scholarly journals Analysis of vascularization in thyroid gland nodes with superb microvascular imaging (SMI) and CD34 expression histology: a pilot study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Thomas Studeny ◽  
Wolfgang Kratzer ◽  
Julian Schmidberger ◽  
Tilmann Graeter ◽  
Thomas F. E. Barth ◽  
...  
Keyword(s):  
Image Analysis ◽  
Thyroid Gland ◽  
Follicular Carcinoma ◽  
Diagnostic Value ◽  
Malignant Tumours ◽  
Tissue Slices ◽  
Computational Evaluation ◽  
Superb Microvascular Imaging ◽  
Microvascular Imaging ◽  
Cd34 Expression

Abstract Background The Doppler sonography technique known as "superb microvascular imaging" (SMI) is advancing sonographic micro vascularization imaging in various disciplines. In this study, we aimed to determine whether SMI could reliably reproduce the blood flow in thyroid nodes and whether malignancy could be diagnosed, based on vascularization properties. Immunhistochemical staining by CD34 and SMI where used to determine the vascularization of nodes in terms of quantified vascularization parameters gained by computational evaluation. Methods We used image analysis programs to investigate whether the quantitative value for vascularization strength in the thyroid node, measured with SMI, was correlated with the actual degree of vascularization, determined microscopically. We included 16 patients that underwent thyroid resections. We prepared thyroid gland tissue slices for immunohistochemistry and labelled endothelial cells with CD34 to visualize blood vessels microscopically. We used image analysis programs, ImageJ, to quantify SMI Doppler sonographic measurements and CellProfiler to quantify CD34 expression in histological sections. We evaluated the numeric values for diagnostic value in node differentiation. Furthermore, we compared these values to check for correlations. Results Among the 16 nodes studied, three harboured malignant tumours (18.75%): two papillary and one follicular carcinoma. Among the 13 benign lesions (81.25%), four harboured follicular adenomas. Malignant and benign nodes were not significantly different in sonographic (0.88 ± 0.89 vs. 1.13 ± 0.19; p = 0.2790) or immunohistochemical measurements of vascularization strength (0.05 ± 0.05 vs. 0.08 ± 0.06; p = 0.2260). Conclusion We found a positive, significant correlation (r = 0.55588; p = 0.0254) between SMI (quantitative values for vascularization strength) and immunohistochemistry (CD34 staining) evaluations of thyroid nodes.

scholarly journals Diagnostic Value of Superb Microvascular Imaging in Parotid Tumors

2020 ◽  
Vol 26 ◽  
Author(s):  
Lihui Zhao ◽  
Jie Mu ◽  
Yiran Mao ◽  
Xiaojie Xin
Keyword(s):  
Diagnostic Value ◽  
Parotid Tumors ◽  
Superb Microvascular Imaging ◽  
Microvascular Imaging

Comparing the Diagnostic Value of Superb Microvascular Imaging With Color and Power Doppler in Primary and Secondary Liver Tumors

2021 ◽  
Vol 1 (2) ◽  
pp. 26-31
Author(s):  
Muhammad O. Awiwi ◽  
◽  
Omer Bagcilar ◽  
Migena Gjoni ◽  
Serkan Akbas ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Power Doppler ◽  
Diagnostic Value ◽  
Superb Microvascular Imaging ◽  
Microvascular Imaging ◽  
Color And Power Doppler

scholarly journals Evaluation of parenchymal vascularity of the thyroid gland with vascularization index by color superb microvascular imaging in patients with Graves’ disease

2021 ◽  
Vol 21 (84) ◽  
pp. e41-e47
Author(s):  
Abidin Kılınçer ◽  
◽  
Mehmet Sedat Durmaz ◽  
Cem Onur Kıraç ◽  
Süleyman Baldane ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Region Of Interest ◽  
Clinical Findings ◽  
Graves Disease ◽  
Asymptomatic Group ◽  
Free Region ◽  
Superb Microvascular Imaging ◽  
Index Value ◽  
Microvascular Imaging ◽  
Vascularization Index

