scholarly journals Assessment of cognitive functions in patients with multiple sclerosis applying the normative values of the Rao’s brief repeatable battery in the Portuguese population

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Claudia Sousa ◽  
◽  
Mariana Rigueiro-Neves ◽  
Ana Margarida Passos ◽  
Aristides Ferreira ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Neuropsychological Assessment ◽  
Clinical Sample ◽  
Geographic Location ◽  
Clinical Population ◽  
Normative Values ◽  
Portuguese Population ◽  
Good Ability ◽  
Repeatable Battery

Abstract Background The Brief Repeatable Battery of Neuropsychological Tests (BRBN-T) is one of the most sensitive and used measures for detecting cognitive impairment in Multiple Sclerosis (MS). Objective The aim of this study was to adapt and validate this battery to the Portuguese population of MS patients. Methods The Portuguese version of the BRBN-T was applied to a stratified control national sample of 326 individuals considering sex, age, educational level and geographic location and also a clinical sample of 115 MS patients from several national hospitals. Through the exploration of its psychometrics properties, the Portuguese BRBN-T norms were produced. Results The normative data is presented as a regression-based formula to adjust test scores for gender, education and age, and the results reveal the BRBN-T has the ability to differentiate between MS patients and healthy participant’s cognitive performance. Conclusion This study demonstrated in our clinical population a good ability to detect cognitive impairment. Its clearly contributed to reinforcing the neuropsychological assessment in Portugal in patients with MS, by providing a new set of instruments, which can be used in the clinical practice, and in future studies. Moreover, it will allow a rigorous and precise support in relation to neuropsychological assessment for future longitudinal studies and clinical trials.

scholarly journals Evaluation of the effects of group psychotherapy on cognitive function in patients with multiple sclerosis with cognitive dysfunction and depression

2015 ◽  
Vol 73 (2) ◽  
pp. 90-95 ◽  
Author(s):  
Emine Bilgi ◽  
Hasan Hüseyin Özdemir ◽  
Ayhan Bingol ◽  
Serpil Bulut
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Group Psychotherapy ◽  
Cognitive Dysfunction ◽  
Beck Depression Inventory ◽  
Neuropsychological Tests ◽  
Depression Severity ◽  
Group Members ◽  
Repeatable Battery

Objective This study will evaluate how decreasing depression severity via group psychotherapy affects the cognitive function of patients with multiple sclerosis (MS) who are also diagnosed with depression and cognitive dysfunction. Method MS patients completed the Brief Repeatable Battery of Neuropsychological Tests and Beck Depression Inventory (BDI). The group members diagnosed with depression and cognitive dysfunction underwent group psychotherapy for 3 months. Upon completion of psychotherapy, both tests were readministered. Results Depression and cognitive dysfunction were comorbid in 15 (13.9%) of patients. Although improvement was detected at the end of the 3-month group psychotherapy intervention, it was limited to the BDI and the Paced Auditory Test. Conclusion Group psychotherapy might decrease cognitive impairment in MS patients.

scholarly journals Short Report: Prevalence of Cognitive Impairment in Newly Diagnosed Relapsing-Remitting Multiple Sclerosis

2018 ◽  
Vol 20 (4) ◽  
pp. 153-157 ◽  
Author(s):  
Giulia DiGiuseppe ◽  
Mervin Blair ◽  
Sarah A. Morrow
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Processing Speed ◽  
Clinical Population ◽  
Clinical Event ◽  
Routine Practice ◽  
Short Report ◽  
Newly Diagnosed ◽  
Mood Symptoms ◽  
Relapsing Remitting

