Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study

Abstract Background The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction. Methods We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n = 161) or hyperthyroidism (n = 15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay. Results Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR = 0.66; 95% CI: 0.33–1.31; P = 0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR = 0.12; 95% CI: 0.01–0.93; P = 0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P = 0.003). Conclusions Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.

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Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study

10.21203/rs.2.10023/v1 ◽

2019 ◽

Author(s):

Cosme Alvarado-Esqu ◽

Agar Ramos-Nevarez ◽

Carlos Alberto Guido-Arreola ◽

Sandra Margarita Cerrillo-Soto ◽

Alma Rosa Pérez-Álamos ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Matched Control ◽

Case Control ◽

Negative Association ◽

Control Group ◽

Igg Antibodies ◽

Age And Gender ◽

Matched Control Group ◽

And Gender ◽

Toxoplasma Gondii Infection

Abstract Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction. Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism or hyperthyroidism and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay. Results: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR=0.66; 95% CI: 0.33-1.31; P=0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (1/83: 1.2% vs 23/257: 8.6%; OR=0.12; 95% CI: 0.01-0.93; P=0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P=0.003). Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.

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Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study

10.21203/rs.2.10023/v3 ◽

2019 ◽

Author(s):

Cosme Alvarado-Esqu ◽

Agar Ramos-Nevarez ◽

Carlos Alberto Guido-Arreola ◽

Sandra Margarita Cerrillo-Soto ◽

Alma Rosa Pérez-Álamos ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Matched Control ◽

Case Control ◽

Negative Association ◽

Control Group ◽

Igg Antibodies ◽

Age And Gender ◽

Matched Control Group ◽

And Gender ◽

Toxoplasma Gondii Infection

Abstract Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction. Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n=161) or hyperthyroidism (n=15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti- Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay. Results: Anti- T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR=0.66; 95% CI: 0.33-1.31; P =0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR=0.12; 95% CI: 0.01-0.93; P =0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P =0.003). Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.

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Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study

10.21203/rs.2.10023/v4 ◽

2019 ◽

Author(s):

Cosme Alvarado-Esqu ◽

Agar Ramos-Nevarez ◽

Carlos Alberto Guido-Arreola ◽

Sandra Margarita Cerrillo-Soto ◽

Alma Rosa Pérez-Álamos ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Matched Control ◽

Case Control ◽

Negative Association ◽

Control Group ◽

Igg Antibodies ◽

Age And Gender ◽

Matched Control Group ◽

And Gender ◽

Toxoplasma Gondii Infection

Abstract Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction. Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n=161) or hyperthyroidism (n=15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti- Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay. Results: Anti- T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR=0.66; 95% CI: 0.33-1.31; P =0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR=0.12; 95% CI: 0.01-0.93; P =0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P =0.003). Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.

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Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study

10.21203/rs.2.10023/v2 ◽

2019 ◽

Author(s):

Cosme Alvarado-Esqu ◽

Agar Ramos-Nevarez ◽

Carlos Alberto Guido-Arreola ◽

Sandra Margarita Cerrillo-Soto ◽

Alma Rosa Pérez-Álamos ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Matched Control ◽

Case Control ◽

Negative Association ◽

Control Group ◽

Igg Antibodies ◽

Age And Gender ◽

Matched Control Group ◽

And Gender ◽

Toxoplasma Gondii Infection

Abstract Background: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction. Methods: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n=161) or hyperthyroidism (n=15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay. Results: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR=0.66; 95% CI: 0.33-1.31; P=0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR=0.12; 95% CI: 0.01-0.93; P=0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P=0.003). Conclusions: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.

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Age and Gender Differences in Left Ventricular Function among Patients with Stable Angina and a Matched Control Group

Cardiology ◽

10.1159/000177107 ◽

1996 ◽

Vol 87 (4) ◽

pp. 287-293 ◽

Cited By ~ 6

Author(s):

Sven V. Eriksson ◽

Inge Björkander ◽

Claes Held ◽

Paul Hjemdahl ◽

Lennart Forslund ◽

...