Aim of the study: To determine the parenchymal vascularity of the thyroid gland with color superb microvascular imaging in patients with Graves’ disease, and compare the vascularization index values with healthy subjects. Materials and methods: The thyroid glands of 37 patients whose laboratory and clinical findings were consistent with Graves’ disease, and 40 asymptomatic subjects with normal laboratory values, were examined using color superb microvascular imaging. Measurements of the vascularization index were performed with a free region of interest which was drawn along the outer margin of the gland on the color superb microvascular imaging mode. The vascularization index values obtained in the Graves’ disease and control groups were compared. A correlation analysis was performed between the vascularization index values and laboratory and grayscale US parameters. Results: The median vascularization index value of the thyroid parenchyma in patients with Graves’ disease was significantly higher than in the asymptomatic group [median (min–max); 12 (2.3–32.1) vs 5.04 (1.1–10.8), p <0.001]. When the cutoff value of the vascularization index is determined as 6.3, Graves’ disease can be diagnosed with 83.8% sensitivity and 70% specificity. Conclusions: The vascularization index obtained with color superb microvascular imaging can be a quantitative indicator of parenchymal vascularity in the diagnosis of Graves’ disease, and serve as a supportive tool.

scholarly journals Assessment of thyroid gland vascularity with superb microvascular imaging in healthy children and its relationship with potential factors

2020 ◽  
Vol 33 (9) ◽  
pp. 1139-1145
Author(s):  
Mehmet Ozturk ◽  
Mehmet Sedat Durmaz ◽  
Fatih Ateş ◽  
Turgay Kara ◽  
Funda Gökgöz Durmaz ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Age Groups ◽  
Thyroid Stimulating Hormone ◽  
Left Lobe ◽  
Healthy Children ◽  
Significant Difference ◽  
Superb Microvascular Imaging ◽  
Potential Factors ◽  
The Right ◽  
Microvascular Imaging

AbstractObjectivesTo define thyroid gland vascularity index (VI) values in healthy children with the superb microvascular imaging (SMI) method and to assess whether or not there is a correlation with potential factors that may affect these values.MethodsThis prospective study included a total of 138 children, their ages varying from 3–17 years. Cases were divided into three subgroups according to age: 3–6, 7–12 and 13–17 years. Gender, age, height, weight, body mass index (BMI), thyroid-stimulating hormone (TSH) and free thyroxine (fT4) values were recorded. Volume and SMI measurements were performed with a 14 L5 mHz linear transducer. VI measurements were performed in the transverse and longitudinal planes and correlation with basic descriptive data was researched.ResultsMean age was 11.14 ± 3.34 years and BMI was 19.95 ± 4.92. VI values were 4.59 ± 2.34 in the right lobe and 4.23 ± 2.73 for the left lobe, with no significant difference identified. There were no significant differences in mean VI for all parenchyma regarding gender and age groups. While there was no correlation identified with mean VI for all parenchyma with TSH and fT4, there was, however, a negative correlation with BMI.ConclusionsReference VI values for normal thyroid glands in healthy children and adolescents were defined with the SMI method. There was no correlation between the VI values and age, gender, volume, TSH and fT4 values, while there was a negative significant correlation with BMI.

Positron emission mammography in the diagnosis of breast cancer

2016 ◽  
Vol 55 (01) ◽  
pp. 15-20 ◽  
Author(s):  
J. Farahati ◽  
A. G. Müller ◽  
E. Gillman ◽  
M. Hentschel ◽  
F. H. H. Müller
Keyword(s):  
Breast Cancer ◽  
High Specificity ◽  
Diagnostic Value ◽  
Glandular Tissue ◽  
Breast Cancer Patients ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Interventional Study ◽  
Positron Emission Mammography ◽  
Positron Emission

SummaryAim: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). Patients, methods: In a singlesite, non-interventional study, 108 patients (107 women, 1 man) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq 18F-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, tumours (PUVmaxtumour), benign lesions (PUVmaxnormal breast) and also in healthy tissues on the contralateral side (PUVmaxcontralateral breast). These values were compared and contrasted. In addition, the ratios of PUVmaxtumour / PUVmaxcontralateral breast and PUVmaxnormal breast / PUVmaxcontralateral breast were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected carcinoma. Results: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the patient cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78 ± 2.47 was identified in malignant tumours, while a mean PUVmaxnormal breast of 1.17 ± 0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between tumour and healthy glandular tissue in breast cancer patients (3.15 ± 1.58) was found to be significantly higher than the ratio for benign lesions (1.17 ± 0.41, p < 0.001). Conclusion: PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.

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