Abstract Background: Cognitive impairment is common in multiple sclerosis (MS) and can manifest early in the disease process, sometimes as early as the first demyelinating event. However, the frequency of cognitive impairment in a newly diagnosed MS population has not been evaluated comprehensively in a clinical population. We sought to examine the prevalence of cognitive impairment in relapsing-remitting MS (RRMS) within a year of diagnosis in a clinic where cognitive testing at diagnosis is part of routine practice. Methods: A retrospective medical record review of persons with RRMS assessed in a cognitive MS clinic identified 107 patients assessed by the Minimal Assessment of Cognitive Function in Multiple Sclerosis battery within 1 year of a confirmed RRMS diagnosis. Results: The cohort was predominantly female (n = 82 [76.6%]) and white (n = 93 [86.9%]). Only 36 patients (33.6%) were diagnosed as having RRMS based on a second clinical event. Processing speed was the most frequently impaired domain (n = 38 [35.5%]). Only 37 patients (34.6%) were within normal limits on all cognitive domains. Regarding mood symptoms, 25 patients (23.4%) were positive for depressive symptoms; 59 (55.1%), for anxiety. Severe fatigue was correlated with a lower score on the Symbol Digit Modalities Test (SDMT) (r = −0.380, P < .001), and higher depressive scores were correlated with lower performance on the SDMT (r = −0.397, P < .001) and the Paced Auditory Serial Addition Test (r = −0.254, P = .009). Conclusions: Cognitive impairment, specifically processing speed, and mood symptoms are frequently present in persons with newly diagnosed RRMS.

A short version of Rao's Brief Repeatable Battery as a screening tool for cognitive impairment in multiple sclerosis

2009 ◽  
Vol 23 (2) ◽  
pp. 268-275 ◽  
Author(s):  
E. Portaccio ◽  
B. Goretti ◽  
V. Zipoli ◽  
G. Siracusa ◽  
S. Sorbi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Screening Tool ◽  
Short Version ◽  
Repeatable Battery

The Brief Repeatable Battery of Neuropsychological Tests: normative values allow application in multiple sclerosis clinical practice

2001 ◽  
Vol 7 (4) ◽  
pp. 263-267 ◽  
Author(s):  
J.B. Boringa ◽  
R.H.C. Lazeron ◽  
I.E.W. Reuling ◽  
H.J. Adèr ◽  
L.E.M.A. Pfennings ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Neuropsychological Tests ◽  
Normative Values ◽  
Repeatable Battery

The Brief Repeatable Battery of Neuropsychological Tests: normative values allow application in multiple sclerosis clinical practice

2001 ◽  
Vol 7 (4) ◽  
pp. 263-267 ◽  
Author(s):  
J B Boringa ◽  
R HC Lazeron ◽  
I EW Reuling ◽  
H J Adèr ◽  
L EMA Pfennings ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Test Scores ◽  
Neuropsychological Tests ◽  
Word List ◽  
Normative Values ◽  
Gender And Education ◽  
Selective Reminding ◽  
Repeatable Battery ◽  
Serial Addition ◽  
Selective Reminding Test

The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is a sensitive measure of cognitive impairment in multiple sclerosis (MS) patients. It consists of the Selective Reminding Test, the 10/36 Spatial Recall Test, the Symbol Digit Modalities Test, the Paced Auditory Serial Addition Test and the Word List Generation Test. We administered one of two parallel versions of the test battery to 140 healthy subjects to produce normative values for both versions. As expected, test scores were influenced by certain variables like age, gender and education. Although constructed as two equivalent versions, for some tests the two versions showed significant differences in test scores, which could not be explained by differences in these variables.

scholarly journals Computerized neuropsychological assessment devices in multiple sclerosis: A systematic review

2019 ◽  
Vol 25 (14) ◽  
pp. 1848-1869 ◽  
Author(s):  
Curtis M Wojcik ◽  
Meghan Beier ◽  
Kathleen Costello ◽  
John DeLuca ◽  
Anthony Feinstein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Neuropsychological Assessment ◽  
Vital Signs ◽  
Reliability And Validity ◽  
Good Evidence ◽  
Computerized Testing ◽  
Online Databases ◽  
Computer Based ◽  
Test Retest Reliability