Keyword(s):

Gender Differences ◽

Left Ventricular Function ◽

Stable Angina ◽

Matched Control ◽

Left Ventricular ◽

Control Group ◽

Age And Gender ◽

Matched Control Group ◽

Age And Gender Differences ◽

And Gender

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Echocardiographic Findings in Patients with Atrial Septal Aneurysm: A Prospective Case-Control Study

Cardiology Research and Practice ◽

10.1155/2019/3215765 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Ramazan Atak ◽

Mehmet Ileri ◽

Selcuk Ozturk ◽

Ahmet Korkmaz ◽

Ertan Yetkin

Keyword(s):

Mitral Valve ◽

Matched Control ◽

Mitral Valve Regurgitation ◽

Congenital Deformity ◽

Control Group ◽

Atrial Septal Aneurysm ◽

Valve Regurgitation ◽

Age And Gender ◽

Matched Control Group ◽

And Gender

Background. Atrial septal aneurysm (ASA) is a congenital deformity of the interatrial septum with a prevalence of 1-2% in the adult population. Although ASA has been supposed to be an incidental finding in echocardiographic examination, its structural and clinical associations have gained an increasing interest. Aim. To investigate and compare the clinical features and echocardiographic parameters between ASA patients and age- and gender-matched control group patients. Methods. 410 patients with ASA were enrolled in the study, prospectively. After the exclusion of 33 patients, the remaining 377 patients comprised the study group. The control group consisted of 377 age- and gender-matched patients without ASA. Results. Aortic valve regurgitation and mitral valve regurgitation were more often observed in patients with ASA, and percentages of patients with ascending aortic aneurysm (AAA), patent foramen ovale (PFO), and atrial septal defect (ASD) were higher in ASA patients compared to control group patients. Aortic root diameter was larger in ASA patients compared to control group patients (29.2 ± 3.9, 28.6 ± 3.1, p=0.05, respectively). Ascending aorta diameter was higher in ASA patients compared to patients without ASA (44 ± 0.3, 41.5 ± 0.2, p=0.02). Logistic regression analysis revealed that mitral valve regurgitation (OR: 2.05, 95% CI : 1.44–2.92, p<0.001) and PFO (OR: 11.62, 95% CI : 2.64–51.02, p=0.001) were positively and independently associated with the presence of ASA. AAA tended to be statistically and independently associated with ASA (OR: 2.69, 95% CI : 0.97–7.47, p=0.05). Conclusions. We have demonstrated a higher incidence of mitral/aortic valvular regurgitations, AAA, PFO, and ASD in ASA patients compared to age- and gender-matched control group patients. In addition, we have shown that ASA is significantly and positively associated with mild mitral regurgitation and PFO.

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Fourier-Based Footfall Placement Variability in Parkinson’s Disease

BioMed Research International ◽

10.1155/2019/2689609 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Sunghoon Shin ◽

Bee-oh Lim ◽

Michael J. Socie ◽

Jacob J. Sosonff ◽

Ki-Kwang Lee

Keyword(s):

Matched Control ◽

Center Of Pressure ◽

Control Group ◽

Contributing Factors ◽

Age And Gender ◽

Matched Control Group ◽

Average Performance ◽

Targeted Interventions ◽

Yahr Scale ◽

And Gender

The current investigation examined whether Parkinson’s patients (PD) have greater Fourier-based footfall placement gait with the greatest mobility dysfunction variability (FPV) than the age and gender matched control group and that variability would be the greatest in the PD participants with the greatest mobility dysfunction indexed Hoehn/Yahr scale. 35 persons undergoing PD and 30 age-matched controls participated in this investigation. Participants repeated two trials’ normal walking and average and variability parameters of gait were measured using a 3.66 m electronic walkway. FPV was quantified as a change in the center of pressure during gait. Persons with PD were divided into two groups based on Hoehn/Yahr scale. Overall, persons with PD had smaller average performance indexed by mean and greater gait variability than controls as indexed by CV and Fourier-based variability (p’s<0.05). Moreover, PD with higher mobility dysfunction had not only greater variability in traditional parameters but also greater Fourier-based variability than nonfallers with MS (p<.001) with higher effect size (η2=0.37 vs.0.18-0.29). These observations highlight the fact that footfall placement variability is related to mobility dysfunction in PD. Further study is necessary to determine contributing factors to an increased FPV and whether targeted interventions such as exercise can reduce FPV.

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