◽  
Resource Use ◽  
Healthcare Resource ◽  
Disease Status ◽  
Healthcare Resource Use ◽  
The Uk

Adherence, quality of life, health care resource use, and functional impairment among patients with oral multiple myeloma (MM) treatments.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e19519-e19519
Author(s):  
Brian Ung ◽  
Shaloo Gupta ◽  
Kejal Parikh ◽  
Ryan Liebert ◽  
Safiya Abouzaid ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Myeloma ◽  
Functional Impairment ◽  
Resource Use ◽  
Cross Sectional Survey ◽  
Or Education ◽  
Activity Impairment ◽  
Cross Sectional ◽  
Multivariable Analyses

e19519 Background: Few studies have assessed the relationship between adherence to prescribed therapies and patient (Pt)-reported outcomes (PRO) in Multiple Myeloma (MM). Pt-reported adherence and its association with quality of life (QoL), healthcare resource use (HRU) and functional impairment among pts on oral MM treatments were assessed. Methods: This was a cross-sectional survey of 118 US adult MM pts identified from the Light Speed Research panel, who were currently on a regimen which included an oral therapy. Pt’s experiences using the Morisky Medication Adherence Scale-4 (MMAS-4), the Work Productivity and Activity Impairment, and the Functional Assessment of Cancer Therapy (FACT)-MM were examined. Higher FACT-MM scores indicated better health-related QoL. Pts were characterized by their MMAS score; score =4 and score ≤3 (max score =4). Pts in each score grouping were summarized based on pt characteristics, treatment history, HRU and PROs. Multivariable analyses estimated the association between MMAS score group and study outcomes. Results: A total of 72 (61%) pts reported a MMAS score = 4 and 46 (39%) pts had a score ≤3. Pts with a score =4 were older (59.2 vs 50.7 years; p<0.001) and were on fewer treatments (1.42 vs 2.13; p<0.001) than with a score ≤3. No differences in race/ethnicity, marital status, income or education level were noted between the two groups. Pts with a score ≤3 had higher levels of absenteeism, impairment while at work (presenteeism), and overall work impairment in descriptive analysis, but only differences in activity impairment (56.5% vs. 39.8%; p=0.015) remained significant in the multivariable analyses. Pts with a score = 4 reported higher FACT-MM scores (106.9 vs 89.2; p<0.001) than pts with a score ≤3, a trend seen in all FACT-MM subscores. More pts with a score ≤3 also reported being overwhelmed or frustrated by having to reschedule MM appointments (64% vs. 26%; p=0.002). Conclusions: Among MM pts on oral treatments, high adherence is associated with improved QoL and a lower level of activity impairment. There may also be a relationship between frustration in managing MM related appointments and levels of adherence.

scholarly journals Quality of Life, Care Resource Use, and Costs of Dementia in 8 European Countries in a Cross-Sectional Cohort of the Actifcare Study

2018 ◽  
Vol 66 (3) ◽  
pp. 1027-1040 ◽  
Author(s):  
Ron L.H. Handels ◽  
Anders Sköldunger ◽  
Anja Bieber ◽  
Rhiannon Tudor Edwards ◽  
Manuel Gonçalves-Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Resource Use ◽  
European Countries ◽  
Life Care ◽  
Cross Sectional

scholarly journals Health-Related Quality of Life and Medical Resource Use in Patients with Osteoporosis and Depression: A Cross-Sectional Analysis from the National Health and Nutrition Examination Survey

2020 ◽  
Vol 17 (3) ◽  
pp. 1124 ◽  
Author(s):  
Shih-Feng Weng ◽  
Hui-Ru Hsu ◽  
Yao-Lin Weng ◽  
Kai-Jen Tien ◽  
Hao-Yun Kao
Keyword(s):  
Quality Of Life ◽  
Resource Use ◽  
Nutrition Examination Survey ◽  
Medical Resource ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Related Quality ◽  
Health Related

Background: Patients with either osteoporosis or depression are prone to develop other diseases and require more medical resources than do the general population. However, there are no studies on health-related quality of life (HRQoL) and medical resource use by osteoporosis patients with comorbid depression. We conducted this study for clarifying it. Methods: This cross-sectional study from 2005 to 2010 (6 years) analyzed 9776 National Health and Nutrition Examination Survey (NHANES) patients > 40 years old. Each patient was assigned to one of four groups: osteoporosis-positive(+) and depression-positive(+) (O+/D+); O+/D−; O−/D+; O−/D−. We used multivariate linear and logistic regression model to analyze the HRQoL and medical resource use between groups. Results: The O+/D+ group reported more unhealthy days of physical health, more unhealthy days of mental health, and more inactive days during a specified 30 days. The adjusted odds ratios (AORs) of O+/D+ patients who had poor general health (7.40, 95% CI = 4.80–11.40), who needed healthcare (3.25, 95% CI = 2.12–5.00), and who had been hospitalized overnight (2.71, 95% CI = 1.89–3.90) were significantly highest. Conclusions: Low HRQoL was significantly more prevalent in D+/O+ patients. We found that depression severity more significantly affected HRQoL than did osteoporosis. However, both diseases significantly increased the risk of high medical resource use.

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