scholarly journals Salivary flow rate and the risk of cognitive impairment among Korean elders: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Minh-Tung Do ◽  
Huong Vu ◽  
Jong-Koo Lee ◽  
Sang-Min Park ◽  
Joung-Sik Son ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Flow Rate ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Salivary Flow Rate ◽  
Multivariable Logistic Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Denture Status

Abstract Background Salivary function has been suggested to be associated with cognitive impairment. However, the effect of salivary flow rate (SFR) on cognitive impairment remains unclear. This study aimed to investigate whether SFR is associated with cognitive impairment among Korean elders. Methods This cross-sectional study included 649 elders aged 65 and older in the Korean community-dwelling population. Cognitive impairment was assessed using the Mini-Mental Status Examination. Unstimulated SFR was measured and dichotomized. Denture status, age, sex, education level, smoking, drinking, diabetes, hypertension, and obesity were considered confounders. Multivariable logistic regression analysis was applied to assess the adjusted association. Stratified analysis by sex and denture status was performed to clarify the effect modification. Results Participants without cognitive impairment showed a higher SFR level than those with cognitive impairment (0.81 mL/min for non-cognitive impairment versus 0.52 mL/min for cognitive impairment, p < 0.001). After controlling for confounders, participants with low SFR (< 0.3 mL/min) were more likely to have cognitive impairment by 1.5 times than participants with normal SFR (odds ratio [OR] = 1.5, confidence interval [CI] = 1.05–2.10). The association of low SFR with cognitive impairment was higher in women and dentate participants: about 10% higher in women (OR = 1.63, CI = 1.07–2.50) and about 22% higher in dentate participants (OR = 1.82, CI = 1.41–2.90). Conclusions Salivary flow rate is independently associated with cognitive impairment among Korean elders. The association was modified in females and dentate elders. Physicians and dentists should consider low SFR and cognitive impairment as a risk factor between them in clinics.

scholarly journals Salivary nitric oxide, Simplified Oral Hygiene Index, and salivary flow rate in smokers and non-smokers: a cross-sectional study

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1744
Author(s):  
Endang Winiati Bachtiar ◽  
Atikah Cyntia Putri ◽  
Boy Muchlis Bachtiar
Keyword(s):  
Nitric Oxide ◽  
Flow Rate ◽  
Oral Hygiene ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Sectional Study ◽  
Cross Sectional ◽  
Oxide Concentration ◽  
Nitric Oxide Concentration

Background: Salivary nitric oxide plays an important role as an antibacterial agent in the oral cavity. Here, we analyze salivary nitric oxide, Simplified Oral Hygiene Index (OHI-S) scores and the salivary flow rate in smokers and non-smokers which has not been done previously. Methods: A cross sectional study included 25 smokers and 25 non-smokers. Their OHI-S results were categorized as “good,” “medium,” or “bad.” Unstimulated saliva samples were collected, and their nitric oxide concentration was measured using the Griess method. Results: The salivary flow rate in smokers was lower, at 0.30 ml/minute, compared to non-smokers who had a salivary flow rate of 0.33 ml/minute. This was statistically insignificant. There was a significant difference in the concentrations of nitric oxide between smokers and non-smokers (p < 0.05). Smokers had higher concentrations than non-smokers (185.4 µM Vs 114.60 µM). In addition, there was a moderate positive correlation (r = 0.305) between the concentration of salivary nitric oxide level and the OHI-S results. Conclusions: It was concluded that salivary nitric oxide concentration was higher in smokers, and the oral hygiene condition of smokers was poor.

Normal variant, salivary flow rate, and taste sensitivity as oral health profile in the elderly community in Surabaya: A cross-sectional study

2020 ◽  
Vol 12 (6) ◽  
pp. 532
Author(s):  
AdiastutiE Parmadiati ◽  
NurinaF Ayuningtyas ◽  
Desiana Radithia ◽  
DiahS Ernawati ◽  
Saka Winias ◽  
...  
Keyword(s):  
Oral Health ◽  
Flow Rate ◽  
The Elderly ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Taste Sensitivity ◽  
Health Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association between genetic taste sensitivity, 2D:4D ratio, dental caries prevalence, and salivary flow rate in 6-14-year-old children: a cross-sectional study

2016 ◽  
Vol 10 (3) ◽  
pp. 142-147 ◽  
Author(s):  
Chintamaneni Raja Lakshmi ◽  
Doppalapudi Radhika ◽  
Mpv Prabhat ◽  
Sujana mulk Bhavana ◽  
Nallamilli Sai Madhavi
Keyword(s):  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Taste Sensitivity ◽  
Sectional Study ◽  
Caries Prevalence ◽  
Cross Sectional

scholarly journals Salivary nitric oxide, Simplified Oral Hygiene Index, and salivary flow rate in smokers and non-smokers: a cross-sectional study