Background: The proliferation of computerized neuropsychological assessment devices (CNADs) for screening and monitoring cognitive impairment is increasing exponentially. Previous reviews of computerized tests for multiple sclerosis (MS) were primarily qualitative and did not rigorously compare CNADs on psychometric properties. Objective: We aimed to systematically review the literature on the use of CNADs in MS and identify test batteries and single tests with good evidence for reliability and validity. Method: A search of four major online databases was conducted for publications related to computerized testing and MS. Test–retest reliability and validity coefficients and effect sizes were recorded for each CNAD test, along with administration characteristics. Results: We identified 11 batteries and 33 individual tests from 120 peer-reviewed articles meeting the inclusion criteria. CNADs with the strongest psychometric support include the CogState Brief Battery, Cognitive Drug Research Battery, NeuroTrax, CNS-Vital Signs, and computer-based administrations of the Symbol Digit Modalities Test. Conclusion: We identified several CNADs that are valid to screen for MS-related cognitive impairment, or to supplement full, conventional neuropsychological assessment. The necessity of testing with a technician, and in a controlled clinic/laboratory environment, remains uncertain.

Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test

2006 ◽  
Vol 12 (2) ◽  
pp. 187-195 ◽  
Author(s):  
J Sepulcre ◽  
S Vanotti ◽  
R Hernández ◽  
G Sandoval ◽  
F Cáceres ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Educational Level ◽  
Physical Disability ◽  
Healthy Controls ◽  
Z Score ◽  
Disabled Patients ◽  
Repeatable Battery ◽  
And Performance ◽  
Cognitive Measurement

Aims To assess the cognitive impairment of multiple sclerosis (MS) patients using the Brief Repeatable Battery-Neuropsychology (BRB-N) test. Methods The performance of 59 patients with MS in the BRB-N test was assessed and compared with 152 matched healthy controls (HC). Results In most tests, MS patients performed worse than controls. Age and educational level strongly influenced the performance of the subjects. The Symbol Digit Modality Test (SDMT) best correlated with the other individual tests and contributed most to the general BRB-N factor. Furthermore, a correlation between physical disability and performance in some BRB-N tests was observed. Indeed, patients with progressive MS and greater physical disability performed worse in some tests than less disabled patients with relapsing MS. By creating a global BRB-N Z score, we found that patients generally performed 0.7 standard deviation (SD) below the level of controls. We obtained cut-off values stratified by age and education to determinate cognitive impairment in MS patients. Conclusions Our data show that cognitive impairment is prevalent amongst MS patients, and that a single cognitive measurement might be useful for monitoring patients during the progression of this illness.

scholarly journals Normative values of the Brief Repeatable Battery of Neuropsychological Tests in a Brazilian population sample: discrete and regression–based norms

2018 ◽  
Vol 76 (3) ◽  
pp. 163-169 ◽  
Author(s):  
Alfredo Damasceno ◽  
Juliana Machado Santiago dos Santos Amaral ◽  
Amilton Antunes Barreira ◽  
Jefferson Becker ◽  
Dagoberto Callegaro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Educational Level ◽  
Neuropsychological Tests ◽  
Normative Data ◽  
Population Sample ◽  
Brazilian Population ◽  
Normative Values ◽  
Healthy Individuals ◽  
Repeatable Battery ◽  
Healthy Participants

ABSTRACT Objective Cognitive dysfunction is common in multiple sclerosis. The Brief Repeatable Battery of Neuropsychological Tests (BRB–N) was developed to assess cognitive functions most–frequently impaired in multiple sclerosis. However, normative values are lacking in Brazil. Therefore, we aimed to provide continuous and discrete normative values for the BRB–N in a Brazilian population sample. Methods We recruited 285 healthy individuals from the community at 10 Brazilian sites and applied the BRB–N version A in 237 participants and version B in 48 participants. Continuous norms were calculated with multiple–regression analysis. Results Mean raw scores and the 5th percentile for each neuropsychological measure are provided, stratified by age and educational level. Healthy participants' raw scores were converted to scaled scores, which were regressed on age, sex and education, yielding equations that can be used to calculate predicted scores. Conclusion Our normative data allow a more widespread use of the BRB–N in clinical practice and research.

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