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 1744
Author(s):  
Endang Winiati Bachtiar ◽  
Atikah Cyntia Putri ◽  
Boy Muchlis Bachtiar
Keyword(s):  
Nitric Oxide ◽  
Flow Rate ◽  
Oral Hygiene ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Sectional Study ◽  
Cross Sectional ◽  
Oxide Concentration ◽  
Nitric Oxide Concentration

Background: Salivary nitric oxide plays an important role as an antibacterial agent in the oral cavity. Here, we analyze salivary nitric oxide, Simplified Oral Hygiene Index (OHI-S) scores and the salivary flow rate in smokers and non-smokers which has not been done previously. Methods: A cross sectional study included 25 smokers and 25 non-smokers. Their OHI-S results were categorized as “good,” “medium,” or “bad.” Unstimulated saliva samples were collected, and their nitric oxide concentration was measured using the Griess method. Results: The salivary flow rate in smokers was lower, at 0.30 ml/minute, compared to non-smokers who had a salivary flow rate of 0.33 ml/minute. This was statistically insignificant. There was a significant difference in the concentrations of nitric oxide between smokers and non-smokers (p < 0.05). Smokers had higher concentrations than non-smokers (185.4 µM Vs 114.60 µM). In addition, there was a moderate positive correlation (r = 0.305) between the concentration of salivary nitric oxide level and the OHI-S results. Conclusions: It was concluded that salivary nitric oxide concentration was higher in smokers, and the oral hygiene condition of smokers was poor.

scholarly journals Relationships between functional fitness and cognitive impairment in Chinese community-dwelling older adults: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. e020695 ◽  
Author(s):  
Mei Yang ◽  
Yan Guo ◽  
Jie Gong ◽  
Mengyao Deng ◽  
Niannian Yang ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Functional Fitness ◽  
Sectional Study ◽  
Chinese Community ◽  
Cross Sectional ◽  
Community Dwelling Older Adults

scholarly journals Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate

2019 ◽  
Vol 52 (4) ◽  
pp. 197
Author(s):  
Irna Sufiawati ◽  
S. Suniti ◽  
Revi Nelonda ◽  
Rudi Wisaksana ◽  
Agnes Rengga Rendati ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Flow Rate ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Research Subjects ◽  
Aids Patients ◽  
Cross Sectional ◽  
Whole Saliva ◽  
Hiv Aids

Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox’s questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p<0.05), but not with gB-1. There was no significant relationship between xerostomia and SFR rates in the research subjects with HCMV positive saliva (p> 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.

scholarly journals Oral and systemic factors in xerostomia

2021 ◽  
Vol 69 ◽  
Author(s):  
Maria Sueli Marques SOARES ◽  
Raquel Lopes CAVALCANTI ◽  
Luiz Felipe Fernandes GONÇALVES ◽  
Ionária Oliveira de ASSIS
Keyword(s):  
Flow Rate ◽  
Systemic Disease ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Systemic Diseases ◽  
Chi Square ◽  
Cross Sectional ◽  
Salivary Ph ◽  
Oral Symptoms

ABSTRACT Objective: The aim of this study was to evaluate the relationship among the following features: hyposalivation, systemic diseases and drug use, oral symptoms, dental condition, salivary flow and salivary pH, as well. Methods: A cross-sectional study was performed with 50 participants diagnosed with xerostomia, randomly selected and distributed in two groups: 25 with hyposalivation and 25 without hyposalivation, paired in age and sex. Unstimulated Salivary Flow Rate (USFR), Decayed, Missing, Filled, Teeth (DMFT) index and salivary pH were determined. The Mann-Whitney test and chi-square test were applied, considering significant for p-values <0.05. Results: Among the participants with hyposalivation, 88% used drugs and 96% presented systemic disease. And among those without hyposalivation, 48% used drugs and 64% presented systemic disease. The ones with hyposalivation showed the highest levels of dysgeusia (60%) and burn mouth (36%). There were statistically significant differences for the medians of USFR (0.08ml/minute / 0.2ml/minute) (p = 0.000), pH (6/7) (p = 0.000) and DMFT (22/17) (p = 0.004) obtained from participants with hyposalivation and without hyposalivation, respectively. Only in the group with hyposalivation there was a statistically significant association of unstimulated salivary flow rate with age (p = 0.035), type of systemic disease (p = 0.049) and pH (p=0.032) and DMFT demonstrated an association with systemic diseases (p = 0.015). Conclusion: The research results have suggested that hyposalivation worsens dental status triggering oral symptoms, and that salivary flow is influenced by the type of systemic disease and age group.

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